Towards applying NMR relaxometry as a diagnostic tool for bone and soft tissue sarcomas : a pilot study

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 668119 (project “IDentIFY”). This work received support from the EURELAX COST Action CA15209, supported by COST (European Cooperation in Science and Technology). The authors would like to thank Professor David Lurie for his continuous support.Peer reviewedPublisher PD

Mechanism of Water Dynamics in Hyaluronic Dermal Fillers Revealed by Nuclear Magnetic Resonance Relaxometry

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under project “IDentIFY”, grant agreement No 668119.Peer reviewedPublisher PD

Slow dynamics of solid proteins : Nuclear Magnetic Resonance relaxometry versus Dielectric Spectroscopy

Acknowledgement This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 668119 (project “IDentIFY”).Peer reviewedPublisher PD

1H spin-lattice NMR relaxation in the presence of residual dipolar interactions : Dipolar relaxation enhancement

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 668119 (project “IDentIFY”). The role of COST Action CA15209 (European Network on NMR Relaxometry) is also acknowledged.Peer reviewedPublisher PD

Dynamics of Solid Proteins by Means of Nuclear Magnetic Resonance Relaxometry

Funding This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 668119 (project “IDentIFY”).Peer reviewedPublisher PD

Insights into the Effect of Magnetic Confinement on the Performance of Magnetic Nanocomposites in Magnetic Hyperthermia and Magnetic Resonance Imaging

The combination of superparamagnetic iron oxide nanoparticles (SPIONs) and lipid matrices enables the integration of imaging, drug delivery, and therapy functionalities into smart theranostic nanocomposites. SPION confinement creates new interactions primarily among the embedded SPIONs and then between the nanocomposites and the surroundings. Understanding the parameters that rule these interactions in real interacting (nano)systems still represents a challenge, making it difficult to predict or even explain the final (magnetic) behavior of such systems. Herein, a systematic study focused on the performance of a magnetic nanocomposite as a magnetic resonance imaging (MRI) contrast agent and magnetic hyperthermia (MH) effector is presented. The effect of stabilizing agents and magnetic loading on the final physicochemical and, more importantly, functional properties (i.e., blocking temperature, specific absorption rate, relaxivity) was studied in detail

Security theory and practice: Germany towards security problems and international cooperation in the 21st century

Z wprowadzenia: "Pierwsze ćwierćwiecze XXI wieku obfituje w dyskusje na temat wagi i znaczenia wyzwań międzynarodowych. Również niemieccy politycy prezentują strategie i programy osiągania przez Niemcy celów i interesów na arenie międzynarodowej. Ocena realizacji niemieckiej polityki bezpieczeństwa oraz poziomu współpracy międzynarodowej wymaga uwzględnienia wielu czynników o charakterze podmiotowym i przedmiotowym. Minister obrony Ursula von der Leyen proponowała „przywództwo z centrum”, a prezydent Joachim Gauck postulował zwiększenie „odpowiedzialności międzynarodowej” Niemiec. Podczas gdy minister spraw zagranicznych Guido Westerwelle opowiedział się za trwaniem przy „kulturze wstrzemięźliwości”, socjaldemokraci Sigmar Gabriel i Frank-Walter Steinmeier optowali za polityką zaangażowania Niemiec. Kanclerz Angela Merkel odnosząc się do dyskusji dotyczących rozbrojenia podkreślała, że odstraszanie stanowi istotny element stabilizacji środowiska międzynarodowego i postulowała realistyczne podejście do problematyki zbrojeń."(...

Water Dynamics in Highly Concentrated Protein Systems—Insight from Nuclear Magnetic Resonance Relaxometry

1H spin-lattice relaxation experiments have been performed for water–Bovine Serum Albumin (BSA) mixtures, including 20%wt and 40%wt of BSA. The experiments have been carried out in a frequency range encompassing three orders of magnitude, from 10 kHz to 10 MHz, versus temperature. The relaxation data have been thoroughly analyzed in terms of several relaxation models with the purpose of revealing the mechanisms of water motion. For this purpose, four relaxation models have been used: the data have been decomposed into relaxation contributions expressed in terms of Lorentzian spectral densities, then three-dimensional translation diffusion has been assumed, next two-dimensional surface diffusion has been considered, and eventually, a model of surface diffusion mediated by acts of adsorption to the surface has been employed. In this way, it has been demonstrated that the last concept is the most plausible. Parameters describing the dynamics in a quantitative manner have been determined and discussed

Understanding spin dynamics

Experimental methods employing spin resonance effects (nuclear magnetic resonance and electron spin resonance) are broadly used in molecular science due to their unique potential to reveal mechanisms of molecular motion, structure, and interactions. The developed techniques bring together biologists investigating dynamics of proteins, material science researchers looking for better electrolytes, or nanotechnology scientists inquiring into dynamics of nano-objects. Nevertheless, one can profit from the rich source of information provided by spin resonance methods only when appropriate theoretical models are available. The obtained experimental results reflect intertwined quantum–mechanical and dynamical properties of molecular systems, and to interpret them one has to first understand the quantum–mechanical principles of the underlying processes. This book concentrates on the theory of spin resonance phenomena and the relaxation theory, which have been discussed from first principles to introduce the reader to the language of quantum mechanics used to describe the behaviour of atomic nuclei and electrons. There is a long way from knowing complex formulae to apply them correctly to describe the studied system. The book shows through examples how symbols can be "replaced" in equations by using properties of real systems to formulate descriptions that link the quantities observed in spin resonance experiments with dynamics and structure of molecules