Not So Fast: Cultivating miRs as Kinks in the Chain of the Cell Cycle.

In this issue of Cancer Cell, Hydbring and colleagues define a novel class of microRNAs (miRNAs), deemed cell-cycle-targeting miRNAs, that target several cyclins/CDKs, reduce tumor cell growth, and induce apoptosis. These miRNAs effectively suppressed chemoresistant patient-derived xenograft growth in vivo, and efficacy could be prospectively predicted with an expression-based algorithm

Extending the redshift distribution of submm galaxies: Identification of a z~4 submm galaxy

We present the identification of a bright submillimeter galaxy (SMG) in the field of Abell 2218. The galaxy has a spectroscopic redshift of ~4, and is currently the highest redshift SMG known. It is detected at all wavelengths from optical to submm, including the Spitzer IRAC bands. We discuss the properties of this galaxy, which is undergoing intense star formation at a rate~600 Msun/yr. We also compare the properties to those of radio-preselected submm-bright galaxies. The z~4 result extends the redshift distribution of SMGs.Comment: 4 pages, 4 figures, uses asp2004.sty. To appear in the proceedings of the conference "Infrared Diagnostics of Galaxy Evolution", Pasadena, CA, 14-16 November 2005, ed. R. Char

Physical properties and morphology of a newly identified compact z=4.04 lensed submillimeter galaxy in Abell 2218

We present the identification of a bright submm source, SMMJ163555.5+661300, detected in the lensing cluster Abell2218, for which we have accurately determined the position using observations from the Submillimeter Array (SMA). The identified optical counterpart has a spectroscopic redshift of z=4.044+-0.001 if we attribute the single emission line detected at lambda=6140AA to Lyman-alpha. This redshift identification is in good agreement with the optical/near-infrared photometric redshift as well as the submm flux ratio S_450/S_850~1.6, the radio-submm flux ratio S_1.4/S_850 < 0.004, and the 24um to 850um flux ratio S_24/S_850 < 0.005. Correcting for the gravitational lensing amplification of ~5.5, we find that the source has a far-infrared luminosity of 1.3x10^12 Lsun, which implies a star formation rate of 230 Msun/yr. This makes it the lowest-luminosity SMG known at z>4 to date. Previous CO(4-3) emission line obserations yielded a non-detection, for which we derived an upper limit of the CO line luminosity of L'_CO = 0.3x10^10 K km/s/pc^2, which is not inconsistent with the L'_CO - L_FIR relation for starburst galaxies. The best fit model to the optical and near-infrared photometry give a stellar population with an age of 1.4 Gyr and a stellar mass of 1.6x10^10 Msun. The optical morphology is compact and in the source plane the galaxy has an extent of ~6kpc x 3kpc with individual star forming knots of <500 pc in size. J163556 is not resolved in the SMA data and we place a strict upper limit on the size of the starburst region of 8kpc x 3kpc, which implies a lower limit on the star formation rate surface density of 12 Msun/yr/kpc^2. The redshift of J163556 extends the redshift distribution of faint, lensed SMGs, and we find no evidence that these have a different redshift distribution than bright SMGs.Comment: Accepted for publication in ApJ. 11 pages, 7 figure

Integrating case-based reasoning and hypermedia documentation: an application for the diagnosis of a welding robot at Odense steel shipyard

Reliable and effective maintenance support is a vital consideration for the management within today's manufacturing environment. This paper discusses the development of a maintenance system for the world's largest robot welding facility. The development system combines a case-based reasoning approach for diagnosis with context information, as electronic on-line manuals, linked using open hypermedia technology. The work discussed in this paper delivers not only a maintenance system for the robot stations under consideration, but also a design framework for developing maintenance systems for other similar applications

Computer program developed for flowsheet calculations and process data reduction

Computer program PACER-65, is used for flowsheet calculations and easily adapted to process data reduction. Each unit, vessel, meter, and processing operation in the overall flowsheet is represented by a separate subroutine, which the program calls in the order required to complete an overall flowsheet calculation

The Total Filmmaker: thinking of screenwriting, directing and editing as one role

As screenwriting continues to establish itself as a discrete discipline in academia, either in alignment with creative writing departments or film and media practice departments, there is a danger that such developments may entrench a distancing of the craft from the cinematic form itself and that such a distancing may ultimately reinforce the screenplay's propensity for dramaturgy and the dramatic, rather than the sensory and experiential of the cinematic. Closely related creative stages in telling cinematic stories include directing and editing and this article seeks to argue, with reference to personal screen practice, that screenwriting, directing and editing are, in fact, three variations of the same thing. The article proposes the notion of the Total Filmmaker who embraces all three aspects of the cinematic storyteller. If the ultimate aim is to create a narrative that fully utilises the unique properties of the cinematic form in telling a story, rather than being dominated by the theatricality of dramatically driven classical narratives. How might one explore the relationship between screenwriting, directing and editing? Can an integrated approach to creating the cinematic blueprint change the way we think of pedagogy and screenwriting