SPACK FIREWALL RESTRICTION WITH SECURITY IN CLOUD OVER VIRTUAL ENVIRONMENT

ABSTRACT Security issues in cloud concern

RADIATION ASSISTED THERMONUCLEAR BURN WAVE DYNAMICS IN HEAVY ION FAST IGNITION OF CYLINDRICAL DT FUEL TARGET

Dynamics of thermonuclear burn wave propagation assisted by thermal radiation precursor in a heavy ion fast ignition of cy-lindrical deuterium-tritium (DT) fuel target are studied by two dimensional radiation hydrodynamic simulations using Multi-2D code. Thermal radiations, as they propagate ahead of the burn wave, suffer multiple reflections and preheat the fuel, are found to play a vital role in burn wave dynamics. After fuel ignition, the burn wave propagates in a steady state manner for some time. Multiple reflection and absorption of radiation at the fuel-tamper interface, fuel ablation and radial implosion driven by ablative shock and fast fusion rates on the fuel axis, at relatively later times, result into filamentary wave front. Strong pressure gradients are developed and sausage like structures behind the front are appeared. The situation leads to relatively reduced and non-uniform radial fuel burning and burn wave propagation. The fuel burning due to DD reaction is also taken into account and over-all fusion energy and fusion power density, due to DT and DD reactions, during the burn wave propagation are determined as a function of time

Attitudes toward effective hand washing and a new low-cost hand washing device to reduce the spread of COVID-19 cases in central and southeastern Bangladesh

Background: During the Covid-19 pandemic, the risk is high for people to contact the virus. The risk multiplies at crowded places. To combat the problem in a country like Bangladesh, where hygienic practices are poor, we manufactured a user-friendly hand washing device. The public use of this device will ensure a hygienic lifestyle for people. Methods: Manufactured in Bangladesh’s Cumilla and unveiled on August 15, 2020, this “Foot Press Hand washing Device” is a system requiring only a foot pressing to operate. It was designed based on the hydraulic pressure of the air pump having two operational aspects- soap ejection and water outlet. An online cross-sectional survey on 450 individuals in three cities and a face-to-face survey in a Bangladesh village were conducted to assess users’ satisfaction. Results: A total of 73.1% and 70.1% respondents in two surveys used a hand washing device in the past six months, 71.8% and 73.8% prioritized 20-second hand washing, 37.6% and 68.7% voiced importance of health hygiene against Covid-19. A total of 71.0% and 78.1% found the device unique while 71.2% and 74.7% believed it useful against Covid-19, 68.0% and 73.3% believed it suitable for rural people, 71.8% and 73.6% believed that it could be placed in a crowded place, 44.4% and 65.1% found it user-friendly for rural people. Conclusions: The device helps restrict virus transmission by washing hands with soap water in public places. This low-cost device can be produced using locally available materials. Future studies are needed to assess its effectiveness to prevent Covid-19 and hygiene-related infections

Surfactant proteins SP-A and SP-D modulate uterine contractile events in ULTR myometrial cell line

Pulmonary surfactant proteins SP-A and SP-D are pattern recognition innate immune molecules. However, there is extrapulmonary existence, especially in the amniotic fluid and at the feto-maternal interface. There is sufficient evidence to suggest that SP-A and SP-D are involved in the initiation of labour. This is of great importance given that preterm birth is associated with increased mortality and morbidity. In this study, we investigated the effects of recombinant forms of SP-A and SP-D (rhSP-A and rhSP-D, the comprising of trimeric lectin domain) on contractile events in vitro, using a human myometrial cell line (ULTR) as an experimental model. Treatment with rhSP-A or rhSP-D increased the cell velocity, distance travelled and displacement by ULTR cells. rhSP-A and rhSP-D also affected the contractile response of ULTRs when grown on collagen matrices showing reduced surface area. We investigated this effect further by measuring contractility-associated protein (CAP) genes. Treatment with rhSP-A and rhSP-D induced expression of oxytocin receptor (OXTR) and connexin 43 (CX43). In addition, rhSP-A and rhSP-D were able to induce secretion of GROα and IL-8. rhSP-D also induced the expression of IL-6 and IL-6 Ra. We provide evidence that SP-A and SP-D play a key role in modulating events prior to labour by reconditioning the human myometrium and in inducing CAP genes and pro-inflammatory cytokines thus shifting the uterus from a quiescent state to a contractile one

SHANK3 controls maturation of social reward circuits in the VTA.

Haploinsufficiency of SHANK3, encoding the synapse scaffolding protein SHANK3, leads to a highly penetrant form of autism spectrum disorder. How SHANK3 insufficiency affects specific neural circuits and how this is related to specific symptoms remains elusive. Here we used shRNA to model Shank3 insufficiency in the ventral tegmental area of mice. We identified dopamine (DA) and GABA cell-type-specific changes in excitatory synapse transmission that converge to reduce DA neuron activity and generate behavioral deficits, including impaired social preference. Administration of a positive allosteric modulator of the type 1 metabotropic glutamate receptors mGluR1 during the first postnatal week restored DA neuron excitatory synapse transmission and partially rescued the social preference defects, while optogenetic DA neuron stimulation was sufficient to enhance social preference. Collectively, these data reveal the contribution of impaired ventral tegmental area function to social behaviors and identify mGluR1 modulation during postnatal development as a potential treatment strategy

Fundamental role of C1q in autoimmunity and inflammation

C1q, historically viewed as the initiating component of the classical complement pathway, also exhibits a variety of complement-independent activities in both innate and acquired immunity. Recent studies focusing on C1q\u27s suppressive role in the immune system have provided new insight into how abnormal C1q expression and bioactivity may contribute to autoimmunity. In particular, molecular networks involving C1q interactions with cell surface receptors and other ligands are emerging as mechanisms involved in C1q\u27s modulation of immunity. Here, we discuss the role of C1q in controlling immune cell function, including recently elucidated mechanisms of action, and suggest how these processes are critical for maintaining tissue homeostasis under steady-state conditions and in preventing autoimmunity