Methodological Approach to Measure the Quality of Life of the Region’s Population

The article is devoted to the urgent problem of the regional development, i.e. to the development of methodological tools to evaluate the quality of life of the population in the region. The article considers the concept of “quality of life”, and the terms related thereto; and substantiate the author’s position with respect to the concept. The existing domestic and foreign approaches to evaluate the quality of life of the population were analyzed, and the application of the comprehensive approach was reasoned within this study. The criteria for evaluation of the quality of life of the population were distinguished. The authors proposed the methodological approach that considers not only objective indicators of the quality of life presented in the statistical reports of the Russian Federal State Statistics Service, but also employs subjective evaluations of the local population enabling more appropriate evaluation of the quality of life in the region. The methodological tools of the research include mathematical methods of statistical data processing and online survey of the population about the level of satisfaction with various aspects of their life. The methodological tools were tested using the example of the Sverdlovsk Region that is characterized both by the steady improvement of statistical indicators of the quality of life and by low satisfaction of population with certain aspects of the quality of life, which generally decreases the integrated indicator of the quality of life despite positive dynamics of social and economic development of the region and vigorous social policy of the regional authorities. The proposed methodology was used in the evaluation of the quality of life of the Sverdlovsk Region population as part of the development of the Concept of comprehensive regional program “New quality of life of Ural residents” (Decree of the Governor of the Sverdlovsk Region No. 45-UG dated January 29, 2014 “On the Concept of the life quality improvement for the Sverdlovsk Region population before 2030 year — “New quality of life of Ural residents”).The article has been prepared with the support of the grant of the Russian Foundation for Basic Research (RFBR) No. 15-06-09169 “Development of methodical measurement tools and evaluation of the impact of social, economic, medical and demographic factors on mortality rates of working-age population”

A Role for Integrin avß3 in Invasion Activity of Highly Metastatic Syrian Hamster Fibroblasts

The expression of extracellular matrix (ECM) specific receptors, integrins, was investigated in two closely related strains of oncogenically transformed fibroblasts drastically differing in spontaneous metastasizing. The highly metastatic cells (HM) were shown to express in their surface membranes much higher levels of collagen/vitronectin-specific integrin avß3, as compared to their lowly metastatic counterparts (LM). Inhibition of the avß3-mediated signal transduction strongly reduced the in vitro invasiveness of HM, whereas stimulation of avß3 signaling markedly augmented their invasive activity. The data obtained provide a direct evidence for implication of avß3 integrin in invasive phenotype of the oncotransformed fibroblasts

Management of teacher scientific-methodical work in vocational educational institutions on the basis of project-target approach

The relevance of the subject under analysis is determined by the lack of theoretical development of the problem of management of teacher scientific-methodical work in vocational educational institutions based upon innovative approaches in the framework of project paradigm. The purpose of the article is to develop and test a science-based structural-functional model of management of teacher scientific-methodical work on the basis of project-target approach. The primary method of study is modeling, which allows to consider the problem as a process of purposeful obtaining skills by teachers of secondary vocational educational institutions to conduct scientific-methodical work on the basis of project-target approach. The article presents a structural-functional model of management of teacher scientific-methodical work. The model comprises a series of components: target, methodological, content, organizational and procedural, evaluation-resultative. The article also suggests a complex of organizational-pedagogical conditions for management of teacher scientific-methodical work on the basis of project-target approach: developing and organizing a management system of teacher scientific-methodical work; building a purposeful teachers’ motivation for scientific-methodical work in the context of changing socio-economic conditions; organizing a system of teachers’ professional development in the field of scientific-methodical work on the basis of project-target approach. The content of the article can be used by Heads of vocational educational organizations, Deputy heads who control methodical work in educational organizations, heads of teacher training programs, as well as college and university teachers in their training students of higher and secondary vocational education. © 2016 Shakuto, Dorozhkin and Kozlova

Expression of Integrins, Anchorage Dependent Apoptosis and Invasiveness of Multidrug Resistant Human Breast Carcinoma Cells

The aim of the study was to investigate the role of integrins in anchorage dependent apoptosis (anoikis) and in vitro invasion of human breast cancer cell line MCF-7 and its multidrug resistant subline MCF-7Dox. Acquisition of MDR was associated with markedly decreased expression of collagen specific a2ß1 and avß3 integrins, laminin specific a3ß1 and a6ß1 receptors and dramatic up-regulation of fibronectin specific a5ß1 integrin. The MDR subline was substantially more resistant to anoikis than their wild type counterparts. Furthermore, MCF-7Dox cells secreted MMP-9 collagenase and invaded Matrigel. We demonstrate for the first time that stimulation of ß1 integrin signaling strongly sensitizes MCF-7 cells to anoikis

The role of a2ß1 integrin in anchorage dependent apoptosis of breast carcinoma and hepatoma cells

The role of collagen specific a2ß1 integrin in anchorage dependent apoptosis (anoikis) was investigated. Stimulation of a2ß1 signaling with immobilized anti-a2 antibody markedly sensitized human MCF-7 breast carcinoma and HepG2 hepatoma cells to anoikis. Accordingly, down-regulation of a2ß1 by a2-specific siRNA decreased the percentage of cells undergoing anoikis. These results for the first time provide direct evidence that a2ß1 receptor can transduce the signal to promote death in matrix deprived cells

Beryllium Materials and Their Application in Energetics of Future

Beryllium materials are widely used in science and technology. They are of importance both for nuclear and thermonuclear energy applications. Additionally, metallic beryllium is transparent to x-ray radiation and used in the manufacture of X-ray windows and refractive x-ray lenses. SC “VNIINM” has developed beryllium materialsfor various purposes: for coating of the ITER’s first wall, for focusing and controlling X-ray radiation. Porous beryllium is of particular interest as it is an upcoming trend as a temper and neutron multiplier in blankets of thermonuclear facilities. A unique combination of X-ray optical properties also makes it possible to use porous beryllium in imaging devices in a synchrotron radiation beam (speckle suppressor). Keywords: beryllium composite, porosity, beryllium-foam, ITER, X-ray optic

Synthesis and Attestation of Titanium Dioxide Nanotubes Based Photocatalyst for Water and Air Purification out of Harmful Organic Impurities

In the present work we have synthesized nanotubular TiO2 film with a nonstoichiometric layer in the vicinity of titanium foil by anodization during 120 min. The catalytic activity of nanotubular titanium dioxide films formed during the oxidation of acetone to carbon dioxide under the action of visible light with a wavelength of 450 nm was found to be approximately 2 times higher compared to standard titanium dioxide (Degussa P25). Such a pronounced enhancement of activity may be attributed to a more efficient absorption of visible light by the films due to narrowing of the optical gap because of difference in the nonstoichiometry of titanium dioxide near the interface between nanotubular film and the titanium foil substrate. Keywords: photocatalysis, nonstoichiometric titanium dioxide, purification of wate