Sustainability of Mahogany Production in Plantations: Does Resource Availability Influence Susceptibility of Young Mahogany Plantation Stands to Hypsipyla robusta Infestation?

Hypsipyla robusta Moore (Lepidoptera: Pyralidae), like many other moth species, shows selectivity when choosing host plants for its eggs. Four Meliaceae species (Khaya grandifoliola, K. ivorensis, Swietenia macrophyla, and Entandrophragma cylindricum) were established in a moist semideciduous forest in Ghana to study this selectivity at 12 and 21 months after planting. The analysis of variance (ANOVA) at a P-value of 0.05 was used to test the significance of differences in infestation by H. robusta between the species. H. robusta attacks were recorded by month 12 after planting in the field, and only Khaya spp. was attacked, with attacks evident on 15.5% of K grandifoliola and 6.6% K. ivorensis. Saplings in blocks closer to an older H. robusta infested K. grandifoliola stand had more infestation compared to saplings further away. The mean percentage of K. grandifoliola attacked was 38.9%, 38.9%, 13.3%, and 7.4% in 4 different plots located increasingly further away from the older infested plantation. A similar trend was found in K. ivorensis with 28.4%, 7.1%, 0.0%, and 0.0% in the plots located increasingly further away from the infested stand. These results indicate a higher number of shoot borer attacks at the edge of the plantation and in proximity to other infested plantations. After 21 months, the fastest-growing species and the fastest-growing individuals within the species were the most infested. K. grandifoliola recorded the fastest growth and most attacks followed by K. ivorensis and S. macrophylla. E. cylindricum recorded the least growth and no H. robusta infestation. After 21 months, the mean percentages of trees attacked were 59.1%, 23.7%, 5.6%, and 0.0% for K. grandifoliola, K. ivorensis, S. macrophylla, and E. cylindricum, respectively. Within species, the fastest-growing saplings experienced the most attacks. A positive correlation was observed between the plant size and H. robusta attacks (R2 = 0.76). Attacks resulted in the death of the apical shoot and the proliferation of multiple shoots in only the Khaya spp., with K. ivorensis recording a lower number of shoots than K. grandifoliola. These proliferated shoots were also attacked, and a positive correlation was observed between the number of proliferated shoots and H. robusta attacks (R2 = 0.84). These findings will assist plantation developers, forest managers, and investors in mahogany plantations to devise integrated pest management strategies to reduce the impact of Hypsipyla attacks on their plantations

Patella sleeve fracture injury: a case report

Patella sleeve fracture is a rare injury that occurs in children and is characterized by an avulsion of extensive sleeve of cartilage and periosteum with small bony fragments, usually from the inferior pole of the patella. It is important to make this diagnosis promptly and act accordingly, because a delay or misdiagnosis will result in severe permanent disability to the affected child. A case of this injury is presented to create awareness among physicians, especially front-liners within the medical community in Sub-Saharan Africa, where such an injury has been rarely reported in the literature. The presentation, evaluation, management and outcome over a six months period is being presented

Response of hydro-physical properties of a Chromic Luvisol in Ghana to different methods of application of Mucuna pruriens as a soil amendments

The study assessed the response of hydro-physical properties of Chromic Luvisol to different methods of application of Mucuna pruriens as a soil amendments in two separate experiments. A Randomized Complete Block Design (RCBD) with three replications was used with the following treatments: 7.04t/ha Mucuna pruriens as green manure (GM), 7.04t/ha Mucuna pruriens as live mulch (LM), 7.04t/ha Mucuna pruriens as in-situ mulch (IM) and a control plot which had no Mucuna pruriens as soil amendment. Data were collected on gravimetric (θ_g) and volumetric moisture content ( θ_v), residual moisture storage(R), sorptivity(s), cumulative infiltration (I), bulk density (ρ_b), total porosity (f), aeration porosity (ξ_a), aggregate stability (ASt) and soil temperature, for assessment of hydro-physical properties of the soil. The results from the experiments indicated that Mucuna pruriens as live mulch used as amendment significantly reduce bulk density (ρ_b), increased total porosity (f) and aeration porosity (ξ_a) thus it gave significant improvement on those soil physical properties measured while Mucuna pruriens as in-situ mulch improved aggregate stability (ASt) and gave optimal soil temperature. In the assessment of soil volumetric moisture content ( θ_v), residual moisture storage(R), sorptivity(s), cumulative infiltration(I), the study shows that Mucuna pruriens as in-situ mulch recorded the optimal values and was closely followed by Mucuna pruriens as live mulch

The p12 Domain Is Unstructured in a Murine Leukemia Virus p12-CAN Gag Construct

The Gag polyproteins of gammaretroviruses contain a conserved p12 domain between MA and CA that plays critical roles in virus assembly, reverse transcription and nuclear integration. Here we show using nuclear magnetic resonance, that p12 is unstructured in a Moloney murine leukemia virus (MMLV) Gag fragment that includes the N-terminal domain of CA (p12-CAN). Furthermore, no long range interactions were observed between the domains, as has been previously predicted. Flexibility appears to be a common feature of Gag “late” domains required for virus release during budding. Residues near the N-terminus of CAN that form a β-hairpin in the mature CA protein are unfolded in p12-CAN, consistent with proposals that hairpin formation helps trigger capsid assembly

Biophysics of Lower Back Pain

Lower back pain is one of the most predominant problems in the general public. It has been traditionally regarded as a mechanical problem by both orthodox and complementary practitioners. This study was conducted to evaluate the lumbosacral angle which is an inherent cause of lower back pain and also investigate the shearing and compressing forces on the lumbar spine. The study was carried out at in a Hospital within the …. Metropolis. A total of 210 patients’ data consisting of 72 males and 138 females was considered. The lumbosacral angle was measured using Ferguson’s method with the MicroDicom software. Patients were grouped into ages; 0 – 20, 21 – 30, 31 – 40, 41 – 50, 51 – 60, 61 – 70, 71 – 80 and 81 – 100. The number of patients in each age group was; 7, 12, 26, 28, 56, 27, 11 and 7 respectively. The average lumbosacral angle evaluated, according to age group was; 36.3º, 39º, 35.81º, 36.23º, 36.55º, 37.5º, 35.89 º and 34.92º. The overall lumbosacral mean was determined to be 36.50º. The lumbosacral angle evaluated was used to determine the corresponding compressive and shear forces at the lumbar region which are the principal predictors of the lower back pain

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

¹H-¹⁵N correlation (HSQC) spectrum obtained for MMLV p12CA^N.

<p>Assignments are shown for signals in less-crowded regions of the spectrum. Red peaks represent signals folded in the ¹⁵N dimension.</p

NMR chemical shift and relaxation data that identify regions of structure and mobility in p12CA^N.

<p>(A) Amino acid sequence of p12CA^N (arrow denotes proteolytic cleavage site). Residues of CA^N that adopt α-helical conformations in the N-MLV CA^N crystal structure are denoted by colored rectangles. (B) NMR chemical shift indices for the backbone Cα atoms of p12CA^N. Positive values denote helical regions, negative values denote regions of β-structure, and stretches of residues with near-zero values denote random coil conformations. For comparison, α-helical segments observed in the N-MLV CA^N crystal structure are aligned at the top of the panel. (C) ¹⁵N{¹H} heteronuclear NOE (XNOE) data obtained for p12CA^N. Values near 1.0 reflect reduced molecular motion, and smaller or negative values reflect motion on a fast (ps-ns) timescale.</p