209 research outputs found
Drawing as a Facilitator of Critical Data Discourse: Reflecting on Problems with Digital Health Data Through Expressive Visualizations of the Unseen Body Landscape
In a 1.5-hour workshop, we used drawing and self-reflection prompts to facilitate a value-driven discussion of personal and institutional data practices. Activities included mark-making in time with one's heartbeat, creating an inventory of one's personal data, and creating a qualitative personal health visualization. This article details the workshop structure and exercises and includes a summary of the discussion, which constructively encompassed both the empowering and the uncomfortable aspects of digital health data collection in a constructive manner. The workshop's design used the format of hands-on, expressive drawing activities to enable participants to achieve depth and breadth in a relatively short discussion about personal health, data autonomy, institutional trust, and consent. Critical discourse about data, especially health data, is a valuable experience for every person whose health data has been or is being collected; and approaches that take personal data as a starting point can support the practice of digital/data sovereignty more broadly
Tailoring the structure of polymer networks with iniferter-mediated photo-growth
Using dissipative particle dynamics (DPD), we developed a computational approach to capture the photo-controlled radical polymerization (βphoto-growthβ) of polymer gels containing trithiocarbonate (TTC) groups within the network strands. Using this model, we focused on a βprimary gelβ and illuminated the sample to activate the TTCs, which then interacted with monomer and cross-linker in the solution. At low TTC concentrations, gels composed of compatible monomers formed two distinct, spatially separated layers. Conversely, at high TTC concentration, gels formed from incompatible components displayed a well-intermixed structure. Hence, in the presence of light, variations in the TTC concentration provide a new approach for controllably tailoring the structure of polymer gels, and thereby tailoring the functionality of the network.National Science Foundation (U.S.). Designing Materials to Revolutionize and Engineer our Future (CHE-1334703
New resource-efficient and green synthesis methods for biologically active derivatives of urea
Developed were highly effective solvent-free processes for preparation of substituted ureas containingpharmacophore substituents (benzhydryl ureas, dihydroquinazolinones, semicarbazones, thiosemicarbazonesand guanylhydrazones), consistent with green chemistry principles for environmentally friendlyorganic synthesis methods
Friction Drag on a Particle Moving in a Nematic Liquid Crystal
The flow of a liquid crystal around a particle does not only depend on its
shape and the viscosity coefficients but also on the direction of the
molecules. We studied the resulting drag force on a sphere moving in a nematic
liquid crystal (MBBA) in a low Reynold's number approach for a fixed director
field (low Ericksen number regime) using the computational artificial
compressibility method. Taking the necessary disclination loop around the
sphere into account, the value of the drag force anisotropy
(F_\perp/F_\parallel=1.50) for an exactly computed field is in good agreement
with experiments (~1.5) done by conductivity diffusion measurements. We also
present data for weak anchoring of the molecules on the particle surface and of
trial fields, which show to be sufficiently good for most applications.
Furthermore, the behaviour of the friction close to the transition point
nematic isotropic and for a rod-like and a disc-like liquid crystal will be
given.Comment: 23 pages RevTeX, including 3 PS figures, 1 PS table and 1 PS-LaTeX
figure; Accepted for publication in Phys. Rev.
Effective triplet interactions in nematic colloids
Three-body effective interactions emerging between parallel cylindrical rods
immersed in a nematic liquid crystals are calculated within the Landau-de
Gennes free energy description. Collinear, equilateral and midplane
configurations of the three colloidal particles are considered. In the last two
cases the effective triplet interaction is of the same magnitude and range as
the pair one
Preparation de formamide de la benzophenone oxime et les O-derives
ΠΠ΅Π½Π·Π³ΠΈΠ΄ΡΠΈΠ»ΠΌΠΎΡΠ΅Π²ΠΈΠ½Ρ ΡΠ²Π»ΡΡΡΡΡ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΠΌΠΈ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡΠΌΠΈ, ΠΏΡΠΎΡΠ²Π»ΡΡΡΠΈΠΌΠΈ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΡΡΠ΄ΠΎΡΠΎΠΆΠ½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ, Π° ΡΡΠ±ΡΡΡΠ°ΡΡ Π² ΡΠΈΠ½ΡΠ΅Π·Π΅ Π±Π΅Π½Π·Π³ΠΈΠ΄ΡΠΈΠ»ΠΌΠΎΡΠ΅Π²ΠΈΠ½ -Π±Π΅Π½Π·Π³ΠΈΠ΄ΡΠΈΠ»Π°ΠΌΠΈΠ½Ρ. ΠΠΎΡΡΠΎΠΌΡ ΡΠ΅Π»ΡΡ Π½Π°ΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΡ Π±ΡΠ»Π° ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΡΠ΄ΠΎΠ±Π½ΠΎΠ³ΠΎ ΠΈ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈ Π²ΡΠ³ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΡΠΏΠΎΡΠΎΠ±Π° ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ Π±Π΅Π½Π·Π³ΠΈΠ΄ΡΠΈΠ»Π°ΠΌΠΈΠ½ΠΎΠ².ΠΠ΅ΡΠ²ΡΠΌ ΡΡΠ°ΠΏΠΎΠΌ ΡΠ°Π±ΠΎΡΡ Π±ΡΠ»ΠΎ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΎΠΊΡΠΈΠΌΠ°Π±Π΅Π½Π·ΠΎΡΠ΅Π½ΠΎΠ½Π°, ΠΊΠΎΡΠΎΡΡΠΉ Π² Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅ΠΌ Π²ΠΎΡΡΡΠ°Π½Π°Π²Π»ΠΈΠ²Π°Π»ΡΡ Π΄ΠΎ Π±Π΅Π½Π·Π³ΠΈΠ΄ΡΠΈΠ»Π°ΠΌΠΈΠ½Π°. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ,Π½Π°ΠΌΠΈ Π±ΡΠ» Π½Π°ΠΉΠ΄Π΅Π½ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΌΠ΅ΡΠΎΠ΄ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ ΠΎΠΊΡΠΈΠΌΠ°Π±Π΅Π½Π·ΠΎΡΠ΅Π½ΠΎΠ½Π° ΠΈ Π΅Π³ΠΎ Π-ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ
Π΄ΠΎ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠ΅Π³ΠΎ ΡΠΎΡΠΌΠ°ΠΌΠΈΠ΄Π°., ΠΊΠΎΡΠΎΡΡΠΉ, ΠΊΠ°ΠΊ ΠΈΠ·Π²Π΅ΡΡΠ½ΠΎ ΠΏΡΠΈ Π³ΠΈΠ΄ΡΠΎΠ»ΠΈΠ·Π΅ ΠΎΠ±ΡΠ°Π·ΡΠ΅Ρ Π±Π΅Π½Π·Π³ΠΈΠ΄ΡΠΈΠ»Π°ΠΌΠΈΠ½
The Impact of Combination Therapy with Rivaroxaban and Acetylsalicylic Acid in Patients with Coronary Heart Disease on the Achievement of the Target for Reducing Mortality from Cardiovascular Diseases of the Federal Project "Fight against Cardiovascular Diseases"
Aim. To assess the outcomes of combination therapy with rivaroxaban and acetylsalicylic acid (ASA) in patients with stable coronary artery disease (CAD) and a high risk of thrombotic events on the set targets of Ministry of Health for reduction of cardiovascular mortality in Russia.Material and methods. The development of the model for analysis in MS Excel included the following stages: calculation of the population of patients with stable CAD who can be treated with combination therapy (rivaroxaban and ASA); calculation of the number of deaths due to cardiovascular disease (CVD), number of strokes and myocardial infarction (MI) in the current scenario (patients receive monotherapy with ASA) and simulated scenario (some patients switch from monotherapy to combination therapy); estimation the impact of the number of avoided cases of deaths due to combination therapy on set target for reducing CVD mortality in 2024 year; sensitivity analysis to assess the sustainability of outcomes.Results. Total number of eligible patients for combination therapy was estimated as 1.08 million patients. Based on the simulation results, it was determined that with the reallocation of patients from monotherapy with ASA to combination therapy with rivaroxaban and ASA, the number of avoided deaths in 2022 will be 973 cases, in 2023 β 1,622 cases, in 2024 β 3,245 cases, which will make it possible to reach 6.7%, 7.4% and 11.1% of the set target for reduction of mortality from CVD in the respective years. In addition, the gradual reallocation of patients from monotherapy to combination therapy might decrease the cases of stroke and MI in 973 and 649 cases by 2022, 1,622 and 1,082 cases by 2023, and 3 245 and 2 163 cases by 2024 year, respectively. Sensitivity analysis showed that outcomes are sustainable.Conclusion. The use of combination therapy of rivaroxaban and ASA in patients with stable CAD and high thrombotic risk will allow to achieve up to 11.1% of the set target for reduction of mortality from CVD by 2024 in Russia and can also potentially impact on another set target for reduction mortality from cerebrovascular diseases by reducing the number of strokes. Thereby, this therapy can be considered for drug provision programmes for patients with stable CAD and high thrombotic risk to fulfill the goals to reduce mortality from CVD
Drag on particles in a nematic suspension by a moving nematic-isotropic interface
We report the first clear demonstration of drag on colloidal particles by a moving nematic-isotropic
interface. The balance of forces explains our observation of periodic, strip-like structures that are produced by the movement of these particles
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