5,326 research outputs found
Randomized Trial of Antibiotics in Addition to Tocolytic Therapy to Treat Preterm Labor
Objective: The objective of this study was to assess whether antibiotic
therapy plus tocolysis given to women in preterm labor would prolong pregnancy
compared with tocolysis alone
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Rhythm in the speech of a person with right hemisphere damage: Applying the pairwise variability index
Although several aspects of prosody have been studied in speakers with right hemisphere damage (RHD), rhythm remains largely uninvestigated. This study compares the rhythm of an Australian English speaker with right hemisphere damage (due to a stroke, but with no concomitant dysarthria) to that of a neurologically unimpaired individual. The speakers' rhythm is compared using the pairwise variability index (PVI) which allows for an acoustic characterization of rhythm by comparing the duration of successive vocalic and intervocalic intervals. A sample of speech from a structured interview between a speech and language therapist and each participant was analysed. Previous research has shown that speakers with RHD may have difficulties with intonation production, and therefore it was hypothesized that there may also be rhythmic disturbance. Results show that the neurologically normal control uses a similar rhythm to that reported for British English (there are no previous studies available for Australian English), whilst the speaker with RHD produces speech with a less strongly stress-timed rhythm. This finding was statistically significant for the intervocalic intervals measured (t(8) = 4.7, p < .01), and suggests that some aspects of prosody may be right lateralized for this speaker. The findings are discussed in relation to previous findings of dysprosody in RHD populations, and in relation to syllable-timed speech of people with other neurological conditions
I-fibrinogen as an oncophilic radiodiagnostic agent: distribution kinetics in tumour-bearing mice.
Fibrinogen radioiodinated by the iodine monochloride method was tested as a tumour radiodiagnostic agent in mice. The I-fibrinogen cleared from the blood of tumour-bearing mice more rapidly than from that of normal mice, but it cleared from the whole body more slowly, suggesting it accumulated in a substantial tumour-related compartment in the abnormal mice. The tumour concentration steadily increased for 4 h after injection, at which time it reached a peak concentration of 11-4% of the injected dose/g. This concentration was higher than the peak concentration for Ga-citrate (not reached until 24 h) or any other oncophilic radiopharmaceutical tested in this tumour model. The early accumulation is consistent with the use of 123I as a tracer label for fibrinogen. A combination of the large tumour concentration of I-fibrinogen, an increased catabolic rate induced by chemical modification, and the exceptional nuclear properties of 123I for scintigraphic imaging, could lead to a very useful radiodiagnostic procedure for cancer
Cooling of Molecular Ion Beams
An overview of the use of stored ion beams and phase space cooling (electron cooling) is given for the field of molecular physics. Emphasis is given to interactions between molecular ions and electrons studied in the electron cooler: dissociative recombination and, for internally excited molecular ions, electron-induced ro-vibrational cooling. Diagnostic methods for the transverse ion beam properties and for the internal exciation of the molecular ions are discussed, and results for phase space cooling and internal (vibrational) cooling are presented for hydrogen molecular ions
Feasibility study for a numerical aerodynamic simulation facility. Volume 1
A Numerical Aerodynamic Simulation Facility (NASF) was designed for the simulation of fluid flow around three-dimensional bodies, both in wind tunnel environments and in free space. The application of numerical simulation to this field of endeavor promised to yield economies in aerodynamic and aircraft body designs. A model for a NASF/FMP (Flow Model Processor) ensemble using a possible approach to meeting NASF goals is presented. The computer hardware and software are presented, along with the entire design and performance analysis and evaluation
Factors Associated with Persistence with Teriparatide Therapy: Results from the DANCE Observational Study
Purpose. Determine patient-reported reasons for discontinuation with teriparatide. Methods. Patients taking teriparatide in a multicenter, prospective, and observational study were given three questionnaires: baseline, follow-up questionnaire 1 (QF1, 2 to 6 months), and follow-up questionnaire 2 (QF2, 12 months). Discontinuation reported at QF1 and QF2 was defined as âearlyâ and âlate,â respectively, and remaining patients were considered persistent. Cochran-Armitage trend test was used to identify factors associated with discontinuation. Results. Side effects, concern about improper use, injection difficulties, and several patient-perceived physician issues were associated with early discontinuation. Low patient-perceived importance of continuing treatment, side effects, difficulty paying, and low patient-perceived physician knowledge were associated with late discontinuation. The most common specific reasons selected for discontinuing treatment were âconcerns about treatment outweighing the benefitsâ (n = 53) and âdifficulty payingâ (n = 47). Conclusions. Persistence with teriparatide is dependent on managing side effects, addressing financial challenges, proper training, and obtaining support from the healthcare provider
Dissipation of potassium and proton gradients inhibits mitochondrial hyperpolarization and cytochrome c release during neural apoptosis.
Exposure of rat hippocampal neurons or human D283 medulloblastoma cells to the apoptosis-inducing kinase inhibitor staurosporine induced rapid cytochrome c release from mitochondria and activation of the executioner caspase-3. Measurements of cellular tetramethylrhodamine ethyl ester fluorescence and subsequent simulation of fluorescence changes based on Nernst calculations of fluorescence in the extracellular, cytoplasmic, and mitochondrial compartments revealed that the release of cytochrome c was preceded by mitochondrial hyperpolarization. Overexpression of the anti-apoptotic protein Bcl-xL, but not pharmacological blockade of outward potassium currents, inhibited staurosporine-induced hyperpolarization and apoptosis. Dissipation of mitochondrial potassium and proton gradients by valinomycin or carbonyl cyanide p-trifluoromethoxy-phenylhydrazone also potently inhibited staurosporine-induced hyperpolarization, cytochrome c release, and caspase activation. This effect was not attributable to changes in cellular ATP levels. Prolonged exposure to valinomycin induced significant matrix swelling, and per se also caused release of cytochrome c from mitochondria. In contrast to staurosporine, however, valinomycin-induced cytochrome c release and cell death were not associated with caspase-3 activation and insensitive to Bcl-xL overexpression. Our data suggest two distinct mechanisms for mitochondrial cytochrome c release: (1) active cytochrome c release associated with early mitochondrial hyperpolarization, leading to neuronal apoptosis, and (2) passive cytochrome c release secondary to mitochondrial depolarization and matrix swelling
Testbeam and Laboratory Characterization of CMS 3D Pixel Sensors
The pixel detector is the innermost tracking device in CMS, reconstructing
interaction vertices and charged particle trajectories. The sensors located in
the innermost layers of the pixel detector must be upgraded for the ten-fold
increase in luminosity expected with the High- Luminosity LHC (HL-LHC) phase.
As a possible replacement for planar sensors, 3D silicon technology is under
consideration due to its good performance after high radiation fluence. In this
paper, we report on pre- and post- irradiation measurements for CMS 3D pixel
sensors with different electrode configurations. The effects of irradiation on
electrical properties, charge collection efficiency, and position resolution of
3D sensors are discussed. Measurements of various test structures for
monitoring the fabrication process and studying the bulk and surface
properties, such as MOS capacitors, planar and gate-controlled diodes are also
presented.Comment: 14 page
Landscape-Level Long-Term Biological Research and Monitoring Plan for the Crane Trust
Our obligation is to make sure we are effectively utilizing science to meet the objectives of the Platte River Whooping Crane Maintenance Trust (1981) laid out in its charter âto rehabilitate and preserve a portion of the habitat for Whooping Cranes and other migratory birds in the Big Bend reach of the Platte River between Overton and Chapman (i.e., Central Platte River Valley), Nebraskaâ. The original declaration is aimed at maintaining âthe physical, hydrological, and biological integrity of the Big Bend area as a life-support system for the Whooping Crane and other migratory species that utilize it.â It was clear from the institutionâs founding that to accomplish this goal it was necessary to study the effectiveness of land conservation and management actions in providing habitat for Whooping Cranes and other migratory bird species. Quality habitat necessarily comprises all the components that Whooping Cranes and other migratory bird life require to complete their migrations âfood and shelterâ including nutrient rich diet items such as invertebrates, vascular plants, herpetofauna, fish, and small mammals as well as suitable roosting and foraging locations including wide braided rivers and undisturbed wet meadows (Allen 1952; Steenhof et al. 1988; Geluso 2013; Caven et al. 2019, 2021). Article âAâ of the Crane Trustâs (1981) declaration is âto establish a written habitat monitoring plan which can be used to describe change inâŠ[habitat] within the Big Bend of the Platte RiverâŠutilized by Sandhill Cranes and Whooping CranesâŠ.â Following initial inventories including avian (Hay and Lingle 1982), vegetation (Kolstad 1981; Nagel 1981), small mammals (Springer 1981), herpetofauna (Jones et al. 1981), insects (Ratcliffe 1981), and fish (Cochar and Jenson 1981), a variety of excellent research has continued at the Crane Trust (https://cranetrust.org/conservation-research/publications/). However, despite the clarity of the Trustâs original declaration, long-term habitat monitoring has not progressed unabated throughout the history of the Crane Trust.https://digitalcommons.unl.edu/zeabook/1130/thumbnail.jp
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