Les enjeux quotidiens avec lesquels doivent vivre les personnes schizophrènes désinstitutionnalisées de la région des Bois-Francs : le point de vue d'intervenants spécialisés

Affiche présentée dans le cadre du colloque de l'ARC "La gestion de la propriété intellectuelle : courants de pensée et facteurs de succès", lors du 81e Congrès de l'Acfas à l'Université Laval, le 8 mai 2013.Le deuxième prix ex aequo a été décerné à Geneviève Rivard au concours des Prix étudiants 2012-2013 de l'ARC.Dans le monde, une personne sur cent souffre de schizophrénie. Or ce trouble reste méconnu, malgré les souffrances qui y sont associées. Peu de chercheurs ont étudié les enjeux sociaux entourant la vie des schizophrènes. La présente recherche décrit ces enjeux selon le point de vue d'intervenants en santé mentale. Les résultats obtenus nous informent sur la vie quotidienne des schizophrènes et sur leurs relations avec leur entourage. Suit une discussion sur les relations interpersonnelles difficiles des personnes atteintes ainsi que les préjugés entretenus par la population

L'usage des sources primaires dans les manuels du secondaire en Histoire et éducation à la citoyenneté au Québec

Le Renouveau pédagogique, mis en place au Québec en 2005 à l’ordre secondaire, a eu pour effet de forcer plusieurs enseignants à remettre en question leurs pratiques pédagogiques avec l’approche par compétences. Considérant que les recherches sur l’ancien programme d’histoire ont démontré que les enseignants utilisaient la plupart du temps le manuel comme outil unique, que les manuels contenaient peu de sources primaires et que l’usage de sources est maintenant prescrit par le ministère de l’Éducation, du Loisir et du Sport, nous analysons dans cette recherche l’usage des sources primaires dans les nouveaux manuels d’Histoire et éducation à la citoyenneté du niveau secondaire. L’analyse de nos résultats nous a permis de fournir les outils nécessaires afin de répondre à notre question de recherche. Nous avons constaté la présence majoritaire des sources primaires dans les manuels. Par contre, celles-ci n’étaient pas toujours incluses dans une situation d’apprentissage avec au moins une compétence disciplinaire et, dans encore moins de cas, dans une tâche complexe en lien avec la méthode historique.Educational Renewal, established in Quebec in 2005 at the secondary level had the effect of forcing many teachers to question their teaching practices with the skills approach. Considering that research on the old history program showed that teachers used mostly textbook as a unique tool, that contained few primary sources and these sources are now prescribed by the ministry of Education, Recreation and Sport, we determine in this research the use of primary sources in the new history and citizenship education textbooks of at the secondary level. The analysis of our results allowed us to provide the tools necessary to answer our research question. Our first observation was to note the presence of the majority of primary sources in the textbooks. They were not always included in a learning situation, including at least one of disciplinary skill and, in even fewer cases, in a complex task in connection with the historical method

Can ‘Hebb’ Be Distracted? Testing the Susceptibility of Sequence Learning to Auditory Distraction

Sequence learning plays a key role in many daily activities such as language and skills acquisition. The present study sought to assess the nature of the Hebb repetition effect—the enhanced serial recall for a repeated sequence of items compared to random sequences—by examining the vulnerability of this classical sequence-learning phenomenon to auditory distraction. Sound can cause unwanted distraction by either interfering specifically with the processes involved in the focal task (interference-by-process), or by diverting attention away from a focal task (attentional capture). Participants were asked to perform visual serial recall, in which one to-be-remembered sequence was repeated every four trials, while ignoring irrelevant sound. Whereas both changing-state (Experiment 1) and deviant sounds (Experiment 2) disrupted recall performance compared to steady-state sounds, performance for the repeated sequence increased across repetitions at the same rate regardless of the sound condition. Such findings suggest that Hebbian sequence learning is impervious to environmental interference, which provides further evidence that the Hebb repetition effect is an analogue of word-form learning

Electric potential across epidermis and its role during wound healing can be studied by using an in vitro reconstructed human skin

Background : After human epidermis wounding, transepithelial potential (TEP) present in nonlesional epidermis decreases and induces an endogenous direct current epithelial electric field (EEF) that could be implicated in the wound re-epithelialization. Some studies suggest that exogenous electric stimulation of wounds can stimulate healing, although the mechanisms remain to be determined. The Problem : Little is known concerning the exact action of the EEF during healing. The mechanism responsible for TEP and EEF is unknown due to the lack of an in vitro model to study this phenomenon. Basic Science Advances : We carried out studies by using a wound created in a human tissue-engineered skin and determined that TEP undergoes ascending and decreasing phases during the epithelium formation. The in vitro TEP measurements over time in the wound were corroborated with histological changes and with in vivo TEP variations during porcine skin wound healing. The expression of a crucial element implicated in Na+ transport, Na+/K+ ATPase pumps, was also evaluated at the same time points during the re-epithelialization process. The ascending and decreasing TEP values were correlated with changes in the expression of these pumps. The distribution of Na+/K+ ATPase pumps also varied according to epidermal differentiation. Further, inhibition of the pump activity induced a significant decrease of the TEP and of the re-epithelization rate. Clinical Care Relevance : A better comprehension of the role of EEF could have important future medical applications regarding the treatment of chronic wound healing. Conclusion : This study brings a new perspective to understand the formation and restoration of TEP during the cutaneous wound healing process

The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection

Autoantibodies to components of apoptotic cells, such as anti-perlecan antibodies, contribute to rejection in organ transplant recipients. However, mechanisms of immunization to apoptotic components remain largely uncharacterized. We used large-scale proteomics, with validation by electron microscopy and biochemical methods, to compare the protein profiles of apoptotic bodies and apoptotic exosome-like vesicles, smaller extracellular vesicles released by endothelial cells downstream of caspase-3 activation. We identified apoptotic exosome-like vesicles as a central trigger for production of anti-perlecan antibodies and acceleration of rejection. Unlike apoptotic bodies, apoptotic exosome-like vesicles triggered the production of anti-perlecan antibodies in naïve mice and enhanced anti-perlecan antibody production and allograft inflammation in mice transplanted with an MHC (major histocompatibility complex)–incompatible aortic graft. The 20S proteasome core was active within apoptotic exosome-like vesicles and controlled their immunogenic activity. Finally, we showed that proteasome activity in circulating exosome-like vesicles increased after vascular injury in mice. These findings open new avenues for predicting and controlling maladaptive humoral responses to apoptotic cell components that enhance the risk of rejection after transplantation

SARS-CoV-2 spike antigen-specific B cell and antibody responses in pre-vaccination period COVID-19 convalescent males and females with or without post-covid condition

BackgroundFollowing SARS-CoV-2 infection a significant proportion of convalescent individuals develop the post-COVID condition (PCC) that is characterized by wide spectrum of symptoms encompassing various organs. Even though the underlying pathophysiology of PCC is not known, detection of viral transcripts and antigens in tissues other than lungs raise the possibility that PCC may be a consequence of aberrant immune response to the viral antigens. To test this hypothesis, we evaluated B cell and antibody responses to the SARS-CoV-2 antigens in PCC patients who experienced mild COVID-19 disease during the pre-vaccination period of COVID-19 pandemic.MethodsThe study subjects included unvaccinated male and female subjects who developed PCC or not (No-PCC) after clearing RT-PCR confirmed mild COVID-19 infection. SARS-CoV-2 D614G and omicron RBD specific B cell subsets in peripheral circulation were assessed by flow cytometry. IgG, IgG3 and IgA antibody titers toward RBD, spike and nucleocapsid antigens in the plasma were evaluated by ELISA.ResultsThe frequency of the B cells specific to D614G-RBD were comparable in convalescent groups with and without PCC in both males and females. Notably, in females with PCC, the anti-D614G RBD specific double negative (IgD-CD27-) B cells showed significant correlation with the number of symptoms at acute of infection. Anti-spike antibody responses were also higher at 3 months post-infection in females who developed PCC, but not in the male PCC group. On the other hand, the male PCC group also showed consistently high anti-RBD IgG responses compared to all other groups.ConclusionsThe antibody responses to the spike protein, but not the anti-RBD B cell responses diverge between convalescent males and females who develop PCC. Our findings also suggest that sex-related factors may also be involved in the development of PCC via modulating antibody responses to the SARS-CoV-2 antigens

SARS-CoV-2 spike antigen-specific B cell and antibody responses in pre-vaccination period COVID-19 convalescent males and females with or without post-covid condition

Background Following SARS-CoV-2 infection a significant proportion of convalescent individuals develop the post-COVID condition (PCC) that is characterized by wide spectrum of symptoms encompassing various organs. Even though the underlying pathophysiology of PCC is not known, detection of viral transcripts and antigens in tissues other than lungs raise the possibility that PCC may be a consequence of aberrant immune response to the viral antigens. To test this hypothesis, we evaluated B cell and antibody responses to the SARS-CoV-2 antigens in PCC patients who experienced mild COVID-19 disease during the pre-vaccination period of COVID-19 pandemic. Methods The study subjects included unvaccinated male and female subjects who developed PCC or not (No-PCC) after clearing RT-PCR confirmed mild COVID-19 infection. SARS-CoV-2 D614G and omicron RBD specific B cell subsets in peripheral circulation were assessed by flow cytometry. IgG, IgG3 and IgA antibody titers toward RBD, spike and nucleocapsid antigens in the plasma were evaluated by ELISA. Results The frequency of the B cells specific to D614G-RBD were comparable in convalescent groups with and without PCC in both males and females. Notably, in females with PCC, the anti-D614G RBD specific double negative (IgD-CD27-) B cells showed significant correlation with the number of symptoms at acute of infection. Anti-spike antibody responses were also higher at 3 months post-infection in females who developed PCC, but not in the male PCC group. On the other hand, the male PCC group also showed consistently high anti-RBD IgG responses compared to all other groups. Conclusions The antibody responses to the spike protein, but not the anti-RBD B cell responses diverge between convalescent males and females who develop PCC. Our findings also suggest that sex-related factors may also be involved in the development of PCC via modulating antibody responses to the SARS-CoV-2 antigens

Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

BACKGROUND Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important following large-scale mortality spikes, such as the COVID-19 pandemic. When systematically analysed, mortality rates and life expectancy allow comparisons of the consequences of causes of death globally and over time, providing a nuanced understanding of the effect of these causes on global populations. METHODS The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 cause-of-death analysis estimated mortality and years of life lost (YLLs) from 288 causes of death by age-sex-location-year in 204 countries and territories and 811 subnational locations for each year from 1990 until 2021. The analysis used 56 604 data sources, including data from vital registration and verbal autopsy as well as surveys, censuses, surveillance systems, and cancer registries, among others. As with previous GBD rounds, cause-specific death rates for most causes were estimated using the Cause of Death Ensemble model-a modelling tool developed for GBD to assess the out-of-sample predictive validity of different statistical models and covariate permutations and combine those results to produce cause-specific mortality estimates-with alternative strategies adapted to model causes with insufficient data, substantial changes in reporting over the study period, or unusual epidemiology. YLLs were computed as the product of the number of deaths for each cause-age-sex-location-year and the standard life expectancy at each age. As part of the modelling process, uncertainty intervals (UIs) were generated using the 2·5th and 97·5th percentiles from a 1000-draw distribution for each metric. We decomposed life expectancy by cause of death, location, and year to show cause-specific effects on life expectancy from 1990 to 2021. We also used the coefficient of variation and the fraction of population affected by 90% of deaths to highlight concentrations of mortality. Findings are reported in counts and age-standardised rates. Methodological improvements for cause-of-death estimates in GBD 2021 include the expansion of under-5-years age group to include four new age groups, enhanced methods to account for stochastic variation of sparse data, and the inclusion of COVID-19 and other pandemic-related mortality-which includes excess mortality associated with the pandemic, excluding COVID-19, lower respiratory infections, measles, malaria, and pertussis. For this analysis, 199 new country-years of vital registration cause-of-death data, 5 country-years of surveillance data, 21 country-years of verbal autopsy data, and 94 country-years of other data types were added to those used in previous GBD rounds. FINDINGS The leading causes of age-standardised deaths globally were the same in 2019 as they were in 1990; in descending order, these were, ischaemic heart disease, stroke, chronic obstructive pulmonary disease, and lower respiratory infections. In 2021, however, COVID-19 replaced stroke as the second-leading age-standardised cause of death, with 94·0 deaths (95% UI 89·2-100·0) per 100 000 population. The COVID-19 pandemic shifted the rankings of the leading five causes, lowering stroke to the third-leading and chronic obstructive pulmonary disease to the fourth-leading position. In 2021, the highest age-standardised death rates from COVID-19 occurred in sub-Saharan Africa (271·0 deaths [250·1-290·7] per 100 000 population) and Latin America and the Caribbean (195·4 deaths [182·1-211·4] per 100 000 population). The lowest age-standardised death rates from COVID-19 were in the high-income super-region (48·1 deaths [47·4-48·8] per 100 000 population) and southeast Asia, east Asia, and Oceania (23·2 deaths [16·3-37·2] per 100 000 population). Globally, life expectancy steadily improved between 1990 and 2019 for 18 of the 22 investigated causes. Decomposition of global and regional life expectancy showed the positive effect that reductions in deaths from enteric infections, lower respiratory infections, stroke, and neonatal deaths, among others have contributed to improved survival over the study period. However, a net reduction of 1·6 years occurred in global life expectancy between 2019 and 2021, primarily due to increased death rates from COVID-19 and other pandemic-related mortality. Life expectancy was highly variable between super-regions over the study period, with southeast Asia, east Asia, and Oceania gaining 8·3 years (6·7-9·9) overall, while having the smallest reduction in life expectancy due to COVID-19 (0·4 years). The largest reduction in life expectancy due to COVID-19 occurred in Latin America and the Caribbean (3·6 years). Additionally, 53 of the 288 causes of death were highly concentrated in locations with less than 50% of the global population as of 2021, and these causes of death became progressively more concentrated since 1990, when only 44 causes showed this pattern. The concentration phenomenon is discussed heuristically with respect to enteric and lower respiratory infections, malaria, HIV/AIDS, neonatal disorders, tuberculosis, and measles. INTERPRETATION Long-standing gains in life expectancy and reductions in many of the leading causes of death have been disrupted by the COVID-19 pandemic, the adverse effects of which were spread unevenly among populations. Despite the pandemic, there has been continued progress in combatting several notable causes of death, leading to improved global life expectancy over the study period. Each of the seven GBD super-regions showed an overall improvement from 1990 and 2021, obscuring the negative effect in the years of the pandemic. Additionally, our findings regarding regional variation in causes of death driving increases in life expectancy hold clear policy utility. Analyses of shifting mortality trends reveal that several causes, once widespread globally, are now increasingly concentrated geographically. These changes in mortality concentration, alongside further investigation of changing risks, interventions, and relevant policy, present an important opportunity to deepen our understanding of mortality-reduction strategies. Examining patterns in mortality concentration might reveal areas where successful public health interventions have been implemented. Translating these successes to locations where certain causes of death remain entrenched can inform policies that work to improve life expectancy for people everywhere. FUNDING Bill & Melinda Gates Foundation

Traités de verre : Réflexions sur l’interprétation

The interpretation of international treaties represents the first true stage of their implementation, necessary to their respect as a code of conduct and their application as a norm in a case of litigation. Even if the articles 31 to 33 of the Vienna Convention on the Law of Treaties codify the “ general rule” of interpretation and its complementary means, blurredness remains on the privileged methods of the different actors– notably the ICJ– to execute the text. The theory of sign and language provides a theoretical basis delimiting the nature of general textual interpretation. It proposes that each signification is composed by the addition of a perceptible signifier to a conceptual signified and a contextual referent. Thus, despite the iterative nature of the signifier– its property to repeat itself in different situations– each and every change of context diffracts its first meaning, which necessarily becomes the result of a cultural filter. In other words, there is no perfectly clear text. Law is a social phenomenon and its rules are only valid if their conception parameters and legitimating protocols are accessible and rigorous. If “ law is what States make of it”, treaties appear to be conventional texts in a strict sense, which means they are based on language conventions that constitute more than a perfectly clear intermediary from the signifier to the signified. Physical science has demonstrated that even the most limpid of glasses produces an effect of diffraction, an optical phenomenon of slight deviation of the luminous rays. By analogy, the fact that a text is iterative precludes any quest for the explicit and exclusive intention of the transmitter of the norm. Once again becoming subjects of law when the treaty is cast off, the State parties are submitted to the filter of interpretation for which the Vienna Convention on the Law of Treaties provides a pertinent holistic frame, even if only partially put into practice to this day.L’interprétation des traités internationaux représente la première véritable étape de mise en oeuvre nécessaire à leur respect en tant que code de conduite et à leur application en tant que norme dans le cas d’un litige. Quoique les articles 31 à 33 de la Convention de Vienne sur le droit des traités codifient la «règle générale » d’interprétation et ses moyens complémentaires, un certain flou demeure quant aux méthodes privilégiées par les différents acteurs, notamment la Cour internationale de justice, pour exécuter le texte. La théorie générale du signe et du langage fournit certainement une base théorique susceptible de circonscrire la nature de l’interprétation textuelle en général. Elle propose en effet que toute signification est composée de l’addition d’un signifiant perceptible à un signifié conceptuel et à un référent contextuel. Ainsi, malgré la nature itérative du signifiant, c’est-à-dire la propriété de se répéter dans différentes situations, tout changement de contexte en diffracte le sens premier, qui devient nécessairement la résultante d’un filtre culturel. En d’autres termes, il n’existe pas de texte parfaitement clair. Le droit est un phénomène social et ses règles ne sont valides que dans la mesure où leurs paramètres de conception et leur protocole de légitimation se révèlent accessibles et rigoureux. Si «law is what States make of it » , il convient certainement de concevoir le traité comme un texte conventionnel au sens strict, c’est-à-dire basé sur des conventions langagières constituant davantage qu’un intermédiaire parfaitement transparent du signifiant au signifié. La science physique a depuis longtemps démontré que même le verre le plus limpide produit un effet de diffraction, un phénomène optique de déviation subtile des rayons lumineux. Par analogie, l’itérabilité du texte interdit conséquemment d’y rechercher explicitement et exclusivement l’intention du ou des destinateurs de la norme. Redevenus sujets de droit une fois les amarres du traité larguées, les États parties se voient soumis au filtre de l’interprétation dont la Convention de Vienne sur le droit des traités fournit un cadre holistique certes pertinent, bien que partialement mis en oeuvre à ce jour.Lévesque Jean-François. Traités de verre : Réflexions sur l’interprétation. In: Revue Québécoise de droit international, volume 19-1, 2006. pp. 53-78