27 research outputs found
The Liberating Consequences of Creative Work: How a Creative Outlet Lifts the Physical Burden of Secrecy
A newly emerging stream of research suggests creativity can be fruitfully explored, not as an outcome variable, but as a contributor to the general cognitive and behavioral responding of the individual. In this paper, we extend this nascent area of research on the consequences of creativity by showing that working on a creative task can contribute to feelings of liberation— feelings that can help people to overcome psychological burdens. We illustrate the liberating effects of creativity by integrating the embodied cognition literature with recent research showing that keeping a secret is experienced as a psychological and physical burden. While secrecy is metaphorically related to physical burden, creativity is metaphorically associated with freedom to “think outside the box” and explore beyond normal constraints. Thus, we predict permission to be creative may actually feel liberating and feelings of liberation may, in turn, lift the physical burden of keeping a big secret. The results of three studies supported our prediction and suggest that the opportunity to be creative may be a way for people to unburden without directly revealing secrets that could cause shame and embarrassment. We discuss the implications of our results for future research on the psychological consequences of performing creative work
Harnessing water fleas for water reclamation:A nature-based tertiary wastewater treatment technology
Mind the gap between ICES nations' future seafood consumption and aquaculture production
As the human population grows and climate change threatens the stability of seafood sources, we face the key question of how we will meet increasing demand, and do so sustainably. Many of the 20 International Council for the Exploration of the Sea (ICES) member nations have been global leaders in the protection and management of wild fisheries, but to date, most of these nations have not developed robust aquaculture industries. Using existing data and documentation of aquaculture targets from government and industry, we compiled and analysed past trends in farmed and wild seafood production and consumption in ICES nations, as well as the potential and need to increase aquaculture production by 2050. We found that the majority of ICES nations lacks long-term strategies for aquaculture growth, with an increasing gap between future domestic production and consumption—resulting in a potential 7 million tonne domestic seafood deficit by 2050, which would be supplemented by imports from other countries (e.g. China). We also found recognition of climate change as a concern for aquaculture growth, but little on what that means for meeting production goals. Our findings highlight the need to prioritize aquaculture policy to set more ambitious domestic production goals and/or improve sustainable sourcing of seafood from other parts of the world, with explicit recognition and strategic planning for climate change affecting such decisions. In short, there is a need for greater concerted effort by ICES member nations to address aquaculture’s long-term future prospects
The Vehicle, Fall 1983
Vol. 25, No. 1
Table of Contents
Amish BoyDevon Flesorpage 3
SyllogismJ. Maura Davispage 3
Ten SecondsD.L. Lewispage 4
The Cedar ChestBridget M. Howepage 4
A Christmas With CarolSteve Longpage 5
TeethMichelle Mitchellpage 7
An I-Love-You PoemD.L. Lewispage 8
The Dragon SlayerSusan Gradypage 8
A DefinitionAmy J. Eadespage 9
FingernailsSuzanne Hornpage 10
The Liar\u27s TableBrook Wilsonpage 10
Fifi\u27s Last PartySteve Longpage 12
Absence/PresenceSuzanne Hornpage 13
From the Rantings of a Mad Astronomy StudentAmy J. Eadespage 13
In the Name of the Father, the Son, and MachiavelliF. Link Rapierpage 15
Errant LoverBecky Lawsonpage 16
DaddyKevin Lylespage 16
GhostsGary Ervinpage 17
TangoF. Link Rapierpage 17
Grandma\u27s SlippersBecky Lawsonpage 18
EdgesAmy J. Eadespage 19
Having ChildrenDevon Flesorpage 20
Young Black GirlKevin Lylespage 21
CatSuzanne Hornpage 22
Breakfast for OneMichelle Mitchellpage 22
A Modest ProposalBrooke Sanfordpage 23
Post MortemF. Link Rapierpage 26
Who Said I Forgot?Lynne Krausepage 27
The Corner Booth at StuckeysMaggie Kennedypage 28
The First DayDavis Brydenpage 29
DownLynne Krausepage 30
Fairie RingDevon Flesorpage 31
The LaundrymatKathy Fordpage 32
Sunday in OctoberBridget M. Howepage 32
The Kitchen WindowMaggie Kennedypage 33
UntitledChristina Maire Vitekpage 34
8th Grade Field Trip to SpringfieldMichelle Mitchellpage 34
Children of the FortiesF. Link Rapierpage 35
one winter and i was eightGary Ervinpage 35
Don\u27t we all know?Thomas B. Waltrippage 36
The TravelerMaggie Kennedypage 36
The VisitKathy Fordpage 40
CubismMaggie Kennedypage 40https://thekeep.eiu.edu/vehicle/1042/thumbnail.jp
The Vehicle, Fall 1983
Vol. 25, No. 1
Table of Contents
Amish BoyDevon Flesorpage 3
SyllogismJ. Maura Davispage 3
Ten SecondsD.L. Lewispage 4
The Cedar ChestBridget M. Howepage 4
A Christmas With CarolSteve Longpage 5
TeethMichelle Mitchellpage 7
An I-Love-You PoemD.L. Lewispage 8
The Dragon SlayerSusan Gradypage 8
A DefinitionAmy J. Eadespage 9
FingernailsSuzanne Hornpage 10
The Liar\u27s TableBrook Wilsonpage 10
Fifi\u27s Last PartySteve Longpage 12
Absence/PresenceSuzanne Hornpage 13
From the Rantings of a Mad Astronomy StudentAmy J. Eadespage 13
In the Name of the Father, the Son, and MachiavelliF. Link Rapierpage 15
Errant LoverBecky Lawsonpage 16
DaddyKevin Lylespage 16
GhostsGary Ervinpage 17
TangoF. Link Rapierpage 17
Grandma\u27s SlippersBecky Lawsonpage 18
EdgesAmy J. Eadespage 19
Having ChildrenDevon Flesorpage 20
Young Black GirlKevin Lylespage 21
CatSuzanne Hornpage 22
Breakfast for OneMichelle Mitchellpage 22
A Modest ProposalBrooke Sanfordpage 23
Post MortemF. Link Rapierpage 26
Who Said I Forgot?Lynne Krausepage 27
The Corner Booth at StuckeysMaggie Kennedypage 28
The First DayDavis Brydenpage 29
DownLynne Krausepage 30
Fairie RingDevon Flesorpage 31
The LaundrymatKathy Fordpage 32
Sunday in OctoberBridget M. Howepage 32
The Kitchen WindowMaggie Kennedypage 33
UntitledChristina Maire Vitekpage 34
8th Grade Field Trip to SpringfieldMichelle Mitchellpage 34
Children of the FortiesF. Link Rapierpage 35
one winter and i was eightGary Ervinpage 35
Don\u27t we all know?Thomas B. Waltrippage 36
The TravelerMaggie Kennedypage 36
The VisitKathy Fordpage 40
CubismMaggie Kennedypage 40https://thekeep.eiu.edu/vehicle/1042/thumbnail.jp
Science Impacts of the SPHEREx All-Sky Optical to Near-Infrared Spectral Survey: Report of a Community Workshop Examining Extragalactic, Galactic, Stellar and Planetary Science
SPHEREx is a proposed SMEX mission selected for Phase A. SPHEREx will carry
out the first all-sky spectral survey and provide for every 6.2" pixel a
spectra between 0.75 and 4.18 m [with R41.4] and 4.18 and 5.00
m [with R135]. The SPHEREx team has proposed three specific science
investigations to be carried out with this unique data set: cosmic inflation,
interstellar and circumstellar ices, and the extra-galactic background light.
It is readily apparent, however, that many other questions in astrophysics and
planetary sciences could be addressed with the SPHEREx data. The SPHEREx team
convened a community workshop in February 2016, with the intent of enlisting
the aid of a larger group of scientists in defining these questions. This paper
summarizes the rich and varied menu of investigations that was laid out. It
includes studies of the composition of main belt and Trojan/Greek asteroids;
mapping the zodiacal light with unprecedented spatial and spectral resolution;
identifying and studying very low-metallicity stars; improving stellar
parameters in order to better characterize transiting exoplanets; studying
aliphatic and aromatic carbon-bearing molecules in the interstellar medium;
mapping star formation rates in nearby galaxies; determining the redshift of
clusters of galaxies; identifying high redshift quasars over the full sky; and
providing a NIR spectrum for most eROSITA X-ray sources. All of these
investigations, and others not listed here, can be carried out with the nominal
all-sky spectra to be produced by SPHEREx. In addition, the workshop defined
enhanced data products and user tools which would facilitate some of these
scientific studies. Finally, the workshop noted the high degrees of synergy
between SPHEREx and a number of other current or forthcoming programs,
including JWST, WFIRST, Euclid, GAIA, K2/Kepler, TESS, eROSITA and LSST.Comment: Report of the First SPHEREx Community Workshop,
http://spherex.caltech.edu/Workshop.html , 84 pages, 28 figure
SCHEMA-Designed Variants of Human Arginase I and II Reveal Sequence Elements Important to Stability and Catalysis
Arginases catalyze the divalent cation-dependent hydrolysis of l-arginine to urea and l-ornithine. There is significant interest in using arginase as a therapeutic anti-neogenic agent against l-arginine auxotrophic tumors and in enzyme replacement therapy for treating hyperargininemia. Both therapeutic applications require enzymes with sufficient stability under physiological conditions. To explore sequence elements that contribute to arginase stability we used SCHEMA-guided recombination to design a library of chimeric enzymes composed of sequence fragments from the two human isozymes Arginase I and II. We then developed a novel active learning algorithm that selects sequences from this library that are both highly informative and functional. Using high-throughput gene synthesis and our two-step active learning algorithm, we were able to rapidly create a small but highly informative set of seven enzymatically active chimeras that had an average variant distance of 40 mutations from the closest parent arginase. Within this set of sequences, linear regression was used to identify the sequence elements that contribute to the long-term stability of human arginase under physiological conditions. This approach revealed a striking correlation between the isoelectric point and the long-term stability of the enzyme to deactivation under physiological conditions
Transformation of Human Mesenchymal Cells and Skin Fibroblasts into Hematopoietic Cells
Patients with prolonged myelosuppression require frequent platelet and occasional granulocyte transfusions. Multi-donor transfusions induce alloimmunization, thereby increasing morbidity and mortality. Therefore, an autologous or HLA-matched allogeneic source of platelets and granulocytes is needed. To determine whether nonhematopoietic cells can be reprogrammed into hematopoietic cells, human mesenchymal stromal cells (MSCs) and skin fibroblasts were incubated with the demethylating agent 5-azacytidine (Aza) and the growth factors (GF) granulocyte-macrophage colony-stimulating factor and stem cell factor. This treatment transformed MSCs to round, non-adherent cells expressing T-, B-, myeloid-, or stem/progenitor-cell markers. The transformed cells engrafted as hematopoietic cells in bone marrow of immunodeficient mice. DNA methylation and mRNA array analysis suggested that Aza and GF treatment demethylated and activated HOXB genes. Indeed, transfection of MSCs or skin fibroblasts with HOXB4, HOXB5, and HOXB2 genes transformed them into hematopoietic cells. Further studies are needed to determine whether transformed MSCs or skin fibroblasts are suitable for therapy
Research Article pubs.acs.org/synthbio SCHEMA-Designed Variants of Human Arginase I and II Reveal Sequence Elements Important to Stability and Catalysis
ABSTRACT: Arginases catalyze the divalent cation-dependent hydrolysis of L-arginine to urea and L-ornithine. There is significant interest in using arginase as a therapeutic antineogenic agent against L-arginine auxotrophic tumors and in enzyme replacement therapy for treating hyperargininemia. Both therapeutic applications require enzymes with sufficient stability under physiological conditions. To explore sequence elements that contribute to arginase stability we used SCHEMA-guided recombination to design a library of chimeric enzymes composed of sequence fragments from the two human isozymes Arginase I and II. We then developed a novel active learning algorithm that selects sequences from this library that are both highly informative and functional. Using high-throughput gene synthesis and our two-step active learning algorithm, we were able to rapidly create a small but highly informative set of seven enzymatically active chimeras that had an average variant distance of 40 mutations from the closest parent arginase. Within this set of sequences, linear regression was use