Estudo para determinação da frequência de deformidade do mento em Chironomus sancticaroli (Diptera: chironomidae) em cultura de laboratório

The midge Chironomus sancticaroli (Diptera: Chironomidae) has been used in ecotoxicological tests because it is sensitive to a variety of inorganic pollutants. Among the parameters used to evaluate the toxicity of a substance is the frequency of mentum deformity, which is part of the oral system of this organism. However, there is still no consensus on the baseline level (percentage) of acceptable deformities in laboratory cultures not exposed to pollutants. The determination of this variable is important to ensure the validity of bioassays and to compare cultures from different research and teaching institutions. Once this value is established, it will also be used to monitor the quality of organisms cultured, since factors such as inbreeding could increase the frequency of mentum deformity. Thus, the objective of this study was to quantify the percentage of mentum deformity in the fourth instar of C. sancticaroli larvae from the culture of the Laboratory of Aquatic Ecosystems, at Embrapa Meio Ambiente. The average frequency of mentum deformity obtained was 6,63%. It is believed that factors such as the renewal of the culture with the inclusion of spawns from the laboratories of other institutions, as well as the control of the quality of the dilution water and the sediment of the breeding may have contributed to a low frequency of mentum deformity of the culture observed in this study.142sensível a uma variedade de poluentes inorgânicos. Um dos parâmetros utilizados para avaliar a toxicidade de uma substância é a frequência de deformidade do mento, que faz parte do sistema oral deste organismo. Entretanto, ainda não há consenso a respeito do nível basal (porcentagem) de deformidade aceitável em culturas de laboratório não expostas a poluentes. A determinação desta variável é importante para assegurar a validade de bioensaios e comparar culturas de diferentes instituições de pesquisa e ensino. Uma vez estabelecido, este número também será usado para o controle da qualidade dos organismos criados, já que fatores como o endocruzamento poderiam aumentar a frequência de deformidade do mento. Assim, o objetivo deste estudo foi quantificar a porcentagem de deformidade do mento em larvas de quarto instar de C. sancticaroli de cultura do Laboratório de Ecossistemas Aquáticos da Embrapa Meio Ambiente. A média de frequência de deformidade obtida para a cultura foi de 6,63%. Acredita-se que fatores como a renovação da cultura com a inclusão de desovas de laboratórios de outras instituições, assim como o controle da qualidade da água de diluição e do sedimento da criação, podem ter contribuído para uma baixa frequência de deformidade do mento da cultura

Recent Developments in Algorithmic Teaching

Abstract. The present paper surveys recent developments in algorith-mic teaching. First, the traditional teaching dimension model is recalled. Starting from the observation that the teaching dimension model some-times leads to counterintuitive results, recently developed approaches are presented. Here, main emphasis is put on the following aspects derived from human teaching/learning behavior: the order in which examples are presented should matter; teaching should become harder when the memory size of the learners decreases; teaching should become easier if the learners provide feedback; and it should be possible to teach infinite concepts and/or finite and infinite concept classes. Recent developments in the algorithmic teaching achieving (some) of these aspects are presented and compared.

Adjuvant Hepatic Arterial Infusion Pump Chemotherapy After Resection of Colorectal Liver Metastases: Results of a Safety and Feasibility Study in The Netherlands

Background: The 10-year overall survival with adjuvant hepatic arterial infusion pump (HAIP) chemotherapy after resection of colorectal liver metastases (CRLMs) was 61% in clinical trials from Memorial Sloan Kettering Cancer Center. A pilot study was performed to evaluate the safety and feasibility of adjuvant HAIP chemotherapy in patients with resectable CRLMs. Study Design: A phase II study was performed in two centers in The Netherlands. Patients with resectable CRLM without extrahepatic disease were eligible. All patients underwent complete resection and/or ablation of CRLMs and pump implantation. Safety was determined by the 90-day HAIP-related postoperative complications from the day of pump placement (Clavien–Dindo classification, grade III or higher) and feasibility by the successful administration of the first cycle of HAIP chemotherapy. Results: A total of 20 patients, with a median age of 57 years (interquartile range [IQR] 51–64) were included. Grade III or higher HAIP-related postoperative complications were found in two patients (10%), both of whom had a reoperation (without laparotomy) to replace a pump with a slow flow rate or to reposition a flipped pump. No arterial bleeding, arterial dissection, arterial thrombosis, extrahepatic perfusion, pump pocket hematoma, or pump pocket infections were found within 90 days after surgery. After a median of 43 days (IQR 29–52) following surgery, all patients received the first dose of HAIP chemotherapy, which was completed un

Measurement of the W+W- Production Cross Section in ppbar Collisions at sqrt(s)=1.96 TeV using Dilepton Events

We present a measurement of the W+W- production cross section using 184/pb of ppbar collisions at a center-of-mass energy of 1.96 TeV collected with the Collider Detector at Fermilab. Using the dilepton decay channel W+W- -> l+l-vvbar, where the charged leptons can be either electrons or muons, we find 17 candidate events compared to an expected background of 5.0+2.2-0.8 events. The resulting W+W- production cross section measurement of sigma(ppbar -> W+W-) = 14.6 +5.8 -5.1 (stat) +1.8 -3.0 (syst) +-0.9 (lum) pb agrees well with the Standard Model expectation.Comment: 8 pages, 2 figures, 2 tables. To be submitted to Physical Review Letter

Adjuvant hepatic arterial infusion pump chemotherapy and resection versus resection alone in patients with low-risk resectable colorectal liver metastases - the multicenter randomized controlled PUMP trial

Background Recurrences are reported in 70% of all patients after resection of colorectal liver metastases (CRLM), in which half are confined to the liver. Adjuvant hepatic arterial infusion pump (HAIP) chemotherapy aims to reduce the risk of intrahepatic recurrence. A large retrospective propensity score analysis demonstrated that HAIP chemotherapy is particularly effective in patients with low-risk oncological features. The aim of this randomized controlled trial (RCT) --the PUMP trial-- is to investigate the efficacy of adjuvant HAIP chemotherapy in low-risk patients with resectable CRLM. Methods This is an open label multicenter RCT. A total of 230 patients with resectable CRLM without extrahepatic disease will be included. Only patients with a clinical risk score (CRS) of 0 to 2 are eligible, meaning: patients are allowed to have no more than two out of five poor prognostic factors (disease-free interval less than 12 months, node-positive colorectal cancer, more than 1 CRLM, largest CRLM more than 5 cm in diameter, serum Carcinoembryonic Antigen above 200 μg/L). Patients randomized to arm A undergo complete resection of CRLM without any adjuvant treatment, which is the standard of care in the Netherlands. Patients in arm B receive an implantable pump at the time of CRLM resection and start adjuvant HAIP chemotherapy 4–12 weeks after surgery, with 6 cycles of floxuridine scheduled. The primary endpoint is progression-free survival (PFS). Secondary endpoints include overall survival, hepatic PFS, safety, quality of life, and cost-effectiveness. Pharmacokinetics of intra-arterial administration of floxuridine will be investigated as well as predictive biomarkers for the efficacy of HAIP chemotherapy. In a side study, the accuracy of CT angiography will be compared to radionuclide scintigraphy to detect extrahepatic perfusion. We hypothesize that adjuvant HAIP chemotherapy leads to improved survival, improved quality of life, and

Municipal Waste Management in Norway and the Netherlands: From In-House Provision to Inter-Municipal Cooperation

The organization of local public services is assumed to have gone through three developmental stages, from originally being organized in-house, to the New Public Management (NPM) epoch, to the contemporary period of post-NPM and re-municipalization. On the basis of Van Thiel’s typology of agencies we analyze how the emergence of organizational forms has occurred in the field of waste management in Norway and the Netherlands. We find that the trajectory of reform in both countries does not match the three developmental stages. Moreover, there are significant differences in the organization of waste management in the two countries in these stages. Additionally, in spite of differences in terms of crisis experience, we find common features such as increasing agentification, a strong tendency towards “inter-municipalization,” and no convincing signs of re-municipalization

Keepaway soccer: From machine learning testbed to benchmark

Abstract. Keepaway soccer has been previously put forth as a testbed for machine learning. Although multiple researchers have used it successfully for machine learning experiments, doing so has required a good deal of domain expertise. This paper introduces a set of programs, tools, and resources designed to make the domain easily usable for experimentation without any prior knowledge of RoboCup or the Soccer Server. In addition, we report on new experiments in the Keepaway domain, along with performance results designed to be directly comparable with future experimental results. Combined, the new infrastructure and our concrete demonstration of its use in comparative experiments elevate the domain to a machine learning benchmark, suitable for use by researchers across the field. 1 Introduction Keepaway soccer in the Soccer Server used at RoboCup has been previouslyput forth as a testbed for machine learning [15]. Since then it has been used fo