Effects of Cardiac Structural Remodelling During Heart Failure on Cardiac Excitation – Insights from a Heterogeneous 3D Model of the Rabbit Atria

Heart failure is a leading cause of morbidity and mortality in the western world. One of the effects of heart failure is the structural remodelling of cardiac tissue, including tissue dilation and development of fibrosis. It is therefore important to study these changes and their effect on cardiac activity, in order to gain a better understanding of the underlying mechanisms in arrhythmogenesis, which will hopefully enable us to develop better treatments for heart failure. In this study we developed biophysically detailed models of the rabbit atria for normal and heart failure conditions. These models were used to study the effects of structural remodelling of heart failure on cardiac excitation wave conduction. Anatomical reconstructions of the control and heart failure hearts were based on contrast enhanced micro-CT imaging. Fibre orientation was extracted from the control and heart failure datasets. Effects of heart failure geometry on the activation pattern of atrial excitation waves were analyzed. It was found that atrial activation time increased from the control to the heart failure case in both isotropic and anisotropic conditions, which is attributed primarily to the dilation of tissue caused by heart failure

Sinteza backstepping regulatora za praćenje maksimalne proizvodnje energije u fotonaponskim sustavima

This work presents a new control method to track the maximum power point of a grid-connected photovoltaic (PV) system. A backstepping controller is designed to be applied to a buck-boost DC-DC converter in order to achieve an optimal PV array output voltage. This nonlinear control is based on Lyapunov functions assuring the local stability of the system. Control reference voltages are initially estimated by a regression plane, avoiding local maximum and adjusted with a modified perturb and observe method (P&O). Thus, the maximum power extraction of the generating system is guaranteed. Finally, a DC-AC converter is controlled to supply AC current in the point of common coupling (PCC) of the electrical network. The performance of the developed system has been analyzed by means a simulation platform in Matlab/Simulink helped by SymPowerSystem Blockset. Results testify the validity of the designed control method.Ovaj rad predstavlja novu metodu upravljanja za slije.enje točke maksimalne snage fotonaponskog (PV) sustava. Dana je sinteza backstepping regulatora za primjenu u silazno-uzlaznom DC-DC pretvaraču za postizanje optimalnog izlaznog napona PV-a. Ova je nelinearna metoda upravljanja zasnovana na Ljapunovim funkcijama osiguravajući tako lokalnu stabilnost sustava. Upravljačke reference napona prvo su estimirane korištenjem regresijske ravnine izbjegavajući lokalne maksimume, a zatim podešene tzv. modificiranom perturbiraj i uoči metodom (P&O). Prema tome, zagarantirano je maksimalno izvlačenje energije iz sustava proizvodnje. Naposlijetku, DC-AC pretvaračem upravlja se na način da osigurava željena izmjenična struja u točki zajedničkog spoja (PCC) elektroenergetske mreže. Ponašanje razvijenog sustava analizirano je kroz simulacije provedene u Matlab/Simulink okruženju uz korištenje SymPowerSystem biblioteke

Vertical profiles of aerosol mass concentration derived by unmanned airborne in situ and remote sensing instruments during dust events

In situ measurements using unmanned aerial vehicles (UAVs) and remote sensing observations can independently provide dense vertically resolved measurements of atmospheric aerosols, information which is strongly required in climate models. In both cases, inverting the recorded signals to useful information requires assumptions and constraints, and this can make the comparison of the results difficult. Here we compare, for the first time, vertical profiles of the aerosol mass concentration derived from light detection and ranging (lidar) observations and in situ measurements using an optical particle counter on board a UAV during moderate and weak Saharan dust episodes. Agreement between the two measurement methods was within experimental uncertainty for the coarse mode (i.e. particles having radii  > 0.5µm), where the properties of dust particles can be assumed with good accuracy. This result proves that the two techniques can be used interchangeably for determining the vertical profiles of aerosol concentrations, bringing them a step closer towards their systematic exploitation in climate models

Aerosol absorption profiling from the synergy of lidar and sun-photometry : The ACTRIS-2 campaigns in Germany, Greece and Cyprus

© The Authors, published by EDP Sciences. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0/).Aerosol absorption profiling is crucial for radiative transfer calculations and climate modelling. Here, we utilize the synergy of lidar with sun-photometer measurements to derive the absorption coefficient and single scattering albedo profiles during the ACTRIS-2 campaigns held in Germany, Greece and Cyprus. The remote sensing techniques are compared with in situ measurements in order to harmonize and validate the different methodologies and reduce the absorption profiling uncertainties.Peer reviewe

Measurements of particle backscatter, extinction, and lidar ratio at 1064 nm with the rotational raman method in Polly-XT

We replaced a 1064-nm interference filter of a Polly-XT lidar system by a 1058-nm filter to observe pure rotational Raman backscattering from atmospheric Nitrogen and Oxygen. Polly-XT is compact Raman lidar with a Nd:YAG laser (20 Hz, 200 mJ at 1064 nm) and a 30-cm telescope mirror which applies photomultipliers in photoncounting mode. We present the first measured signals at 1058 nm and the derived extinction profile from measurements aboard RV Polarstern and in Leipzig. In combination with another Polly-XT system we could also derive particle backscatter and lidar ratio profiles at 1064 nm

Measurements of particle backscatter, extinction, and lidar ratio at 1064 nm with the rotational raman method in Polly-XT

We replaced a 1064-nm interference filter of a Polly-XT lidar system by a 1058-nm filter to observe pure rotational Raman backscattering from atmospheric Nitrogen and Oxygen. Polly-XT is compact Raman lidar with a Nd:YAG laser (20 Hz, 200 mJ at 1064 nm) and a 30-cm telescope mirror which applies photomultipliers in photoncounting mode. We present the first measured signals at 1058 nm and the derived extinction profile from measurements aboard RV Polarstern and in Leipzig. In combination with another Polly-XT system we could also derive particle backscatter and lidar ratio profiles at 1064 nm

3D Structure of Saharan Dust Transport Towards Europe as Seen by CALIPSO

We present a 3D multi-year monthly mean climatology of Saharan dust advection over Europe using an area-optimized pure dust CALIPSO product. The product has been developed by applying EARLINET-measured dust lidar ratios and depolarization-based dust discrimination methods and it is shown to have a very good agreement in terms of AOD when compared to AERONET over Europe/North Africa and MODIS over Mediterranean. The processing of such purely observational data reveals the certain seasonal patterns of dust transportation towards Europe and the Atlantic Ocean. The physical and optical properties of the dust layer are identified for several areas near the Saharan sources, over the Mediterranean and over continental Europe

3D Structure of Saharan Dust Transport Towards Europe as Seen by CALIPSO

We present a 3D multi-year monthly mean climatology of Saharan dust advection over Europe using an area-optimized pure dust CALIPSO product. The product has been developed by applying EARLINET-measured dust lidar ratios and depolarization-based dust discrimination methods and it is shown to have a very good agreement in terms of AOD when compared to AERONET over Europe/North Africa and MODIS over Mediterranean. The processing of such purely observational data reveals the certain seasonal patterns of dust transportation towards Europe and the Atlantic Ocean. The physical and optical properties of the dust layer are identified for several areas near the Saharan sources, over the Mediterranean and over continental Europe