In the name of God and rifles: the Neo- Pentecostal and securitarian rise in Brazil (2003-2019)

Este artículo analiza la evolución del espacio político brasileño en los poderes legislativo y ejecutivo, a partir de la convergencia de la aproximación entre pautas y actores de seguridad y el cristianismo neopentecostal; proceso que experimentó un momento de ascensión en los años 2000 y se consumó con la elección como presidente del país de Jair Bolsonaro en octubre de 2018. A través del análisis de actas gubernamentales, propuestas legislativas y materiales periodísticos, se trazan los perfiles de las principales agrupaciones armamentísticas/securitarias y neopentecostales en el legislativo brasileño. Tomando como objeto de estudio el Frente Parlamentario Evangélico y el Frente Parlamentario de Seguridad Pública, se demuestra el crecimiento, entre 2011 y 2019, de su influencia y alineamiento mutuo.This article analyses the evolution of the Brazilian political space in the legislative and executive powers, focusing specifically on the increasing convergence between security and Neo-Pentecostal actors and affairs, culminating in Jair Bolsonaro's election as president in October 2018. By analysing government proceedings, legislative proposals and journalistic materials, this article traces the profiles of the main pro-armament/ security and Neo-Pentecostal associations in the Brazilian legislature. Taking the Evangelical Parliamentary Front and the Parliamentary Front of Public Security as objects of study, this study demonstrates their growing mutual influence and alignment between 2011 and 2019

Computerized feeding systems in active stables Effects on heart rate and heart rate variability in horses

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Naturwissenschaftliche Bildung für alle Kinder

Lück G. Naturwissenschaftliche Bildung für alle Kinder. In: Franz EK, Trumpa S, Esslinger-Hinz I, eds. Inklusion: eine Herausforderung für die Grundschulpädagogik. Entwicklungslinien der Grundschulpädagogik. Vol 11. Baltmannsweiler: Schneider-Verl. Hohengehren; 2014: 119-128

Daytime Sleepiness in Patients Diagnosed with Sarcoidosis Compared with the General Population

Background. The aim of this study was to analyze daytime sleepiness in a sample of patients diagnosed with sarcoidosis. Methods. A sample of 1197 German sarcoidosis patients was examined with the Epworth Sleepiness Scale (ESS), the Fatigue Assessment Scale, the Hospital Anxiety and Depression Scale, the Pittsburgh Sleep Quality Index, and the Short-Form Health Survey (SF-8). The patients’ ESS mean scores were compared with those obtained from a large general population sample. Results. Exactly 50% of the patients reached the criterion (ESS > 10) for excessive daytime sleepiness, compared with only 22.1% in the general population. The effect size for the mean score difference between both samples was d=0.62. The number of affected organs and the number of concomitant diseases proved to be significant independent predictors of daytime sleepiness. Sleepiness was associated with fatigue (r=0.45), anxiety (r=0.23), depression (r=0.28), sleep problems (r=0.23), and detriments in physical (r=−0.29) and mental (r=−0.28) quality of life. Conclusions. The issue of excessive daytime sleepiness should be considered in the management of sarcoidosis

Fatigue in cancer patients: comparison with the general population and prognostic factors

Purpose: The aims of this examination were to compare cancer patients' fatigue burden with that of the general population, to identify clinical factors that are associated with fatigue, and to test psychometric properties of the fatigue questionnaire MFI-20 including the short-form MFI-10. Methods: A sample of 1818 German cancer patients was tested with the MFI-20. Results: The study confirmed that the cancer patients demonstrate a high level of burden from fatigue. The effect size for the comparison between the cancer patients and a sample of the general population (n = 1993) was d = 0.58 based on MFI-20 total scores. In the cancer patients' sample, females reported slightly higher levels of fatigue than males did (p < 0.05). There was no significant effect of age on fatigue. Advanced tumor stage, the presence of metastases, and a 'poorer' Eastern Cooperative Oncology Group (ECOG) performance status were significantly associated with fatigue. The results of the confirmatory factor analyses (CFAs) only partly confirmed the factorial structure of the MFI-20. Conclusion: Despite the insufficient CFA indices, we believe that the scale structure of the MFI-20 should not be changed and that calculating a total fatigue score is justifiable. For those seeking a shorter questionnaire, the MFI-10, which only contains those 10 items which positively indicate fatigue, is a good alternative

Teamarbeit und Team-Teaching in inklusiven Grundschulen

Serke B, Urban M, Lütje-Klose B. Teamarbeit und Team-Teaching in inklusiven Grundschulen. In: Franz E-K, Trumpa S, Esslinger-Hinz I, eds. Inklusion: Eine Herausforderung für die Grundschulpädagogik. Entwicklungslinien der Grundschulpädagogik. Vol 11. Baltmannsweiler: Schneider Verlag Hohengehren; 2014: 249-260.Durch fortschreitende inklusive Schulentwicklungsprozesse verstärkt sich die Notwendigkeit einer Kooperation zwischen verschiedenen Lehrkräften und anderen Professionen, die einen wesentlichen Faktor für das Gelingen gemeinsamen Unterrichts darstellt. In diesem Beitrag steht die intraprofessionelle Kooperaion zwischen Grundschullehrkräften und Lehrkräften für sonderpädagogische Förderung im Fokus. Im Beitrag werden auf der Grundlage empirischer Studien hemmende und förderliche Bedingungen für kooperative Prozesse in der Grundschule herausgearbeitet

Deep proteome profiling of human mammary epithelia at lineage and age resolution.

Age is the major risk factor in most carcinomas, yet little is known about how proteomes change with age in any human epithelium. We present comprehensive proteomes comprised of >9,000 total proteins and >15,000 phosphopeptides from normal primary human mammary epithelia at lineage resolution from ten women ranging in age from 19 to 68 years. Data were quality controlled and results were biologically validated with cell-based assays. Age-dependent protein signatures were identified using differential expression analyses and weighted protein co-expression network analyses. Upregulation of basal markers in luminal cells, including KRT14 and AXL, were a prominent consequence of aging. PEAK1 was identified as an age-dependent signaling kinase in luminal cells, which revealed a potential age-dependent vulnerability for targeted ablation. Correlation analyses between transcriptome and proteome revealed age-associated loss of proteostasis regulation. Age-dependent proteome changes in the breast epithelium identified heretofore unknown potential therapeutic targets for reducing breast cancer susceptibility

Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand-Addicted Pancreatic Cancer.

WNT signaling promotes pancreatic ductal adenocarcinoma (PDAC) through diverse effects on proliferation, differentiation, survival, and stemness. A subset of PDAC with inactivating mutations in ring finger protein 43 (RNF43) show growth dependency on autocrine WNT ligand signaling and are susceptible to agents that block WNT ligand acylation by Porcupine O-acyltransferase, which is required for proper WNT ligand processing and secretion. For this study, global transcriptomic, proteomic, and metabolomic analyses were performed to explore the therapeutic response of RNF43-mutant PDAC to the Porcupine inhibitor (PORCNi) LGK974. LGK974 disrupted cellular bioenergetics and mitochondrial function through actions that included rapid mitochondrial depolarization, reduced mitochondrial content, and inhibition of oxidative phosphorylation and tricarboxylic acid cycle. LGK974 also broadly altered transcriptional activity, downregulating genes involved in cell cycle, nucleotide metabolism, and ribosomal biogenesis and upregulating genes involved in epithelial-mesenchymal transition, hypoxia, endocytosis, and lysosomes. Autophagy and lysosomal activity were augmented in response to LGK974, which synergistically inhibited tumor cell viability in combination with chloroquine. Autocrine WNT ligand signaling dictates metabolic dependencies in RNF43-mutant PDAC through a combination of transcription dependent and independent effects linked to mitochondrial health and function. Metabolic adaptations to mitochondrial damage and bioenergetic stress represent potential targetable liabilities in combination with PORCNi for the treatment of WNT ligand-addicted PDAC

Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information

The G protein-coupled P2Y12 receptor (P2Y12R) is an important antithrombotic target and of great interest for pharmaceutical discovery. Its recently solved, highly divergent crystallographic structures in complex either with nucleotides (full or partial agonist) or with a nonnucleotide antagonist raise the question of which structure is more useful to understand ligand recognition. Therefore, we performed extensive molecular modeling studies based on these structures and mutagenesis, to predict the binding modes of major classes of P2Y12R ligands previously reported. Various nucleotide derivatives docked readily to the agonist-bound P2Y12R, but uncharged nucleotide-like antagonist ticagrelor required a hybrid receptor resembling the agonist-bound P2Y12R except for the top portion of TM6. Supervised molecular dynamics (SuMD) of ticagrelor binding indicated interactions with the extracellular regions of P2Y12R, defining possible meta-binding sites. Ureas, sulfonylureas, sulfonamides, anthraquinones and glutamic acid piperazines docked readily to the antagonist-bound P2Y12R. Docking dinucleotides at both agonist- and antagonist-bound structures suggested interactions with two P2Y12R pockets. Thus, our structure-based approach consistently rationalized the main structure-activity relationships within each ligand class, giving useful information for designing improved ligands

Irritability and Emotional Impulsivity as Core Feature of ADHD and ODD in Children (May, 10.1007/s10862-022-09974-8, 2022)

The categorical approach of diagnosing mental disorders entails the problem of frequently occurring comorbidities, suggesting a more parsimonious structure of psychopathology. In this study, we therefore aim to assess how affective dysregulation (AD) is associated with attention-deficit/hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD) in children. To assess AD in children aged 8-12 years (n = 391), we employed the parent version of a newly constructed parent rating scale. Following item reduction, we conducted exploratory and confirmatory factor analyses to establish a factorial structure of AD. One core dimension was identified, comprising irritability and emotional impulsivity, and two smaller dimensions, comprising positive emotionality and exuberance. Subsequently, we examined five different latent factor models - a unidimensional model, a first-order correlated factor model, a second-order correlated factor model, a traditional bifactor model, and a bifactor S-1 model, in which the first-order factor AD-Irritability/Emotional Impulsivity (II) was modeled as the general reference factor. A bifactor S-1 model with the a priori defined general reference domain AD-II provided the best fit to our data and was straightforward to interpret. This model showed excellent model fit and no anomalous factor loadings. This still held true, when comparing it to bifactor S-1 models with ADHD/ODD-related reference factors. Differential correlations with emotion regulation skills and the established Parent Proxy Anger Scale validate the interpretation of the different dimensions. Our results suggest that irritability/emotional impulsivity might be a common core feature of ADHD and ODD