The beam energy measurement system for the Beijing electron-positron collider

The beam energy measurement system (BEMS) for the upgraded Beijing electron-positron collider BEPC-II is described. The system is based on measuring the energies of Compton back-scattered photons. The relative systematic uncertainty of the electron and positron beam energy determination is estimated as 2 \cdot 10^{-5}. The relative uncertainty of the beam's energy spread is about 6 %

Slewing Mirror Telescope and the Data-Acquisition System for the UFFO-Pathfinder

The Ultra-Fast Flash Observatory (UFFO) aims to detect the earliest moment of Gamma-Ray Bursts (GRBs) which is not well known, resulting into the enhancement of GRB mechanism understanding. The pathfinder mission was proposed to be a scaled-down version of UFFO, and only contains the UFFO Burst Alert & Trigger Telescope (UBAT) measuring the X-ray/gamma-ray with the wide-field of view and the Slewing Mirror Telescope (SMT) with a rapid-response for the UV/optical photons. Once the UBAT detects a GRB candidate with the position accuracy of 10 arcmin, the SMT steers the UV/optical photons from the candidate to the telescope by the fast rotatable mirror and provides the early UV/optical photons measurements with 4 arcsec accuracy. The SMT has a modified Ritchey-Chrètien telescope with the aperture size of 10 cm diameter including the rotatable mirror and the image readout by the intensified charge-coupled device. There is a key board called the UFFO Data Acquisition system (UDAQ) that manages the communication of each telescope and also of the satellite and the UFFO overall operation. This pathfinder is designed and built within the limited size and weight of  ~20 kg and the low power consumption up to  ~30 W. We will discuss the design and performance of the UFFO-pathfinder, and its integration to the Lomonosov satellite

Design and implementation of electronics and data acquisition system for Ultra-Fast Flash Observatory

The Ultra-Fast Flash Observatory (UFFO) Pathfinder for Gamma-Ray Bursts (GRBs) consists of two telescopes. The UFFO Burst Alert & Trigger Telescope (UBAT) handles the detection and localization of GRBs, and the Slewing Mirror Telescope (SMT) conducts the measurement of the UV/optical afterglow. UBAT is equipped with an X-ray detector, analog and digital signal readout electronics that detects X-rays from GRBs and determines the location. SMT is equipped with a stepping motor and the associated electronics to rotate the slewing mirror targeting the GRBs identified by UBAT. First the slewing mirror points to a GRB, then SMT obtains the optical image of the GRB using the intensified CCD and its readout electronics. The UFFO Data Acquisition system (UDAQ) is responsible for the overall function and operation of the observatory and the communication with the satellite main processor. In this paper we present the design and implementation of the electronics of UBAT and SMT as well as the architecture and implementation of UDAQ

Calibration and Simulation of the GRB trigger detector of the Ultra Fast Flash Observatory

The UFFO (Ultra-Fast Flash Observatory) is a GRB detector on board the Lomonosov satellite, to be launched in 2013. The GRB trigger is provided by an X-ray detector, called UBAT (UFFO Burst Alarm & Trigger Telescope), which detects X-rays from the GRB and then triggers to determine the direction of the GRB and then alerts the Slewing Mirror Telescope (SMT) to turn in the direction of the GRB and record the optical photon fluxes. This report details the calibration of the two components: the MAPMTs and the YSO crystals and simulations of the UBAT. The results shows that this design can observe a GRB within a field of view of ±35° and can trigger in a time scale as short as 0.2 – 1.0 s after the appearance of a GRB X-ray spike

Development of Motorized Slewing Mirror Stage for the UFFO Project

The Ultra-Fast Flash Observatory (UFFO) is a space observatory for optical follow-ups of gamma ray bursts (GRBs), aiming to explore the first 60 seconds of GRBs optical emission. UFFO is utilized to catch early optical emissions from GRBs within few sec after trigger using a Gimbal mirror which redirects the optical path rather than slewing entire spacecraft. We have developed a 15 cm two-axis Gimbal mirror stage for the UFFO-Pathfinder which is going to be on board the Lomonosov satellite which is to be launched in 2013. The stage is designed for fast and accurate motion with given budgets of 3 kg of mass and 3 Watt of power. By employing stepping motors, the slewing mirror can rotate faster than 15 deg/sec so that objects in the UFFO coverage (60 deg × 60 deg) can be targeted in ~1 sec. The obtained targeting resolution is better 2 arcmin using a close-loop control with high precision rotary encoder. In this presentation, we will discuss details of design, manufacturing, space qualification tests, as well as performance tests

In-Flight Calibrations of UFFO-Pathfinder

The Ultra-Fast Flash Observatory (UFFO), which will be launched onboard the Lomonosov spacecraft, contains two crucial instruments: UFFO Burst Alert & Trigger Telescope (UBAT) for detection and localization of Gamma-Ray Bursts (GRBs) and the fast-response Slewing Mirror Telescope (SMT) designed for the observation of the prompt optical/UV counterparts. Here we discuss the in-space calibrations of the UBAT detector and SMT telescope. After the launch, the observations of the standard X-ray sources such as pulsar in Crab nebula will provide data for necessary calibrations of UBAT. Several standard stars will be used for the photometric calibration of SMT. The celestial X-ray sources, e.g. X-ray binaries with bright optical sources in their close angular vicinity will serve for the cross-calibration of UBAT and SMT

Ultra-Fast Flash Observatory: Fast Response Space Missions for Early Time Phase of Gamma Ray Bursts

One of the unexplored domains in the study of gamma-ray bursts (GRBs) is the early time phase of the optical light curve. We have proposed Ultra-Fast Flash Observatory (UFFO) to address this question through extraordinary opportunities presented by a series of small space missions. The UFFO is equipped with a fast-response Slewing Mirror Telescope that uses a rapidly moving mirror or mirror array to redirect the optical beam rather than slewing the entire spacecraft or telescope to aim the optical instrument at the GRB position. The UFFO will probe the early optical rise of GRBs with sub-second response, for the first time, opening a completely new frontier in GRB and transient studies. Its fast response measurements of the optical emission of dozens of GRB each year will provide unique probes of the burst mechanism and test the prospect of GRB as a new standard candle, potentially opening up the z > 10 universe. We describe the current limit in early photon measurements, the aspects of early photon physics, our soon-to-be-launched UFFO-pathfinder mission, and our next planned mission, the UFFO-100

Non-AIDS defining cancers in the D:A:D Study-time trends and predictors of survival : a cohort study

BACKGROUND:Non-AIDS defining cancers (NADC) are an important cause of morbidity and mortality in HIV-positive individuals. Using data from a large international cohort of HIV-positive individuals, we described the incidence of NADC from 2004-2010, and described subsequent mortality and predictors of these.METHODS:Individuals were followed from 1st January 2004/enrolment in study, until the earliest of a new NADC, 1st February 2010, death or six months after the patient's last visit. Incidence rates were estimated for each year of follow-up, overall and stratified by gender, age and mode of HIV acquisition. Cumulative risk of mortality following NADC diagnosis was summarised using Kaplan-Meier methods, with follow-up for these analyses from the date of NADC diagnosis until the patient's death, 1st February 2010 or 6 months after the patient's last visit. Factors associated with mortality following NADC diagnosis were identified using multivariable Cox proportional hazards regression.RESULTS:Over 176,775 person-years (PY), 880 (2.1%) patients developed a new NADC (incidence: 4.98/1000PY [95% confidence interval 4.65, 5.31]). Over a third of these patients (327, 37.2%) had died by 1st February 2010. Time trends for lung cancer, anal cancer and Hodgkin's lymphoma were broadly consistent. Kaplan-Meier cumulative mortality estimates at 1, 3 and 5 years after NADC diagnosis were 28.2% [95% CI 25.1-31.2], 42.0% [38.2-45.8] and 47.3% [42.4-52.2], respectively. Significant predictors of poorer survival after diagnosis of NADC were lung cancer (compared to other cancer types), male gender, non-white ethnicity, and smoking status. Later year of diagnosis and higher CD4 count at NADC diagnosis were associated with improved survival. The incidence of NADC remained stable over the period 2004-2010 in this large observational cohort.CONCLUSIONS:The prognosis after diagnosis of NADC, in particular lung cancer and disseminated cancer, is poor but has improved somewhat over time. Modifiable risk factors, such as smoking and low CD4 counts, were associated with mortality following a diagnosis of NADC

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

Chemical Modification of Plant Alkaloids. 7. T-Reaction of an Aloperine Derivative

N-(2-Carboxy-5-nitrophenyl)aloperine was prepared from aloperine and 2-fluoro-5-nitrobenzaldehyde and condensed with 1,3-dimethylbarbituric acid via a T-reaction with opening of the piperidine ring and formation of 1,3-dimethyl-5-{5-nitro-2-[3-(10-oxo-7-azatricyclo[7.3.1.02,7]trideca-11-en-12-yl)propylamino]} benzylhexahydro-2,4,6-pyrimidinetrione. The structure of the prepared compound was studied by an X-ray crystal structure analysis. © 2017, Springer Science+Business Media, LLC