Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review

Apolipoprotein E is a polymorphic and multifunctional protein with numerous roles in lipoprotein metabolism. The three common isoforms apoE2, apoE3 and apoE4 show isoform-specific functional properties including different susceptibilities to diseases. ApoE4 is an accepted risk factor for Alzheimer's disease and cardiovascular disorders. Recently, associations between apoE4 and infectious diseases have been demonstrated. This review summarises how apoE4 may be involved in the infection incidence and associated pathologies of specific infectious diseases, namely hepatitis C, human immunodeficiency virus disease and herpes simplex

Cerebrospinal fluid biomarkers in Alzheimer’s disease, vascular dementia and ischemic stroke patients: a critical analysis

Vascular factors are thought to contribute to the development of disease pathology in neurodegenerative dementia such as Alzheimer’s disease (AD). Another entity, called vascular dementia (VaD), comprises a less defined group of dementia patients having various vascular diseases that especially emerge in the elderly population and require valid options for examination and differential diagnosis. In the context of a retrospective study, we analyzed the cerebrospinal fluid (CSF) biomarkers t-tau, p-tau and Aß42 of a total of 131 patients with AD (n = 47), mild cognitive impairment (MCI) (n = 22), VaD (n = 44) and stroke (n = 18). We found a remarkable alteration in CSF biomarker profile in AD, VaD and in acute ischemic events. CSF profile in AD patients was altered in a very similar way as in stroke patients, without statistical differences. In stroke, increase depend largely on size and duration after the initial event. Total tau levels were useful to differ between VaD and stroke. Aß42 decreased in a similar way in AD, VaD and stroke and had a trend to lower levels in MCI but not in controls

Экономика предприятия (организации)

Представлен дополнительный материал для подготовки к государственному экзамену по курсу «Экономика предприятия (организации)». Для студентов специализации 1-26 02 03 07 «Маркетинг предприятий промышленности» дневной и заочной форм обучения

Patterns of sexual behaviour associated with repeated chlamydia testing and infection in men and women : a latent class analysis

Background Adolescents and young adults are at higher risk of acquiring Chlamydia trachomatis infection (chlamydia), so testing is promoted in these populations. Studies have shown that re-testing for chlamydia is common amongst them. We investigated how sexual risk behaviour profiles are associated with repeated testing for chlamydia. Methods We used baseline data from a cohort of 2814 individuals recruited at an urban STI -clinic. We applied latent class (LC) analysis using 9 manifest variables on sexual behaviour and substance use self-reported by the study participants. We fitted ordered logistic regression to investigate the association of LC membership with the outcomes repeated testing during the past 12 months and lifetime repeated testing for chlamydia. Models were fit separately for men and women. Results We identified four LCs for men and three LCs for women with increasing gradient of risky sexual behaviour. The two classes with the highest risk among men were associated with lifetime repeated testing for chlamydia: adjOR = 2.26 (95%CI: 1.50-3.40) and adjOR = 3.03 (95%CI: 1.93-4.74) as compared with the class with lowest risk. In women, the class with the highest risk was associated with increased odds of repeated lifetime testing (adjOR =1.85 (95%CI: 1.24-2.76)) and repeated testing during past 12 months (adjOR = 1.72 (95%CI: 1.16-2.54)). An association with chlamydia positive test at the time of the study and during the participant's lifetime was only found in the male highest risk classes. Conclusion Prevention messages with regard to testing for chlamydia after unprotected sexual contact with new/casual partners seem to reach individuals in highest risk behaviour classes who are more likely to test repeatedly. Further prevention efforts should involve potentially more tailored sex-specific interventions taking into consideration risk behaviour patterns

not opaque flow – Workflows zur Aufbereitung und Auswertung historischer Dokumente

Deep Learning hat bereits neue Erkenntnisse in den digitalen Geisteswissenschaften ermöglicht. Vormoderne Sprachen und Sprachen des globalen Südens bringen allerdings Herausforderungen mit sich, die aktuell diesen analytischen Zugriff in diesem Bereich noch nicht erlauben. Das Projekt "The Flow" entwickelt Lösungen für solche historische Korpora in den Bereichen Handschriftenerkennung, Entitätsidentifikation, Event-Extraktion, Topic Modeling und Clustering. Die Entwicklung der Webanwendung nopaque zielt darauf ab, diese bestehenden Methoden bzw. Werkzeuge in einem übergreifenden Workflow zu verbinden. Der Workshop stellt den aktuellen Stand von nopaque bzw. den Workflow vor. Ziel ist es, bei der Etablierung eines allgemein anwendbaren Workflows für Deep Learning die Vielfalt der Quellen und geisteswissenschaftlichen Forschung zu berücksichtigen. Wir laden Teilnehmer:innen ein, Ideen und Erfahrungen einzubringen und Implementierungen für nicht standardisierte Layouts, Schriften und Sprachen zu diskutieren. Der Workshop trägt dazu bei, unser Projektziel zu erreichen: maschinelles Lernen in allen Bereichen der Geschichtswissenschaft zugänglicher zu machen