Spatial and structural stability in thermoelasto-dynamics on a half-cylinder

EnThe linear nonhomogeneous thermoelastodynamic problem in a half-cylinder is considered subject to assigned initial conditions, and to the displacement and temperature being specified over the base, and vanishing on the lateral boundary. Spatial stability, derived from a differential inequality, establishes that the mean-square volume integrals of displacement and temperature are bounded above by a decaying function of axial distance for each finite positive time instant. Structural stability, which here relates to continuous dependence of the displacement on the thermal coupling, depends upon the construction of further differential inequalities

Atomic quasi-Bragg diffraction in a magnetic field

We report on a new technique to split an atomic beam coherently with an easily adjustable splitting angle. In our experiment metastable helium atoms in the |{1s2s}^3S_1 M=1> state diffract from a polarization gradient light field formed by counterpropagating \sigma^+ and \sigma^- polarized laser beams in the presence of a homogeneous magnetic field. In the near-adiabatic regime, energy conservation allows the resonant exchange between magnetic energy and kinetic energy. As a consequence, symmetric diffraction of |M=0> or |M=-1> atoms in a single order is achieved, where the order can be chosen freely by tuning the magnetic field. We present experimental results up to 6th order diffraction (24 \hbar k momentum splitting, i.e., 2.21 m/s in transverse velocity) and present a simple theoretical model that stresses the similarity with conventional Bragg scattering. The resulting device constitutes a flexible, adjustable, large-angle, three-way coherent atomic beam splitter with many potential applications in atom optics and atom interferometry.Comment: 4 pages, 5 figure

Epistatic Interactions in {NS5A} of Hepatitis {C} Virus Suggest Drug Resistance Mechanisms

Hepatitis C virus (HCV) causes a major health burden and can be effectively treated by direct-acting antivirals (DAAs). The non-structural protein 5A (NS5A), which plays a role in the viral genome replication, is one of the DAAs’ targets. Resistance-associated viruses (RAVs) harbouring NS5A resistance-associated mutations (RAMs) have been described at baseline and after therapy failure. A mutation from glutamine to arginine at position 30 (Q30R) is a characteristic RAM for the HCV sub/genotype (GT) 1a, but arginine corresponds to the wild type in the GT-1b; still, GT-1b strains are susceptible to NS5A-inhibitors. In this study, we show that GT-1b strains with R30Q often display other specific NS5A substitutions, particularly in positions 24 and 34. We demonstrate that in GT-1b secondary substitutions usually happen after initial R30Q development in the phylogeny, and that the chemical properties of the corresponding amino acids serve to restore the positive charge in this region, acting as compensatory mutations. These findings may have implications for RAVs treatment

Evaluation of subcutaneous implantable cardioverter-defibrillator performance in patients with ion channelopathies from the EFFORTLESS cohort and comparison with a meta-analysis of transvenous ICD outcomes

Background: The subcutaneous implantable cardioverter-defibrillator (S-ICD) is an alternative to conventional transvenous ICD (TV-ICD) therapy to reduce lead complications. Objective: To evaluate outcomes in channelopathy vs patients with structural heart disease in the EFFORTLESS-SICD Registry and with a previously reported TV-ICD meta-analysis in channnelopathies. Methods: The EFFORTLESS registry includes 199 patients with channelopathies (Brugada syndrome 83, long QT syndrome 24, idiopathic ventricular fibrillation 78, others 14) and 786 patients with structural heart disease. Results: Channelopathy patients were younger (39 ± 14 years vs 51 ± 17 years; P 200 beats per minute (P = .0002). Annualized appropriate shock, IAS, and complication rates appear to be lower for the S-ICD vs meta-analysis TV-ICD patients, particularly lead complications. Conclusion: EFFORTLESS demonstrates similar S-ICD efficacy and a nonsignificant, lower rate of IAS in channelopathy patients as compared to structural heart disease. Comparable IAS rates were achieved with the device programmed to higher rates for channelopathy patients

Density matrix renormalization group for the Berezinskii-Kosterlitz-Thouless transition of the 19-vertex model

We embody the density matrix renormalization group (DMRG) method for the 19-vertex model on a square lattice in order to investigate the Berezinskii-Kosterlitz-Thouless transition. Elements of the transfer matrix of the 19-vertex model are classified in terms of the total value of arrows in one layer of the square lattice. By using this classification, we succeed to reduce enormously the dimension of the matrix which has to be diagonalized in the DMRG method. We apply our method to the 19-vertex model with the interaction $K=1.0866$ and obtain $c=1.006(1)$ for the conformal anomaly. PACS. 05.90.+m, 02.70.-cComment: RevTeX style, 20 pages, 12 figure

Phase transitions in self-dual generalizations of the Baxter-Wu model

We study two types of generalized Baxter-Wu models, by means of transfer-matrix and Monte Carlo techniques. The first generalization allows for different couplings in the up- and down triangles, and the second generalization is to a $q$-state spin model with three-spin interactions. Both generalizations lead to self-dual models, so that the probable locations of the phase transitions follow. Our numerical analysis confirms that phase transitions occur at the self-dual points. For both generalizations of the Baxter-Wu model, the phase transitions appear to be discontinuous.Comment: 29 pages, 13 figure

Roughening Induced Deconstruction in (100) Facets of CsCl Type Crystals

The staggered 6-vertex model describes the competition between surface roughening and reconstruction in (100) facets of CsCl type crystals. Its phase diagram does not have the expected generic structure, due to the presence of a fully-packed loop-gas line. We prove that the reconstruction and roughening transitions cannot cross nor merge with this loop-gas line if these degrees of freedom interact weakly. However, our numerical finite size scaling analysis shows that the two critical lines merge along the loop-gas line, with strong coupling scaling properties. The central charge is much larger than 1.5 and roughening takes place at a surface roughness much larger than the conventional universal value. It seems that additional fluctuations become critical simultaneously.Comment: 31 pages, 9 figure

Equilibrium shapes and faceting for ionic crystals of body-centered-cubic type

A mean field theory is developed for the calculation of the surface free energy of the staggered BCSOS, (or six vertex) model as function of the surface orientation and of temperature. The model approximately describes surfaces of crystals with nearest neighbor attractions and next nearest neighbor repulsions. The mean field free energy is calculated by expressing the model in terms of interacting directed walks on a lattice. The resulting equilibrium shape is very rich with facet boundaries and boundaries between reconstructed and unreconstructed regions which can be either sharp (first order) or smooth (continuous). In addition there are tricritical points where a smooth boundary changes into a sharp one and triple points where three sharp boundaries meet. Finally our numerical results strongly suggest the existence of conical points, at which tangent planes of a finite range of orientations all intersect each other. The thermal evolution of the equilibrium shape in this model shows strong similarity to that seen experimentally for ionic crystals.Comment: 14 Pages, Revtex and 10 PostScript figures include

Monte Carlo simulation of ice models

We propose a number of Monte Carlo algorithms for the simulation of ice models and compare their efficiency. One of them, a cluster algorithm for the equivalent three colour model, appears to have a dynamic exponent close to zero, making it particularly useful for simulations of critical ice models. We have performed extensive simulations using our algorithms to determine a number of critical exponents for the square ice and F models.Comment: 32 pages including 15 postscript figures, typeset in LaTeX2e using the Elsevier macro package elsart.cl