Problems and prospects of development of ecological tourism in Ireland

The paper presents the research on the development of ecological tourism in Ireland. The basic directions and problems of development of ecotourism. Income from ecotourism in the country was analyzed in the article, as well as the model for the attraction of tourists to Irelan

The infrastructure of public catering in the context of tourist city space development

To assess the impact of environmental factors on the activities of catering enterprises of the Belgorod region and the quality of customer service, the authors proposed a method using STEP-analysis and SWOT-analysis. The analysis of environmental factors was carried out on the basis of the expert evaluation results conducted in two stage

Detection of diphtheria antitoxin by four different methods

ObjectiveTo investigate the reliability of the different methods used in Norway and Russia for detection of diphtheria antitoxin.MethodsOne hundred and twenty-two sera were selected among Russian serum samples previously collected for seroepidemiologic studies of diphtheria antitoxin. The sera were selected to cover the total antitoxin range and were analyzed by four different antidiphtheria toxin assays: an in vitro toxin neutralization test using Vero cells (in vitro NT), an in vivo neutralization test using rabbit skin inoculation (in vivo NT), an indirect enzyme immunoassay (EIA) and a passive hemagglutination assay (PHA). The results were expressed according to the international standard as: not protected (<0.01 IU/mL), relatively protected (0.01–0.1 IU/mL) or protected (≤0.1 IU/mL). The sensitivity, specificity and inter-rater agreement (K or Kw) of each method were related to the in vitro NT selected as the reference method.ResultsThe in vivo NT test corresponded very well with the in vitro NT in its ability to differentiate between protection/relative protection and no protection (sensitivity 97%, specificity 87% and K=0.84). The EIA test showed a high sensitivity (96%), but since many sera were categorized as protected rather than not protected, the specificity (30%) and inter-rater agreement (K=0.29) were low. The PHA test had a very high specificity (100%) but a low sensitivity (86%).ConclusionsThe agreement between the two neutralization tests was high. If none of the neutralization assays is routinely available, the PHA test can be used to predict the need for vaccination on an individual basis but should not be used for seroepidemiologic studies, since the protection rate for diphtheria would be falsely too low, due to the lower sensitivity. The indirect EIA test used in this study should not be used routinely

Sociological diagnostics of crowdsourcing technology in the practice of regional management

The article proposes a methodology for identifying and analyzing the technology of crowdsourcing, examines the main stages of the formation, and analyzes the implementation of crowdsourcing technology into the practice of regional managemen

Gradients of Taxonomic Diversity among Local Floras in the Russian Arctic

Latitudinal and longitudinal changes in taxonomic variables were analyzed in 319 local floras in the Russian Arctic. Within the studied segment of latitudinal gradient, most changes can be described in terms of linear regression with negative coefficients (a number of species, genera and families), or positive coefficients (a proportion of the leading families and genera). However, the mean number of species in a family or genus almost does not change with increasing latitude, although it slightly increases as one moves eastward. The proportion of monocots does not correlate with latitude, but slightly decreases as one moves eastward. Proportions of various families change asynchronously. Although correlation with longitude was less pronounced, mean species richness was specific to many subprovinces, even within a certain subzone. These differences reflect both the diversity of landscapes and the history of flora formation. Keywords: the Arctic, local floras, latitudinal and longitudinal gradient, floristic subprovince

Gastrointestinal Bleeding in Antithrombotic Therapy in Patients with Coronary Heart Disease: Risk Factors, Pathogenesis and Treatment

Aim. Description of risk factors, pathogenesis and treatment strategies of gastrointestinal bleeding (GIB) in the course of antithrombotic therapy in patients with coronary heart disease (CHD).Key points. Risk factors of GIB during antithrombotic therapy in CHD patients include: GIB, gastric and/or duodenal ulcer in the history, reflux esophagitis, presence of H. pylori, inflammatory bowel disease, diverticula, haemorrhoids, angiodysplasia, gastrointestinal neoplasia, age above 65 years, concomitant treatment with non-steroidal anti-inflammatory drugs (NSAIDs), glomerular filtration rate &lt;50 mL/min, high doses of direct oral anticoagulants (DOACs) ≥3 in HAS-BLED score. Pathogenesis of GIB in the course of antithrombotic therapy is associated with systemic hypocoagulation and local damaging effects of these drugs. Strategies of GIB treatment during DOAC therapy in patients with CHD are determined by severity of bleeding and threat to life. Aside to standard conservative measures, endoscopic or surgical haemostasis requires usage of antidotes to suppress effects of DOACs and other specific drugs in severe cases.Conclusion. GIB associated with antithrombotic therapy in CHD patients poses a serious medical problem of growing importance with wider application of anticoagulant drugs. Antithrombotic therapy requires accurate decision making, risk assessment, careful monitoring of the patient’s condition and timely diagnosis of gastrointestinal disorders following good rationale in GIB prevention

Molecular epidemiology of serogroup a meningitis in Moscow, 1969 to 1997.

Molecular analysis of 103 serogroup A Neisseria meningitidis strains isolated in Moscow from 1969 to 1997 showed that four independent clonal groupings were responsible for successive waves of meningococcal disease. An epidemic from 1969 to the mid-1970s was caused by genocloud 2 of subgroup III, possibly imported from China. Subsequent endemic disease through the early 1990s was caused by subgroup X and then by subgroup VI, which has also caused endemic disease elsewhere in eastern Europe. A 1996 epidemic was part of the pandemic spread from Asia of genocloud 8 of subgroup III. Recent genocloud 8 epidemic disease in Moscow may represent an early warning for spread of these bacteria to other countries in Europe

Investigation of the structure and microhardness of Mo-Fe-C coatings obtained by the electron beam injected in the atmosphere

In this work 'Mo-Fe-C' coatings fabricated on medium carbon steel by non-vacuum electron beam cladding were investigated. The structure of coatings and transition zones were studied by scanning electron microscopy (SEM). It was shown that an increase of Fe percentage in the cladding mixture led to a decrease of the eutectic volume fraction in the coating and was accompanied by the formation of the gradient structure between the coating and a substrate material. Measurements of microhardness in the cross section of samples revealed that the cladding of a 'Mo-C powder mixture contributed to a 4.5-fold increase of microhardness

Проявление ожога верхушки внутренних листьев кочана на гибридах белокочанной капусты среднепозднего и позднего сроков созревания.

Relevance. The most complex and common physiological disease on the cabbage is a tip burn, associated with impaired Ca2 + transport inside the plant. Of all the ways to control this physiological disease, the most effective is the cultivation of tolerant hybrids. Material and methods.The aim of the research was to evaluate the mid-late and late ripening F1 hybrids of white cabbage for a tip burn and to determine the degree of hybrids responsiveness to calcium deficiency depending on weather conditions. The studies were carried out at breeding and experimental plot of the vegetable growing department at All-Russian Rice Research Institute in 2017-2019 on drip irrigation. Material - hybrid combinations of ARRRI breeding.Results. The manifestation of a physiological disturbance called “burn of the top of the inner leaves of the cabbage head” or “tip burn” on individual hybrids was observed during all years of cultivation, but to a different degree; The greatest damage to the heads was recorded in the years (2017 and 2019) with high productivity, which is due to the intensive assimilation ability against the background of warm sunny weather. In 2019, the manifestation of burns was noted in 25% of hybrids, which allowed them to be divided into 4 groups, depending on the degree of damage and the spread of the disease.It was established that hybrids with overmature standing for 2.5-3 weeks and also hybrids that were promptly removed at the time of mass technical ripeness had a high degree of damage. The lines that are most often found in hybrid combinations with signs of burns (269-824, Agr1321, 269Jas13, Byum112, Yas25, etc.) were identified, but it is rather difficult to assume the nature of inheritance, and, therefore, to develop the principle of pair selection when developing relatively stable hybrids also not yet possible.Актуальность. Наиболее сложное и часто встречаемое физиологическое заболевание на капусте – ожог верхушки внутренних листьев кочана (tip burn), связанное с нарушениями транспорта Са2+ внутри растения. Из всех способов контроля данного физиологического заболевания наиболее эффективным является выращивание толерантных гибридов.Материал и методика.Цель исследований – провести оценку гибридов F1 капусты белокочанной среднепозднего и позднего сроков созревания на поражение ожогом верхушки внутренних листьев кочана и выявить степень отзывчивости гибридов к недостатку поступления кальция в зависимости от погодных условий. Исследования проводили на селекционно-опытном участке отдела овощеводства во «ВНИИ риса» в 2017-2019 годах на капельном поливе. Материал – гибридные комбинации селекции «ВНИИ риса».Результаты. Проявление физиологического нарушения под названием «ожог верхушки внутренних листьев кочана» или «tip burn» на отдельных гибридах наблюдали во все годы выращивания, но в разной степени; наибольшее поражение кочанов было зафиксировано в 2017 и 2019 годах с высокой урожайностью, что обусловлено интенсивной ассимиляционной способностью на фоне теплой солнечной погоды. В 2019 году проявление ожога отмечено на 25% гибридов, что позволило их разделить на 4 группы, в зависимости от степени поражения и распространения заболевания. Установлено, что высокую степень поражения имели гибриды с перестоем на корню 2,5-3 недели и также гибриды, убранные своевременно на момент массовой технической спелости. Выделены линии, которые наиболее часто встречаются в гибридных комбинациях с признаками ожога (269-824, Агр1321, 269Яс13, Бюм112, Яс25 и др.), но предположить характер наследования довольно сложно, и, следовательно, разработать принцип подбора пар при создании относительно устойчивых гибридов тоже не представляется пока возможным. Более точным критерием ценности линий по устойчивости к ожогу будет оценка их комбинационной способности по данному признаку. Чтобы избежать появления новых гибридов, склонных к проявлению tip burn, необходимо испытания на селекционном участке проводить на высоком агротехническом фоне и регулярно тестировать в момент уборки кочаны для выявления данного нарушения

Double Spin Asymmetries A_NN and A_SS at sqrt{s}=200 GeV in Polarized Proton-Proton Elastic Scattering at RHIC

We present the first measurements of the double spin asymmetries A_NN and A_SS at sqrt{s}=200 GeV, obtained by the pp2pp experiment using polarized proton beams at the Relativistic Heavy Ion Collider (RHIC). The data were collected in the four momentum transfer t range 0.01<|t|<0.03 (GeV/c)^2. The measured asymmetries, which are consistent with zero, allow us to estimate upper limits on the double helicity-flip amplitudes phi_2 and phi_4 at small t as well as on the difference Delta(sigma_T) between the total cross sections for transversely polarized protons with antiparallel or parallel spin orientations.Comment: 13 pages with 3 figures. Final version accepted by Phys. Lett.