Kierunki zmian w instytucjonalnej opiece nad dziećmi do lat 3 w świetle oczekiwań rodzin – studium przypadku

New solutions in the field of childcare under the age of 3 were introduced in Poland in 2011. This article, based on a survey conducted among Wroclaw families, provides arguments for the thesis that actual implementation of these new solutions is by far insufficient. An analysis of the instruments showed that nurseries are the most popular and recognizable ones – in contrast to other quite unpopular services, such as children’s clubs, daily caregivers and nannies employed on a contractual basis. The results of the research presented in this article, indicate the existence of constraints on both the supply side, including issues related to financial, legal and organizational aspects, as well as on the demand side. The new solutions introduced in 2011 seem not to fully meet the expectations of families

The molecular portrait of triple-negative breast cancer: the LAG3 gene single nucleotide polymorphism rs2365094 has no impact on the clinical picture

Introduction. Triple-negative breast cancer (TNBC) is characterized by a lack of estrogen, progesterone and human epidermal growth factor receptors. It is the one of most heterogeneous and highly-aggressive breast cancers, resulting in fast progression. In humans, the lymphocyte activation gene 3 (LAG3) is located on chromosome 12p13 and encodes an immune-regulatory molecule. The aim of the study was to perform a molecular analysis of LAG3 gene polymorphisms. Material and method. The presence of single-nucleotide polymorphisms (SNPs) at rs2365094 was determined in 30 TNBC patients and 30 healthy controls using polymerase chain reaction (PCR) and commercially-available TaqMan SNP Genotyping Assays. SNP status was the compared with clinical outcome. Results. The allelic alterations in LAG3 gene SNP in rs2365094 appear to have no influence on the clinicopathological picture among TNBC patients. The carriage rate for a single allele did not differ significantly between patients and controls. Conclusions. No significant relationship was observed between rs2365094 SNP status and clinicopathological determinants

The molecular portrait of triple-negative breast cancer: the LAG3 gene single nucleotide polymorphism rs2365094 has no impact on the clinical picture

Introduction. Triple-negative breast cancer (TNBC) is characterized by a lack of oestrogen, progesterone and human epidermal growth factor receptors. It is the one of most heterogeneous and highly-aggressive breast cancers, resulting in fast progression. In humans, the lymphocyte activation gene 3 (LAG3) is located on chromosome 12p13 and encodes an immune-regulatory molecule. The aim of the study was to perform a molecular analysis of LAG3 gene polymorphisms.  Material and method. The presence of single-nucleotide polymorphisms (SNPs) at rs2365094 was determined in 30 TNBC patients and 30 healthy controls using a polymerase chain reaction (PCR) and commercially-available TaqMan SNP Genotyping Assays. SNP status was then compared with the clinical outcome.  Results. The allelic alterations in LAG3 gene SNP in rs2365094 appear to have no influence on the clinicopathological picture among TNBC patients. The carriage rate for a single allele did not differ significantly between patients and controls.  Conclusions. No significant relationship was observed between the rs2365094 SNP status and clinicopathological determinants.

Emphysematous Pancreatitis: A Rare Complication

We describe a case of emphysematous pancreatitis, a rare and serious complication of acute pancreatitis, which has a high mortality rate

A numerical implementation of the Dynamic Thermal Network method for long time series simulation of conduction in multi-dimensional non-homogeneous solids

The Dynamic Thermal Network (DTN) approach to the modelling of transient conduction was conceived by Claesson (1999,2002,2003) as an extension of the network representation of steady-state conduction processes. The method is well suited to the simulation of building fabric components such as framed walls and thermally massive structures such as basements but can also be applied to the long timescale simulation of other conduction problems. The theoretical basis of the method and its discretized form is outlined in this paper and a new numerical procedure for the calculation of the necessary weighting factor data is presented. Such data has previously been generated for three-dimensional bodies by a heuristic process of blending analytical solutions and numerical data. The numerical approach reported here has the advantage of accommodating parametric representations of multi-dimensional geometries and allows the data to be produced in an automated fashion and so more easily incorporated into simulation tools. Enhancements to the data reduction procedure and a generalised approach to representing complex boundary conditions are also presented. The numerical procedure has been validated by a series of comparisons with analytical conduction heat transfer solutions and discretization errors were found to be acceptably small. Compared to numerical methods, calculations using the DTN method were found to be up to four orders of magnitude quicker but with comparable accuracy

Phase change materials as smart nanomaterials for thermal energy storage in buildings

Nowadays, energy production and consumption in buildings play an important role in the economic development of countries. For instance, buildings are central to the EU?s energy efficiency policy, as nearly 40% of final energy consumption and 36% of greenhouse gas emissions are attributable to houses, offices, shops, and other buildings. For achievement of highly energy-efficient buildings, significant paradigm shifts are necessary, particularly in the production requirements for cost-effective, durable, energy-efficient building envelopes. The application of phase change materials (PCMs) for thermal energy storage (TES) in building envelopes can assist the reduction of energy demands associated to the heating/cooling necessary to ensure adequate inner thermal comfort. PCMs are defined as a group of materials that can store/release relevant quantities of thermal energy upon a change in their physical phase (latent heat). In many applications, such storage of energy leads to energy conservation within the system (i.e. the building), thus resulting in improved energy efficiency. Heat is absorbed or released when the material changes from solid to liquid and vice versa. Therefore, PCMs readily and predictably change their phase with a certain input of energy and release this energy at a later time. PCMs must have a suitable phase change temperature range and the latent heat of fusion for the building environment. The optimal phase change temperature depends on the comfort temperature. Also, a PCM must have an adequate conductivity rate to be able to react fast to indoor temperature variations. However, the phase change temperature ranges of the typical PCMs used in buildings are limited, and their thermal conductivity is low. To further improve the efficiency of the energy saving with PCM, the possibility of using more than one type of PCM with distinct melting ranges and specific enthalpies (termed as hybrid PCM) is reported here. Furthermore, a numerical study is conducted to investigate the mixture of nanoparticles and PCM as alternative way to enhance the thermal properties of PCM. On the basis of knowledge acquired here, concept of nanoparticle with PCM system can be employed to scopes of energy-efficient residential and commercial buildings.(undefined)info:eu-repo/semantics/publishedVersio

Assessment of Economic Security of Households Based on a Scenario Analysis

The article proposes a method to assess the level of economic security, based on the analysis of scenarios of future events. These scenarios cover realistically possible combinations of future events, both positive and negative, allowing for an assessment of their financial implications. The empirical part of the paper contains the results of applying the proposed method to the Polish data. In the scenarios considered, changes in the situation of individuals in the labour market and changes in the level of income and expenditure are taken into account

Stan badań nad polskimi czasopismami pszczelarskimi

State of research into Polish apiarian journals The author of the article examines studies focusing in Polish apiarian journals. In order to determine the state of research in this respect, the author has used numerous general and specialist bibliographies, studies dealing with the history of Polish bee-keeping from the 19th century until the present as well as studies from related disciplines agriculture, horticulture. He has concluded that the current state of knowledge of apiarian periodicals is fragmentary, which is linked largely to the fact that they are scattered and incomplete. He stresses that so far scholars interested in apiarian journals have been primarily bibliographers, historians of natural sciences, regional studies specialists and practitioners. The current lack of relevant analyses opens up new, interesting research fields, e.g. studies of the various apiarian periodicals, their specificity and nature specialist, amateur, popular, scientific, their role in the popularisation of science information about conferences, associations, eminent specialists, books, manuals, newspapers and periodicals and expertise, their publishing geography and growth dynamics. Among research questions worthy of note is the need to include private collections in the research, which could reveal hitherto unknown Polish apiarian periodicals and, consequently, make the list of identified and analysed titles more complete.State of research into Polish apiarian journals The author of the article examines studies focusing in Polish apiarian journals. In order to determine the state of research in this respect, the author has used numerous general and specialist bibliographies, studies dealing with the history of Polish bee-keeping from the 19th century until the present as well as studies from related disciplines agriculture, horticulture. He has concluded that the current state of knowledge of apiarian periodicals is fragmentary, which is linked largely to the fact that they are scattered and incomplete. He stresses that so far scholars interested in apiarian journals have been primarily bibliographers, historians of natural sciences, regional studies specialists and practitioners. The current lack of relevant analyses opens up new, interesting research fields, e.g. studies of the various apiarian periodicals, their specificity and nature specialist, amateur, popular, scientific, their role in the popularisation of science information about conferences, associations, eminent specialists, books, manuals, newspapers and periodicals and expertise, their publishing geography and growth dynamics. Among research questions worthy of note is the need to include private collections in the research, which could reveal hitherto unknown Polish apiarian periodicals and, consequently, make the list of identified and analysed titles more complete