Chemical constituents of the soft corals Sinularia vanderlandi and Sinularia gravis from the coast of Madagascar

© 2016 The Royal Society of Chemistry.The crude extracts of the Madagascan soft corals Sinularia vanderlandi and Sinularia gravis (Alcyoniidae) showed activity against Plasmodium falciparum which led us to study their chemical constituents. The new cadinane-type sesquiterpenoid vanderlandin (1) has been obtained from S. vanderlandi along with 24-methylenecholesterol (2). Four new compounds, the spatane-type diterpenoid gravilin (3), the monoalkylmonoacylglycerol 4, the dihomoditerpenoid ketone 5, and isodecaryiol (9), along with the three known compounds (+)-(S)-geranyllinalool (6), (-)-(R)-nephthenol (7), and 11,12-epoxysarcophytol A (8) have been isolated from the methanol extract of S. gravis. The structures were elucidated based on extensive spectroscopic methods, in particular various 2D NMR techniques. The structure of isodecaryiol (9) including its absolute configuration could be confirmed by X-ray diffraction

Chemical constituents of the soft corals Sinularia vanderlandi and Sinularia gravis from the coast of Madagascar

© 2016 The Royal Society of Chemistry. The crude extracts of the Madagascan soft corals Sinularia vanderlandi and Sinularia gravis (Alcyoniidae) showed activity against Plasmodium falciparum which led us to study their chemical constituents. The new cadinane-type sesquiterpenoid vanderlandin (1) has been obtained from S. vanderlandi along with 24-methylenecholesterol (2). Four new compounds, the spatane-type diterpenoid gravilin (3), the monoalkylmonoacylglycerol 4, the dihomoditerpenoid ketone 5, and isodecaryiol (9), along with the three known compounds (+)-(S)-geranyllinalool (6), (-)-(R)-nephthenol (7), and 11,12-epoxysarcophytol A (8) have been isolated from the methanol extract of S. gravis. The structures were elucidated based on extensive spectroscopic methods, in particular various 2D NMR techniques. The structure of isodecaryiol (9) including its absolute configuration could be confirmed by X-ray diffraction

Development and Evaluation of Curcumin Loaded Nanoparticles for Treatment of Diabetes

A nanometer is one billionth of a metre, hence nanotechnology is an intersection of science, engineering, and technology that works with structures and materials at the nanoscale scale, often in the range of 1 to 100 nanometers. Materials frequently display distinctive and innovative features at this scale that are distinct from those at the macroscopic or even microscopic levels. Nanotechnology is the manipulation, design, and control of materials and devices at the nanoscale to produce new products, technologies, and applications. Nanotechnology is essential to the development of tailored medication delivery systems, imaging agents, and diagnostic instruments in medicine. It offers the promise for more targeted treatments that are also less likely to cause negative effects. Since ancient times, turmeric (Curcuma longa L.) has been widely used as a spice and a remedy. Curcumin, a polyphenol that aids in the prevention and management of neurological, pulmonary, cardiovascular, metabolic, inflammatory, and autoimmune illnesses as well as some malignancies, is the primary active component of turmeric. Curcumin does have certain disadvantages, though, including limited water solubility, poor absorption, rapid metabolism, rapid systemic elimination, inadequate bioavailability subpar pharmacokinetics, low stability, and subpar penetration targeting effectiveness. A typical approach is to encapsulate curcumin in nanocarriers for targeted distribution to get over these disadvantages. Concerns have been raised about the degradation of nanocarrier products. In this study, curcumin nanoparticles and nanocurcumin were created without the aid of nanocarriers. To do this, raw turmeric rhizome was soxhlet extracted to obtain curcumin. The stock solutions of various curcumin concentrations made in dichloromethane were sonicated for varying lengths of time and included in boiling water at various flow rates. With 5.00 mg/mL of stock solution concentration, 0.10 mL/min flow rate, and 30 minutes of sonication, an average particle size of 82 04 nm was produced. Particle size seems to decline with sonication time but tends to increase with flow rate and curcumin content in the stock solution. Although nanocurcumins are amorphous, X-ray diffraction reveals crisp and powerful diffraction peaks for curcumin, suggesting its integrity and high crystallinity. The presence of all the functional groups of curcumin in nanocurcumin is confirmed by Fourier-transform infrared spectroscopy spectra. Images obtained using transmission and scanning electron microscopy display the morphology of completely spherical objects

第117回北海道整形外科外傷研究会 ; 主題 : 人工関節周辺骨折

© The Royal Society of Chemistry.We investigated the three soft corals Sarcophyton stellatum, Capnella fungiformis and Lobophytum crassum and the sponge Pseudoceratina arabica, which have been collected at the coast of Madagascar. In addition to previously known marine natural products, S. stellatum provided the new (+)-enantiomer of the cembranoid (1E,3E,11E)-7,8-epoxycembra-1,3,11,15-tetraene (2). Capnella fungiformis afforded three new natural products, ethyl 5-[(1E,5Z)-2,6-dimethylocta-1,5,7-trienyl]furan-3-carboxylate (6), ethyl 5-[(1E,5E)-2,6-dimethylocta-1,5,7-trienyl]furan-3-carboxylate (7) and the diepoxyguaiane sesquiterpene oxyfungiformin (9a). The extracts of all three soft corals exhibited moderate activities against the malarial parasite Plasmodium falciparum. Extracts of the sponge Pseudoceratina arabica proved to be very active against a series of Gram-positive and Gram-negative bacteria

Selbsthilfe: Wegweiser zu gesundheitlichen und sozialen Gruppen

Krankheiten, Rückschläge und schwierige Lebenslagen können jeden treffen, jederzeit. Insbesondere seelische Belastungen, unklare Diagnosen, chronische Leiden, schwere Operationen oder plötzliche Unfälle verändern die Prioritäten im Leben. Dann braucht es ärztliche Hilfe, familiären Beistand und reichlich Geduld. Die KISS unterstützt die Gruppen bei der Organisation ihrer Treffen, stellt insbesondere Räume zur Verfügung, hilft bei Neugründungen und vermittelt Kontakte. Die Mitarbeiterinnen kennen sich nicht nur bestens in der Dresdner Selbsthilfegruppen-Landschaft aus, sie halten auch Verbindungen über Stadtgrenzen hinaus und sind für alle da, die Selbsthilfe gerade für sich entdecken, die passende Gruppe suchen oder Beratung zum Thema möchten. Außerdem stellen sie diese hilfreiche Broschüre zusammen und Online-Informationen auf dresden.de/selbsthilfe bereit. In der Online-Datenbank können sich interessierte Dresdnerinnen und Dresdner mit Hilfe einer Schlagwortsuche über die lokalen Selbsthilfegruppen informieren. Redaktionsschluss: September 202

Celebration Schedule 2013 (Saturday)

Full presentation schedule for Celebration, Saturday, May 4, 201

Pro-Ana-Foren - berechtigt oder gefährlich?

Thema der Arbeit sind Pro-Ana-Foren. Die zentrale Frage lautet: Sind Pro-Ana-Foren gefährlich und gehören verboten, oder haben sie ihre Berechtigung? Diese Fragen sollen anhand einer Online-Befragung geklärt werden. Ziel der Arbeit ist es die Gefährlichkeit, aber auch die möglichen positiven Aspekte der Foren einzuschätzen. Insgesamt betrachtet kann durch die Untersuchungsergebnisse für gewisse, zu Beginn der Arbeit angenommene Gefahren, Entwarnung gegeben werden. Andere von den Foren ausgehende Gefahren müssen aber bestätigt werden. Da durch die Untersuchung jedoch gleichzeitig auch bedeutungsvolle positive Forenaspekte deutlich werden, erscheint ein gänzliches Verbot von Pro-Ana-Foren unangebracht. Stattdessen könnte es sinnvoll sein, bisherige Bemühungen im Kampf gegen gefährliche Pro-Ana-Angebote zu ergänzen. Mit den Untersuchungsergebnissen wird kein Anspruch auf Repräsentativität erhoben

Archiv Bibliographia Judaica – Deutschsprachiges Judentum Online

The Bibliographica Judaica Archive in Frankfurt am Main has spent decades gathering the biobibliographical data of about 20,000 German Jewish personalities. This unique data stock is now available on De Gruyter’s ABJ – German Judaism Online database. This supplementary volume provides an introduction to the history of the archive's origins and to its significance in the history of scholarship