Exhaled Nitric Oxide in Children with Asthma and Short-Term PM(2.5) Exposure in Seattle

The objective of this study was to evaluate associations between short-term (hourly) exposures to particulate matter with aerodynamic diameters < 2.5 μm (PM(2.5)) and the fractional concentration of nitric oxide in exhaled breath (Fe(NO)) in children with asthma participating in an intensive panel study in Seattle, Washington. The exposure data were collected with tapered element oscillation microbalance (TEOM) PM(2.5) monitors operated by the local air agency at three sites in the Seattle area. Fe(NO) is a marker of airway inflammation and is elevated in individuals with asthma. Previously, we reported that offline measurements of Fe(NO) are associated with 24-hr average PM(2.5) in a panel of 19 children with asthma in Seattle. In the present study using the same children, we used a polynomial distributed lag model to assess the association between hourly lags in PM(2.5) exposure and Fe(NO) levels. Our model controlled for age, ambient NO levels, temperature, relative humidity, and modification by use of inhaled corticosteroids. We found that Fe(NO) was associated with hourly averages of PM(2.5) up to 10–12 hr after exposure. The sum of the coefficients for the lag times associated with PM(2.5) in the distributed lag model was 7.0 ppm Fe(NO). The single-lag-model Fe(NO) effect was 6.9 [95% confidence interval (CI), 3.4 to 10.6 ppb] for a 1-hr lag, 6.3 (95% CI, 2.6 to 9.9 ppb ) for a 4-hr lag, and 0.5 (95% CI, −1.1 to 2.1 ppb) for an 8-hr lag. These data provide new information concerning the lag structure between PM(2.5) exposure and a respiratory health outcome in children with asthma

Advanced spectroscopic investigation of colour centres in LiF crystals irradiated with monochromatic hard x-rays

Nominally-pure lithium fluoride (LiF) crystals were irradiated with monochromatic hard x-rays of energy 5, 7, 9 and 12 keV at the METROLOGIE beamline of the SOLEIL synchrotron facility, in order to understand the role of the selected x-ray energy on their visible photoluminescence (PL) response, which is used for high spatial resolution 2D x-ray imaging detectors characterized by a wide dynamic range. At the energies of 7 and 12 keV the irradiations were performed at five different doses corresponding to five uniformly irradiated areas, while at 5 and 9 keV only two irradiations at two different doses were carried out. The doses were planned in a range between 4 and 1.4 × 103 Gy (10.5 mJ cm−3 to 3.7 J cm−3), depending on the x-ray energy. After irradiation at the energies of 7 and 12 keV, the spectrally-integrated visible PL intensity of the F2 and F3+ colour centres (CCs) generated in the LiF crystals, carefully measured by fluorescence microscopy under blue excitation, exhibits a linear dependence on the irradiation dose in the investigated dose range. This linear behaviour was confirmed by the optical absorption spectra of the irradiated spots, which shows a similar linear behaviour for both the F2 and F3+ CCs, as derived from their overlapping absorption band at around 450 nm. At the highest x-ray energy, the average concentrations of the radiation-induced F, F2 and F3+ CCs were also estimated. The volume distributions of F2 defects in the crystals irradiated with 5 and 9 keV x-rays were reconstructed in 3D by measuring their PL signal using a confocal laser scanning microscope operating in fluorescence mode. On-going investigations are focusing on the results obtained through this z-scanning technique to explore the potential impact of absorption effects at the excitation laser wavelength

Associations between Health Effects and Particulate Matter and Black Carbon in Subjects with Respiratory Disease

We measured fractional exhaled nitric oxide (FE(NO)), spirometry, blood pressure, oxygen saturation of the blood (SaO(2)), and pulse rate in 16 older subjects with asthma or chronic obstructive pulmonary disease (COPD) in Seattle, Washington. Data were collected daily for 12 days. We simultaneously collected PM(10) and PM(2.5) (particulate matter ≤10 μm or ≤2.5 μm, respectively) filter samples at a central outdoor site, as well as outside and inside the subjects’ homes. Personal PM(10) filter samples were also collected. All filters were analyzed for mass and light absorbance. We analyzed within-subject associations between health outcomes and air pollution metrics using a linear mixed-effects model with random intercept, controlling for age, ambient relative humidity, and ambient temperature. For the 7 subjects with asthma, a 10 μg/m(3) increase in 24-hr average outdoor PM(10) and PM(2.5) was associated with a 5.9 [95% confidence interval (CI), 2.9–8.9] and 4.2 ppb (95% CI, 1.3–7.1) increase in FE(NO), respectively. A 1 μg/m(3) increase in outdoor, indoor, and personal black carbon (BC) was associated with increases in FE(NO) of 2.3 ppb (95% CI, 1.1–3.6), 4.0 ppb (95% CI, 2.0–5.9), and 1.2 ppb (95% CI, 0.2–2.2), respectively. No significant association was found between PM or BC measures and changes in spirometry, blood pressure, pulse rate, or SaO(2) in these subjects. Results from this study indicate that FE(NO) may be a more sensitive marker of PM exposure than traditional health outcomes and that particle-associated BC is useful for examining associations between primary combustion constituents of PM and health outcomes

La nueva embajada alemana, en Madrid

This embassy involves two buildings, which, because of their style, appropriate aspect, the fine taste of their design, and the highly efficient manner in which the volumes agree with the building site, constitutes a singular ornament to one of the best zones of Madrid. All the materials are traditional in Spanish constructional practice, and were carefully chosen: their full plastic and chromatic quality being well utilised.Los dos edificios que componen el conjunto constituyen, por su tratamiento, por su representatividad, por el gusto con que han sido construidos y por el respetuoso trato dado a los volúmenes del aprovechamiento autorizado, un ornato singular en una de las zonas más nobles y vistosas de la capital de España. Todos los materiales empleados son los tradicionales del país anfitrión y fueron elegidos con esmero, conservándolos en toda su pureza plástica de carácter y cromática

First urology simulation boot camp in the United Kingdom

Objective: Simulation is now firmly established in modern surgical training and is applicable not only to acquiring surgical skills but also to non-surgical skills and professionalism. A 5-day intensive Urology Simulation Boot Camp was run to teach emergency procedural skills, clinical reasoning, and communication skills using clinical scenario simulations, endoscopic and laparoscopic trainers. This paper reports the educational value of this first urology boot camp. Subjects and methods: Sixteen urology UK trainees completed pre-course questionnaires on their operative experience and confidence level in common urological procedures. The course included seven modules covering basic scrotal procedures, laparoscopic skills, ureteroscopy, transurethral resection of the prostate and bladder tumour, green light laser prostatectomy, familiarisation with common endoscopic equipment, bladder washout to remove clots, bladder botox injection, setting up urodynamics. Emergency urological conditions were managed using scenarios on SimMan®. The main focus of the course was hands-on training using animal models, bench-top models and virtual reality simulators. Post-course assessment and feedback on the course structure and utility of knowledge gained together with a global outcome score was collected. Results: Overall all the sections of feedback received score of over 4.5/5, with the hands-on training on simulators getting the best score 4.8/5. When trainees were asked “The training has equipped me with enhanced knowledge, understanding and skills,” the average score was 4.9/5.0. The vast majority of participants felt they would recommend the boot camp to future junior trainees. Conclusion: This first UK Urology Simulation Boot Camp has demonstrated feasibility and effectiveness in enhancing trainee’s experience. Given these positive feedbacks there is a good reason to expect that future courses will improve the overall skills of a new urology trainee

Two Regional Mental Health Treatment Facilities

One of the major social programs of the 1960s was the development of community mental health centers. As with most early attempts at evaluation, the results were pessimistic. This article reanalyzes one of the earliest, and best-known, evaluations of a community-based treatment facility. Following the conceptual framework of Campbell and his associates, it was found that the various threats to the validity of the findings indicate a consistent and systematic bias against detecting a positive effect for the new mental health center. In light of recent federal legislation mandating formal evaluations, appropriate procedures are discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68090/2/10.1177_0193841X7900300403.pd

Ballistic matter waves with angular momentum: Exact solutions and applications

An alternative description of quantum scattering processes rests on inhomogeneous terms amended to the Schroedinger equation. We detail the structure of sources that give rise to multipole scattering waves of definite angular momentum, and introduce pointlike multipole sources as their limiting case. Partial wave theory is recovered for freely propagating particles. We obtain novel results for ballistic scattering in an external uniform force field, where we provide analytical solutions for both the scattering waves and the integrated particle flux. Our theory directly applies to p-wave photodetachment in an electric field. Furthermore, illustrating the effects of extended sources, we predict some properties of vortex-bearing atom laser beams outcoupled from a rotating Bose-Einstein condensate under the influence of gravity.Comment: 42 pages, 8 figures, extended version including photodetachment and semiclassical theor

Subthreshold Xi- Production in Collisions of p(3.5 GeV)+Nb

Results on the production of the double-strange cascade hyperon $\mathrm{\Xi^-}$ are reported for collisions of p\,(3.5~GeV)\,+\,Nb, studied with the High Acceptance Di-Electron Spectrometer (HADES) at SIS18 at GSI Helmholtzzentrum for Heavy-Ion Research, Darmstadt. For the first time, subthreshold $\mathrm{\Xi^-}$ production is observed in proton-nucleus interactions. Assuming a $\mathrm{\Xi^-}$ phase-space distribution similar to that of $\mathrm{\Lambda}$ hyperons, the production probability amounts to $P_{\mathrm{\Xi^-}}=(2.0\,\pm0.4\,\mathrm{(stat)}\,\pm 0.3\,\mathrm{(norm)}\,\pm 0.6\,\mathrm{(syst)})\times10^{-4}$ resulting in a $\mathrm{\Xi^-/(\Lambda+\Sigma^0)}$ ratio of $P_{\mathrm{\Xi^-}}/\ P_{\mathrm{\Lambda+\Sigma^0}}=(1.2\pm 0.3\,\mathrm{(stat)}\pm0.4\,\mathrm{(syst)})\times10^{-2}$. Available model predictions are significantly lower than the estimated$\mathrm{\Xi^-}$ yield.Comment: 6 pages, 3 figure