Artificial Olfaction in the 21st Century

The human olfactory system remains one of the most challenging biological systems to replicate. Humans use it without thinking, where it can measure offer protection from harm and bring enjoyment in equal measure. It is the system's real-time ability to detect and analyze complex odors that makes it difficult to replicate. The field of artificial olfaction has recruited and stimulated interdisciplinary research and commercial development for several applications that include malodor measurement, medical diagnostics, food and beverage quality, environment and security. Over the last century, innovative engineers and scientists have been focused on solving a range of problems associated with measurement and control of odor. The IEEE Sensors Journal has published Special Issues on olfaction in 2002 and 2012. Here we continue that coverage. In this article, we summarize early work in the 20th Century that served as the foundation upon which we have been building our odor-monitoring instrumental and measurement systems. We then examine the current state of the art that has been achieved over the last two decades as we have transitioned into the 21st Century. Much has been accomplished, but great progress is needed in sensor technology, system design, product manufacture and performance standards. In the final section, we predict levels of performance and ubiquitous applications that will be realized during in the mid to late 21st Century

3-Hexanoyl-1-tosylindole. A Highly Stereospecific Preparation of 3-Alkyl-Substituted Indoles

The title molecule, 1-(1-tosyl-3-indolyl)-1-hexanone, C21H23NO3S, is configured so that the indole moiety eclipses one sulfonyl O atom and the toluene ring the other. As expected, the hexanoyl O atom is almost coplanar with the delocalized indole system

Description and Characterisation of a Large Array of Sensors Mimicking an Artifical Olfactory Epithelium

Biological olfactory systems show high sensitivity and exquisite discriminatory capacity to odorants. These characteristics are due to hierarchical signal processing of the large numbers of sensory inputs that occurs within the olfactory system. In testing realistic computational models of the olfactory system, large numbers of chemical sensor inputs are required. So far, sensory devices that may serve as model inputs to an artificial olfactory system do not exist. The development of a large scale array of chemical sensors able to mimic the olfactory receptor neurons is described, and these have been characterised in terms of their variability and degree of redundancy. Using this device it is possible to start testing computational hypotheses appropriate to biological chemosensory systems and adapt them to the artificial olfaction

Roadmap on printable electronic materials for next-generation sensors

The dissemination of sensors is key to realizing a sustainable, ‘intelligent’ world, where everyday objects and environments are equipped with sensing capabilities to advance the sustainability and quality of our lives—e.g., via smart homes, smart cities, smart healthcare, smart logistics, Industry 4.0, and precision agriculture. The realization of the full potential of these applications critically depends on the availability of easy-to-make, low-cost sensor technologies. Sensors based on printable electronic materials offer the ideal platform: they can be fabricated through simple methods (e.g., printing and coating) and are compatible with high-throughput roll-to-roll processing. Moreover, printable electronic materials often allow the fabrication of sensors on flexible/stretchable/biodegradable substrates, thereby enabling the deployment of sensors in unconventional settings. Fulfilling the promise of printable electronic materials for sensing will require materials and device innovations to enhance their ability to transduce external stimuli—light, ionizing radiation, pressure, strain, force, temperature, gas, vapours, humidity, and other chemical and biological analytes. This Roadmap brings together the viewpoints of experts in various printable sensing materials—and devices thereof—to provide insights into the status and outlook of the field. Alongside recent materials and device innovations, the roadmap discusses the key outstanding challenges pertaining to each printable sensing technology. Finally, the Roadmap points to promising directions to overcome these challenges and thus enable ubiquitous sensing for a sustainable, ‘intelligent’ world