Electron Spin Resonance Study on Irradiated Styrene in Crystalline and Glassy States

Styrene was irradiated at-196°C to give a five-line spectrum with a coupling constant of about 16 gauss. This is attributed to the free radical When a mixture of styrene and 2-methyltetrahydrofuran was irradiated, a broad singlet spectrum (total width 33 gauss) was superposed on the seven-line spectrum due to the methyltetrahydrofuran radical and no sharp singlet spectrum due to trapped electrons was observed. This broad singlet spectrum is thought to be due to styrene anion radicals. This spectrum was bleached by visible light and saturated appreciably with increasing microwave power. Similar phenomena were observed for a styrene-3-methylpentane mixture

Association of Clinical Features with Human Leukocyte Antigen in Japanese Patients with Ulcerative Colitis

【Background】 The human leukocyte antigen (HLA) region has been found to be involved in the pathogenesis of inflammatory bowel disease (IBD), which is classified into ulcerative colitis (UC) and Crohn’s disease (CD), by genome-wide association studies. The aim of this study was to confirm whether HLA-alleles confer susceptibility to UC and to determine whether HLA-allel1es are associated with the clinical phenotypes in Japanese patients with UC. 【Methods】 In this study, HLA typing was performed by PCR-sequence-specific oligonucleotides (PCR-SSO) to confirm the correlation between UC and HLA alleles (for HLA-A, B, DRB1) in 45 Japanese UC patients. In addition, whether the HLA alleles are related to patient and clinical background characteristics was examined. 【Results】 Overall, 62.2%, and 66.7% of the 45 UC patients had HLA-B*52 and HLA-DRB1*15, respectively. These allele frequencies were significantly higher than in previously reported Japanese control persons (P < 0.0001). The frequencies of extraintestinal manifestations [odds ratio (OR) = 0.12, P = 0.039] and a history of colectomy (OR = 0.18, P = 0.046) were lower in HLA-B*52-positive UC patients than in HLA-B*52 negative UC patients. The white blood cell (WBC) count was significantly higher in HLA-DRB1*15-positive patients (9430 ± 4592/μL) than in HLA-DRB1*15-negative patients (6729 ± 2160/μL). Thus, HLA-B*52 and DRB1*15 appear to be associated with disease features and severity in Japanese UC patients. 【Conclusion】 These results indicate that HLA-B*52 and DRB1*15 are not only associated with overall UC susceptibility, but also with the clinical phenotypes in Japanese patients

Alteration of FHR pattern and cerebral metabolic rate of glucose of the fetus measured by positron emission tomography during progress of acidemia. The significance of overshoot acceleration in FHR

Peer Reviewe

男性看護師のキャリア発達に関する意識と行動

急性期病院に勤務する男性看護師７名に対するインタビューから、男性看護師のキャリア発達に関する意識と行動について検討した。その結果、【キャリア発達に対する消極性】【経験の蓄積と技術研鑽への意欲】【職場における役割の獲得】【専門性の追求】及び【看護職への価値形成】のカテゴリー、男性看護師の特性として【看護の幅を広げる】、【未発達な男性看護師の立場】及び【家族に対する責任】のカテゴリーが抽出された。家庭を経済的に支える責任を担っているという意識は、男性看護師を継続する意志につながっていた。また、資格取得に伴う経済的負担や看護師としての経験不足は、キャリア発達に対する消極性につながっていた

EGUIDE project and treatment guidelines

Aim: Although treatment guidelines for pharmacological therapy for schizophrenia and major depressive disorder have been issued by the Japanese Societies of Neuropsychopharmacology and Mood Disorders, these guidelines have not been well applied by psychiatrists throughout the nation. To address this issue, we developed the ‘Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment (EGUIDE)’ integrated education programs for psychiatrists to disseminate the clinical guidelines. Additionally, we conducted a systematic efficacy evaluation of the programs. Methods: Four hundred thirteen out of 461 psychiatrists attended two 1‐day educational programs based on the treatment guidelines for schizophrenia and major depressive disorder from October 2016 to March 2018. We measured the participants’ clinical knowledge of the treatment guidelines using self‐completed questionnaires administered before and after the program to assess the effectiveness of the programs for improving knowledge. We also examined the relation between the participants’ demographics and their clinical knowledge scores. Results: The clinical knowledge scores for both guidelines were significantly improved after the program. There was no correlation between clinical knowledge and participant demographics for the program on schizophrenia; however, a weak positive correlation was found between clinical knowledge and the years of professional experience for the program on major depressive disorder. Conclusion: Our results provide evidence that educational programs on the clinical practices recommended in guidelines for schizophrenia and major depressive disorder might effectively improve participants’ clinical knowledge of the guidelines. These data are encouraging to facilitate the standardization of clinical practices for psychiatric disorders