The lab management practices of “Research Exemplars” that foster research rigor and regulatory compliance: A qualitative study of successful principal investigators

IntroductionConducting rigorous scientific inquiry within the bounds of research regulation and acceptable practice requires a principal investigator to lead and manage research processes and personnel. This study explores the practices used by investigators nominated as exemplars of research excellence and integrity to produce rigorous, reproducible research and comply with research regulations.MethodsUsing a qualitative research design, we interviewed 52 principal investigators working in the United States at top research universities and the National Institutes of Health Intramural Research Program. We solicited nominations of researchers meeting two criteria: (1) they are federally-funded researchers doing high-quality, high-impact research, and (2) have reputations for professionalism and integrity. Each investigator received an initial nomination addressing both criteria and at least one additional endorsement corroborating criteria 2. A panel of researchers and our research team reviewed the nominations to select finalists who were invited to participate. The cohort of "Research Exemplars" includes highly accomplished researchers in diverse scientific disciplines. The semi-structured interview questions asked them to describe the routine practices they employ to foster rigor and regulatory compliance. We used inductive thematic analysis to identify common practices.ResultsThe exemplars identified a core set of 8 practices and provided strategies for employing them. The practices included holding regular team meetings, encouraging shared ownership, providing supervision, ensuring adequate training, fostering positive attitudes about compliance, scrutinizing data and findings, and following standard operating procedures. Above all, the use of these practices aim to create a psychologically safe work environment in which lab members openly collaborate to scrutinize their work and share in accountability for rigorous, compliant research.ConclusionsResearchers typically receive limited systematic training in how to lead and manage their research teams. Training and education for principal investigators should include essential leadership and management practices and strategies that support doing high-quality research with integrity

Management Strategy Evaluation for the Atlantic Surfclam, \u3ci\u3eSpisula solidissima\u3c/i\u3e, Using a Fisheries Economics Model

The Atlantic surfclam, Spisula solidissima, is an economically valuable bivalve harvested along the northeastern United States. The surfclam’s range has contracted and the center of the stock’s distribution has shifted north driven by warmer bottom water temperatures. Declining landings per unit effort (LPUE) in the Mid-Atlantic Bight (MAB) is one result. Declining stock abundance and LPUE suggest that overfishing may be occurring off New Jersey. The objective of this project is to perform a management strategy evaluation (MSE) for Spisula solidissima. The terminal goal is to identify a preferred management option that promotes enhanced surfclam productivity in the MAB and increased fishery viability as indicated by improvement in performance metrics. The active agents of the MSE model are individual fishing boats with economic and quota constraints influenced by captain’s behaviors over a spatially varying population. Management alternatives include two closure rules and three closure durations. Simulations showed that LPUE increased under most alternative strategies, by up to 21%, compared to present-day management. The number of clams per bushel was up to 7% greater under present-day management suggesting that the alternative strategies resulted in the landing of larger clams. Stock biomass increased under most alternate strategies, up to 17%, compared to stock biomass using present-day management. When incidental mortality increased, the benefits seen under alternative management were enhanced. Benefits of alternative management under reduced abundances remained equivalent or increased in comparison to results with present-day abundance. These outcomes suggest that the preferred management option identified by the MSE approach could be valuable in insulating the stock and commercial fishery from further decline

Exploring Messages African American Men Receive About Attending a Predominantly White University

This article discusses the findings of a focus group study of 10 African American undergraduate men at a predominantly White Southern research institution.  The authors explored African American menâs struggles with persistence through graduation.  Findings suggest that prior to college, participants faced distracting messages about what it means to attend a PWI from their families, schools, and community.  Implications for establishing partnerships with African American families, schools, and community organizations are discussed

Electrical Properties of Carbon Fiber Support Systems

Carbon fiber support structures have become common elements of detector designs for high energy physics experiments. Carbon fiber has many mechanical advantages but it is also characterized by high conductivity, particularly at high frequency, with associated design issues. This paper discusses the elements required for sound electrical performance of silicon detectors employing carbon fiber support elements. Tests on carbon fiber structures are presented indicating that carbon fiber must be regarded as a conductor for the frequency region of 10 to 100 MHz. The general principles of grounding configurations involving carbon fiber structures will be discussed. To illustrate the design requirements, measurements performed with a silicon detector on a carbon fiber support structure at small radius are presented. A grounding scheme employing copper-kapton mesh circuits is described and shown to provide adequate and robust detector performance.Comment: 20 pages, 11 figures, submitted to NI

Cover Crop Impacts on Soil Water Status

Water is a primary concern for producers in the Great Plains; as such, research is warranted to quantify how much cover crops affect the amount of soil water available to subsequent cash crops. Cover crop mixes have been marketed as a means to conserve water in no-till cropping systems following winter wheat (Triticum aestivum L.) harvest. The objectives of this study are to quantify changes in soil profile water content in the presence of different cover crops and mixtures of increasing species complexity, to quantify their biomass productivity and quality, and to quantify the impact of cover crops on subsequent corn (Zea mays L.) yields. We hypothesized the change in soil water brought on by the cover crop treatments would be correlated to the quantity of biomass produced and the species composition, rather than mixture complexity. Soil moisture was measured using a neutron probe to a depth of 9 ft. Results from 2013–14 showed no difference in water use between cover crop mixtures and single species. Cover crops depleted the soil profile by a maximum of 3.5 in. during growth, but fallow was able to gain 0.75 in. of water during the same period. At the time of corn planting, soil moisture under all cover crops had replenished to levels at cover crop emergence, except for the brassicas, which had extracted water from deeper in the profile. Corn yields were reduced following the grass cover crops and the six-species mix. Corn yields were more closely related to the carbon:nitrogen (C:N) ratio of the cover crop residue than to profile soil moisture at corn emergence. The fact that yields were similar for corn after fallow and for corn after brassica cover crops implied that water was not the cause of yield reductions after the other cover crops

Management Strategy Evaluation for the Atlantic Surfclam (Spisula solidissima) Using a Spatially Explicit, Vessel-Based Fisheries Model

The commercially valuable Atlantic surfclam (Spisula solidissima) is harvested along the northeastern continental shelf of the United States. Its range has contracted and shifted north, driven by warmer bottom water temperatures. Declining landings per unit of effort (LPUE) in the Mid-Atlantic Bight (MAB) is one result. Declining stock abundance and LPUE suggest that overfishing may be occurring off New Jersey. A management strategy evaluation (MSE) for the Atlantic surfclam is implemented to evaluate rotating closures to enhance Atlantic surfclam productivity and increase fishery viability in the MAB. Active agents of the MSE model are individual fishing vessels with performance and quota constraints influenced by captains\u27 behavior over a spatially varying population. Management alternatives include 2 rules regarding closure locations and 3 rules regarding closure durations. Simulations showed that stock biomass increased, up to 17%, under most alternative strategies in relation to estimated stock biomass under present- day management, and LPUE increased under most alternative strategies, by up to 21%. When incidental mortality caused by the fishery increased, the benefits seen under the alternative management were enhanced. These outcomes suggest that area management involving rotating closures could be valuable in insulating the stock and the commercial fishery from further declines as a northerly shift in range proceeds

Property Taxation in Virginia

The Virginia Constitution mandates that all property within the state, except exempt property, must be taxed. In light of the constitution\u27s directive, this note examines the present Virginia property taxation structure in order to provide the practitioner with a guide to its application and operation

The Layer 0 Inner Silicon Detector of the D0 Experiment

This paper describes the design, fabrication, installation and performance of the new inner layer called Layer 0 (L0) that was inserted in the existing Run IIa Silicon Micro-Strip Tracker (SMT) of the D0 experiment at the Fermilab Tevatron collider. L0 provides tracking information from two layers of sensors, which are mounted with center lines at a radial distance of 16.1 mm and 17.6 mm respectively from the beam axis. The sensors and readout electronics are mounted on a specially designed and fabricated carbon fiber structure that includes cooling for sensor and readout electronics. The structure has a thin polyimide circuit bonded to it so that the circuit couples electrically to the carbon fiber allowing the support structure to be used both for detector grounding and a low impedance connection between the remotely mounted hybrids and the sensors.Comment: 28 pages, 9 figure

Lithographically defined synthesis of transition metal dichalcogenides

Transition metal dichalcogenides (TMDs) promise to revolutionize optoelectronic applications. While monolayer exfoliation and vapor phase growth produce extremely high quality 2D materials, direct fabrication at wafer scale remains a significant challenge. Here, we present a method that we call ‘lateral conversion’, which enables the synthesis of patterned TMD structures, with control over the thickness down to a few layers, at lithographically predefined locations. In this method, chemical conversion of a metal-oxide film to TMD layers proceeds by diffusion of precursor propagating laterally between silica layers, resulting in structures where delicate chalcogenide films are protected from contamination or oxidation. Lithographically patterned WS2 structures were synthesized by lateral conversion and analyzed in detail by hyperspectral Raman imaging, scanning electron microscopy and transmission electron microscopy. The rate of conversion was investigated as a function of time, temperature, and thickness of the converted film. In addition, the process was extended to grow patterned MoS2, WSe2, MoSe2 structures, and to demonstrate unique WS2/SiO2 multilayer structures. We believe this method will be applicable to a variety of additional chalcogenide materials, and enable their incorporation into novel architectures and devices