A case with CMTX1 disease showing transient ischemic-attack-like episodes

Charcot-Marie-Tooth (CMT) disease is a hereditary neurologic disease which affects the sensorial and motor fibers of the peripheral nerves. CMTX1 is an X-linked dominantly inherited subtype of CMT and is caused by mutations in gap junction beta 1 gene (GJB1). A small proportion of GJB1 mutations are associated with recurrent central nervous system findings. We describe a 15-year-old male patient with CMTX1 who had stroke-like findings along with foot deformities and peripheral neuropathy. Strokes and stroke-like attacks are rarely seen in children and adolescents. Herein, neurological signs, MRI findings and genetic results of a CMTX1 case are presented and discussed

Parental psychological distress associated with COVID-19 outbreak: A large-scale multicenter survey from Turkey

Aims: Pandemics can cause substantial psychological distress; however, we do not know the impact of the COVID-19 related lockdown and mental health burden on the parents of school age children. We aimed to comparatively examine the COVID-19 related the stress and psychological burden of the parents with different occupational, locational, and mental health status related backgrounds. Methods: A large-scale multicenter online survey was completed by the parents (n = 3,278) of children aged 6 to 18 years, parents with different occupational (health care workers—HCW [18.2%] vs. others), geographical (İstanbul [38.2%] vs. others), and psychiatric (child with a mental disorder [37.8%]) backgrounds. Results: Multivariable logistic regression analysis showed that being a HCW parent (odds ratio 1.79, p <.001), a mother (odds ratio 1.67, p <.001), and a younger parent (odds ratio 0.98, p =.012); living with an adult with a chronic physical illness (odds ratio 1.38, p <.001), having an acquaintance diagnosed with COVID-19 (odds ratio 1.22, p =.043), positive psychiatric history (odds ratio 1.29, p <.001), and living with a child with moderate or high emotional distress (odds ratio 1.29, p <.001; vs. odds ratio 2.61, p <.001) were independently associated with significant parental distress. Conclusions: Parents report significant psychological distress associated with COVID-19 pandemic and further research is needed to investigate its wider impact including on the whole family unit. © The Author(s) 2020

Quality of Life, Depressive Symptoms, and Personality Traits in Syrian Refugee Adolescents

Purpose Refugee adolescents' quality of life (Qol) was not investigated during the Covid-19 pandemic which have a potential impact on refugee adolescents' Qol. In this study, it is planned to investigate refugee adolescents' Qol and its association with depression and quality of life

Analysis of Content Profiles, Antioxidant and Anticancer Properties in Endemic <i>Hypericum salsolifolium</i>

This study investigated the antioxidant and anticancer properties, phenolic compounds, and content profile of Hypericum salsolifolium plant extracts prepared with different solvents. The total phenolic content, total flavonoid content, and antioxidant potential [(2,2-diphenyl-1-picrylhydrazyl, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), ferric reducing antioxidant power, and cupric reducing antioxidant capacity assays] of Hypericum salsolifolium extracts obtained using solvents of different polarities (hexane, dichloromethane, methanol, and water) were measured using spectrophotometric methods. The contents of the extracts were analyzed using liquid chromatography–mass spectrometry and inductively coupled plasma—mass spectrometry methods. Anticancer detection was performed in human lung carcinoma cells using the 3-4,5-dimethylthiazol-2,5-diphenyltetrazolium bromide, annexin-V, and cell cycle assays, as well as fluorescence detection of acridine orange/ethidium bromide staining. The methanolic extract was determined to have higher activation values of total phenolics, total flavonoids, ferric reducing antioxidant power, and in the 2,2-diphenyl-1-picrylhydrazyl assay than the other extracts, and the aqueous extract had higher values in the 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and cupric reducing antioxidant capacity assays. The methanolic extract showed a cytotoxic effect against human lung carcinoma cells (IC50: 141.96 µg/mL). It was found that Hypericum salsolifolium extract showed antioxidant and anticancer activities. It was concluded that this plant can be used as a nutritional supplement due to its glucose, phenolic compound, amino acid, and vitamin content

Usability Testing Of Digital Libraries: The Experience Of Eprints

Digital libraries should provide a qualified service in allowing their users to access data within a well-organized format. It is critical to enrich interaction among users and the interface. To measure the level of interaction, common analyses such as usability tests or socio-technical analyses are practiced throughout the literature. The interfaces can be enhanced with the data gathered from these types of analyses. The main aim of this study is to realize a qualitative usability test for the users of the Digital Archive of Hacettepe University Department of Information Management. The archive in question was exclusively created by this paper's authors who have participated in the project. In our case, a formal usability test was chosen for the analysis and a total of 5participants -not only from library staff or those who practiced information sciences- but also from different areas have participated in the study. The test was divided into three sections; pre-test, usability test and post-test. A total of 4questions were identified which aimed at measuring the ease of finding an article, accessing full texts, signing up for a new account and finding a given author. The preliminary findings showed that the most convenient option that EPrints software provided was in finding an article, as all of the participants have managed to answer this question fairly easy and quick. On the other hand, the most challenging situation proved to be signing up for a new account. The main reason behind this was discovered to be the sending and receiving of the confirmation e-mails in the activation procedure. There are a few papers in the literature which evaluates EPrints through utilizing usability test. Consequently, the results from this study can be considered important in not only improving the quality of the tested archive, but also the EPrints software itself. (C) 2014 Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creavativecommons.org/licenses/by-nc-nd/3.0/). Selection and peer-review under responsibility of the 3rd International Conference on Integrated InformationWo

Usability Testing of Digital Libraries: The Experience of EPrints

AbstractDigital libraries should provide a qualified service in allowing their users to access data within a well-organized format. It is critical to enrich interaction among users and the interface. To measure the level of interaction, common analyses such as usability tests or socio-technical analyses are practiced throughout the literature. The interfaces can be enhanced with the data gathered from these types of analyses. The main aim of this study is to realize a qualitative usability test for the users of the Digital Archive of Hacettepe University Department of Information Management. The archive in question was exclusively created by this paper's authors who have participated in the project. In our case, a formal usability test was chosen for the analysis and a total of 5participants -not only from library staff or those who practiced information sciences- but also from different areas have participated in the study. The test was divided into three sections; pre-test, usability test and post-test. A total of 4questions were identified which aimed at measuring the ease of finding an article, accessing full texts, signing up for a new account and finding a given author. The preliminary findings showed that the most convenient option that EPrints software provided was in finding an article, as all of the participants have managed to answer this question fairly easy and quick. On the other hand, the most challenging situation proved to be signing up for a new account. The main reason behind this was discovered to be the sending and receiving of the confirmation e-mails in the activation procedure. There are a few papers in the literature which evaluates EPrints through utilizing usability test. Consequently, the results from this study can be considered important in not only improving the quality of the tested archive, but also the EPrints software itself

A case with CMTX1 disease showing transient ischemic-attack-like episodes

Charcot-Marie-Tooth (CMT) disease is a hereditary neurologic disease which affects the sensorial and motor fibers of the peripheral nerves. CMTX1 is an X-linked dominantly inherited subtype of CMT and is caused by mutations in gap junction beta 1 gene (GJB1). A small proportion of GJB1 mutations are associated with recurrent central nervous system findings. We describe a 15-year-old male patient with CMTX1 who had stroke-like findings along with foot deformities and peripheral neuropathy. Strokes and stroke-like attacks are rarely seen in children and adolescents. Herein, neurological signs, MRI findings and genetic results of a CMTX1 case are presented and discussed. (c) 2017 Polish Neurological Society. Published by Elsevier Sp. z o.o. All rights reserved