195 research outputs found
Surface Dynamics of the Cyclohexadienyl Radical Adsorbed on Silica Gel Investigated Using Avoided Level-Crossing Muon Spin Resonance
Prevalence of Dyskinesia and OFF by 30-Minute Intervals Through the Day and Assessment of Daily Episodes of Dyskinesia and OFF: Novel Analyses of Diary Data from Gocovri Pivotal Trials.
BACKGROUND: Parkinson\u27s disease (PD) patients using levodopa commonly develop dyskinesia and OFF episodes that reduce quality of life.
OBJECTIVE: Evaluate prevalence of troublesome dyskinesia and OFF through the day, assessed by 30-minute intervals, as well as the mean number and duration of troublesome dyskinesia and OFF episodes, transitions between PD states, and effects of Gocovri® (amantadine) extended release capsules on these episodes.
METHODS: Evaluate diary data from pooled Gocovri phase 3, placebo-controlled trials-analyzed for 17 hours following wake-up-at baseline and week 12.
RESULTS: Diaries were evaluable for 162 patients. At baseline, 67% of patients woke up OFF, with prevalence decreasing to 13% at 2 hours and then remaining relatively steady at ∼12% (range, 6-17%) across half-hour intervals thereafter. Troublesome dyskinesia prevalence rose steadily from 5% to 24% over the first 2 hours, then fluctuated between 20% and 44% through the rest of the waking day. At baseline, patients experienced a mean of 3.0 daily episodes of troublesome dyskinesia (average duration 2.0 hours each), and 2.2 daily episodes of OFF (average duration 1.1 hour each). At week 12, Gocovri-treated patients showed greater reductions than placebo in troublesome dyskinesia and OFF episodes per day (treatment difference: -1.0 episodes and -0.4 episodes, respectively) and average episode duration (treatment difference: -0.6 hours and -0.3 hours, respectively). Mean duration of individual episodes of ON without troublesome dyskinesia (Good ON) increased by 5.0 hours for Gocovri, compared with 2.0 hours for placebo. Patients taking Gocovri experienced 2.2 fewer transitions between states than patients taking placebo.
CONCLUSIONS: Troublesome dyskinesia and OFF occurred in the morning and throughout the waking day. Gocovri-treated patients experienced fewer, shorter episodes of both troublesome dyskinesia and OFF, thereby increasing the duration of continuous Good ON episodes and reducing the frequency of transitions between motor states
'Alive after five' : constructing the neoliberal night in Newcastle upon Tyne.
The development of the ‘night-time economy’ in the UK through the 1990s has been associated with neoliberal urban governance. Academics have, however, begun to question the use and the scope of the concept ‘neoliberalism’. In this paper, I identify two common approaches to studying neoliberalism, one exploring neoliberalism as a series of policy networks, the other exploring neoliberalism as the governance of subjectivities. I argue that to understand the urban night, we need to explore both these senses of ‘neoliberalism’.
As a case study, I take the ‘Alive After Five’ project, organised by the Business Improvement District in Newcastle-upon-Tyne, which sought to extend shopping hours in order to encourage more people to use the city at night. Drawing from Actor-Network-Theory, I explore the planning, the translation, and the practice of this new project. In doing so, I explore the on-going nature and influence of neoliberal policy on the urban night in the UK
Local Magnetic Susceptibility of the Positive Muon in the Quasi 1D S=1/2 Antiferromagnet KCuF
We report muon spin rotation measurements of the local magnetic
susceptibility around a positive muon in the paramagnetic state of the quasi
one-dimensional spin 1/2 antiferromagnet KCuF. Signals from two distinct
sites are resolved which have a temperature dependent frequency shift which is
different than the magnetic susceptibility. This difference is attributed to a
muon induced perturbation of the spin 1/2 chain.Comment: 13 pages, 4 figures, The 2002 International Conference on Muon Spin
Rotation, Relaxation and Resonance, Virginia. US
Hyperfine Fields in an Ag/Fe Multilayer Film Investigated with 8Li beta-Detected Nuclear Magnetic Resonance
Low energy -detected nuclear magnetic resonance (-NMR) was used
to investigate the spatial dependence of the hyperfine magnetic fields induced
by Fe in the nonmagnetic Ag of an Au(40 \AA)/Ag(200 \AA)/Fe(140 \AA) (001)
magnetic multilayer (MML) grown on GaAs. The resonance lineshape in the Ag
layer shows dramatic broadening compared to intrinsic Ag. This broadening is
attributed to large induced magnetic fields in this layer by the magnetic Fe
layer. We find that the induced hyperfine field in the Ag follows a power law
decay away from the Ag/Fe interface with power , and a field
extrapolated to T at the interface.Comment: 5 pages, 4 figure. To be published in Phys. Rev.
Spin Echo Decay in a Stochastic Field Environment
We derive a general formalism with which it is possible to obtain the time
dependence of the echo size for a spin in a stochastic field environment. Our
model is based on ``strong collisions''. We examine in detail three cases
where: (I) the local field is Ising-like, (II) the field distribution is
continuous and has a finite second moment, and (III) the distribution is
Lorentzian. The first two cases show a T2 minimum effect and are exponential in
time cubed for short times. The last case can be approximated by a
phenomenological stretched exponential.Comment: 11 pages + 3 postscript figure
Efficacy results of pimavanserin from a multi-center, open-label extension study in Parkinson's disease psychosis patients
© 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.Introduction: Pimavanserin, a selective 5-HT2A inverse agonist/antagonist, was approved for hallucinations and delusions associated with Parkinson's disease psychosis (PDP). We present durability of response with pimavanserin in patients with PDP for an additional 4 weeks of treatment.
Methods: This was an open-label extension (OLE) study in patients previously completing one of three double-blind, placebo-controlled (Core) studies. All patients received pimavanserin 34 mg once daily. Efficacy assessments included the Scale for the Assessment of Positive Symptoms (SAPS) PD and H + D scales, Clinical Global Impression (CGI) Improvement and Severity scales and Caregiver Burden Scale (CBS), through 4 weeks in the OLE. Safety assessments were conducted at each visit.
Results: Of 459 patients, 424 (92.4%) had a Week 4 efficacy assessment. At Week 4 (10 weeks total treatment), SAPS-PD mean (standard deviation) change from OLE baseline was -1.8 (5.5) and for SAPS-H + D was -2.1 (6.2) with pimavanserin 34 mg. Patients receiving placebo during the Core studies had greater improvements (SAPS-PD -2.9 [5.6]; SAPS-H + D -3.5 [6.3]) during the OLE. For participants treated with pimavanserin 8.5 or 17 mg during the Core studies, further improvement was observed during the OLE with pimavanserin 34 mg. The mean change from Core Study baseline for SAPS-PD score was similar among prior pimavanserin 34 mg and prior placebo-treated participants (-7.1 vs. -7.0). The CGI-I response rate (score of 1 or 2) at Week 4 was 51.4%. Adverse events were reported by 215 (46.8%) patients during the first 4 weeks of OLE. The most common AEs were fall (5.9%), hallucination (3.7%), urinary tract infection (2.8%), insomnia (2.4%), and peripheral edema (2.2%) CONCLUSIONS: Patients previously on pimavanserin 34 mg during three blinded core studies had durability of efficacy during the subsequent 4 week OLE SAPS-PD assessment. Patients previously on blinded placebo improved after 4 weeks of OL pimavanserin treatment. These results in over 400 patients from 14 countries support the efficacy of pimavanserin for treating PDP.info:eu-repo/semantics/publishedVersio
Muonium as a hydrogen analogue in silicon and germanium; quantum effects and hyperfine parameters
We report a first-principles theoretical study of hyperfine interactions,
zero-point effects and defect energetics of muonium and hydrogen impurities in
silicon and germanium. The spin-polarized density functional method is used,
with the crystalline orbitals expanded in all-electron Gaussian basis sets. The
behaviour of hydrogen and muonium impurities at both the tetrahedral and
bond-centred sites is investigated within a supercell approximation. To
describe the zero-point motion of the impurities, a double adiabatic
approximation is employed in which the electron, muon/proton and host lattice
degrees of freedom are decoupled. Within this approximation the relaxation of
the atoms of the host lattice may differ for the muon and proton, although in
practice the difference is found to be slight. With the inclusion of zero-point
motion the tetrahedral site is energetically preferred over the bond-centred
site in both silicon and germanium. The hyperfine and superhyperfine
parameters, calculated as averages over the motion of the muon, agree
reasonably well with the available data from muon spin resonance experiments.Comment: 20 pages, including 9 figures. To appear in Phys. Rev.
Giant Vortices Below the Surface of NbSe Detected Using Low Energy -NMR
A low energy radioactive beam of polarized Li has been used to observe
the vortex lattice near the surface of superconducting NbSe. The
inhomogeneous magnetic field distribution associated with the vortex lattice
was measured using depth-resolved -detected NMR. Below one
observes the characteristic lineshape for a triangular vortex lattice which
depends on the magnetic penetration depth and vortex core radius. The size of
the vortex core varies strongly with magnetic field. In particular in a low
field of 10.8 mT the core radius is much larger than the coherence length. The
possible origin of these giant vortices is discussed.Comment: 5 pages, 3 figures. Submitted to Phys. Rev. Let
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