Morfoanatomia das partes vegetativas aéreas das espécies medicinais Holocalyxn Balansae Micheli, Patagonula Americana L. E Prunus Brasiliensis Dietrich

Orientadora : Profa. Dra. Marcia do Rocio DuarteDissetação (mestrado) - Universidade Federal do Paraná, Setor de Ciências da Saúde, Programa de Pós-Graduação em Ciências Farmacêuticas. Defesa: Curitiba,26/03/2010Bibliografia: fls. 61-68Área de concentração: Insumos, medicamentos e correlatosResumo: Pertencentes à flora nativa, Holocalyx balansae Micheli (Fabaceae), conhecido popularmente como pau-alecrim, Patagonula americana L. (Boraginaceae), denominado de guajuvira, e Prunus brasiliensis Dietrich (Rosaceae), vulgarmente referido como pessegueiro-do-mato, são espécies arbóreas, cujas folhas e caules são utilizados na medicina popular com diferentes propósitos. Objetivando-se agregar conhecimento à flora brasileira e contribuir na identificação farmacognóstica de potenciais drogas vegetais, este trabalho estudou a morfoanatomia das partes vegetativas aéreas dessas plantas medicinais. Folhas adultas e fragmentos de caules jovens foram fixados, seccionados à mão livre ou emblocados em glicol-metacrilato e seccionados em micrótomo, sendo os cortes obtidos posteriormente corados. Paralelamente, foram realizados testes microquímicos usuais e microscopia eletrônica de varredura. Holocalyx balansae possui folhas alternas, compostas, com folíolos paripinados. Estes são lanceolados e têm estômatos anomocíticos e anisocíticos restritos à face abaxial da epiderme e mesofilo dorsiventral. A nervura central mostra secção transversal plana e um feixe vascular colateral circundado por bainhas esclerenquimática e cristalífera. O caule tem uma bainha esclerenquimática composta de fibras e células pétreas, envolvendo os cilindros floemático e xilemático. Alguns tricomas tectores ocorrem no pecíolo e no caule. Cristais prismáticos de oxalato de cálcio e compostos fenólicos estão presentes na folha e no caule. Em P. americana encontram-se folhas alternas, simples, elíptico-obovadas e levemente serrilhadas. A folha é hipoestomática, com estômatos anomocíticos. Possui mesofilo dorsiventral, e nervura central com secção plano-convexa e vários feixes colaterais em arco fechado. No caule, ocorre uma bainha esclerenquimática incompleta ao redor do sistema vascular. O floema é estratificado e cuneiforme. Compostos fenólicos e cristais de oxalato de cálcio são encontrados na folha e no caule. As folhas de P. brasiliensis são alternas, simples, elípticas a lanceoladas e de margem lisa. São hipoestomáticas, com estômatos anomocíticos. O mesofilo é dorsiventral. A nervura central possui secção côncavo-convexa e um feixe vascular colateral em arco aberto. No caule, há cilindros floemático e xilemático contínuos, sendo que ocorrem grupos de fibras no floema. Compostos fenólicos e drusas de oxalato de cálcio encontram-se na folha e no caule. Quando considerados em conjunto para cada espécie, os caracteres descritos são úteis na identificação dessas plantas medicinais nativas.Abstract: Belonging to the native flora, Holocalyx balansae Micheli (Fabaceae), popularly known as pau-alecrim in Portuguese, Patagonula americana L. (Boraginaceae), called guajuvira, and Prunus brasiliensis Dietrich (Rosaceae), commonly referred as pessegueiro-do-mato, are woody species whose leaves and stems are used in folk medicine for different purposes. Aiming to expand knowledge on Brazilian flora and contribute for the pharmacognostic identification of potential vegetal drugs, this work has studied the morpho-anatomy of aerial vegetative organs of these medicinal plants. Fully-grown leaves and fragments of young stems were fixed, either sectioned by free-hand or embedded in glycol-methacrylate and sectioned by microtome, and then the sections were stained. In parallel, standard microchemical tests and scanning electron microscopy were performed as well. Holocalyx balansae has alternate, compound leaves, with paripinnate leaflets. These are lanceolate and have anomocytic and anisocytic stomata confined to the abaxial side of the epidermis, and dorsiventral mesophyll. The midrib shows plano cross-section and one collateral vascular bundle encircled by sclerenchymatic and crystalliferous sheaths. The stem has a sclerenchymatic sheath consisting of fibres and stone cells involving the phloem and xylem cylinders. Some non-glandular trichomes occur in the petiole and stem. Calcium oxalate prisms and phenolic substances are present in the leaf and stem. In P. americana it is found alternate, simple and elliptic-obovate leaves with a slightly serrate margin. The leaf is hypostomatic, with anomocytic stomata. It has dorsiventral mesophyll and a plano-convex midrib with various collateral vascular bundles in open arc. In the stem, it occurs an incomplete sclerenchymatic sheath enclosing the vascular system. The phloem is stratified and cuneiform. Phenolic substances and calcium oxalate crystals are encountered in the leaf and stem. The leaves of P. brasiliensis are alternate, simple, elliptic to lanceolate, with straight margin. They are hypostomatic, with anomocytic stomata. The mesophyll is dorsiventral. The midrib has concave-convex cross-section and one collateral vascular bundle in open arc. In the stem, there are complete phloem and xylem cylinders, and groups of fibres occur in the phloem. Phenolic substances and calcium oxalate druses are encountered in the leaf and stem. The described characters, considered all together for each species, are useful for the identification of these medicinal plants

Síntese de porfirinas C-Alditol e C-Glicosídeo meso-substituídas

Orientador : Prof. Dr. Alan Guilherme GonçalvesCoorientadora : Profª. Drª. Sandra Mara BarreiraTese (doutorado) - Universidade Federal do Paraná, Setor de Ciências da Saúde, Programa de Pós-Graduação em Ciências Farmacêuticas. Defesa: Curitiba, 30/03/2015Inclui referências : fls. 204-217Resumo: As glicoporfirinas têm chamado a atenção nos últimos anos devido a potencial ação sítio-específica proporcionada pela porção glicídica destes compostos na terapia fotodinâmica (PDT) do câncer e na fotoinativação de micro-organismos (PDI). Uma das formas de ligação entre porfirinas e carboidratos consiste na formação de uma nova ligação carbono-carbono, dando origem a porfirinas do tipo C-alditol ou Cglicosídeo. Em geral, C-glicosídeos são reconhecidos por apresentar alta estabilidade frente a enzimas em meios biológicos. Este trabalho compreendeu o desenvolvimento de rotas sintéticas voltadas à obtenção de porfirinas C-alditol e Cglicosídeo meso-substituídas com potencial aplicação na PDT e PDI. Para tal, a abordagem sintética desenvolvida no presente trabalho envolveu o preparo de intermediários dietilditioacetal peracetilados (e outros grupos protetores) de três monossacarídeos (galactose, glucose e manose), um dissacarídeo (lactose) e um dissacarídeo derivado de polissacarídeo (agarose). Os derivados dietilditioacetais foram convertidos em dipirrometanos, sendo os mesmos empregados na síntese das porfirinas correspondentes. Foram avaliadas diferentes condições de síntese de porfirinas através da utilização de TFA ou BF3O(Et)2 como catalisadores, e SeO2 ou DDQ como agentes oxidantes. Este estudo deu origem a 24 novas porfirinas Calditol e C-glicosídeo meso-substituídas, nas quais incluem-se derivados apresentando diferentes grupos protetores na porção glicídica, diferentes grupos aromáticos (fenil, pentafluorofenil e piridil) ligados às posições meso, derivados neutros e catiônicos, e derivados C-alditol ?,?-insaturados. Ainda, quatro clorinas Calditol foram sintetizadas. Parte das porfirinas sintetizadas foram submetidas a estudos conformacionais baseados em ressonância magnética nuclear (RMN) e estudos fotofísicos. Adicionalmente, comparou-se a atividade antitumoral de porfirinas acetiladas e desacetiladas frente às células UM-MC-3. As porfirinas testadas não apresentaram citotoxicidade na ausência de luz. Os resultados reportados neste trabalho mostraram a porfirina 49 (porfirina C-alditol desacetilada, derivada da galactose) como um agente terapêutico promissor no tratamento de câncer de bexiga por PDT. Palavras-chave: Porfirinas, glicoporfirinas, terapia fotodinâmica, inativação fotodinâmica.Abstract: Glycoporphyrins have become of interest because of the current effort to develop target-specific photosensitizers, which are promising in the photodynamic therapy (PDT) for cancer and in the photoinactivation of microorganisms (PDI). One of the forms of connecting porphyrins to carbohydrates is based on the formation of a new carbon-carbon bond, giving rise to compounds known as C-alditolporphyrins and C-glycoporphyrins. C-Glycosides are recognized by their high stability in biological media. The aim of this work was the development of synthetic routes to prepare meso-substituted C-alditolporphyrins and C-glycoporphyrins with potential application in PDT and PDI. For this purpose, the synthetic approach herein developed involved the preparation of hydroxy-protected diethyl dithioacetals intermediates from three monosaccharides (galactose, glucose and mannose), a disaccharide (lactose) and a disaccharide obtained from a polysaccharide (agarose). The diethyl dithioacetals derivatives were converted into dipyrranes, which were employed for the synthesis of the corresponding porphyrins. Different conditions of porphyrins synthesis were evaluated by using TFA or BF3O(Et)2 as catalyst, and SeO2 or DDQ as oxidizing agent. This study allowed the synthesis of 24 new meso-substituted Calditolporphyrins and C-glycoporphyrins, including derivatives presenting different hydroxy-protecting groups on the carbohydrate moiety, different aromatic groups (phenyl, pentafluorophenyl and pyridyl) attached to meso positions, neutral and cationic derivatives, and ?,?-unsaturated C-alditolporphyrins. Furthermore, four Calditolchlorins could also be obtained. Part of the porphyrins synthesized were submitted to conformational studies based on nuclear magnetic resonance (NMR) and photophysical studies. In addition, the antitumor activity of the acetylated and deacetylated porphyrins on UM-MC-3 cells was evaluated. The porphyrins tested showed no cytotoxicity in the absence of light. The results reported herein indicated porphyrin 49 (deacetylated C-alditolporphyrin derived from galactose) as a promising therapeutic agent for the treatment of bladder cancer by PDT. Key-words: Porphyrins, glycoporphyrins, photodynamic therapy, photodynamic inactivation

Síntese de porfirinas e glicoporfirinas : utilização do dióxido de selênio (SeO2) como agente oxidante

Orientador : Prof. Dr. Alan Guilherme GonçalvesCo-orientador : Profª Drª Sandra M.W. BarreiraDissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências da Saúde, Programa de Pós-Graduação em Ciências Farmacêuticas. Defesa: Curitiba, 22/02/2011Inclui referênciasÁrea de concentração: Insumos, medicamentos e correlatosResumo: A sintese de glicoporfirinas atrai grande interesse devido as suas aplicacoes, tais como na terapia fotodinamica do cancer e inativacao de micro-organismos. Mesotetra- arilporfirinas podem ser sintetizadas a partir de pirrol e aldeidos, numa reacao catalisada por um acido (normalmente, BF3O(Et)2 ou TFA), seguindo-se de uma oxidacao (com DDQ ou p-cloranil). Neste trabalho, o passo oxidativo foi realizado com o SeO2, um oxidante heterogeneo, ao inves das quinonas tradicionalmente utilizadas, DDQ ou p-cloranil. Foram avaliadas as quantidades de BF3O(Et)2 ou I2 necessarias para a etapa inicial de condensacao em combinacao com um excesso de SeO2, definindo as novas condicoes de sintese de porfirinas, as quais empregaram benzaldeido e pirrol (ou 5-fenildipirrometano) como materiais iniciais. As condicoes brandas de reacao aliadas a simplicidade da purificacao dos produtos, torna este metodo uma boa opcao para a sintese deste tipo de composto. Alem disso, dois compostos ineditos na literatura foram sintetizados: -(1-desoxi)- 2,3,4,5,6-penta-O-acetil-D-galactitoldipirrometano e ,10-[bis(fenil)]-10ƒ¿,20ƒÀ-[bis(1- desoxi)-2,3,4,5,6-penta-O-acetil-D-galactitol]porfirina.Abstract: The synthesis of glycoporphyrins attracts widespread interest because of their potential applications as photodynamic cancer therapy and inactivation of microorganisms. Meso-tetraarylporphyrins are synthesized from pyrrole and aldehydes by the use of catalytic amounts of BF3O(Et)2 or TFA and DDQ or pchloranil as oxidant, in a two-step, one flask procedure. In this work, the oxidative step was herein conducted with heterogeneous oxidant SeO2 instead of the usual quinones DDQ or p-chloranil. Evaluation of BF3O(Et)2 or I2 amount for the condensation first step combined with excess of SeO2 defined orphyrin synthesis conditions employing benzaldehydes and pyrrole (or 5-phenyldipyrromethane) as starting materials. The simplicity of the workup, allied with reaction mild conditions, makes this method a good option for the synthesis of this kind of compound. Furthermore, two new compounds were synthesized: 5-(1-deoxy)-,2,3,4,5,6-O-acetyl- D-galactitol dipyrromethane and ,10-[bis(phenil)]-10á,20â-[bis(1-deoxy)-2,3,4,5,6- enta-O-acetyl-D-galactitol] porphyrin

Consulta de enfermagem pré-operatória em cirurgia de ambulatório: importância para a satisfação do utente

A cirurgia de ambulatório em Portugal intensificou-se desde 2007 e têm-se repercutido em maior satisfação dos utentes, na diminuição do tempo de internamento e na diminuição do risco de infeções adquiridas em cuidados de saúde. Demonstrando assim, várias vantagens para o utente, como a desdramatização do ato operatório, o menor afastamento da vida familiar, a personalização da admissão e a mais rápida reinserção familiar e profissional. Objetivo geral: analisar a relação entre a consulta de enfermagem pré-operatória com a informação, as expectativas e a satisfação dos utentes numa unidade de cirurgia de ambulatório de uma unidade local de saúde do norte de Portugal. Metodologia: estudo transversal analítico, realizado em 140 utentes, que foram submetidos a cirurgia de ambulatório e preencheram na totalidade o inquérito de satisfação, 20 por cada umas das 7 especialidades, no período de 25 de novembro de 2019 e 13 de março de 2020. Os dados foram transpostos para grelha de registos. O estudo obteve favorável da comissão de ética. Resultados: tiveram consulta de enfermagem 14,3% dos utentes, da especialidade de cirurgia geral, 66,4% concorda que teve informação necessária para a cirurgia proposta, 65,7% concorda ligeiramente que a experiência cirúrgica esteve dentro das expectativas, 76,4% está completamente satisfeita relativamente à sua experiência cirúrgica. A consulta de enfermagem associou-se, significativamente, com informação necessária para a cirurgia proposta, com as expectativas cirúrgicas do utente e satisfação do utente relativamente à experiência cirúrgica (p<0,05). Conclusão: concluímos que os utentes que tiveram consulta pré-operatória de enfermagem, obtêm mais informação para a cirurgia proposta, melhoram as expectativas e a satisfação relativamente à experiência cirúrgica são mais elevadas. Sugerimos que seja implementada a consulta de enfermagem a todos os utentes intervencionados e a realização de outros estudos capazes de permitir generalizações.Outpatient surgery in Portugal has intensified since 2007 and has resulted in greater user satisfaction, reduced hospital stay and reduced risk of infections acquired in healthcare. Thus demonstrating several advantages for the user, such as the reduction of dramatization of the operative act, less separation from family life, personalization of admission and faster family and professional reintegration. General objective: to analyze the relationship between the preoperative nursing consultation and the information, expectations and satisfaction of users in an outpatient surgery unit of a local health unit in the north of Portugal. Methodology: analytical cross-sectional study, carried out on 140 users, who underwent outpatient surgery and fully completed the satisfaction survey, 20 for each of the 7 specialties, between November 25, 2019 and March 13, 2020. The data was transposed to the grid of records. The study received a favorable opinion from the ethics committee. Results: 14.3% of the users had a nursing consultation, from the general surgery specialty, 66.4% agreed that they had the necessary information for the proposed surgery, 65.7% slightly agree that the surgical experience was within expectations, 76, 4% are completely satisfied with their surgical experience. The nursing consultation was significantly associated with the information needed for the proposed surgery, with the patient's surgical expectations and the patient's satisfaction with the surgical experience (p<0.05). Conclusion: we concluded that users, who had a preoperative nursing consultation, obtain more information for the proposed surgery, improve expectations and satisfaction with the surgical experience are higher. We suggest the implementation of the nursing consultation for all users involved and that other studies be carried out capable of allowing generalizations

Leaf and stem morpho-anatomy of Cordia americana (L.) Gottschling & J.S. Mill., Boraginaceae

Cordia americana (L.) Gottschling & J.S. Mill. is a tree which belongs to the Boraginaceae family and is native to the South of Brazil, Paraguay and Argentine, where it is commonly known as guajuvira and guayaibí. In folk medicine, the leaves are used as emollient, antimicrobial and anti-inflammatory, as well as the stem has antidiarrheal and hepatoprotective effects. Preliminary phytochemical studies have shown the presence of tannins, coumarins, quinones and cinnamaldehyde derivatives. This work has investigated the leaf and stem morpho-anatomy of C. americana, in order to contribute to the pharmacognostic quality control. Samples of adult leaves and young stems were fixed, either sectioned by freehand or embedded in glycol methacrylate and sectioned by microtome, and then the sections were stained. In parallel, microchemical tests and scanning electron microscopy were also performed. The leaves are alternate, simple, elliptic-obovate and slightly serrate. Anomocytic stomata occur on the abaxial surface. The mesophyll is dorsiventral and the midrib has a plano-convex cross-section and various collateral vascular bundles in closed arc. In the stem, it is encountered phellogen installed superficially and a discontinuous sclerenchymatic sheath encircling the vascular system. The phloem is stratified and cuneiform. Phenolic compounds and calcium oxalate crystals are present in the leaf and stem.Colegio de Farmacéuticos de la Provincia de Buenos Aire

A design method for robust and quadratic optimal MIMO linear controllers

a b s t r a c t In this paper a design method was formulated to deal with robustness and performance specifications for any MIMO linear controller. The controller tuning procedure was expressed as an optimization problem in which novel time-domain integrals of the weighted squared error and weighted squared control signals, with initial state zero and inputs not necessarily defined over the Lebesgue normed space ðL 2 þ Þ, were minimized. The control robustness is achieved by constraining the minimization such that the maximum complex/real ratio of the closed-loop control system eigenvalues was lower than one. The proposed tuning method was applied in the design of linear controllers with PID structure for a CSTR with disturbance noise and a nonlinear CSTR with control signal saturations, both reported in literature. The results show that the proposed control systems surpass the performance and robustness characteristics of the controllers designed with other reported methods

Pharmacokinetic-Pharmacodynamic Modeling of the Antinociceptive Effect of Diclofenac in the Rat 1

ABSTRACT The relationship between the pharmacokinetics and the antinociceptive effect of diclofenac was evaluated using the paininduced functional impairment model in the rat. Male Wistar rats were injected with uric acid in the knee joint of the right hind limb, which induced its dysfunction. Once the dysfunction was complete, animals received a p.o. dose of 0.56, 1, 1.8, 3.2, 5.6 or 10 mg/kg of sodium diclofenac, and the antinociceptive effect and drug blood concentration were simultaneously evaluated at selected times for a period of 6 h. Diclofenac produced a dose-dependent antinociceptive effect, measured as a recovery of the functionality of the injured limb. However, the onset of the antinociceptive effect was delayed with respect to blood concentrations. Moreover, the effect lasted longer than expected from pharmacokinetic data. Therefore, when functionality index was plotted against diclofenac blood concentration, an anticlockwise hysteresis loop was observed for all doses. Hysteresis collapse was achieved using the effect-compartment model, and the plot of functionality index against diclofenac concentration in the effect-compartment data was well fitted by the sigmoidal E max model. Our data suggest slow equilibrium kinetics between diclofenac concentration in blood and at its site of action, which leads to a delayed onset of the antinociceptive effect as well as a longer duration of the response resulting from drug accumulation in synovial fluid. Diclofenac is an NSAID that has been shown to be effective for relieving pain in rheumatic and nonrheumatic diseases On the other hand, it has been established that the relationship between pharmacokinetic properties and pharmacologic effect is the basis for a more rational drug regimen design, because it allows prediction of the time course of the intensity of the effect There are reports wherein the anti-inflammatory and antinociceptive effect of diclofenac cannot be directly explained by circulating concentrations in animals Materials and Methods Animals. Male Wistar rats (weighing, 180-220 g) from our own breeding facilities [Crl:(WI)BR], were used in this study. Animals were housed in a room with controlled temperature (22 Ϯ 1°C) for at least 2 days before the study. Food was withheld for 12 h before the Received for publication May 10, 1996. 1 This work is supported by CONACYT, grant 0250-M. ABBREVIATIONS: AUC, area under the blood concentration-time curve; AUC E , area under the functionality index-time curve; C, blood concentration; C max , maximal concentration; E max , maximal effect; E max obs , maximal observed effect; Ke0, transference rate constant from site effect; PIFIR, pain-induced functional impairment model in the rat; PE, polyethylene; NSAID, nonsteroidal anti-inflammatory drug; FI, functionality index

O valor das árvores: árvores e floresta urbana de Lisboa

Doutoramento em Arquitectura Paisagista - Instituto Superior de AgronomiaO objectivo desta dissertação é apresentar os benefícios das árvores urbanas como entidades mensuráveis. Desde há muito que são conhecidos os benefícios da presença de árvores na cidade e, no entanto, são recentes os estudos e a sistematização destes benefícios, incidindo sobre factores como temperatura do ar, ensombramento, qualidade do ar, melhoria de hidrologia urbana, controle da erosão, aumento da biodiversidade, redução do ruído, economia de energia e, ainda, benefícios mais dificilmente mensuráveis como os estéticos, psicológicos e socioeconómicos. Desde 2002 recolheram-se dados relativos a parâmetros biofísicos, sob a influência do copado e sem ele, tendo-se elaborado um estudo de conforto bioclimático. Em 2004 realizaram-se inquéritos com vista à abordagem dos benefícios socioeconómicos, psicológicos e de frequência de uso das áreas arborizadas de Lisboa. O aprofundamento da revisão bibliográfica e de modelos testados para quantificar os vários benefícios das árvores urbanas, levaram ao conhecimento do programa STRATUM e à aplicação prática deste modelo a Lisboa. Os resultados dos benefícios líquidos da presença das árvores de arruamento de Lisboa, obtidos pelo modelo, indicam efectivos benefícios quanto à poupança de energia e melhoria da qualidade do ar mas sobretudo relativamente à redução dos picos de cheia no sistema de hidrologia urbana bem como no aumento do valor imobiliário das propriedades vizinhas

Influence of multiple infection and relatedness on virulence: Disease dynamics in an experimental plant population and its castrating parasite. PLoS One 2014

Abstract The level of parasite virulence, i.e., the decrease in host&apos;s fitness due to a pathogen, is expected to depend on several parameters, such as the type of the disease (e.g., castrating or host-killing) and the prevalence of multiple infections. Although these parameters have been extensively studied theoretically, few empirical data are available to validate theoretical predictions. Using the anther smut castrating disease on Silene latifolia caused by Microbotryum lychnidis-dioicae, we studied the dynamics of multiple infections and of different components of virulence (host death, non-recovery and percentage of castrated stems) during the entire lifespan of the host in an experimental population. We monitored the number of fungal genotypes within plants and their relatedness across five years, using microsatellite markers, as well as the rates of recovery and host death in the population. The mean relatedness among genotypes within plants remained at a high level throughout the entire host lifespan despite the dynamics of the disease, with recurrent new infections. Recovery was lower for plants with multiple infections compared to plants infected by a single genotype. As expected for castrating parasites, M. lychnidis-dioicae did not increase host mortality. Mortality varied across years but was generally lower for plants that had been diseased the preceding year. This is one of the few studies to have empirically verified theoretical expectations for castrating parasites, and to show particularly i) that castrated hosts live longer, suggesting that parasites can redirect resources normally used in reproduction to increase host lifespan, lengthening their transmission phase, and ii) that multiple infections increase virulence, here in terms of non-recovery and host castration

Are quality and innovation management conflicting activities?

a b s t r a c t It is commonplace to assert that hard components of quality management inhibit innovation. In fact, the relationship between these two activities (quality and innovation management) is complex and, as claimed in this paper, bi-directional. Some recent works suggest that innovative companies are used to change management and therefore would find adopting quality management routines less demanding and less expensive than non-innovative companies. This paper builds on this view and proposes that innovation capabilities linked to certain valuable resources (better conditions) favor the implementation of hard components of total quality management. Innovation capabilities are key dynamic capabilities accumulated over time. In order to capture their complexities, they are modeled in a broad manner including both product and process innovations, as well as R&amp;D and high technological level. For verifying the hypotheses, a random-effect probit model is tested on a large multi-industry panel of Spanish firms. Unobservable individual heterogeneity and time effects are controlled with this approach, which means a noteworthy improvement over previous research. The results strongly confirm the positive link between innovation capabilities and quality management. It is also demonstrated that some resources of the firm facilitate standardization and quality control activities. These findings have important managerial implications. On the one hand, developing innovation capabilities will permit companies to be proactive in the adoption of standardized management systems. On the other hand, quality and innovation departments should cooperate in order to ease the standardization of new products and processes