2,648 research outputs found
A Full Shell Model Study of a~=~48 Nuclei
Exact diagonalizations with a minimally modified realistic force lead to
detailed agreement with measured level schemes and electromagnetic transitions
in Ca, Sc, Ti, V, Cr and Mn.
Gamow-Teller strength functions are systematically calculated and reproduce the
data to within the standard quenching factor. Their fine structure indicates
that fragmentation makes much strength unobservable. As a by-product, the
calculations suggest a microscopic description of the onset of rotational
motion. The spectroscopic quality of the results provides strong arguments in
favour of the general validity of monopole corrected realistic forces, which is
discussed.Comment: 30 pages, LaTeX with epsf.sty, 14 Postscript figures included and
compressed using uufiles. Completely new version of previous preprint
nucl-th/9307001. FTUAM-93/01, CRN/PT 93-3
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Expression of interfacial Seebeck coefficient through grain boundary engineering with multi-layer graphene nanoplatelets
Expression of energy filtering to boost thermoelectric performance through grain boundary engineering utilising graphene.</p
The hind- and midfoot alignment analyzed after a medializing calcaneal osteotomy using a 3D weight bearing CT
Common-path interferometric label-free protein sensing with resonant dielectric nanostructures
Research toward photonic biosensors for point-of-care applications and personalized medicine is driven by the need for high-sensitivity, low-cost, and reliable technology. Among the most sensitive modalities, interferometry offers particularly high performance, but typically lacks the required operational simplicity and robustness. Here, we introduce a common-path interferometric sensor based on guided-mode resonances to combine high performance with inherent stability. The sensor exploits the simultaneous excitation of two orthogonally polarized modes, and detects the relative phase change caused by biomolecular binding on the sensor surface. The wide dynamic range of the sensor, which is essential for fabrication and angle tolerance, as well as versatility, is controlled by integrating multiple, tuned structures in the field of view. This approach circumvents the trade-off between sensitivity and dynamic range, typical of other phase-sensitive modalities, without increasing complexity. Our sensor enables the challenging label-free detection of procalcitonin, a small protein (13 kDa) and biomarker for infection, at the clinically relevant concentration of 1 pg mL−1, with a signal-to-noise ratio of 35. This result indicates the utility for an exemplary application in antibiotic guidance, and opens possibilities for detecting further clinically or environmentally relevant small molecules with an intrinsically simple and robust sensing modality
Synthesis of 1-Substituted Carbazolyl-1,2,3,4-tetrahydro- and Carbazolyl-3,4-dihydro-β-carboline Analogs as Potential Antitumor Agents
A series of 1-substituted carbazolyl-1,2,3,4-tetrahydro- and carbazolyl-3,4-dihydro-β-carboline analogs have been synthesized and evaluated for antitumor activity against human tumor cells including KB, DLD, NCI-H661, Hepa, and HepG2/A2 cell lines. Among these, compounds 2, 6, 7, and 9 exhibited the most potent and selective activity against the tested tumor cells. As for inhibition of topoisomerase II, compounds 1–14 and 18 showed better activity than etoposide. Among them, compounds 3, 4, 7, 9, and 10 exhibited potent activity. The structure and activity relationship (SAR) study revealed correlation between carbon numbers of the side chain and biological activities. The molecular complex with DNA for compound 2 was proposed
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Unsupervised anomaly detection in printed circuit boards through student–teacher feature pyramid matching
Copyright: © 2021 by the authors. Deep learning methods are currently used in industries to improve the efficiency and quality of the product. Detecting defects on printed circuit boards (PCBs) is a challenging task and is usually solved by automated visual inspection, automated optical inspection, manual inspection, and supervised learning methods, such as you only look once (YOLO) of tiny YOLO, YOLOv2, YOLOv3, YOLOv4, and YOLOv5. Previously described methods for defect detection in PCBs re-quire large numbers of labeled images, which is computationally expensive in training and requires a great deal of human effort to label the data. This paper introduces a new unsupervised learning method for the detection of defects in PCB using student–teacher feature pyramid matching as a pre‐trained image classification model used to learn the distribution of images without anomalies. Hence, we extracted the knowledge into a student network which had same architecture as the teacher network. This one‐step transfer retains key clues as much as possible. In addition, we incor-porated a multi‐scale feature matching strategy into the framework. A mixture of multi‐level knowledge from the features pyramid passes through a better supervision, known as hierarchical feature alignment, which allows the student network to receive it, thereby allowing for the detection of various sizes of anomalies. A scoring function reflects the probability of the occurrence of anom-alies. This framework helped us to achieve accurate anomaly detection. Apart from accuracy, its inference speed also reached around 100 frames per second.Ministry of Science and Technology (MOST) of Taiwan (grant number: MOST 109-2622-E-155-007), Avary Holding (Shenzhen) Co., Ltd and Boardtek Electronics Corporation, Taiwan
Large-Theta(13) Perturbation Theory of Neutrino Oscillation for Long-Baseline Experiments
The Cervera et al. formula, the best known approximate formula of neutrino
oscillation probability for long-baseline experiments, can be regarded as a
second-order perturbative formula with small expansion parameter epsilon \equiv
Delta m^2_{21} / Delta m^2_{31} \simeq 0.03 under the assumption s_{13} \simeq
epsilon. If theta_{13} is large, as suggested by a candidate nu_{e} event at
T2K as well as the recent global analyses, higher order corrections of s_{13}
to the formula would be needed for better accuracy. We compute the corrections
systematically by formulating a perturbative framework by taking theta_{13} as
s_{13} \sim \sqrt{epsilon} \simeq 0.18, which guarantees its validity in a wide
range of theta_{13} below the Chooz limit. We show on general ground that the
correction terms must be of order epsilon^2. Yet, they nicely fill the mismatch
between the approximate and the exact formulas at low energies and relatively
long baselines. General theorems are derived which serve for better
understanding of delta-dependence of the oscillation probability. Some
interesting implications of the large theta_{13} hypothesis are discussed.Comment: Fig.2 added, 23 pages. Matches to the published versio
Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.
We developed a systematic approach to map human genetic networks by combinatorial CRISPR-Cas9 perturbations coupled to robust analysis of growth kinetics. We targeted all pairs of 73 cancer genes with dual guide RNAs in three cell lines, comprising 141,912 tests of interaction. Numerous therapeutically relevant interactions were identified, and these patterns replicated with combinatorial drugs at 75% precision. From these results, we anticipate that cellular context will be critical to synthetic-lethal therapies
Intraprostatic Botulinum Toxin Type A injection in patients with benign prostatic enlargement: duration of the effect of a single treatment
<p>Abstract</p> <p>Background</p> <p>Botulinum Toxin Type-A (BoNT/A) intraprostatic injection can induce prostatic involution and improve LUTS and urinary flow in patients with Benign Prostatic Enlargement (BPE). However, the duration of these effects is unknown. The objective of this work was to determine the duration of prostate volume reduction after one single intraprostatic injection of 200U of Botulinum Toxin Type-A.</p> <p>Methods</p> <p>This is an extension of a 6 month study in which 21 frail elderly patients with refractory urinary retention and unfit for surgery were submitted to intraprostatic injection of BoNT/A-200U, by ultrasound guided transrectal approach. In spite of frail conditions, eleven patients could be followed during 18 months. Prostate volume, total serum PSA, maximal flow rate (Qmax), residual volume (PVR) and IPSS-QoL scores were determined at 1, 3, 6, 12 and 18 months post-treatment.</p> <p>Results</p> <p>Mean prostate volume at baseline, 82 ± 16 ml progressively decreased from month one coming to 49 ± 9,5 ml (p = 0,003) at month six. From this moment on, prostate volume slowly recovered, becoming identical to baseline at 18 months (73 ± 16 ml, p = 0.03). Albeit non significant, serum PSA showed a 25% decrease from baseline to month 6. The 11 patients resumed spontaneous voiding at month one. Mean Qmax was 11,3 ± 1,7 ml/sec and remained unchanged during the follow-up period. PVR ranged from 55 ± 17 to 82 ± 20 ml and IPSS score from10 to 12 points.</p> <p>Conclusion</p> <p>Intraprostatic BoNT/A injection is safe and can reduce prostate volume for a period of 18 months. During this time a marked symptomatic improvement can be maintained.</p
Bacillus anthracis Protease InhA Increases Blood-Brain Barrier Permeability and Contributes to Cerebral Hemorrhages
Hemorrhagic meningitis is a fatal complication of anthrax, but its pathogenesis remains poorly understood. The present study examined the role of B. anthracis-secreted metalloprotease InhA on monolayer integrity and permeability of human brain microvasculature endothelial cells (HBMECs) which constitute the blood-brain barrier (BBB). Treatment of HBMECs with purified InhA resulted in a time-dependent decrease in trans-endothelial electrical resistance (TEER) accompanied by zonula occluden-1 (ZO-1) degradation. An InhA-expressing B. subtilis exhibited increased permeability of HBMECs, which did not occur with the isogenic inhA deletion mutant (ΔinhA) of B. anthracis, compared with the corresponding wild-type strain. Mice intravenously administered with purified InhA or nanoparticles-conjugated to InhA demonstrated a time-dependent Evans Blue dye extravasation, leptomeningeal thickening, leukocyte infiltration, and brain parenchymal distribution of InhA indicating BBB leakage and cerebral hemorrhage. Mice challenged with vegetative bacteria of the ΔinhA strain of B. anthracis exhibited a significant decrease in leptomeningeal thickening compared to the wildtype strain. Cumulatively, these findings indicate that InhA contributes to BBB disruption associated with anthrax meningitis through proteolytic attack on the endothelial tight junctional protein zonula occluden (ZO)-1
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