Phase diagram regions deduced for strongly correlated systems via unitary transformation

From known phase diagram regions of different model Hamiltonians describing strongly correlated systems we deduced new domains of the ground state phase diagram of the same model by an unitary transformation. Different types of extended Hubbard Hamiltonians were used for the starting point and the existence of new stable spin-density wave, charge-density wave, ferromagnetic state and a paramagnetic insulator is demonstrated. The used procedure itself is dimension independent

Influence of the isospin and hypercharge chemical potentials on the location of the CEP in the mu_B-T phase diagram of the SU(3)_L x SU(3)_R chiral quark model

We investigate the influence of the asymmetric quark matter (rho_u\ne rho_d\ne rho_s) on the mass of the quasiparticles and the phase diagram of the chiral quark model parametrized at one-loop level of the renormalized theory, using the optimized perturbation theory for the resummation of the perturbative series. The effect of various chemical potentials introduced in the grand canonical ensemble is investigated with the method of relativistic many-body theory. The temperature dependence of the topological susceptibility is estimated with the help of the Witten-Veneziano mass formula.Comment: RevTeX4, 13 pages, 6 figures, version accepted for publication in Phys. Rev.

Hőkezelési Döntéstámogató Rendszer bevezetése az ISD Dunaferrnél

Az acélok edzési technológiájának tervezésére numerikus szimulációs rendszer kifejlesztésére és bevezetésére került sor az ISD Dunaferrnél. A Hõkezelési Döntéstámogató Rendszer az edzett munkadarabok elvárt tulajdonságegyüttesének kialakításához szükséges hõkezelési paraméterek kiválasztásához nyújt segítséget. A rendszer alkalmazhatóságát egy esettanulmányon keresztül mutatjuk b

A Nucleotide-dependent and HRDC Domain-dependent Structural Transition in DNA-bound RecQ Helicase

The allosteric communication between the ATP- and DNA-binding sites of RecQ helicases enables efficient coupling of ATP hydrolysis to translocation along single-stranded (ss) DNA and, in turn, the restructuring of multi-stranded DNA substrates during genome maintenance processes. In this study we used the tryptophan fluorescence signal of E. coli RecQ helicase to decipher the kinetic mechanism of the interaction of the enzyme with ssDNA. Rapid kinetic experiments revealed that ssDNA binding occurs in a two-step mechanism in which the initial binding step is followed by a structural transition of the DNA-bound helicase. We found that the nucleotide state of RecQ greatly influences the kinetics of the detected structural transition, which leads to a high-affinity DNA-clamped state in the presence of the nucleotide analog ADP.AlF4. The DNA binding mechanism is largely independent of ssDNA length, indicating the independent binding of RecQ molecules to ssDNA and the lack of significant DNA end effects. The structural transition of DNA-bound RecQ was not detected when the ssDNA binding capability of the HRDC domain was abolished or the domain was deleted. The results shed light on the nature of conformational changes leading to processive ssDNA translocation and multi-stranded DNA processing by RecQ helicases

Local characteristics of the standing genetic diversity of European beech with high within-region differentiation at the eastern part of the range

Developing "climate smart forestry" (CSF) indicators in mountain forest regions requires collection and evaluation of local data and their attributes. Genetic resources are listed among the core indicators for forest biological diversity. This study is a report on the evaluation of the standing genetic diversity within and across 12 pure beech stands (Fagus sylvatica L.) established within the CLIMO (CLImate Smart Forestry in MOuntain Regions) project, using nuclear microsatellite markers. The sampling sites were set along the species' distribution range, including the Balkan region and extending towards the Iberian Peninsula. Cores or leaves from 20 to 23 old, mature trees per plot were sampled for DNA analysis. Genetic diversity indices were high across the range (H-E = 0.74-0.81) with the highest in the Bosnian Mountains. Genetic divergence increased significantly with the geographical distance (Mantel test: r = 0.81, p < 0.001). Most of the stands exhibited an excess of heterozygotes, with the highest value at the Hungarian site (H-O/H-E = 1.177), where beech persists close to the eastern xeric limit of the species' distribution. STRUCTURE revealed within-region differentiation in the Balkan Peninsula, where the Bulgarian stand was the most outstanding. The genetic parameters of each stand could be assessed as a resource for CSF indicators interpreted especially at the local level.The authors acknowledge the networking support by the COST (European Cooperation in Science and Technology) Action CLIMO (Climate-Smart Forestry in Mountain Regions -CA15226) financially supported by the EU Framework Programme for Research and Innovation HORIZON 2020. Michal Bosela was additionally supported by the Slovak Research and Development Agency (project Nos. APVV-15-0265 and APVV-19-0183)

Dental Health and Mortality in People With End-Stage Kidney Disease Treated With Hemodialysis: A Multinational Cohort Study

Background Dental disease is more extensive in adults with chronic kidney disease, but whether dental health and behaviors are associated with survival in the setting of hemodialysis is unknown. Study Design Prospective multinational cohort. Setting & Participants 4,205 adults treated with long-term hemodialysis, 2010 to 2012 (Oral Diseases in Hemodialysis [ORAL-D] Study). Predictors Dental health as assessed by a standardized dental examination using World Health Organization guidelines and personal oral care, including edentulousness; decayed, missing, and filled teeth index; teeth brushing and flossing; and dental health consultation. Outcomes All-cause and cardiovascular mortality at 12 months after dental assessment. Measurements Multivariable-adjusted Cox proportional hazards regression models fitted with shared frailty to account for clustering of mortality risk within countries. Results During a mean follow-up of 22.1 months, 942 deaths occurred, including 477 cardiovascular deaths. Edentulousness (adjusted HR, 1.29; 95% CI, 1.10-1.51) and decayed, missing, or filled teeth score ≥ 14 (adjusted HR, 1.70; 95% CI, 1.33-2.17) were associated with early all-cause mortality, while dental flossing, using mouthwash, brushing teeth daily, spending at least 2 minutes on oral hygiene daily, changing a toothbrush at least every 3 months, and visiting a dentist within the past 6 months (adjusted HRs of 0.52 [95% CI, 0.32-0.85], 0.79 [95% CI, 0.64-0.97], 0.76 [95% CI, 0.58-0.99], 0.84 [95% CI, 0.71-0.99], 0.79 [95% CI, 0.65-0.95], and 0.79 [95% CI, 0.65-0.96], respectively) were associated with better survival. Results for cardiovascular mortality were similar. Limitations Convenience sample of clinics. Conclusions In adults treated with hemodialysis, poorer dental health was associated with early death, whereas preventive dental health practices were associated with longer survival

A saturated map of common genetic variants associated with human height

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes(1). Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel(2)) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries.A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants

Deformation induced primary crystallization in a thermally non-primary crystallizing amorphous Al85Ce8Ni5Co2 alloy

Nanocrystallization behavior of Al85Ce8Ni5Co2 amorphous ribbon induced by severe plastic deformation and by linear heating thermal treatment has been compared using differential scanning calorimetry, X-ray diffraction and transmission electron microscopy. Thermal treatment of the as-quenched ribbon results in the joint formation of several crystalline phases, whereas plastic deformation at room temperature induces only primary precipitation of a-Al nanocrystals. This is evidence for the athermal nature of the deformation induced crystallization process