DEVELOPMENT AND EVALUATION OF ANTIDIABETIC POLYHERBAL TABLET USING MEDICINAL PLANTS OF TRADITIONAL USE

Objective: The aim of the present study is to develop and evaluate poly herbal tablet prepared for management of diabetes with enhanced disintegration time. Methods: The polyherbal extract prepared using methanolic extract of selected traditionally used medicinal plants such as Adenanthera pavonina, Kigelia africana, Parkia biglandulosa and Syzygium jambose (1:1:1:2) was evaluated in the alloxan monohydrate induced diabetic rat model. The polyherbal tablets were prepared by wet granulation method with excipients microcrystalline cellulose, dicalcium phosphate dehydrate and sodium starch glycolate. After preformulation studies tablets were evaluated by using weight variation, hardness, friability and disintegration time. The diabetic rats treated with polyherbal extract were compared with the diabetic control rats group. Results: Positive results were obtained in the observed parameters, thus favoring the use of the plants. Pre-formulation study revealed that all the evaluated parameters were found to be within the acceptable limits. The weight variation of the formulated tablets was 1.43 % RSD. The disintegration time of the formulations was found to be 9.50 minutes. The tablets also underwent accelerated stability over the period of three months. No marked changes were observed in all the parameters evaluated during three months of accelerated stability study. Conclusion: Laboratory-scale preparation of polyherbal tablet can lead to new powerful and stable oral dosage formulations for diabetes mellitus and lighten the synergistic area of ​​action of herbs

Formulation and Development of Spirulina (Athrospira plantasis) Loaded Chocolatesas Immunity Boosters

Adults, as well as children, have a great need for nutrients such as Calcium, Iron, Zinc, Protein, and Vitamin B12. Spirulina is very rich in protein, omega 3 and omega 6 oils, vitamin, and mineral, and its incorporation into chocolates will enrich their nutritional values. Spirulina satisfies the nutritional needs by providing all these nutrients, as well as all the essential amino acids. Spirulina is unique and 100% safe. In fact, Spirulina is the only natural food that contains GLA (gamma linoleic acid) an essential fatty acid that is found only in mother’s milk. This GLA plays a very vital in balancing the hormonal system in the body. So it is actually very good to give Spirulina to the children.Our Spirulina Chocolates were prepared by simple incorporation method by addition of 1gm Spirulina by dissolving in 10 ml NaCl as a solubility enhancer as well as to mask the taste and smell. This chocolate form is easier for every individual to chew and absorb. The chocolates were assessed for organoleptic properties, pH, blooming test, and hardness. This significant study revealed the efficacy of Spirulina Chocolate Formulation and it would definitely have a wide scope in the future as an immunity booster and in treatments of malnutrition in children as well. Further study is required to reveal the quantification of constituents present in Spirulina Chocolate formulation by in vivo and invitro studies

Assessment of In vivo Antidiabetic Activity of Adenanthera pavonina (Fabaceae) Extract in Alloxan-induced Diabetic Rats

Objective: Adenanthera pavonina is a deciduous tree commonly used in traditional medicine to treat various ailments such as boils, epilepsy, blood disorders, seizures, inflammation, and rheumatism. However, the use of this plant extract lacks scientific validation as to its effectiveness. Materials and Methods: This study aimed to investigate the in vivo antidiabetic activity of the methanolic extract of A. pavonina leaves in alloxanized diabetic rats. The preliminary phytochemical screening was performed. The antidiabetic property was evaluated by oral administration of plant extract at doses of 200 and 400 mg/kg of body weight and by profiling blood glucose levels at 1, 7, 14, and 21 days using a glucometer. Results: The phytochemical screening reveals the presence of alkaloids, glycosides, phenolic compounds, tannins, saponins, proteins, amino acids, and steroids. The blood glucose level of 200 mg/kg and 400 mg/kg of plant extract on day 21 of the study was 188.41 ± 8.46 mg/dL and 182.01 ± 9.21 mg/dL, respectively, compared to the diabetic control 291.01 ± 10.25 mg/dL. Conclusion: The methanolic extract from the leaves of A. pavonina showed dose-dependent antidiabetic activity in alloxanized diabetic rats. The results suggest that the plant extract has significant (P < 0.01) antidiabetic activity