147 research outputs found
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Prioritizing LowâIncome Groups and the Environment in Communities with Poor Water Quality
When a community has poor water quality, the U.S. Environmental Protection Agency (EPA) requires it to comply with federal standards in accordance with the Clean Water Act (CWA). The projects required to meet these standards can be very costly, so the EPA allows communities facing these regulations to evaluate their ability to afford them. If the EPA determines that ratepayers in the utility district would face an economic burden by meeting these standards, the community is allowed to extend the schedule for reaching compliance. This prolongs diminished environmental conditions beyond what is usually considered acceptable under the CWA. My research analyzes the benefits and costs when a community uses a schedule extension and I find that schedule extensions ultimately reduce the benefits of the improved water quality through delay. I offer an alternative payment structure based on economic principles that capture the benefits lost by extension and are sensitive to cost burden by income group
The radio remnant of SN1993J: an instrumental explanation for the evolving complex structure
We present simulated images of Supernova 1993J at 8.4 GHz using Very Long
Baseline Interferometry (VLBI) techniques. A spherically symmetric source model
is convolved with realistic uv-plane distributions, together with standard
imaging procedures, to assess the extent of instrumental effects on the
recovered brightness distribution. In order to facilitate direct comparisons
between the simulations and published VLBI images of SN1993J, the observed
uv-coverage is determined from actual VLBI observations made in the years
following its discovery.
The underlying source model only exhibits radial variation in its density
profile, with no azimuthal dependence and, even though this model is
morphologically simple, the simulated VLBI observations qualitatively reproduce
many of the azimuthal features of the reported VLBI observations, such as
appearance and evolution of complex azimuthal structure and apparent rotation
of the shell. We demonstrate that such features are inexorably coupled to the
uv-plane sampling.
The brightness contrast between the peaks and the surrounding shell material
are not as prominent in the simulations (which of course assume no antenna- or
baseline-based amplitude or phase errors, meaning no self-calibration
procedures will have incorporated any such features in models). It is
conclusive that incomplete uv-plane sampling has a drastic effect on the final
images for observations of this nature. Difference imaging reveals residual
emission up to the 8 sigma level. Extreme care should be taken when using
interferometric observations to directly infer the structure of objects such as
supernovae.Comment: 14 pages, 10 figures, 2 tables, accepted for publication in MNRA
Expanding e-MERLIN with the Goonhilly Earth Station
A consortium of universities has recently been formed with the goal of using
the decommissioned telecommunications infrastructure at the Goonhilly Earth
Station in Cornwall, UK, for astronomical purposes. One particular goal is the
introduction of one or more of the ~30-metre parabolic antennas into the
existing e-MERLIN radio interferometer. This article introduces this scheme and
presents some simulations which quantify the improvements that would be brought
to the e-MERLIN system. These include an approximate doubling of the spatial
resolution of the array, an increase in its N-S extent with strong implications
for imaging the most well-studied equatorial fields, accessible to ESO
facilities including ALMA. It also increases the overlap between the e-MERLIN
array and the European VLBI Network. We also discuss briefly some niche science
areas in which an e-MERLIN array which included a receptor at Goonhilly would
be potentially world-leading, in addition to enhancing the existing potential
of e-MERLIN in its role as a Square Kilometer Array pathfinder instrument.Comment: 7 pages, 3 figures, to appear in the proceedings of "Astronomy with
megastructures: Joint science with the E-ELT and SKA", 10-14 May 2010, Crete,
Greece (Eds: Isobel Hook, Dimitra Rigopoulou, Steve Rawlings and Aris
Karastergiou
Goonhilly: a new site for e-MERLIN and the EVN
The benefits for the e-MERLIN and EVN arrays of using antennae at the
satellite communication station at Goonhilly in Cornwall are discussed. The
location of this site - new to astronomy - will provide an almost equal
distribution of long baselines in the east-west- and north-south directions,
and opens up the possibility to get significantly improved observations of
equatorial fields with e-MERLIN. These additional baselines will improve the
sensitivity on a set of critical spatial scales and will increase the angular
resolution of e-MERLIN by a factor of two. e-MERLIN observations, including
many allocated under the e-MERLIN Legacy programme, will benefit from the
enhanced angular resolution and imaging capability especially for sources close
to or below the celestial equator (where ESO facilities such as ALMA will
operate) of including the Goonhilly telescopes. Furthermore, the baselines
formed between Goonhilly and the existing stations will close the gap between
the baselines of e-MERLIN and those of the European VLBI Network (EVN) and
therefore enhance the legacy value of e-MERLIN datasets.Comment: 10 pages, 2 figue
Assessing the impact of silicon nanowires on bacterial transformation and viability of Escherichia coli
We investigated the biomaterial interface between the bacteria Escherichia coli DH5α and silicon nanowire patterned surfaces. We optimised the engineering of silicon nanowire coated surfaces using metal-assisted chemical etching. Using a combination of focussed ion beam scanning electron microscopy, and cell viability and transformation assays, we found that with increasing interfacing force, cell viability decreases, as a result of increasing cell rupture. However, despite this aggressive interfacing regime, a proportion of the bacterial cell population remains viable. We found that the silicon nanowires neither resulted in complete loss of cell viability nor partial membrane disruption and corresponding DNA plasmid transformation. Critically, assay choice was observed to be important, as a reduction-based metabolic reagent was found to yield false-positive results on the silicon nanowire substrate. We discuss the implications of these results for the future design and assessment of bacteriaânanostructure interfacing experiments
MESMER: MeerKAT Search for Molecules in the Epoch of Reionization
[Abridged] Observations of molecular gas at all redshifts are critical for
measuring the cosmic evolution in molecular gas density and understanding the
star-formation history of the Universe. The 12CO molecule (J=1-0 transition =
115.27 GHz) is the best proxy for extragalactic H2, which is the gas reservoir
from which star formation occurs, and has been detected out to z~6. Typically,
redshifted high-J lines are observed at mm-wavelengths, the most commonly
targeted systems exhibiting high SFRs (e.g. submm galaxies), and far-IR-bright
QSOs. While the most luminous objects are the most readily observed, detections
of more typical galaxies with modest SFRs are essential for completing the
picture. ALMA will be revolutionary in terms of increasing the detection rate
and pushing the sensitivity limit down to include such galaxies, however the
limited FoV when observing at such high frequencies makes it difficult to use
ALMA for studies of the large-scale structure traced out by molecular gas in
galaxies. This article introduces a strategy for a systematic search for
molecular gas during the EoR (z~7 and above), capitalizing on the fact that the
J=1-0 transition of 12CO enters the upper bands of cm-wave instruments at
high-z. The FoV advantage gained by observing at such frequencies, coupled with
modern broadband correlators allows significant cosmological volumes to be
probed on reasonable timescales. In this article we present an overview of our
future observing programme which has been awarded 6,500 hours as one of the
Large Survey Projects for MeerKAT, the forthcoming South African SKA pathfinder
instrument. Its large FoV and correlator bandwidth, and high-sensitivity
provide unprecedented survey speed for such work. An existing astrophysical
simulation is coupled with instrumental considerations to demonstrate the
feasibility of such observations and predict detection rates.Comment: 7 pages, 4 figures, to appear in the proceedings of "Astronomy with
megastructures: Joint science with the E-ELT and SKA", 10-14 May 2010, Crete,
Greece (Eds: Isobel Hook, Dimitra Rigopoulou, Steve Rawlings and Aris
Karastergiou
Nodal discontinuous Galerkin methods on graphics processors
Discontinuous Galerkin (DG) methods for the numerical solution of partial differential equations have enjoyed considerable success because they are both flexible and robust: They allow arbitrary unstructured geometries and easy control of accuracy without compromising simulation stability. Lately, another property of DG has been growing in importance: The majority of a DG operator is applied in an element-local way, with weak penalty-based element-to-element coupling. The resulting locality in memory access is one of the factors that enables DG to run on off-the-shelf, massively parallel graphics processors (GPUs). In addition, DG's high-order nature lets it require fewer data points per represented wavelength and hence fewer memory accesses, in exchange for higher arithmetic intensity. Both of these factors work significantly in favor of a GPU implementation of DG. Using a single US$400 Nvidia GTX 280 GPU, we accelerate a solver for Maxwell's equations on a general 3D unstructured grid by a factor of around 50 relative to a serial computation on a current-generation CPU. In many cases, our algorithms exhibit full use of the device's available memory bandwidth. Example computations achieve and surpass 200 gigaflops/s of net application-level floating point work. In this article, we describe and derive the techniques used to reach this level of performance. In addition, we present comprehensive data on the accuracy and runtime behavior of the method. (C) 2009 Elsevier Inc. All rights reserved
Mindfulness training for depressed older adults using smartphone technology: Protocol for a fully remote precision clinical trial
BACKGROUND: Precision medicine, optimized interventions, and access to care are catchphrases for the future of behavioral treatments. Progress has been slow due to the dearth of clinical trials that optimize interventions\u27 benefits, individually tailor interventions to meet individual needs and preferences, and lead to rapid implementation after effectiveness is demonstrated. Two innovations have emerged to meet these challenges: fully remote trials and precision clinical trials.
OBJECTIVE: This paper provides a detailed description of Mindful MyWay, a study designed to test online mindfulness training in older adults with depression. Consistent with the concept of fully remote trials using a smartphone app, the study requires no in-person contact and can be conducted with participants anywhere in the United States. Based upon the precision medicine framework, the study assesses participants using high-frequency assessments of symptoms, cognitive performance, and patient preferences to both understand the individualized nature of treatment response and help individually tailor the intervention.
METHODS: Mindful MyWay is an open-label early-phase clinical trial for individuals 65 years and older with current depression. A smartphone app was developed to help coordinate the study, deliver the intervention, and evaluate the acceptability of the intervention, as well as predictors and outcomes of it. The curriculum for the fully remote intervention parallels the mindfulness-based stress reduction curriculum, a protocolized group-based mindfulness training that is typically provided in person. After consent and screening, participants download The Healthy Mind Lab mobile health smartphone app from the Apple App Store, allowing them to complete brief smartphone-based assessments of depressive symptoms and cognitive performance 4 times each day for 4 weeks prior to and after completing the intervention. The intervention consists of an introduction video and 10 weekly mindfulness training sessions, with the expectation to practice mindfulness at home daily. The app collects participant preference data throughout the 10-week intervention period; these high-frequency assessments identify participants\u27 individually dynamic preferences toward the goal of optimizing the intervention in future iterations.
RESULTS: Participant recruitment and data collection began in March 2019. Final end point assessments will be collected in May 2022. The paper describes lessons learned regarding the critical role of early-phase testing prior to moving to a randomized trial.
CONCLUSIONS: The Mindful MyWay study is an exemplar of innovative clinical trial designs that use smartphone technology in behavioral and neuropsychiatric conditions. These include fully remote studies that can recruit throughout the United States, including hard-to-access areas, and collect high-frequency data, which is ideal for idiographic assessment and individualized intervention optimization. Our findings will be used to modify our methods and inform future randomized controlled trials within a precision medicine framework.
TRIAL REGISTRATION: ClinicalTrials.gov NCT03922217; https://clinicaltrials.gov/ct2/show/NCT03922217.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/39233
Controlled dendrimersome nanoreactor system for localised hypochlorite-induced killing of bacteria
Antibiotic resistance is a serious global health problem necessitating new bactericidal approaches such as nanomedicines. Dendrimersomes (DSs) have recently become a valuable alternative nanocarrier to polymersomes and liposomes due to their molecular definition and synthetic versatility. Despite this, their biomedical application is still in its infancy. Inspired by the localized antimicrobial function of neutrophil phagosomes and the versatility of DSs, a simple three-component DS-based nanoreactor with broad-spectrum bactericidal activity is presented. This was achieved by encapsulation of glucose oxidase (GOX) and myeloperoxidase (MPO) within DSs (GOX-MPO-DSs), self-assembled from an amphiphilic Janus dendrimer, that possesses a semipermeable membrane. By external addition of glucose to GOX-MPO-DS, the production of hypochlorite (âOCl), a highly potent antimicrobial, by the enzymatic cascade was demonstrated. This cascade nanoreactor yielded a potent bactericidal effect against two important multidrug resistant pathogens, Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa), not observed for H2O2 producing nanoreactors, GOX-DS. The production of highly reactive species such as âOCl represents a harsh bactericidal approach that could also be cytotoxic to mammalian cells. This necessitates the development of strategies for activating âOCl production in a localized manner in response to a bacterial stimulus. One option of locally releasing sufficient amounts of substrate using a bacterial trigger (released toxins) was demonstrated with lipidic glucose-loaded giant unilamellar vesicles (GUVs), envisioning, e.g., implant surface modification with nanoreactors and GUVs for localized production of bactericidal agents in the presence of bacterial growth
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