The Clusters AgeS Experiment (CASE). I. V209 omega Cen - An Eclipsing Post-Common Envelope Binary in the Globular Cluster omega Cen

We use photometric and spectroscopic observations of the detached eclipsing binary V209 omega Cen to derive the masses, radii, and luminosities of the component stars. The system exhibits total eclipses and, based on the measured systemic velocity and the derived distance, is a member of the globular cluster omega Cen. We obtain 0.945 +/- 0.043 Msun, 0.983 +/- 0.015 Rsun and 6.68 +/- 0.88 Lsun for the cooler, but larger and more luminous primary component. The secondary component has 0.144 +/- 0.008 Msun, 0.425 +/- 0.008 Rsun and 2.26 +/- 0.28 Lsun. The effective temperatures are estimated at 9370 K for the primary and at 10866 K for the secondary. On the color-magnitude diagram of the cluster, the primary component occupies a position between the tip of the blue straggler region and the extended horizontal branch while the secondary component is located close to the red border of the area occupied by hot subdwarfs. However, its radius is too large and its effective temperature is too low for it to be an sdB star. We propose a scenario leading to the formation of a system with such unusual properties with the primary component ``re-born'' from a former white dwarf which accreted a new envelope through mass transfer from its companion. The secondary star has lost most of its envelope while starting its ascent onto the sub-giant branch. It failed to ignite helium in its core and is currently powered by a hydrogen burning shell.Comment: 24 pages, 9 figures, AJ, in pres

The Clusters AgeS Experiment (CASE). II. The Eclipsing Blue Straggler OGLEGC-228 in the Globular Cluster 47 Tuc

We use photometric and spectroscopic observations of the eclipsing binary OGLEGC-228 (V228) to derive the masses, radii, and luminosities of the component stars. Based on measured systemic velocity, proper motion and distance, the system is a blue straggler member of the globular cluster 47 Tuc. Our analysis shows that V228 is a semi-detached Algol. We obtain M=1.512 +/- 0.022 Msun, R=1.357 +/- 0.019 Rsun, L=7.02 +/- 0.050 Lsun for the hotter and more luminous primary component and M=0.200 +/- 0.007 Msun, R=1.238 +/- 0.013 Rsun, L=1.57 +/- 0.09 Lsun for the Roche lobe filling secondary.Comment: 19 pages, 5 figures, AJ, in pres

Minimizing follow-up for space-based transit surveys using full lightcurve analysis

One of the biggest challenges facing large transit surveys is the elimination of false-positives from the vast number of transit candidates. We investigate to what extent information from the lightcurves can identify blend scenarios and eliminate them as planet candidates, to significantly decrease the amount of follow-up observing time required to identify the true exoplanet systems. If a lightcurve has a sufficiently high signal-to-noise ratio, a distinction can be made between the lightcurve of a stellar binary blended with a third star and the lightcurve of a transiting exoplanet system. We perform simulations to determine what signal-to-noise level is required to make the distinction between blended and non-blended systems as function of transit depth and impact parameter. Subsequently we test our method on real data from the first IRa01 field observed by the CoRoT satellite, concentrating on the 51 candidates already identified by the CoRoT team. About 70% of the planet candidates in the CoRoT IRa01 field are best fit with an impact parameter of b>0.85, while less than 15% are expected in this range considering random orbital inclinations. By applying a cut at b<0.85, meaning that ~15% of the potential planet population would be missed, the candidate sample decreases from 41 to 11. The lightcurves of 6 of those are best fit with such low host star densities that the planet-to-star size ratii imply unrealistic planet radii of R>2RJup. Two of the five remaining systems, CoRoT1b and CoRoT4b, have been identified as planets by the CoRoT team, for which the lightcurves alone rule out blended light at 14% (2sigma) and 31% (2sigma). We propose to use this method on the Kepler database to study the fraction of real planets and to potentially increase the efficiency of follow-up.Comment: 13 pages, 11 figures, 2 tables. Accepted for publication in A&

Validation of an AI-based algorithm for measurement of the thoracic aortic diameter in low-dose chest CT

OBJECTIVES: To evaluate the performance of artificial intelligence (AI) software for automatic thoracic aortic diameter assessment in a heterogeneous cohort with low-dose, non-contrast chest computed tomography (CT).MATERIALS AND METHODS: Participants of the Imaging in Lifelines (ImaLife) study who underwent low-dose, non-contrast chest CT (August 2017-May 2022) were included using random samples of 80 participants &lt;50y, ≥80y, and with thoracic aortic diameter ≥40 mm. AI-based aortic diameters at eight guideline compliant positions were compared with manual measurements. In 90 examinations (30 per group) diameters were reassessed for intra- and inter-reader variability, which was compared to discrepancy of the AI system using Bland-Altman analysis, paired samples t-testing and linear mixed models.RESULTS: We analyzed 240 participants (63 ± 16 years; 50 % men). AI evaluation failed in 11 cases due to incorrect segmentation (4.6 %), leaving 229 cases for analysis. No difference was found in aortic diameter between manual and automatic measurements (32.7 ± 6.4 mm vs 32.7 ± 6.0 mm, p = 0.70). Bland-Altman analysis yielded no systematic bias and a repeatability coefficient of 4.0 mm for AI. Mean discrepancy of AI (1.3 ± 1.6 mm) was comparable to inter-reader variability (1.4 ± 1.4 mm); only at the proximal aortic arch showed AI higher discrepancy (2.0 ± 1.8 mm vs 0.9 ± 0.9 mm, p &lt; 0.001). No difference between AI discrepancy and inter-reader variability was found for any subgroup (all: p &gt; 0.05).CONCLUSION: The AI software can accurately measure thoracic aortic diameters, with discrepancy to a human reader similar to inter-reader variability in a range from normal to dilated aortas.</p

VW LMi: tightest quadruple system known. Light-time effect and possible secular changes of orbits

Tightest known quadruple systems VW LMi consists of contact eclipsing binary with P_12 = 0.477551 days and detached binary with P_34 = 7.93063 days revolving in rather tight, 355.0-days orbit. This paper presents new photometric and spectroscopic observations yielding 69 times of minima and 36 disentangled radial velocities for the component stars. All available radial velocities and minima times are combined to better characterize the orbits and to derive absolute parameters of components. The total mass of the quadruple system was estimated at 4.56 M_sun. The detached, non-eclipsing binary with orbital period P = 7.93 days is found to show apsidal motion with U approximately 80 years. Precession period in this binary, caused by the gravitational perturbation of the contact binary, is estimated to be about 120 years. The wide mutual orbit and orbit of the non-eclipsing pair are found to be close to coplanarity, preventing any changes of the inclination angle of the non-eclipsing orbit and excluding occurrence of the second system of eclipses in future. Possibilities of astrometric solution and direct resolving of the wide, mutual orbit are discussed. Nearby star, HD95606, was found to form loose binary with quadruple system VW LMi.Comment: 4 figures. accepted to MNRAS on July 31, 200

Photometry and Spectroscopy of the Optical Companion to the Pulsar PSR J1740-5340 in the Globular Cluster NGC 6397

We present photometric and spectroscopic observations of the optical companion to the millisecond radio pulsar PSR J1740-5340 in the globular cluster NGC 6397. An analysis of the photometric variability in the B, V, and I-bands indicates an inclination of the system of 43.9+-2.1 degrees if the optical companion fills its Roche lobe (a semi-detached configuration). The spectroscopic data show a radial velocity variation with a semi-amplitude of K=137.2 +- 2.4 km/sec, and a system velocity gamma=17.6 +- 1.5 km/sec, consistent with cluster membership. We use these results to derive a mass of the optical companion of M1=0.296 +- 0.034 Msol and M2=1.53 +- 0.19 Msol for the pulsar. There is evidence for secular change of the amplitude of the optical light curve of the variable measured over seven years. The change does not have interpretation and its presence complicates reliable determination of the absolute parameters of the binary.Comment: 24 pages, 9 figures, submitted to A

Reconsider radiation exposure from imaging during immune checkpoint inhibitor trials to reduce risk of secondary cancers in long-term survivors?

Immune checkpoint inhibitors (ICI) have improved outcomes for patients with advanced cancers, and results in increasing numbers of long-term survivors. For registration studies, progression-free survival and disease-free survival often serve as primary endpoints. This requires repeated computed tomography (CT) scans for tumour imaging which might lead to major radiation exposure. To determine this, all immune checkpoint inhibitors trials that led to FDA approval were retrieved up to July 29, 2019. From the available protocols, imaging modalities and schedules used in each trial were identified. The anticipated cumulative number of scans made after 1, 3, 5, and 10 years study participation were calculated. The percentage of lifetime attributable cancer risk was calculated using the Biological Effects of Ionizing Radiation VII report. Fifty-one trials were identified, from which 39 protocols were retrieved. Four were adjuvant trials. All protocols required repeated chest-abdomen imaging and specified CT scans as preferred imaging modality. Median calculated cumulative numbers of chest-abdomen CT scans after 1, 3, 5, and 10 years study participation were 7, 16, 24 and 46, respectively. For ages 20-70 years at study entry, the average lifetime attributable cancer risk after 1 year of study participation ranged from 1.11 to 0.40% for men and from 1.87 to 0.46% for women. At 10 years study participation, this risk increased to a range of 5.91 to 1.96% for men and 9.64 to 2.32% for women. Given high imaging radiation exposure for long-term survivors in current ICI trials an adaptive imaging interval and imaging termination rules should be considered for long-term survivors

NLRC5 promotes transcription of BTN3A1-3 genes and Vγ9Vδ2 T cell-mediated killing

BTN3A molecules-BTN3A1 in particular-emerged as important mediators of Vγ9Vδ2 T cell activation by phosphoantigens. These metabolites can originate from infections, e.g. with Mycobacterium tuberculosis, or by alterations in cellular metabolism. Despite the growing interest in the BTN3A genes and their high expression in immune cells and various cancers, little is known about their transcriptional regulation. Here we show that these genes are induced by NLRC5, a regulator of MHC class I gene transcription, through an atypical regulatory motif found in their promoters. Accordingly, a robust correlation between NLRC5 and BTN3A gene expression was found in healthy, in M. tuberculosis-infected donors' blood cells, and in primary tumors. Moreover, forcing NLRC5 expression promoted Vγ9Vδ2 T-cell-mediated killing of tumor cells in a BTN3A-dependent manner. Altogether, these findings indicate that NLRC5 regulates the expression of BTN3A genes and hence open opportunities to modulate antimicrobial and anticancer immunity