Continuous, Semi-discrete, and Fully Discretized Navier-Stokes Equations

The Navier--Stokes equations are commonly used to model and to simulate flow phenomena. We introduce the basic equations and discuss the standard methods for the spatial and temporal discretization. We analyse the semi-discrete equations -- a semi-explicit nonlinear DAE -- in terms of the strangeness index and quantify the numerical difficulties in the fully discrete schemes, that are induced by the strangeness of the system. By analyzing the Kronecker index of the difference-algebraic equations, that represent commonly and successfully used time stepping schemes for the Navier--Stokes equations, we show that those time-integration schemes factually remove the strangeness. The theoretical considerations are backed and illustrated by numerical examples.Comment: 28 pages, 2 figure, code available under DOI: 10.5281/zenodo.998909, https://doi.org/10.5281/zenodo.99890

Toll-like Receptor 3 L412F Polymorphism Promotes a Persistent Clinical Phenotype in Pulmonary Sarcoidosis

Background: Sarcoidosis is a multisystemic disorder of unknown etiology, characterised by the presence of non-caseating granulomas in target organs. In ninety percent of cases, there is thoracic involvement. Fifty to seventy percent of pulmonary sarcoidosis patients will experience acute, self-limiting disease. For the subgroup of patients who develop persistent disease, no targeted therapy is currently available. Aim: To investigate the potential of the single nucleotide polymorphism (SNP), Toll-like receptor 3 Leu412Phe (TLR3 L412F; rs3775291), as a causative factor in the development of, and in disease persistence in pulmonary sarcoidosis. To investigate the functionality of TLR3 L412F in vitro in primary human lung fibroblasts from pulmonary sarcoidosis patients. Methods: Cohorts of Irish sarcoidosis patients (n=228), healthy Irish controls (n = 263) and a secondary cohort of American sarcoidosis patients (n=123) were genotyped for TLR3 L412F. Additionally, the effect of TLR3 L412F in primary lung fibroblasts from pulmonary sarcoidosis patients was quantitated following TLR3 activation in the context of cytokine and type I interferon production, TLR3 expression, and apoptotic- and fibroproliferative-responses. Results: We report a significant association between TLR3 L412F and persistent clinical disease in two cohorts of Irish and American Caucasians with pulmonary sarcoidosis. Furthermore, activation of TLR3 in primary lung fibroblasts from 412F-homozygous pulmonary sarcoidosis patients resulted in reduced IFN-â and TLR3 expression, reduced apoptosis- and dysregulated fibroproliferative-responses compared with TLR3 wild-type patients. Conclusions: This study identifies defective TLR3 function as a previously unidentified factor in persistent clinical disease in pulmonary sarcoidosis and reveals TLR3 L412F as a candidate biomarker

Oxygen Radicals and Arachidonate Metabolites in Lung Injury a

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72476/1/j.1749-6632.1986.tb18477.x.pd

Maternal protein-energy malnutrition during early pregnancy in sheep impacts the fetal ornithine cycle to reduce fetal kidney microvascular development

This paper identifies a common nutritional pathway relating maternal through to fetal protein-energy malnutrition (PEM) and compromised fetal kidney development. Thirty-one twin-bearing sheep were fed either a control (n=15) or low-protein diet (n=16, 17 vs. 8.7 g crude protein/MJ metabolizable energy) from d 0 to 65 gestation (term, ∼ 145 d). Effects on the maternal and fetal nutritional environment were characterized by sampling blood and amniotic fluid. Kidney development was characterized by histology, immunohistochemistry, vascular corrosion casts, and molecular biology. PEM had little measureable effect on maternal and fetal macronutrient balance (glucose, total protein, total amino acids, and lactate were unaffected) or on fetal growth. PEM decreased maternal and fetal urea concentration, which blunted fetal ornithine availability and affected fetal hepatic polyamine production. For the first time in a large animal model, we associated these nutritional effects with reduced micro- but not macrovascular development in the fetal kidney. Maternal PEM specifically impacts the fetal ornithine cycle, affecting cellular polyamine metabolism and microvascular development of the fetal kidney, effects that likely underpin programming of kidney development and function by a maternal low protein diet

Transmission of the caprine arthritis-encephalitis virus through artificial insemination.

[Transmissão do vírus da artrite-encefalite caprina através da inseminação artificial]

Local conductivity of the (0001) surface of topological insulators based on Bi2Te3

Обнаружена возможность переключать проводимость контакта зонда с поверхностью с уменьшением сопротивления на пять и более порядков по величине. В отличие от локального эффекта на пленке, на микрочешуйке создаваемая область повышенной проводимости могла распространяться на всю ее поверхность.It has been found possible to switch the conductivity of the contact between the probe and the surface with decreasing resistance by five or more orders of magnitude. In contrast to the local effect on the film, on the micro flake, the created region of increased conductivity could propagate to the entire surface of the film

Exclusive Photoproduction of \u3cem\u3eπ\u3c/em\u3e\u3csup\u3e0\u3c/sup\u3e Up to Large Values of Mandlestam Variables \u3cem\u3es\u3c/em\u3e, \u3cem\u3et\u3c/em\u3e, and \u3cem\u3eu\u3c/em\u3e with CLAS

Exclusive photoproduction cross sections have been measured for the process γp → pπ0[e+e−(γ)] with the Dalitz decay final state using tagged photon energies in the range of Eγ = 1.275–5.425 GeV. The complete angular distribution of the final state π0, for the entire photon energy range up to large values of t and u, has been measured for the first time. The data obtained show that the cross section dσ/dt, at mid to large angles, decreases with energy as s−6.89±0.26. This is in agreement with the perturbative QCD quark counting rule prediction of s−7. Paradoxically, the size of angular distribution of measured cross sections is greatly underestimated by the QCD-based generalized parton distribution mechanism at highest available invariant energy s = 11 GeV2. At the same time, the Regge-exchange-based models for π0 photoproduction are more consistent with experimental data