125 research outputs found
Effect of Current Density on Electrodeposition of Nickel-Organic Microcapsules Composite Coatings
A formation of protective composite coatings based on nickel and organic substance of inert nature, containing a corrosion inhibitor, encapsulated in a polymer shell, was studied. The microcapsules were
synthesized in an aqueous-organic emulsion using the method of formation of shell of the modified gelatine
on the surface of microdroplets. Composite coatings were obtained by electrochemical codeposition of nickel
matrix and microcapsules, suspended in the electrolyte. Changes of surface morphology, microhardness
and corrosive properties of coatings with respect to changes of deposition parameters of coatings were
investigated. The distribution of particle sizes in coatings depending on the current density was studied. It was shown that an increase in the mass fraction of the microcapsules in the coating leads to an increase in its corrosion resistance
Measurement of the Spin-Dependence of the pbar-p Interaction at the AD-Ring
We propose to use an internal polarized hydrogen storage cell gas target in
the AD ring to determine for the first time the two total spin-dependent pbar-p
cross sections sigma_1 and sigma_2 at antiproton beam energies in the range
from 50 to 450 MeV. The data obtained are of interest by themselves for the
general theory of pbar-p interactions since they will provide a first
experimental constraint of the spin-spin dependence of the nucleon-antinucleon
potential in the energy range of interest. In addition, measurements of the
polarization buildup of stored antiprotons are required to define the optimum
parameters of a future, dedicated Antiproton Polarizer Ring (APR), intended to
feed a double-polarized asymmetric pbar-p collider with polarized antiprotons.
Such a machine has recently been proposed by the PAX collaboration for the new
Facility for Antiproton and Ion Research (FAIR) at GSI in Darmstadt, Germany.
The availability of an intense stored beam of polarized antiprotons will
provide access to a wealth of single- and double-spin observables, thereby
opening a new window on QCD spin physics.Comment: 51 pages, 23 figures, proposal submitted to the SPS committee of CER
ĐĐ»Đ°ĐŽĐ”ĐœŃĐ”ŃĐșĐ°Ń Đž ĐŽĐ”ŃŃĐșĐ°Ń ŃĐŸŃĐŒĐ° ĐŒĐžŃĐŸŃ ĐŸĐœĐŽŃОалŃĐœĐŸĐč ĐŒĐžĐŸĐżĐ°ŃОО Ń ĐŒŃŃĐ°ŃĐžŃĐŒĐž ĐČ ĐłĐ”ĐœĐ” ĐąĐ2 Ń ŃĐ”ĐœĐŸŃĐžĐżĐŸĐŒ ŃĐżĐžĐœĐ°Đ»ŃĐœĐŸĐč ĐŒŃŃĐ”ŃĐœĐŸĐč Đ°ŃŃĐŸŃОО 5q: пДŃĐČŃĐ” ŃĐ»ŃŃĐ°Đž ĐČ Đ ĐŸŃŃОО
Introduction. Mitochondrial myopathy with thymidine kinase 2 deficiency and spinal muscular atrophy 5q (SMA-5q) are two potentially curable hereditary diseases with different levels of damage to the neuromuscular system and etiology. Early childhood forms have a similar phenotype and are difficult for differential diagnosis.The aim of the study â the description of the clinical and paraclinical characteristics of the mitochondrial myopathy with TK2 deficiency and informing health care specialists about the possibility of optimizing differential diagnosis.Materials and methods. This study involved patients with a previously excluded by molecular genetic method a spinal muscular atrophy 5q diagnosis. Clinical and paraclinical descriptions are presented for 5 patients from 3 families. In addition, 96 patient samples were obtained from the archive of the Research Center for Medical Genetics. The diagnosis based on the clinical and paraclinical features of the disease and the detection of mutations in TK2 gene by sequencing of the NGS panel or TK2 gene directly.Results. Eight patients with mitochondrial myopathy with TK2 from 5 unrelated families have been diagnosed. Three of them have been found retrospectively by analyze of 96 spinal muscular atrophy 5q negative samples.Conclusions. Clinical and molecular genetic characteristics of mitochondrial myopathy with TK2 are presented. The feasibility of differential diagnosis of this rare myopathy with other neuromuscular diseases, including such frequent as spinal muscular atrophy 5q, is shown. The study revealed four previously undescribed mutations in the TK2 gene (c.169G>A (p.Gly57Ser), c.310C>T (p.Arg104Cys), c.338T>A (p.Val113Glu), c.655T>C(p.Trp219Arg)).ĐĐČĐ”ĐŽĐ”ĐœĐžĐ”. ĐĐžŃĐŸŃ
ĐŸĐœĐŽŃОалŃĐœĐ°Ń ĐŒĐžĐŸĐżĐ°ŃĐžŃ Ń ĐœĐ”ĐŽĐŸŃŃĐ°ŃĐŸŃĐœĐŸŃŃŃŃ ŃĐžĐŒĐžĐŽĐžĐœĐșĐžĐœĐ°Đ·Ń 2 (ĐąĐ2) Đž ŃĐżĐžĐœĐ°Đ»ŃĐœĐ°Ń ĐŒŃŃĐ”ŃĐœĐ°Ń Đ°ŃŃĐŸŃĐžŃ 5q â ĐŽĐČĐ° ĐżĐŸŃĐ”ĐœŃОалŃĐœĐŸ ĐșŃŃабДлŃĐœŃŃ
ĐœĐ°ŃлДЎŃŃĐČĐ”ĐœĐœŃŃ
Đ·Đ°Đ±ĐŸĐ»Đ”ĐČĐ°ĐœĐžŃ Ń ŃазлОŃĐœŃĐŒ ŃŃĐŸĐČĐœĐ”ĐŒ ĐżĐŸŃĐ°Đ¶Đ”ĐœĐžŃ ĐœĐ”ŃĐČĐœĐŸ-ĐŒŃŃĐ”ŃĐœĐŸĐč ŃĐžŃŃĐ”ĐŒŃ Đž ŃŃĐžĐŸĐ»ĐŸĐłĐžĐ”Đč. Đ Đ°ĐœĐœĐžĐ” ĐŽĐ”ŃŃĐșОД ŃĐŸŃĐŒŃ ĐžĐŒĐ”ŃŃ ŃŃ
ĐŸĐ¶ĐžĐč ŃĐ”ĐœĐŸŃОп, ŃĐ»ĐŸĐ¶ĐœŃĐč ĐŽĐ»Ń ĐŽĐžŃŃĐ”ŃĐ”ĐœŃОалŃĐœĐŸĐč ĐŽĐžĐ°ĐłĐœĐŸŃŃĐžĐșĐž.ĐŠĐ”Đ»Ń ĐžŃŃĐ»Đ”ĐŽĐŸĐČĐ°ĐœĐžŃ â ĐŸĐżĐžŃĐ°ĐœĐžĐ” ĐșĐ»ĐžĐœĐžĐșĐŸ-паŃĐ°ĐșĐ»ĐžĐœĐžŃĐ”ŃĐșĐžŃ
Ń
Đ°ŃĐ°ĐșŃĐ”ŃĐžŃŃĐžĐș ĐŒĐžŃĐŸŃ
ĐŸĐœĐŽŃОалŃĐœĐŸĐč ĐŒĐžĐŸĐżĐ°ŃОО Ń ĐœĐ”ĐŽĐŸŃŃĐ°ŃĐŸŃĐœĐŸŃŃŃŃ ĐąĐ2, ĐžĐœŃĐŸŃĐŒĐžŃĐŸĐČĐ°ĐœĐžĐ” ŃпДŃОалОŃŃĐŸĐČ ĐŸ ĐČĐŸĐ·ĐŒĐŸĐ¶ĐœĐŸŃŃĐž ĐŸĐżŃĐžĐŒĐžĐ·Đ°ŃОО ĐŽĐžŃŃĐ”ŃĐ”ĐœŃОалŃĐœĐŸĐč ĐŽĐžĐ°ĐłĐœĐŸŃŃĐžĐșĐž.ĐĐ°ŃĐ”ŃĐžĐ°Đ»Ń Đž ĐŒĐ”ŃĐŸĐŽŃ. ĐŃĐ”ĐŒ Đ±ĐŸĐ»ŃĐœŃĐŒ, ĐČĐșĐ»ŃŃĐ”ĐœĐœŃĐŒ ĐČ ĐŸĐ±ŃĐ»Đ”ĐŽĐŸĐČĐ°ĐœĐžĐ”, ĐżŃДЎĐČĐ°ŃĐžŃДлŃĐœĐŸ ĐżĐŸ ŃДзŃĐ»ŃŃĐ°ŃĐ°ĐŒ ĐŒĐŸĐ»Đ”ĐșŃĐ»ŃŃĐœŃŃ
ĐžŃŃĐ»Đ”ĐŽĐŸĐČĐ°ĐœĐžĐč бŃĐ» ĐžŃĐșĐ»ŃŃĐ”Đœ ĐŽĐžĐ°ĐłĐœĐŸĐ· «ŃĐżĐžĐœĐ°Đ»ŃĐœĐ°Ń ĐŒŃŃĐ”ŃĐœĐ°Ń Đ°ŃŃĐŸŃĐžŃ 5q». ĐĐ»ĐžĐœĐžĐșĐŸ-паŃĐ°ĐșĐ»ĐžĐœĐžŃĐ”ŃĐșОД ĐŸĐżĐžŃĐ°ĐœĐžŃ ĐżŃДЎŃŃĐ°ĐČĐ»Đ”ĐœŃ ĐżĐŸ 5 паŃĐžĐ”ĐœŃĐ°ĐŒ Оз 3 ŃĐ”ĐŒĐ”Đč. ĐŃ 96 паŃĐžĐ”ĐœŃĐŸĐČ ĐżŃДЎŃŃĐ°ĐČĐ»Đ”Đœ ŃĐŸĐ»ŃĐșĐŸ Đ±ĐžĐŸĐŒĐ°ŃĐ”ŃОал. ĐĐžĐ°ĐłĐœĐŸĐ· ŃŃŃĐ°ĐœĐ°ĐČлОĐČĐ°Đ»ŃŃ ĐœĐ° ĐŸŃĐœĐŸĐČĐ°ĐœĐžĐž ĐșĐ»ĐžĐœĐžĐșĐŸ-паŃĐ°ĐșĐ»ĐžĐœĐžŃĐ”ŃĐșĐžŃ
ĐŸŃĐŸĐ±Đ”ĐœĐœĐŸŃŃĐ”Đč ĐżŃĐŸŃĐČĐ»Đ”ĐœĐžŃ Đ·Đ°Đ±ĐŸĐ»Đ”ĐČĐ°ĐœĐžŃ Đž ĐČŃŃĐČĐ»Đ”ĐœĐžĐ”ĐŒ ĐŒŃŃĐ°ŃĐžĐč ĐŒĐ”ŃĐŸĐŽĐ°ĐŒĐž ĐżŃŃĐŒĐŸĐłĐŸ ŃĐ”ĐșĐČĐ”ĐœĐžŃĐŸĐČĐ°ĐœĐžŃ ĐłĐ”ĐœĐ° TK2 ОлО Ń ĐżŃĐžĐŒĐ”ĐœĐ”ĐœĐžĐ”ĐŒ ŃĐ°ŃгДŃĐœŃŃ
NGS-ĐżĐ°ĐœĐ”Đ»Đ”Đč.РДзŃĐ»ŃŃĐ°ŃŃ. ĐĐžĐ°ĐłĐœĐŸŃŃĐžŃĐŸĐČĐ°ĐœĐŸ 8 Đ±ĐŸĐ»ŃĐœŃŃ
c ĐŒĐžŃĐŸŃ
ĐŸĐœĐŽŃОалŃĐœĐŸĐč ĐŒĐžĐŸĐżĐ°ŃОДĐč Ń ĐœĐ”ĐŽĐŸŃŃĐ°ŃĐŸŃĐœĐŸŃŃŃŃ ĐąĐ2 Оз 5ĐœĐ”ŃĐŸĐŽŃŃĐČĐ”ĐœĐœŃŃ
ŃĐ”ĐŒĐ”Đč, Оз ĐœĐžŃ
3 Đ±ĐŸĐ»ŃĐœŃŃ
â ŃĐ”ŃŃĐŸŃпДĐșŃĐžĐČĐœĐŸ ĐżŃĐž ŃĐșŃĐžĐœĐžĐœĐłĐ” 96 Đ±ĐžĐŸĐŸĐ±ŃĐ°Đ·ŃĐŸĐČ.ĐŃĐČĐŸĐŽŃ. ĐŃĐžĐČĐ”ĐŽĐ”ĐœĐ° ĐșĐ»ĐžĐœĐžŃĐ”ŃĐșĐ°Ń Đž ĐŒĐŸĐ»Đ”ĐșŃĐ»ŃŃĐœĐŸ-ĐłĐ”ĐœĐ”ŃĐžŃĐ”ŃĐșĐ°Ń Ń
Đ°ŃĐ°ĐșŃĐ”ŃĐžŃŃĐžĐșĐ° ĐŒĐžŃĐŸŃ
ĐŸĐœĐŽŃОалŃĐœĐŸĐč ĐŒĐžĐŸĐżĐ°ŃОО Ń ĐœĐ”ĐŽĐŸŃŃĐ°ŃĐŸŃĐœĐŸŃŃŃŃ ĐąĐ2. ĐĐŸĐșĐ°Đ·Đ°ĐœĐ° ĐœĐ”ĐŸĐ±Ń
ĐŸĐŽĐžĐŒĐŸŃŃŃ ĐŽĐžŃŃĐ”ŃĐ”ĐœŃОалŃĐœĐŸĐč ĐŽĐžĐ°ĐłĐœĐŸŃŃĐžĐșĐž ŃŃĐŸĐč ŃДЎĐșĐŸĐč паŃĐŸĐ»ĐŸĐłĐžĐž Ń ĐŽŃŃĐłĐžĐŒĐž ĐœĐ”ŃĐČĐœĐŸ-ĐŒŃŃĐ”ŃĐœŃĐŒĐž Đ·Đ°Đ±ĐŸĐ»Đ”ĐČĐ°ĐœĐžŃĐŒĐž, ĐČ ŃĐŸĐŒ ŃĐžŃлД ŃĐ°ĐșĐžĐŒ ŃĐ°ŃŃŃĐŒ, ĐșĐ°Đș ŃĐżĐžĐœĐ°Đ»ŃĐœĐ°Ń ĐŒŃŃĐ”ŃĐœĐ°Ń Đ°ŃŃĐŸŃĐžŃ 5q. Đ ŃДзŃĐ»ŃŃĐ°ŃĐ” ĐžŃŃĐ»Đ”ĐŽĐŸĐČĐ°ĐœĐžŃ ĐČŃŃĐČĐ»Đ”ĐœŃ 4ŃĐ°ĐœĐ”Đ” ĐœĐ” ĐŸĐżĐžŃĐ°ĐœĐœŃĐ” ĐŒŃŃĐ°ŃОО ĐČ ĐłĐ”ĐœĐ” TK2 (c.169G>A (p.Gly57Ser), c.310C>T(p.Arg104Cys), c.338T>A (p.Val113Glu), c.655T>C (p.Trp219Arg))
The SHiP experiment at the proposed CERN SPS Beam Dump Facility
The Search for Hidden Particles (SHiP) Collaboration has proposed a general-purpose experimental facility operating in beam-dump mode at the CERN SPS accelerator to search for light, feebly interacting particles. In the baseline configuration, the SHiP experiment incorporates two complementary detectors. The upstream detector is designed for recoil signatures of light dark matter (LDM) scattering and for neutrino physics, in particular with tau neutrinos. It consists of a spectrometer magnet housing a layered detector system with high-density LDM/neutrino target plates, emulsion-film technology and electronic high-precision tracking. The total detector target mass amounts to about eight tonnes. The downstream detector system aims at measuring visible decays of feebly interacting particles to both fully reconstructed final states and to partially reconstructed final states with neutrinos, in a nearly background-free environment. The detector consists of a 50 m long decay volume under vacuum followed by a spectrometer and particle identification system with a rectangular acceptance of 5 m in width and 10 m in height. Using the high-intensity beam of 400 GeV protons, the experiment aims at profiting from the 4 x 10(19) protons per year that are currently unexploited at the SPS, over a period of 5-10 years. This allows probing dark photons, dark scalars and pseudo-scalars, and heavy neutral leptons with GeV-scale masses in the direct searches at sensitivities that largely exceed those of existing and projected experiments. The sensitivity to light dark matter through scattering reaches well below the dark matter relic density limits in the range from a few MeV/c(2) up to 100 MeV-scale masses, and it will be possible to study tau neutrino interactions with unprecedented statistics. This paper describes the SHiP experiment baseline setup and the detector systems, together with performance results from prototypes in test beams, as it was prepared for the 2020 Update of the European Strategy for Particle Physics. The expected detector performance from simulation is summarised at the end
Measurement of associated charm production induced by 400 GeV/c protons
An important input for the interpretation of the measurements of the SHiP ex- periment is a good knowledge of the differential charm production cross section, including cascade production. This is a proposal to measure the associated charm production cross section, employing the SPS 400 GeV/c proton beam and a replica of the first two interaction lengths of the SHiP target. The detection of the produc- tion and decay of charmed hadron in the target will be performed through nuclear emulsion films, employed in an Emulsion Cloud Chamber target structure. In order to measure charge and momentum of decay daughters, we intend to build a mag- netic spectrometer using silicon pixel, scintillating fibre and drift tube detectors. A muon tagger will be built using RPCs. An optimization run is scheduled in 2018, while the full measurement will be performed after the second LHC Long Shutdown
Modern Trends of Organic Chemistry in Russian Universities
© 2018, Pleiades Publishing, Ltd. This review is devoted to the scientific achievements of the departments of organic chemistry in higher schools of Russia within the past decade
Measurement of the muon flux from 400 GeV/c protons interacting in a thick molybdenum/tungsten target
The SHiP experiment is proposed to search for very weakly interacting particles beyond the Standard Model which are produced in a 400 GeV/c proton beam dump at the CERN SPS. About 1011 muons per spill will be produced in the dump. To design the experiment such that the muon-induced background is minimized, a precise knowledge of the muon spectrum is required. To validate the muon flux generated by our Pythia and GEANT4 based Monte Carlo simulation (FairShip), we have measured the muon flux emanating from a SHiP-like target at the SPS. This target, consisting of 13 interaction lengths of slabs of molybdenum and tungsten, followed by a 2.4 m iron hadron absorber was placed in the H4 400 GeV/c proton beam line. To identify muons and to measure the momentum spectrum, a spectrometer instrumented with drift tubes and a muon tagger were used. During a 3-week period a dataset for analysis corresponding to (3.27±0.07) à 1011 protons on target was recorded. This amounts to approximatively 1% of a SHiP spill
Fast simulation of muons produced at the SHiP experiment using generative adversarial networks
This paper presents a fast approach to simulating muons produced in interactions of the SPS proton beams with the target of the SHiP experiment. The SHiP experiment will be able to search for new long-lived particles produced in a 400 GeV/c SPS proton beam dump and which travel distances between fifty metres and tens of kilometers. The SHiP detector needs to operate under ultra-low background conditions and requires large simulated samples of muon induced background processes. Through the use of Generative Adversarial Networks it is possible to emulate the simulation of the interaction of 400 GeV/c proton beams with the SHiP target, an otherwise computationally intensive process. For the simulation requirements of the SHiP experiment, generative networks are capable of approximating the full simulation of the dense fixed target, offering a speed increase by a factor of Script O(106). To evaluate the performance of such an approach, comparisons of the distributions of reconstructed muon momenta in SHiP's spectrometer between samples using the full simulation and samples produced through generative models are presented. The methods discussed in this paper can be generalised and applied to modelling any non-discrete multi-dimensional distribution
The experimental facility for the Search for Hidden Particles at the CERN SPS
The International School for Advanced Studies (SISSA) logo The International School for Advanced Studies (SISSA) logo The following article is OPEN ACCESS The experimental facility for the Search for Hidden Particles at the CERN SPS C. Ahdida44, R. Albanese14,a, A. Alexandrov14, A. Anokhina39, S. Aoki18, G. Arduini44, E. Atkin38, N. Azorskiy29, J.J. Back54, A. Bagulya32Show full author list Published 25 March 2019 ⹠© 2019 CERN Journal of Instrumentation, Volume 14, March 2019 Download Article PDF References Download PDF 543 Total downloads 7 7 total citations on Dimensions. Article has an altmetric score of 1 Turn on MathJax Share this article Share this content via email Share on Facebook Share on Twitter Share on Google+ Share on Mendeley Article information Abstract The Search for Hidden Particles (SHiP) Collaboration has shown that the CERN SPS accelerator with its 400 GeV/c proton beam offers a unique opportunity to explore the Hidden Sector [1â3]. The proposed experiment is an intensity frontier experiment which is capable of searching for hidden particles through both visible decays and through scattering signatures from recoil of electrons or nuclei. The high-intensity experimental facility developed by the SHiP Collaboration is based on a number of key features and developments which provide the possibility of probing a large part of the parameter space for a wide range of models with light long-lived super-weakly interacting particles with masses up to Script O(10) GeV/c2 in an environment of extremely clean background conditions. This paper describes the proposal for the experimental facility together with the most important feasibility studies. The paper focuses on the challenging new ideas behind the beam extraction and beam delivery, the proton beam dump, and the suppression of beam-induced background
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