3D-modeling flight safety in aviation

Evaluation of the effectiveness of the technology is a strong and stable factor of success which results human lives preservation and accidents prevention. 3D-modelling can take an essential part in technology if they are used by true professionals. To prevent risks authors suggest the usage of prediction based on the work of not only quantitative but also qualitative information obtained directly from the experts with sophisticated 3D-models

Determination of Influence of Auxiliary Ingredients on Antioxidant Activity of Extract of Leaves of the Quince and Grapes Seed Meal in Phytogel with the Use of Spectrometric Method with the Dpph Indicator System

To study an impact of auxiliary substances on gel containing extracts of quince leaves and grape seed meal, which is based on polymethylsiloxane.Pharmaco - technological and physicochemical methods. In this study, a spectrophotometric method is applied to determine an antioxidant activity of the gel.We examined an impact of auxiliary substances on the gel. According to the results of studies we chose auxiliary ingredients which improve not only gustatory quality but also technological parameters. Applying spectrometric analysis, we investigated an antioxidant activity of phytogel. The gel has a structure of rigid matrix, which is built through a process of condensation of methylsilanetriol and siloxane bonds between the silicon atoms, which makes it possible to maintain and stabilize active natural ingredients. The experiment proved that the extract of leaves of quince and grape seed meal have some antioxidant activity. But, upon the introduction of stevia extract as a coregent taste, the gel that contains quince leaf extract and grape seed meal increases the antioxidant activity. Phytogel has antioxidant activity of 84% relative to the reference sample, which suggests that the gel can resist the harmful effects of free radicals, which are constantly produced in the human organismIt was confirmed that the addition of auxiliary substances into the gel with the extracts of quince leaves and grape seed meal based on polymethylsiloxane increases bioavailability and therapeutic efficiency, in particular, the antioxidant activity, of the gel.Stevia extract as an adjuvant in the phytogel, as gustatory corrector, increases the antioxidant activity of phyto pharmaceutical drugs

Morpho-functional basis of endothelial dysfunction in diabetes mellitus

The diabetes mellitus (DM) inevitably progresses and leads to complications, among which the main place is occupied by micro- and macroangiopathies. The presence of endothelial damage in DM can be established even before macroscopically significant damage to the vessel. At the same time, there is no summary ED characteristic for diabetes. The aim of the study is to make a comprehensive evaluation of ED in DM -1 and DM-2 types.Materials and methods of research. 60 persons, including 53 DM type 1 and type 2, with a severe course (state of decompensation) participated in the present study. We used the method of estimating ED by the number of circulating desquamation endothelial cells (CECs) at the stages of decomposition with simultaneous determination of NO2- and NO3- metabolites of nitric oxide.Results and discussion. In patients with diabetes, the level of CECs increased in 3-5 times and ranged from 1800 to 11,200 cells / ml. The average amount of CECs in patients with diabetes was 3358.5 ± 366.3 cells / ml.Conclusions: Endothelium is involved in the pathological process at DM. This is evidenced by a significant increase in CECs in the blood plasma. The use of this method allows to detect ED before clinically considerable vascular impairment and reflects the severity of the course and duration of DM