The Skeletal Muscle Microvasculature and Its Effects on Metabolism

Skeletal muscle is a major metabolic organ that plays a critical role in regulating glucose homeostasis and lipid utilization. Impaired muscle metabolic response is evident in diseases such as diabetes, obesity and cardiovascular diseases, and is also often associated with microvascular dysfunction. Here, we investigate the changes that can occur in the muscle microvasculature and the profound impact they can have on metabolism

Body image dissatisfaction among food-related degree students.

Current western society promotes a strong desirability to be thin. The majority of young females are unhappy with their body shape and wish to be thinner. This can lead to many health problems such as addictive exercising, depression and disordered eating. It is also established that certain groups tend to be more prone to body image dissatisfaction (BID) than others. The purpose of this study was to determine if there was a high prevalence of BID and/or disordered eating among students studying a food-related degree course

A three-dimensional view of the remnant of Nova Persei 1901 (GK Per)

We present a kinematical study of the optical ejecta of GK Per. It is based on proper motions measurements of 282 knots from ~20 images spanning 25 years. Doppler-shifts are also computed for 217 knots. The combination of proper motions and radial velocities allows a unique 3-D view of the ejecta to be obtained. The main results are: (1) the outflow is a thick shell in which knots expand with a significant range of velocities, mostly between 600 and 1000 km/s; (2) kinematical ages indicate that knots have suffered only a modest deceleration since their ejection a century ago; (3) no evidence for anisotropy in the expansion rate is found; (4) velocity vectors are generally aligned along the radial direction but a symmetric pattern of non-radial velocities is also observed at specific directions; (5) the total Halpha+[NII] flux has been linearly decreasing at a rate of 2.6 % per year in the last decade. The Eastern nebular side is fading at a slower rate than the Western one. Some of the knots displayed a rapid change of brightness during the 2004-2011 period. Over a longer timescale, a progressive circularization and homogenization of the nebula is taking place; (6) a kinematic distance of 400+-30 pc is determined. These results raise some problems to the previous interpretations of the evolution of GK Per. In particular, the idea of a strong interaction of the outflow with the surrounding medium in the Southwest quadrant is not supported by our data.Comment: Accepted for publication in The Astrophysical Journal (19 pages, 17 figures). Higher resolution version of this article (2.5 MB) is available at http://www.aai.ee/~sinope/ApJ89291_liimets.pd

New insights into the outflows from R Aquarii

R Aquarii is a symbiotic binary surrounded by a large and complex nebula with a prominent curved jet. It is one of the closest known symbiotic systems, and therefore offers a unique opportunity to study the central regions of these systems and the formation and evolution of astrophysical jets. We studied the evolution of the central jet and outer nebula of R Aqr taking advantage of a long term monitoring campaign of optical imaging, as well as of high-resolution integral field spectroscopy. Narrow-band images acquired over a period of more than 21 years are compared in order to study the expansion and evolution of all components of the R Aqr nebula. The magnification method is used to derive the kinematic ages of the features that appear to expand radially. Integral field spectroscopy of the OIII 5007A emission is used to study the velocity structure of the central regions of the jet. New extended features, further out than the previously known hourglass nebula, are detected. The kinematic distance to R Aqr is calculated to be 178 pc using the expansion of the large hourglass nebula. This nebula of R Aqr is found to be roughly 650 years old, while the inner regions have ages ranging from 125 to 290 years. The outer nebula is found to be well described by a ballistic expansion, while for most components of the jet strong deviations from such behaviour are found. We find that the Northern jet is mostly red-shifted while its Southern part is blue-shifted, apparently at odds with findings from previous studies but almost certainly a consequence of the complex nature of the jet and variations in ionisation and illumination between observations.Comment: 13 pages, 8 figures, accepted for publication in A&

Greater Omentectomy Improves Insulin Sensitivity in Nonobese Dogs

Visceral adiposity is strongly associated with insulin resistance; however, little evidence directly demonstrates that visceral fat per se impairs insulin action. Here, we examine the effects of the surgical removal of the greater omentum and its occupying visceral fat, an omentectomy (OM), on insulin sensitivity (SI) and β-cell function in nonobese dogs. Thirteen male mongrel dogs were used in this research study; animals were randomly assigned to surgical treatment with either OM (n = 7), or sham-surgery (SHAM) (n = 6). OM failed to generate measurable changes in body weight (+2%; P = 0.1), or subcutaneous adiposity (+3%; P = 0.83) as assessed by magnetic resonance imaging (MRI). The removal of the greater omentum did not significantly reduce total visceral adipose volume (−7.3 ± 6.4%; P = 0.29); although primary analysis showed a trend for OM to increase SI when compared to sham operated animals (P = 0.078), further statistical analysis revealed that this minor reduction in visceral fat alleviated insulin resistance by augmenting SI of the periphery (+67.7 ± 35.2%; P = 0.03), as determined by the euglycemic-hyperinsulinemic clamp. Insulin secretory response during the hyperglycemic step clamp was not directly influenced by omental fat removal (presurgery 6.82 ± 1.4 vs. postsurgery: 6.7 ± 1.2 pmol/l/mg/dl, P = 0.9). These findings provide new evidence for the deleterious role of visceral fat in insulin resistance, and suggest that a greater OM procedure may effectively improve insulin sensitivity