Mediterranean diet or extended fasting's influence on changing the intestinal microflora, immunoglobulin A secretion and clinical outcome in patients with rheumatoid arthritis and fibromyalgia: an observational study

BACKGROUND: Alterations in the intestinal bacterial flora are believed to be contributing factors to many chronic inflammatory and degenerative diseases including rheumatic diseases. While microbiological fecal culture analysis is now increasingly used, little is known about the relationship of changes in intestinal flora, dietary patterns and clinical outcome in specific diseases. To clarify the role of microbiological culture analysis we aimed to evaluate whether in patients with rheumatoid arthritis (RA) or fibromyalgia (FM) a Mediterranean diet or an 8-day fasting period are associated with changes in fecal flora and whether changes in fecal flora are associated with clinical outcome. METHODS: During a two-months-period 51 consecutive patients from an Integrative Medicine hospital department with an established diagnosis of RA (n = 16) or FM (n = 35) were included in the study. According to predefined clinical criteria and the subjects' choice the patients received a mostly vegetarian Mediterranean diet (n = 21; mean age 50.9 +/-13.3 y) or participated in an intermittent modified 8-day fasting therapy (n = 30; mean age 53.7 +/- 9.4 y). Quantitative aerob and anaerob bacterial flora, stool pH and concentrations of secretory immunoglobulin A (sIgA) were analysed from stool samples at the beginning, at the end of the 2-week hospital stay and at a 3-months follow-up. Clinical outcome was assessed with the DAS 28 for RA patients and with a disease severity rating scale in FM patients. RESULTS: We found no significant changes in the fecal bacterial counts following the two dietary interventions within and between groups, nor were significant differences found in the analysis of sIgA and stool ph. Clinical improvement at the end of the hospital stay tended to be greater in fasting vs. non-fasting patients with RA (p = 0.09). Clinical outcome was not related to alterations in the intestinal flora. CONCLUSION: Neither Mediterranean diet nor fasting treatments affect the microbiologically assessed intestinal flora and sIgA levels in patients with RA and FM. The impact of dietary interventions on the human intestinal flora and the role of the fecal flora in rheumatic diseases have to be clarified with newer molecular analysis techniques. The potential benefit of fasting treatment in RA and FM should be further tested in randomised trials

Mathematical surprises and Dirac's formalism in quantum mechanics

By a series of simple examples, we illustrate how the lack of mathematical concern can readily lead to surprising mathematical contradictions in wave mechanics. The basic mathematical notions allowing for a precise formulation of the theory are then summarized and it is shown how they lead to an elucidation and deeper understanding of the aforementioned problems. After stressing the equivalence between wave mechanics and the other formulations of quantum mechanics, i.e. matrix mechanics and Dirac's abstract Hilbert space formulation, we devote the second part of our paper to the latter approach: we discuss the problems and shortcomings of this formalism as well as those of the bra and ket notation introduced by Dirac in this context. In conclusion, we indicate how all of these problems can be solved or at least avoided.Comment: Largely extended and reorganized version, with new title and abstract and with 2 figures added (published version), 54 page

Geophysical monitoring at the Ketzin pilot site for CO2 storage: New insights into the plume evolution

© 2014 Elsevier Ltd. To date, 3D time-lapse seismic monitoring at the Ketzin CO2 storage pilot site comprised a baseline survey conducted in 2005 and two repeat surveys conducted in 2009 and 2012. At the time of the first repeat survey (22-25kt of CO2), the CO2 plume was found to be concentrated around the injection well with a maximum lateral extent of approximately 300-400m and a thickness of 5-20m. Data from the 2012 survey (61kt of CO2), show further growth and migration of the amplitude anomaly interpreted to be induced by the CO2 injection. The anomaly is similar in shape to that obtained from the 2009 survey, but significantly stronger and larger by ~150m in the N-S direction and by ~200m in the E-W direction. In agreement with the 2009 survey, the new data show a westward propagation of the plume, a trend governed by the complex structure of the reservoir. No evidence of systematic changes in the seismic signature within the overburden is observed. A quantitative assessment of the plume reveals a 15% discrepancy with the injected amount, which could be attributed to the ongoing dissolution processes. However, the estimated quantity also contains significant uncertainty