Climate impact and adaptation to heat and drought stress of regional and global wheat production

Wheat (Triticum aestivum) is the most widely grown food crop in the world threatened by future climate change. In this study, we simulated climate change impacts and adaptation strategies for wheat globally using new crop genetic traits (CGT), including increased heat tolerance, early vigor to increase early crop water use, late flowering to reverse an earlier anthesis in warmer conditions, and the combined traits with additional nitrogen (N) fertilizer applications, as an option to maximize genetic gains. These simulations were completed using three wheat crop models and five Global Climate Models (GCM) for RCP 8.5 at mid-century. Crop simulations were compared with country, US state, and US county grain yield and production. Wheat yield and production from high-yielding and low-yielding countries were mostly captured by the model ensemble mean. However, US state and county yields and production were often poorly reproduced, with large variability in the models, which is likely due to poor soil and crop management input data at this scale. Climate change is projected to decrease global wheat production by −1.9% by mid-century. However, the most negative impacts are projected to affect developing countries in tropical regions. The model ensemble mean suggests large negative yield impacts for African and Southern Asian countries where food security is already a problem. Yields are predicted to decline by −15% in African countries and −16% in Southern Asian countries by 2050. Introducing CGT as an adaptation to climate change improved wheat yield in many regions, but due to poor nutrient management, many developing countries only benefited from adaptation from CGT when combined with additional N fertilizer. As growing conditions and the impact from climate change on wheat vary across the globe, region-specific adaptation strategies need to be explored to increase the possible benefits of adaptations to climate change in the future.info:eu-repo/semantics/publishedVersio

DSMM XI study: dose definition for intravenous cyclophosphamide in combination with bortezomib/dexamethasone for remission induction in patients with newly diagnosed myeloma

A clinical trial was initiated to evaluate the recommended dose of cyclophosphamide in combination with bortezomib and dexamethasone as induction treatment before stem cell transplantation for younger patients with newly diagnosed multiple myeloma (MM). Thirty patients were treated with three 21-day cycles of bortezomib 1.3 mg/m2 on days 1, 4, 8, and 11 plus dexamethasone 40 mg on the day of bortezomib injection and the day after plus cyclophosphamide at 900, 1,200, or 1,500 mg/m2 on day 1. The maximum tolerated dose of cyclophosphamide was defined as 900 mg/m2. At this dose level, 92% of patients achieved at least a partial response. The overall response rate [complete response (CR) plus partial response (PR)] across all dose levels was 77%, with a 10% CR rate. No patient experienced progressive disease. The most frequent adverse events were hematological and gastrointestinal toxicities as well as neuropathy. The results suggest that bortezomib in combination with cyclophosphamide at 900 mg/m2 and dexamethasone is an effective induction treatment for patients with newly diagnosed MM that warrants further investigation

Priority areas for investment in more sustainable and climate-resilient livestock systems

Livestock production supports economic growth, jobs and nutrition, but contributes to and is vulnerable to climate change. A transition is thus needed for livestock systems to become more sustainable and climate resilient, with clear positive effects on the Sustainable Development Goals. It is unclear, however, where the global community should invest to support this change. We identified priority geographies for livestock system investments in 132 low- and middle-income countries (LMICs), at mid- and low latitudes. Our results show that adaptation and mitigation goals are inextricably linked for the vast majority of these countries. An equal weighting of adaptation and mitigation indicators suggests that the top five investment priorities are India, Brazil, China, Pakistan and Sudan. Across LMICs, these act as critical control points for the livestock sector’s interactions with the climate system, land and livelihoods

Exploración de opciones agroecológicas en el sistema de milpa de la Costa Chica, México

Los sistemas de producción de la Costa Chica enfrentan serios problemas de degradación del suelo y baja productividad de maíz y jamaica. Esta situación demanda el diseño e implementación de alternativas agroecológicas para revertir esta problemática. Diversos protocolos experimentales que incluyeron opciones de fertilización e integración de leguminosas se desarrollaron en milpas de agricultores. Con base en los resultados encontrados se realizaron exploraciones a través de modelaje para evaluar el impacto de esas alternativas en el rendimiento de maíz y en el balance de materia orgánica a nivel sistema de producción. Los resultados demostraron que la integración de los componentes evaluados (fertilización, leguminosas y retención de residuos) tuvo efectos positivos en los ingresos familiares y en el balance de materia orgánica.Farming systems in Costa Chica, Mexico face problems related to soil degradation and low crop productivity. This situation requires designing and implementing agroecological alternatives to improve cropping systems. Several experimental trials that included fertilization and intercropping of legumes in current milpa systems were carried out in farmers´ fields. Based on the results modeling explorations were carried out to evaluate the impacts of these field-level agroecological options at farm level. The results showed that the integration of the evaluated components (fertilization, legumes and crop residues retention) had positive effects on family income and organic matter balances.Eje A1 Sistemas de producción de base agroecológica (Trabajos científicos)Facultad de Ciencias Agrarias y Forestale

Current Multiple Myeloma Treatment Strategies with Novel Agents: A European Perspective

This review presents an overview of the most recent data using the novel agents thalidomide, bortezomib, and lenalidomide in the treatment of multiple myeloma and summarizes European treatment practices incorporating these novel agents