Building digital entrepreneurial platform through local community activity and digital skills in aboriginal Australia

© 2018 Pradhan, Beetson & Kutay. This research is situated in the Ngemba community which includes the township known as Brewarrina. It is located approximately 900 kms north west of Sydney and classified ‘Very Remote Australia’. Brewarrina’s recorded Aboriginal population in 2016 was 71.09% contrasted with the total Indigenous Australian population being 2.8%. The Australian Government have identified Brewarrina in the ‘Digital Divide’ category. Closing the gap on socio-economic disadvantage and the digital divide is directly related to economic development and national priorities include Aboriginal peoples’ employment as an identified target under the banner of the 'Close the Gap' initiative. The Australian government stated the national broadband network (NBN) initiative and ICTs would assist in achieving such priorities. Despite such strategies and initiatives, direct action has yet to be realised. This raises opportunities for targeted networking interactions within and beyond community, offering innovative approaches to countering these priorities. This research will implement and verify an innovative model that facilitates community digital entrepreneurship. The model proposes several practical applications, including community members' ability to promote community entrepreneurship and community members’ skills development

Proportional resource allocation in dynamic n-player Blotto games

In this note, we introduce a general model of dynamic n-player multi-battle Blotto contests in which asymmetric resources and non-homogeneous battlefield prizes are possible. Each player’s probability of winning the prize in a battlefield is governed by a ratio-form contest success function and players’ resource allocation on that battlefield. We show that there exists a pure subgame perfect equilibrium in which players allocate their resources in proportion to the battlefield prizes for every history. We also give a sufficient condition that if there are two players and the contest success function is of Tullock type, then the subgame perfect equilibrium is unique

Seismic Analysis of Saturated Sand Deposits with Silt Layers

Liquefaction of saturated sands during earthquakes is known to be the cause of significant earthquake related damages, including loss of bearing capacity, lateral flow and spreading, slope failures. In recent earthquakes including the1999 Marmara Earthquake in Turkey, field observations have indicated that silt inclusions or silt layers in the sandy deposits can have significant effects on development of liquefaction. The objective of this work is to analytically study the behavior of saturated sand deposits with silt layers. For this purpose, a hypothetical soil profile in which silt layers exist has been selected. The selected profile was then modeled and analyzed using the LASS-IV code that has nonlinear effective stress analysis capability. As base motion, rock site recordings of the mentioned earthquakes were utilized. Furthermore, as part of this study, a parametric study has been conducted to further understand the effects of silt layers within sand deposits on the onset of liquefaction. The results of the analyses of various parameters such as depth of silt layer, the relative density of sand layer and maximum base acceleration were tabulated to summarize the effect of silt layers on the onset of liquefaction

Towards Project Portfolio Management for Sustainable Outcomes in the Construction Industry

It is imperative that organisations improve their sustainability and there is a global push to reduce the environmental impact from project activities. This is especially true in construction, yet there is no ex1stmg framework to guide decision making and project portfolio management (PPM) for sustainable construction. This paper discusses the application of project portfolio management to the area of sustainable development in the construction industry. Using the understanding gained from existing PPM practices in a range of industries and the current approaches to risk and sustainability management in the construction industry, we propose a new maturity model for PPM. The maturity model aims to guide the introduction of sustainability factors into multi-project resource scheduling and risk analysis in the coustruction industry, and can be used to make the contribution to sustainability from an overall portfolio more sustainable than the sum of the contribution from individual projects, 1

Adapting a virtual advisor’s verbal conversation based on predicted user preferences: A study of neutral, empathic and tailored dialogue

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Virtual agents that improve the lives of humans need to be more than user-aware and adaptive to the user’s current state and behavior. Additionally, they need to apply expertise gained from experience that drives their adaptive behavior based on deep understanding of the user’s features (such as gender, culture, personality, and psychological state). Our work has involved extension of FAtiMA (Fearnot AffecTive Mind Architecture) with the addition of an Adaptive Engine to the FAtiMA cognitive agent architecture. We use machine learning to acquire the agent’s expertise by capturing a collection of user profiles into a user model and development of agent expertise based on the user model. In this paper, we describe a study to evaluate the Adaptive Engine, which compares the benefit (i.e., reduced stress, increased rapport) of tailoring dialogue to the specific user (Adaptive group) with dialogues that are either empathic (Empathic group) or neutral (Neutral group). Results showed a significant reduction in stress in the empathic and neutral groups, but not the adaptive group. Analyses of rule accuracy, participants’ dialogue preferences, and individual differences reveal that the three groups had different needs for empathic dialogue and highlight the importance and challenges of getting the tailoring right

Embedded Microbubbles for Acoustic Manipulation of Single Cells and Microfluidic Applications.

Acoustically excited microstructures have demonstrated significant potential for small-scale biomedical applications by overcoming major microfluidic limitations. Recently, the application of oscillating microbubbles has demonstrated their superiority over acoustically excited solid structures due to their enhanced acoustic streaming at low input power. However, their limited temporal stability hinders their direct applicability for industrial or clinical purposes. Here, we introduce the embedded microbubble, a novel acoustofluidic design based on the combination of solid structures (poly(dimethylsiloxane)) and microbubbles (air-filled cavity) to combine the benefits of both approaches while minimizing their drawbacks. We investigate the influence of various design parameters and geometrical features through numerical simulations and experimentally evaluate their manipulation capabilities. Finally, we demonstrate the capabilities of our design for microfluidic applications by investigating its mixing performance as well as through the controlled rotational manipulation of individual HeLa cells

A Protein Inventory of Human Ribosome Biogenesis Reveals an Essential Function of Exportin 5 in 60S Subunit Export

A systematic search for human ribosome biogenesis factors shows conservation of many aspects of eukaryotic ribosome synthesis with the well-studied process in yeast and identifies an export route of 60S subunits that is specific for higher eukaryotes

DOR/Tp53inp2 and Tp53inp1 Constitute a Metazoan Gene Family Encoding Dual Regulators of Autophagy and Transcription

Human DOR/TP53INP2 displays a unique bifunctional role as a modulator of autophagy and gene transcription. However, the domains or regions of DOR that participate in those functions have not been identified. Here we have performed structure/function analyses of DOR guided by identification of conserved regions in the DOR gene family by phylogenetic reconstructions. We show that DOR is present in metazoan species. Invertebrates harbor only one gene, DOR/Tp53inp2, and in the common ancestor of vertebrates Tp53inp1 may have arisen by gene duplication. In keeping with these data, we show that human TP53INP1 regulates autophagy and that different DOR/TP53INP2 and TP53INP1 proteins display transcriptional activity. The use of molecular evolutionary information has been instrumental to determine the regions that participate in DOR functions. DOR and TP53INP1 proteins share two highly conserved regions (region 1, aa residues 28–42; region 2, 66–112 in human DOR). Mutation of conserved hydrophobic residues in region 1 of DOR (that are part of a nuclear export signal, NES) reduces transcriptional activity, and blocks nuclear exit and autophagic activity under autophagy-activated conditions. We also identify a functional and conserved LC3-interacting motif (LIR) in region 1 of DOR and TP53INP1 proteins. Mutation of conserved acidic residues in region 2 of DOR reduces transcriptional activity, impairs nuclear exit in response to autophagy activation, and disrupts autophagy. Taken together, our data reveal DOR and TP53INP1 as dual regulators of transcription and autophagy, and identify two conserved regions in the DOR family that concentrate multiple functions crucial for autophagy and transcription