Mitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon ions and cisplatin.

学位記番号：医博甲1700

Vitreous levels of vascular endothelial growth factor in eyes with anterior hyaloidal fibrovascular proliferation

Takaki Kobayashi, Shigeki Machida, Takamitsu Fujiwara, Tadashi Ishibe, Daijiro KurosakaDepartment of Ophthalmology, Iwate Medical University School of Medicine, Iwate, JapanPurpose: To determine the intravitreal levels of vascular endothelial growth factor (VEGF) in eyes with anterior hyaloidal fibrovascular proliferation (AHFVP).Methods: Three eyes of three patients who underwent vitrectomy for proliferative diabetic retinopathy (PDR) and subsequently developed an AHFVP (AHFVP group) were studied. We measured the level of VEGF in vitreous samples collected at the primary and following operations by enzyme-linked immunosorbent assay. The vitreous levels of VEGF in 25 eyes of 22 patients with PDR were also studied as controls (PDR group).Results: The averaged VEGF level in the samples collected at the primary surgery was 1.98 ± 2.23 ng/mL in the PDR group, and it was 9.07, 1.94, and 8.07 ng/mL in the AHFVP cases. After the primary surgery, the VEGF level rose up to 49.50, 15.60, and 50.60 ng/mL at the subsequent surgeries for respective cases of the AHFVP group. These levels of VEGF were more than five times higher than the baseline at the primary surgery.Conclusion: The subsequent increase of the VEGF level after the primary surgery in eyes with an AHFVP suggests that the vitreous levels of VEGF are associated with the development of the AHFVP although only three eyes were studied.Keywords: VEGF, AHFVP, diabetic retinopath

Gauge coupling unification due to non-universal soft supersymmetry breaking

金沢大学理工研究域数物科学系Gauge coupling unification is studied in the MSSM with non-universal soft supersymmetry breaking terms. If gaugino masses are sufficiently smaller than scalar soft masses and the scalar have also certain types of non-universality, the gauge coupling unification scale can be larger than 3 × 1016 GeV even within the MSSM contents. String unification may not need a large threshold correction or a large modulus value. We also discuss the relation to the string model building. © 1994

Gauge Coupling Unification due to Non-universal Soft Supersymmetry Breaking

Gauge coupling unification is studied in the MSSM with non-universal soft supersymmetry breaking terms. If gaugino masses are sufficiently smaller than scalar soft masses and the scalar soft masses have also certain types of non-universality, gauge coupling unification scale can be larger than $3\times 10^{16}$~GeV even within the MSSM contents. String unification may not need a large threshold correction or a large modulus value. We also discuss the relation to the string model building.Comment: 14 pages,LaTeX file included 1 compressed and uuencoded figure, KANAZAWA-94-0

Glyceraldehyde-3-phosphate dehydrogenase interacts with phosphorylated Akt resulting from increased blood glucose in rat cardiac muscle

AbstractHere we describe the interaction of phosphorylated ∼40kDa protein with phosphorylated Akt which is a serine/threonine kinase resulting from increased blood glucose in rat cardiac muscle. Mass spectrometry analysis revealed that this protein was glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Furthermore, increase in Akt and GAPDH phosporylation and induction of their association were both observed after insulin stimulation in the H9c2 cell line derived from embryonic rat ventricle. Moreover, the activation of GAPDH was upregulated when the GAPDH phosphorylation was increased. Our data suggest that GAPDH phosphorylation and association with Akt by insulin treatment have some bearing on the enhancement of GAPDH activity.Structured summaryMINT-7891324, MINT-7891304, MINT-7891314: GAPDH (uniprotkb:P04797) physically interacts (MI:0915) with Akt (uniprotkb:P47196) by anti bait coimmunoprecipitation (MI:0006

Neutron Electric Dipole Moment under Non-Universal Soft SUSY Breaking Terms

金沢大学理工研究域数物科学系The electric dipole moment of the neutron (EDMN) is re·examined in the framework of non-universal soft supersymmetry breaking. We review some features of the relation between the EDMN and non-universal soft supersymmetry breaking terms. It is shown that the constraints on the soft scalar masses and soft CP phases have a rather strong dependence on the non·universality of soft breaking terms. We also show that the soft CP phase if>s which has no natural suppressionmechanism may not contribute significantly to the EDMN in a certain parameter region where the radiative symmetry breaking occurs successfully. If this is the case, if>s may not need to be so small

Non-universal soft scalar masses in superstring theories

金沢大学理工研究域数物科学系We study soft scalar masses in comparison with gaugino masses in 4-dimensional string models. In general non-universal soft masses are derived in orbifold models. We give conditions on modular weights which lead to a large non-degeneracy in the soft scalar mass spectrum. This non-universality is applied to the unification of gauge coupling constants in the minimal string model. © 1995

Suppressing the μ\mu and neutrino masses by a superconformal force

The idea of Nelson and Strassler to obtain a power law suppression of parameters by a superconformal force is applied to understand the smallness of the $\mu$ parameter and neutrino masses in R-parity violating supersymmetric standard models. We find that the low-energy sector should contain at least another pair of Higgs doublets, and that a suppression of \lsim O(10^{-13}) for the $\mu$ parameter and neutrino masses can be achieved generically. The superpotential of the low-energy sector happens to possess an anomaly-free discrete R-symmetry, either $R_3$ or $R_6$, which naturally suppresses certain lepton-flavor violating processes, the neutrinoless double beta decays and also the electron electric dipole moment. We expect that the escape energy of the superconformal sector is \lsim O(10) TeV so that this sector will be observable at LHC. Our models can accommodate to a large mixing among neutrinos and give the same upper bound of the lightest Higgs mass as the minimal supersymmetric standard model.Comment: 24 page