7,106 research outputs found
Hellinger Distance Trees for Imbalanced Streams
Classifiers trained on data sets possessing an imbalanced class distribution
are known to exhibit poor generalisation performance. This is known as the
imbalanced learning problem. The problem becomes particularly acute when we
consider incremental classifiers operating on imbalanced data streams,
especially when the learning objective is rare class identification. As
accuracy may provide a misleading impression of performance on imbalanced data,
existing stream classifiers based on accuracy can suffer poor minority class
performance on imbalanced streams, with the result being low minority class
recall rates. In this paper we address this deficiency by proposing the use of
the Hellinger distance measure, as a very fast decision tree split criterion.
We demonstrate that by using Hellinger a statistically significant improvement
in recall rates on imbalanced data streams can be achieved, with an acceptable
increase in the false positive rate.Comment: 6 Pages, 2 figures, to be published in Proceedings 22nd International
Conference on Pattern Recognition (ICPR) 201
Magnetodielectric coupling of infrared phonons in single crystal CuOSeO
Reflection and transmission as a function of temperature have been measured
on a single crystal of the magnetoelectric ferrimagnetic compound
CuOSeO utilizing light spanning the far infrared to the visible
portions of the electromagnetic spectrum. The complex dielectric function and
optical properties were obtained via Kramers-Kronig analysis and by fits to a
Drude-Lortentz model. The fits of the infrared phonons show a magnetodielectric
effect near the transition temperature (~K). Assignments to
strong far infrared phonon modes have been made, especially those exhibiting
anomalous behavior around the transition temperature
Quantifying Compliance Costs for Small Businesses in New Zealand
This paper reports on a small-scale study of the compliance costs of small New Zealand businesses. Participating firms were asked to keep a record of both time spent and expenditure directly incurred over a thirteen-week period. This differs from previous studies that rely on a firm's recall of how much time has been spent on compliance over the previous year. The results suggest that New Zealand small businesses on average spend less time and money on compliance than has been indicated in previous studies. However a number offirms do perceive compliance to be a major issue and in some cases this perception prevents firms from expanding
Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution II: dynamics.
BackgroundTo accurately describe gene expression and computationally model animal transcriptional networks, it is essential to determine the changing locations of cells in developing embryos.ResultsUsing automated image analysis methods, we provide the first quantitative description of temporal changes in morphology and gene expression at cellular resolution in whole embryos, using the Drosophila blastoderm as a model. Analyses based on both fixed and live embryos reveal complex, previously undetected three-dimensional changes in nuclear density patterns caused by nuclear movements prior to gastrulation. Gene expression patterns move, in part, with these changes in morphology, but additional spatial shifts in expression patterns are also seen, supporting a previously proposed model of pattern dynamics based on the induction and inhibition of gene expression. We show that mutations that disrupt either the anterior/posterior (a/p) or the dorsal/ventral (d/v) transcriptional cascades alter morphology and gene expression along both the a/p and d/v axes in a way suggesting that these two patterning systems interact via both transcriptional and morphological mechanisms.ConclusionOur work establishes a new strategy for measuring temporal changes in the locations of cells and gene expression patterns that uses fixed cell material and computational modeling. It also provides a coordinate framework for the blastoderm embryo that will allow increasingly accurate spatio-temporal modeling of both the transcriptional control network and morphogenesis
Early childhood lung function is a stronger predictor of adolescent lung function in cystic fibrosis than early Pseudomonas aeruginosa infection
Pseudomonas aeruginosa has been suggested as a major determinant of poor pulmonary outcomes in cystic fibrosis (CF), although other factors play a role. Our objective was to investigate the association of early childhood Pseudomonas infection on differences in lung function in adolescence with CF
Biospectroscopy of Nanodiamond-Induced Alterations in Conformation of Intra- and Extracellular Proteins: A Nanoscale IR Study
The toxicity of nanomaterials raises major concerns because of the impact that nanomaterials may have on health,
which remains poorly understood. We need to explore the fate of individual nanoparticles in cells at nano and molecular levels to
establish their safety. Conformational changes in secondary protein structures are one of the main indicators of impaired biological
function and hence, the ability to identify these changes at a nanoscale level offers unique insights into the nanotoxicity of materials.
Here, we used nanoscale infrared spectroscopy and demonstrated for the first time that nanodiamonds induced alterations in
both extra- and intracellular secondary protein structures, leading to the formation of antiparallel β-sheet, β-turns, intermolecular β-
sheet and aggregation of proteins. These conformational changes of the protein structure may result in the loss of functionality of
proteins and in turn lead to adverse effects
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