13 research outputs found
Nucleoside/nucleotide reverse transcriptase inhibitor sparing regimen with once daily integrase inhibitor plus boosted darunavir is non-inferior to standard of care in virologically-suppressed children and adolescents living with HIV â Week 48 results of the randomised SMILE Penta-17-ANRS 152 clinical trial
An Association Between Anxiety and Neurocardiogenic Syncope During Head-Up Tilt Table Testing
A randomized study of remote follow-up of implantable cardioverter defibrillators: safety and efficacy report of the ECOST trial
Cardiac resynchronisation therapy reduces functional mitral regurgitation during dynamic exercise in patients with chronic heart failure: an acute echocardiographic study
OBJECTIVES: To assess nonâinvasively the acute effects of cardiac resynchronisation therapy (CRT) on functional mitral regurgitation (MR) at rest and during dynamic exercise. METHODS: 21 patients with left ventricular (LV) systolic dysfunction and functional MR at rest, treated with CRT, were studied. Each patient performed a symptomâlimited maximal exercise with continuous two dimensional Doppler echocardiography twice. The first exercise was performed with CRT; the second exercise was performed without CRT. Mitral regurgitant flow volume (RV), effective regurgitant orifice area (ERO) and LV dP/dt were measured at rest and at peak exercise. RESULTS: CRT mildly reduced resting mitral ERO (mean 8 (SEM 2) v 11 (2)â
mm(2) without CRT, pâ
â=ââ
0.02) and RV (13 (3) v 18 (3)â
ml without CRT, pâ
â=ââ
0.03). CRT attenuated the spontaneous increase in mitral ERO and RV during exercise (1 (1) v 9 (2)â
mm(2), pâ
â=ââ
0.004 and 1 (1) v 8 (2)â
ml, pâ
â=ââ
0.004, respectively). CRT also significantly increased exerciseâinduced changes in LV dP/dt (140 (46) v 479 (112)â
mmâ
Hg/s, pâ
<â
0.001). CONCLUSION: Attenuation of functional MR, induced by an increase in LV contractility during dynamic exercise, may contribute to the beneficial clinical outcome of CRT in patients with chronic heart failure and LV asynchrony