Neuropsychological analysis of peculiarities of formation of graphomotor skills in primary school children

Functions of serial organization of movements and actions and their role in the formation and development of graphomotor skills (writing in particular) in primary school children (193 pupils of 1st and 3dgrades) were investigated using traditional neuropsychological and new computerized methods. It allowed to trace the processes of automatization of graphomotor skill in normally developed children and to describe specific difficulties of graphomotor activity in children with learning disabilities

Роль семейного врача в профилактике и раннем выявлении рака шейки матки = Family Practitioner’s Role in Prevention and Diagnostics of Cervical Cancer

Lukyanchuk O. V., Velychko V. I., Danilchuk G. A., Kuzeva N. G. Роль семейного врача в профилактике и раннем  выявлении рака шейки матки = Family Practitioner’s Role in Prevention and Diagnostics of Cervical Cancer. Journal of Education, Health and Sport. 2016;6(4):45-62. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.49413http://ojs.ukw.edu.pl/index.php/johs/article/view/3446 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7© The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 05.03.2016. Revised 10.04.2016. Accepted: 10.04.2016.  Роль семейного врача в профилактике и раннем  выявлении рака шейки маткиЛукьянчук О. В., Величко В. И., Данильчук Г. А., Кузева Н. Г.          Одесский национальный медицинский университет Резюме Рак шейки матки остается одним из наиболее распространенных онкологических заболеваний в женской популяции. Основной причиной развития предопухолевых и опухолевых заболеваний шейки матки, влагалища, полового члена, вульвы, гортани и др. является вирус папилломы человека. В настоящее время семейный врач играет важную роль  как в организации выявления предопухолевой патологии репродуктивного тракта, так и в повышении образования населения относительно профилактики предопухолевых и опухолевых заболеваний шейки матки. Ключевые слова: рак шейки матки, вирус папилломы человека, семейный врач, диагностика,  профилактика. Family Practitioner’s Role in Prevention and Diagnostics of Cervical Cancer Lukyanchuk O.V. Head of the Department of Reconstructive and Regenerative Medicine with a Course of Reproduction, oncogynecologyst, Ph.D.Velychko V.I. . Head of the Department of Family Medicine and General Practice, general practitioner, Prof., Ph.D.Danilchuk G.A. Assistant of the Department of Family Medicine and General Practice, general practitioner, Ph.D.Kuzeva N.G.  Assistant of the Department of Reconstructive and Regenerative Medicine with a course of reproduction, gynecologist, Ph.D. Summary Cervical cancer remains one of the most frequent oncological diseases in the female part of the population. The main cause of precancerous and cancerous anomalies of the cervix, vagina, penis, pharynx etc. is Human papillomavirus. Family Practitioners currently play a leading role in organizing preventive measures for precancerous disorders of the reproductive tract and educating the population about prevention of cervical cancers. Keywords: cervical cancer, Human papillomavirus, Family Practitioner, diagnostics, prevention.

The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation

VCP/p97 regulates numerous cellular functions by mediating protein degradation through its segregase activity. Its key role in governing protein homoeostasis has made VCP/p97 an appealing anticancer drug target. Here, we provide evidence that VCP/p97 acts as a regulator of cellular metabolism. We found that VCP/p97 was tied to multiple metabolic processes on the gene expression level in a diverse range of cancer cell lines and in patient-derived multiple myeloma cells. Cellular VCP/p97 dependency to maintain proteostasis was increased under conditions of glucose and glutamine limitation in a range of cancer cell lines from different tissues. Moreover, glutamine depletion led to increased VCP/p97 expression, whereas VCP/p97 inhibition perturbed metabolic processes and intracellular amino acid turnover. GCN2, an amino acid-sensing kinase, attenuated stress signalling and cell death triggered by VCP/p97 inhibition and nutrient shortages and modulated ERK activation, autophagy, and glycolytic metabolite turnover. Together, our data point to an interconnected role of VCP/p97 and GCN2 in maintaining cancer cell metabolic and protein homoeostasis

Роль семейного врача в профилактике и раннем выявлении рака шейки матки = Family Practitioner’s Role in Prevention and Diagnostics of Cervical Cancer

Lukyanchuk O. V., Velychko V. I., Danilchuk G. A., Kuzeva N. G. Роль семейного врача в профилактике и раннем  выявлении рака шейки матки = Family Practitioner’s Role in Prevention and Diagnostics of Cervical Cancer. Journal of Education, Health and Sport. 2016;6(4):45-62. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.49413 http://ojs.ukw.edu.pl/index.php/johs/article/view/3446   The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.03.2016. Revised 10.04.2016. Accepted: 10.04.2016.     Роль семейного врача в профилактике и раннем  выявлении рака шейки матки Лукьянчук О. В., Величко В. И., Данильчук Г. А., Кузева Н. Г.            Одесский национальный медицинский университет   Резюме   Рак шейки матки остается одним из наиболее распространенных онкологических заболеваний в женской популяции. Основной причиной развития предопухолевых и опухолевых заболеваний шейки матки, влагалища, полового члена, вульвы, гортани и др. является вирус папилломы человека. В настоящее время семейный врач играет важную роль  как в организации выявления предопухолевой патологии репродуктивного тракта, так и в повышении образования населения относительно профилактики предопухолевых и опухолевых заболеваний шейки матки.   Ключевые слова: рак шейки матки, вирус папилломы человека, семейный врач, диагностика,  профилактика.   Family Practitioner’s Role in Prevention and Diagnostics of Cervical Cancer   Lukyanchuk O.V. Head of the Department of Reconstructive and Regenerative Medicine with a Course of Reproduction, oncogynecologyst, Ph.D. Velychko V.I. . Head of the Department of Family Medicine and General Practice, general practitioner, Prof., Ph.D. Danilchuk G.A. Assistant of the Department of Family Medicine and General Practice, general practitioner, Ph.D. Kuzeva N.G.  Assistant of the Department of Reconstructive and Regenerative Medicine with a course of reproduction, gynecologist, Ph.D.   Summary   Cervical cancer remains one of the most frequent oncological diseases in the female part of the population. The main cause of precancerous and cancerous anomalies of the cervix, vagina, penis, pharynx etc. is Human papillomavirus. Family Practitioners currently play a leading role in organizing preventive measures for precancerous disorders of the reproductive tract and educating the population about prevention of cervical cancers.   Keywords: cervical cancer, Human papillomavirus, Family Practitioner, diagnostics, prevention

The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation

VCP/p97 regulates numerous cellular functions by mediating protein degradation through its segregase activity. Its key role in governing protein homoeostasis has made VCP/p97 an appealing anticancer drug target. Here, we provide evidence that VCP/p97 acts as a regulator of cellular metabolism. We found that VCP/p97 was tied to multiple metabolic processes on the gene expression level in a diverse range of cancer cell lines and in patient-derived multiple myeloma cells. Cellular VCP/p97 dependency to maintain proteostasis was increased under conditions of glucose and glutamine limitation in a range of cancer cell lines from different tissues. Moreover, glutamine depletion led to increased VCP/p97 expression, whereas VCP/p97 inhibition perturbed metabolic processes and intracellular amino acid turnover. GCN2, an amino acid-sensing kinase, attenuated stress signalling and cell death triggered by VCP/p97 inhibition and nutrient shortages and modulated ERK activation, autophagy, and glycolytic metabolite turnover. Together, our data point to an interconnected role of VCP/p97 and GCN2 in maintaining cancer cell metabolic and protein homoeostasis

The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation

VCP/p97 regulates numerous cellular functions by mediating protein degradation through its segregase activity. Its key role in governing protein homoeostasis has made VCP/p97 an appealing anticancer drug target. Here, we provide evidence that VCP/p97 acts as a regulator of cellular metabolism. We found that VCP/p97 was tied to multiple metabolic processes on the gene expression level in a diverse range of cancer cell lines and in patient-derived multiple myeloma cells. Cellular VCP/p97 dependency to maintain proteostasis was increased under conditions of glucose and glutamine limitation in a range of cancer cell lines from different tissues. Moreover, glutamine depletion led to increased VCP/p97 expression, whereas VCP/p97 inhibition perturbed metabolic processes and intracellular amino acid turnover. GCN2, an amino acid-sensing kinase, attenuated stress signalling and cell death triggered by VCP/p97 inhibition and nutrient shortages and modulated ERK activation, autophagy, and glycolytic metabolite turnover. Together, our data point to an interconnected role of VCP/p97 and GCN2 in maintaining cancer cell metabolic and protein homoeostasis

Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: results of an international multi-centre study

Introduction: Increased mortality has been demonstrated in older adults with coronavirus disease 2019 (COVID-19), but the effect of frailty has been unclear. Methods: This multi-centre cohort study involved patients aged 18 years and older hospitalised with COVID-19, using routinely collected data. We used Cox regression analysis to assess the impact of age, frailty and delirium on the risk of inpatient mortality, adjusting for sex, illness severity, inflammation and co-morbidities. We used ordinal logistic regression analysis to assess the impact of age, Clinical Frailty Scale (CFS) and delirium on risk of increased care requirements on discharge, adjusting for the same variables. Results: Data from 5,711 patients from 55 hospitals in 12 countries were included (median age 74, interquartile range [IQR] 54–83; 55.2% male). The risk of death increased independently with increasing age (>80 versus 18–49: hazard ratio [HR] 3.57, confidence interval [CI] 2.54–5.02), frailty (CFS 8 versus 1–3: HR 3.03, CI 2.29–4.00) inflammation, renal disease, cardiovascular disease and cancer, but not delirium. Age, frailty (CFS 7 versus 1–3: odds ratio 7.00, CI 5.27–9.32), delirium, dementia and mental health diagnoses were all associated with increased risk of higher care needs on discharge. The likelihood of adverse outcomes increased across all grades of CFS from 4 to 9. Conclusion: Age and frailty are independently associated with adverse outcomes in COVID-19. Risk of increased care needs was also increased in survivors of COVID-19 with frailty or older age.</p