An Alternative Approach to Aldol Reactions: Gold-Catalyzed Formation of Boron Enolates from Alkynes

A new method for enolate generation via the gold-catalyzed addition of boronic acids to alkynes is reported. The formation of boron enolates from readily accessible ortho-alkynylbenzeneboronic acids proceeds rapidly with 2 mol % PPh3AuNTf2 at ambient temperature. The enolates undergo aldol reaction with an aldehyde present in the reaction mixture to give cyclic boronate esters, which can be subsequently transformed into phenols, biaryls, or dihydrobenzofurans via oxidation, Suzuki-Miyaura, or intramolecular Chan-Lam coupling, respectively. A combined gold/boronic acid catalyzed aldol condensation reaction of an alkynyl aldehyde was also successfully achieved

Perspectives of Nuclear Physics in Europe: NuPECC Long Range Plan 2010

The goal of this European Science Foundation Forward Look into the future of Nuclear Physics is to bring together the entire Nuclear Physics community in Europe to formulate a coherent plan of the best way to develop the field in the coming decade and beyond.<p></p> The primary aim of Nuclear Physics is to understand the origin, evolution, structure and phases of strongly interacting matter, which constitutes nearly 100% of the visible matter in the universe. This is an immensely important and challenging task that requires the concerted effort of scientists working in both theory and experiment, funding agencies, politicians and the public.<p></p> Nuclear Physics projects are often “big science”, which implies large investments and long lead times. They need careful forward planning and strong support from policy makers. This Forward Look provides an excellent tool to achieve this. It represents the outcome of detailed scrutiny by Europe’s leading experts and will help focus the views of the scientific community on the most promising directions in the field and create the basis for funding agencies to provide adequate support.<p></p> The current NuPECC Long Range Plan 2010 “Perspectives of Nuclear Physics in Europe” resulted from consultation with close to 6 000 scientists and engineers over a period of approximately one year. Its detailed recommendations are presented on the following pages. For the interested public, a short summary brochure has been produced to accompany the Forward Look.<p></p&gt

Spectral fluctuation characterization of random matrix ensembles through wavelets

A recently developed wavelet based approach is employed to characterize the scaling behavior of spectral fluctuations of random matrix ensembles, as well as complex atomic systems. Our study clearly reveals anti-persistent behavior and supports the Fourier power spectral analysis. It also finds evidence for multi-fractal nature in the atomic spectra. The multi-resolution and localization nature of the discrete wavelets ideally characterizes the fluctuations in these time series, some of which are not stationary.Comment: 7 pages, 2 eps figure

Validation of ERA5-Land temperature and relative humidity on four Peruvian glaciers using on-glacier observations

Weather and climate conditions drive the evolution of tropical glaciers which play an important role as water reservoirs for Peruvian inhabitants in the arid coast and semi-arid Andean region. The scarcity of long-term high-quality observations over Peruvian glaciers has motivated the extensive use of reanalysis data to describe the climatic evolution of these glaciers. However, the representativeness and uncertainties of these reanalysis products over these glaciers are still poorly constrained. This study evaluates the ability of the ERA5-Land reanalysis (ERA5L) to reproduce hourly and monthly 2 m air temperature and relative humidity (T2m and Rh2m, respectively) over several Peruvian glaciers. We compared the ERA5L with data from four on-glacier automatic weather stations (AWS), whose hourly time series were completed with nearby stations, for the period January 2017 to December 2019. Results indicates a better performance of the reanalysis for T2m (r >0.80) than for Rh2m (similar to 0.4<

Mesoscopic Analysis of Structure and Strength of Dislocation Junctions in FCC Metals

We develop a finite element based dislocation dynamics model to simulate the structure and strength of dislocation junctions in FCC crystals. The model is based on anisotropic elasticity theory supplemented by the explicit inclusion of the separation of perfect dislocations into partial dislocations bounding a stacking fault. We demonstrate that the model reproduces in precise detail the structure of the Lomer-Cottrell lock already obtained from atomistic simulations. In light of this success, we also examine the strength of junctions culminating in a stress-strength diagram which is the locus of points in stress space corresponding to dissolution of the junction.Comment: 9 Pages + 4 Figure

Contrasting heterozygosity-fitness correlations across life in a long-lived seabird

Selection is a central force underlying evolutionary change and can vary in strength and direction, for example across time and space. The fitness consequences of individual genetic diversity have often been investigated by testing for multilocus heterozygosity-fitness correlations (HFCs), but few studies have been able to assess HFCs across life stages and in both sexes. Here, we test for HFCs using a 26-year longitudinal individual-based data set from a large population of a long-lived seabird (the common tern, Sterna hirundo), where 7,974 chicks and breeders of known age were genotyped at 15 microsatellite loci and sampled for life-history traits over the complete life cycle. Heterozygosity was not correlated with fledging or post-fledging prospecting probabilities, but was positively correlated with recruitment probability. For breeders, annual survival was not correlated with heterozygosity, but annual fledgling production was negatively correlated with heterozygosity in males and highest in intermediately heterozygous females. The contrasting HFCs among life stages and sexes indicate differential selective processes and emphasize the importance of assessing fitness consequences of traits over complete life histories

Exclusive semileptonic decays of D and Ds mesons in the covariant confining quark model

Recently, the BESIII collaboration has reported numerous measurements of various D(s) meson semileptonic decays with significantly improved precision. Together with similar studies carried out at BABAR, Belle, and CLEO, new windows to a better understanding of weak and strong interactions in the charm sector have been opened. In light of new experimental data, we review the theoretical description and predictions for the semileptonic decays of D(s) to a pseudoscalar or a vector meson. This review is essentially an extended discussion of our recently published results obtained in the framework of the covariant confining quark model

Form-factor-independent test of lepton universality in semileptonic heavy meson and baryon decays

In the semileptonic decays of heavy mesons and baryons, the lepton-mass dependence factors out in the quadratic cos2θ coefficient of the differential cosθ distribution. We call the corresponding normalized coefficient the convexity parameter. This observation opens the path to a test of lepton universality in semileptonic heavy meson and baryon decays that is independent of form-factor effects. By projecting out the quadratic rate coefficient, dividing out the lepton-mass-dependent factor, and restricting the phase space integration to the τ lepton phase space, one can define optimized partial rates which, in the Standard Model, are the same for all three (e,μ,τ) modes in a given semileptonic decay process. We discuss how the identity is spoiled by new physics effects. We discuss semileptonic heavy meson decays such as B¯0→D(∗)+ℓ-ν¯ℓ and Bc-→J/ψ(ηc)ℓ-ν¯ℓ and semileptonic heavy baryon decays such as Λb→Λcℓ-ν¯ℓ for each ℓ=e, μ, τ

Exploring patterns of recurrent melanoma in Northeast Scotland to inform the introduction a digital self-examination intervention

Peer reviewedPublisher PD