Identification of regional labor factors of influence on costs for innovation of enterprises in the region

In this paper, we examined the impact of labor loyalty and the labor market situation on the costs of companies in the region on research and development. In the work was carried out the analysis of existing articles and papers on related topics. First of all, it was our task to determine the mathematical model of the concept of loyalty of the workforce, to determine from which economic indicators it can be identified. We have identified and justified the hypothesis that the loyalty of the workforce is the ratio of the following indicators: the number of unemployed and the number of free work places. In the case of such a definition of loyalty, it was important to take the indicators for one group of workers (with the same qualification) to exclude the effects of structural unemployment. So coming to understand the factors on which the loyalty of the labor force in the region is based, we included them in our model to try to establish some relationship between the above variables and the desire of employers to invest in R & D. Based on the analyzed data and the results of testing using econometric methods, the dependence of investments in innovation and labor loyalty in the regions of Russia was proved in this paper. A direct dependence was established that indicates a decrease in loyalty to the employer increases the motivation of the last one to invest in innovation

Influence of high-latitude geomagnetic pulsations on recordings of broadband force-balanced seismic sensors

Seismic broadband sensors with electromagnetic feedback are sensitive to variations of surrounding magnetic field, including variations of geomagnetic field. Usually, the influence of the geomagnetic field on recordings of such seismometers is ignored. It might be justified for seismic observations at middle and low latitudes. The problem is of high importance, however, for observations in Polar Regions (above 60° geomagnetic latitude), where magnitudes of natural magnetic disturbances may be two or even three orders larger. In our study we investigate the effect of ultra-low frequency (ULF) magnetic disturbances, known as geomagnetic pulsations, on the STS-2 seismic broadband sensors. The pulsations have their sources and, respectively, maximal amplitudes in the region of the auroral ovals, which surround the magnetic poles in both hemispheres at geomagnetic latitude (GMLAT) between 60° and 80°. To investigate sensitivity of the STS-2 seismometer to geomagnetic pulsations, we compared the recordings of permanent seismic stations in northern Finland to the data of the magnetometers of the IMAGE network located in the same area. Our results show that temporary variations of magnetic field with periods of 40–150 s corresponding to regular Pc4 and irregular Pi2 pulsations are seen very well in recordings of the STS-2 seismometers. Therefore, these pulsations may create a serious problem for interpretation of seismic observations in the vicinity of the auroral oval. Moreover, the shape of Pi2 magnetic disturbances and their periods resemble the waveforms of glacial seismic events reported originally by Ekström (2003). The problem may be treated, however, if combined analysis of recordings of co-located seismic and magnetic instruments is used

3-D density model of the crust of southern and central Finland obtained from joint interpretation of the SVEKALAPKO crustal P-wave velocity models and gravity data

Peer reviewe

Work of higher education institutes in Kuibyshev in extreme wartime conditions

The article analyses the work of institutes in the city of Kuibyshev during the second world war. The war terms for the higher education institutions in the city of Kuibyshev were caused by the beginning of the Great Patriotic War and set by the normative legal acts which were adopted by federal and municipal, government and party authority. According to these acts all the institutes lost the main part of learning campuses, some of them were supposed to be closed. Laboratories and educational property were moved to the warehouse and as a result lost its value for educational process. It reveals the initiative position of institute directors who objected to closing the institutes and offered the plans of institute work in extreme wartime conditions. The educational process was organized in the own remaining areas as well as in the rented schools and technical colleges in the evening and even night time. The diverse institute work such as learning, scientific, educative, public, economic was changed according to the current objectives and tasks of the state. Moreover, the authors show the contribution of Kuibyshev institutes into the Victory. The authors conclude that spiritual and physical overtension of teaching staff and students, their firm civil position, the support of local party and government authority helped to keep Kuibyshev institutes as the higher education institution system which promoted establishing a strong industrial center during the postwar period in Kuibyshev region

Space Flight and Manual Control: Implications for Sensorimotor Function on Future Missions

Control of vehicles, and other complex mechanical motion systems, is a high-level integrative function of the central nervous system (CNS) that requires good visual acuity, eye-hand coordination, spatial (and, in some cases, geographic) orientation perception, and cognitive function. Existing evidence from space flight research (Paloski et.al., 2008, Clement and Reschke 2008, Reschke et al., 2007) demonstrates that the function of each of these systems is altered by removing (and subsequently by reintroducing) a gravitational field that can be sensed by vestibular, proprioceptive, and haptic receptors and used by the CNS for spatial orientation, navigation, and coordination of movements. Furthermore, much of the operational performance data collected as a function of space flight has not been available for independent analysis, and those data that have been reviewed are equivocal owing to uncontrolled environmental and/or engineering factors. Thus, our current understanding, when it comes to manual control, is limited primarily to a review of those situations where manual control has been a factor. One of the simplest approaches to the manual control problem is to review shuttle landing data. See the Figure below for those landing for which we have Shuttle velocities over the runway threshold

Treatment of patients with bone marrow metastases: the present state of the problem

The paper reviews the data available in the literature on the identification of tumor cells in bone marrow and peripheral blood in different tumors and breast cancer. Analysis of the majority of investigations suggest that the presence of tumor cells in the bone marrow correlates with early disease recurrences and lower survival; to detect bone marrow tumor cells is one of the most important approaches to early identifying metastases and improving the results of treatment for breast cancer. The paper gives the results of an investigation conducted at the N.N. Aleksandrov Republican Research and Practical Center for Oncology and Medical Radiology in 2008 to 2014, which established that the presence of cancer cells in the bone marrow is a poor prognostic sign: the 3-year relapse-free survival of patients with the unaffected and affected bone marrow was 88.7 and 69.3 %, respectively (p < 0.01)

Individual educational trajectory of teaching Russian language to students with hearing impairments in general education school

The article is devoted to the problems of improving the quality of education of children with hearing impairments in secondary general education school.Статья посвящена проблемам совершенствования качества обучения детей младшего школьного возраста с нарушениями слуха (слабослышащих) в условиях общеобразовательной школы

ИННОВАЦИОННОЕ РАЗВИТИЕ ЭКОНОМИКИ (КОНЦЕПЦИЯ ИМПОРТОЗАМЕЩЕНИЯ)

The paper describes the objectives of the import substitution concept adopted by the Government of the Russian Federation: changing the raw-material orientation of the Russian economy; reducing the imports share in the GDP; stimulation of the national economy development in a number of sectors; modernization of seven sectors (energy, space, information technology, defense, communications, transportation, nanotechnology); increasing the level of industrial self-reliance; restructuring of the economy; and refusal from the fragmented catch-up modernization policy. The specific features and factors that determine the development of innovative processes in the Russian economy are identified. The development and marketing of competitive products are associated with a lengthy preparatory phase during which depressive industries are revealed and modernization activities are carried out. The paper presents a classification of methods for the regulation and support of the innovative development of the Russian economy. The import substitution in the industry, apart from the sanctions, is also necessitated by the fall of the ruble that resulted in higher prices for imported complementary goods (indirect import substitution). The paper identifies the causes of difficulties in financing import substitution programs. The results of the study can be used to refine the “Development of Science and Technology” program and the budget policy of the country. Various approaches and methods to implement the restructuring of the economy, modernization and transition to the innovative development have been developed that are described in a number of research papers and legislation instruments but require further development.В статье раскрываются основные задачи принятой Правительством Российской Федерации концепции импортозамещения: изменение сырьевой направленности экономики России, снижение импортоемкости ВВП, стимулирование развития национальной экономики в ряде отраслей, модернизация семи отраслей (энергетика, космос, информационные технологии, оборонная промышленность, связь, транспорт, нанотехнологии), увеличение уров- ня промышленного самообеспечения, необходимость структурной перестройки экономики и отказ от политики фрагментарной догоняющей модернизации. Выделены особенности и факторы, определяющие развитие инновационного процесса в экономике России. Освоение и вывод на рынок конкурентоспособной продукции связаны с достаточно длительным подготовительным этапом, в процессе которого выявляются депрессивные отрасли и принимаются меры по их модернизации. В статье представлена классификация методов регулирования и поддержки инновационного развития экономики России. Необходимость импортозамещения в промышленности, помимо санкций, определилась и в связи с падением курса рубля, что привело к росту цен на импортируемые комплементарные товары (косвенное импортозамещение). В статье определены причины трудностей с финансированием программ импортозамещения. Результаты данного исследования могут служить для доработки программы «Развитие науки и технологий», бюджетной политики государства. В нашей стране разработаны подходы и методы к реализации структурной перестройки экономики, ее модернизации и переходу к инновационному развитию, которые раскрыты в ряде научных работ и законодательных актах, но требуют дальнейшего развития

Possible specialization of motoneuron axonal compartments in synthesis of particular proteins

Spontaneous quantal neurotransmitter release and its modulation was studied on neuromuscular preparations of rat soleus from intact animals and from animals in which colchicine had been applied to the sciatic nerve to block the axonal transport. After six days of colchicine application, neither the spontaneous quantal secretion nor its reaction to potassium-induced membrane depolarization or to activation of the presynaptic acetylcholine receptors with carbachol were disturbed in any way. Keeping in mind the relatively short half-life of proteins that take part in exocytosis and its regulation, it may be concluded that the functioning of the terminal neurosecretory apparatus does not depend on the state of axonal transport. These data are consistent with the earlier hypothesis that some proteins performing their functions in nerve terminals are synthesized directly at the site of their operation, rather than in the perikaryon as traditionally assumed. © 2010 Pleiades Publishing, Ltd

Therapeutic complement targeting in ANCA-associated vasculitides and thrombotic microangiopathy

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are a group of systemic autoimmune disorders characterized by necrotizing inflammation of medium-to-small vessels, a relative paucity of immune deposits, and an association with detectable circulating ANCAs. AAVs include granulomatosis with polyangiitis (renamed from Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). Until recently, AAVs have not been viewed as complement-mediated disorders. However, recent findings predominantly from animal studies demonstrated a crucial role of the complement system in the pathogenesis of AAVs. Complement activation or defects in its regulation have been described in an increasing number of acquired or genetically driven forms of thrombotic microangiopathy. Coinciding with this expanding spectrum of complement-mediated diseases, the question arises as to which AAV patients might benefit from a complement-targeted therapy. Therapies directed against the complement system point to the necessity of a genetic workup of genes of complement components and regulators in patients with AAV. Genetic testing together with pluripotent stem cells and bioinformatics tools may broaden our approach to the treatment of patients with aggressive forms of AAV