Effective action and density functional theory

The effective action for the charge density and the photon field is proposed as a generalization of the density functional. A simple definition is given for the density functional, as the functional Legendre transform of the generator functional of connected Green functions for the density and the photon field, offering systematic approximation schemes. The leading order of the perturbation expansion reproduces the Hartree-Fock equation. A renormalization group motivated method is introduced to turn on the Coulomb interaction gradually and to find corrections to the Hartree-Fock and the Kohn-Sham schemes.Comment: New references and a numerical algorithm added, to appear in Phys. Rev. B. 30 pages, no figure

Implementation of a pharmacogenomics consult service to support the INGENIOUS trial

Hospital systems increasingly utilize pharmacogenomic testing to inform clinical prescribing. Successful implementation efforts have been modeled at many academic centers. In contrast, this report provides insights into the formation of a pharmacogenomics consultation service at a safety-net hospital, which predominantly serves low-income, uninsured, and vulnerable populations. The report describes the INdiana GENomics Implementation: an Opportunity for the UnderServed (INGENIOUS) trial and addresses concerns of adjudication, credentialing, and funding

New insights on low vitamin D plasma concentration as a potential cardiovascular risk factor

The role of Vitamin D hormone in human health and disease is still debated. Recently, growing attention has been paid to its putative role in cardiovascular system homeostasis with several studies that suggested a correlation between low vitamin D levels and increased cardiovascular risk. Several mechanisms are involved in the development of cardiovascular diseases: systemic inflammation, endothelial dysfunction, arterial hypertension and insulin resistance. In the present paper, we have revised the current literature supporting a role for vitamin D in the development of these pathogenetic processes. Finally, we have evaluated the current evidence linking vitamin D to atherosclerosis and its natural consequence, cardiovascular diseases

The onward sweep of social capital: causes and consequences for understanding cities, communities and urban movements

This article examines the way 'social capital' has been deployed by researchers and practitioners in the field of urban movements and community development. It reveals the powerful and in many ways effective role the concept is playing in framing the contemporary reconfigurations of local state-society relations which impact especially on the trajectory of third or voluntary sector development. The article identifies the gaps and weaknesses the 'social capital' perspective responds to, thereby explaining why it looms so large within the urban development discourse. Its own blind spots and ambiguities, however, limit our understanding of contemporary urban change. By prioritizing specific forms of civic engagement (and neglecting others), the concept filters the contemporary reconfigurations in the relationship of civil society, state and market in a peculiar way, which is conducive to supporting the spread of market forces to areas so far beyond the reach of capital. By directing attention to the self-activation potential of different communities, whether in the form of civic engagement of well-to-do volunteers or in the form of activation/reinsertion (into the low-wage labour market) of the marginalized, this new discourse plays a crucial role not only in current efforts to unburden the local (welfare) state, but also in the expansion of market forces into new areas. Copyright Joint Editors and Blackwell Publishing Ltd 2003.