Disinfection of wastewater using ultraviolet radiation

The disadvantages associated with the use of chlorine for disinfection, in conjunction with improvements in ultraviolet radiation disinfection technologies have led to the recent increased use of ultraviolet radiation to provide disinfection of effluents from wastewater treatment plants. The theory of ultraviolet radiation and the engineering design of the ultraviolet disinfection system are discussed in depth. The operational history and records of two wastewater treatment plants that use ultraviolet radiation for disinfection were analyzed in an attempt to develop correlations on the factors that affect ultraviolet radiation disinfection efficiency and to investigate as to whether disinfection with ultraviolet radiation is a legitimate alternative to disinfection with chlorine. One facility is a tertiary wastewater treatment plant while the other is a secondary facility. A high level of disinfection was consistently observed at the tertiary case study facility under the range of operating conditions encountered since the ultraviolet radiation system was put on-line in January 1991. The ultraviolet disinfection system at the secondary case study facility in general provided a satisfactory level of disinfection; however, it was subject to poor disinfection efficiencies upon high plant flows. Based on the performance of the two case study facilities, ultraviolet radiation disinfection systems can be successfully used to disinfect treated wastewater effluents from both secondary and tertiary facilities. Ultraviolet radiation does represent a reliable, safe and practical alternative to disinfection with chlorine

Noncommutative Superspace, N=1/2 Supersymmetry, Field Theory and String Theory

We deform the standard four dimensional $\N=1$ superspace by making the odd coordinates $\theta$ not anticommuting, but satisfying a Clifford algebra. Consistency determines the other commutation relations of the coordinates. In particular, the ordinary spacetime coordinates $x$ cannot commute. We study chiral superfields and vector superfields and their interactions. As in ordinary noncommutative field theory, a change of variables allows us to express the gauge interactions in terms of component fields which are subject to standard gauge transformation laws. Unlike ordinary noncommutative field theories, the change of the Lagrangian is a polynomial in the deformation parameter. Despite the deformation, the noncommutative theories still have an antichiral ring with all its usual properties. We show how these theories with precisely this deformation arise in string theory in a graviphoton background.Comment: 19 page

Nonparametric Bayesian inference for perturbed and orthologous gene regulatory networks

Motivation: The generation of time series transcriptomic datasets collected under multiple experimental conditions has proven to be a powerful approach for disentangling complex biological processes, allowing for the reverse engineering of gene regulatory networks (GRNs). Most methods for reverse engineering GRNs from multiple datasets assume that each of the time series were generated from networks with identical topology. In this study, we outline a hierarchical, non-parametric Bayesian approach for reverse engineering GRNs using multiple time series that can be applied in a number of novel situations including: (i) where different, but overlapping sets of transcription factors are expected to bind in the different experimental conditions; that is, where switching events could potentially arise under the different treatments and (ii) for inference in evolutionary related species in which orthologous GRNs exist. More generally, the method can be used to identify context-specific regulation by leveraging time series gene expression data alongside methods that can identify putative lists of transcription factors or transcription factor targets. Results: The hierarchical inference outperforms related (but non-hierarchical) approaches when the networks used to generate the data were identical, and performs comparably even when the networks used to generate data were independent. The method was subsequently used alongside yeast one hybrid and microarray time series data to infer potential transcriptional switches in Arabidopsis thaliana response to stress. The results confirm previous biological studies and allow for additional insights into gene regulation under various abiotic stresses. Availability: The methods outlined in this article have been implemented in Matlab and are available on request

Direct Integration and Non-Perturbative Effects in Matrix Models

We show how direct integration can be used to solve the closed amplitudes of multi-cut matrix models with polynomial potentials. In the case of the cubic matrix model, we give explicit expressions for the ring of non-holomorphic modular objects that are needed to express all closed matrix model amplitudes. This allows us to integrate the holomorphic anomaly equation up to holomorphic modular terms that we fix by the gap condition up to genus four. There is an one-dimensional submanifold of the moduli space in which the spectral curve becomes the Seiberg--Witten curve and the ring reduces to the non-holomorphic modular ring of the group $\Gamma(2)$. On that submanifold, the gap conditions completely fix the holomorphic ambiguity and the model can be solved explicitly to very high genus. We use these results to make precision tests of the connection between the large order behavior of the 1/N expansion and non-perturbative effects due to instantons. Finally, we argue that a full understanding of the large genus asymptotics in the multi-cut case requires a new class of non-perturbative sectors in the matrix model.Comment: 51 pages, 8 figure

Konishi anomaly approach to gravitational F-terms

We study gravitational corrections to the effective superpotential in theories with a single adjoint chiral multiplet, using the generalized Konishi anomaly and the gravitationally deformed chiral ring. We show that the genus one correction to the loop equation in the corresponding matrix model agrees with the gravitational corrected anomaly equations in the gauge theory. An important ingrediant in the proof is the lack of factorization of chiral gauge invariant operators in presence of a supergravity background. We also find a genus zero gravitational correction to the superpotential, which can be removed by a field redefinition.Comment: 28 pages, uses JHEP3.cl

Open/Closed String Duality for Topological Gravity with Matter

The exact FZZT brane partition function for topological gravity with matter is computed using the dual two-matrix model. We show how the effective theory of open strings on a stack of FZZT branes is described by the generalized Kontsevich matrix integral, extending the earlier result for pure topological gravity. Using the well-known relation between the Kontsevich integral and a certain shift in the closed-string background, we conclude that these models exhibit open/closed string duality explicitly. Just as in pure topological gravity, the unphysical sheets of the classical FZZT moduli space are eliminated in the exact answer. Instead, they contribute small, nonperturbative corrections to the exact answer through Stokes' phenomenon.Comment: 23 pages, 1 figure, harvma

D=2, N=2, Supersymmetric theories on Non(anti)commutative Superspace

The classical action of a two dimensional N=2 supersymmetric theory, characterized by a general K\"{a}hler potential, is written down on a non(anti)commutative superspace. The action has a power series expansion in terms of the determinant of the non(anti)commutativity parameter $C^{\alpha\beta}$. The theory is explicitly shown to preserve half of the N=2 supersymmetry, to all orders in (det C)^n. The results are further generalized to include arbitrary superpotentials as well.Comment: 32 pages, Latex; v2:minor typos corrected and a reference adde

ISA-TAB-Nano: A Specification for Sharing Nanomaterial Research Data in Spreadsheet-based Format

BACKGROUND AND MOTIVATION: The high-throughput genomics communities have been successfully using standardized spreadsheet-based formats to capture and share data within labs and among public repositories. The nanomedicine community has yet to adopt similar standards to share the diverse and multi-dimensional types of data (including metadata) pertaining to the description and characterization of nanomaterials. Owing to the lack of standardization in representing and sharing nanomaterial data, most of the data currently shared via publications and data resources are incomplete, poorly-integrated, and not suitable for meaningful interpretation and re-use of the data. Specifically, in its current state, data cannot be effectively utilized for the development of predictive models that will inform the rational design of nanomaterials. RESULTS: We have developed a specification called ISA-TAB-Nano, which comprises four spreadsheet-based file formats for representing and integrating various types of nanomaterial data. Three file formats (Investigation, Study, and Assay files) have been adapted from the established ISA-TAB specification; while the Material file format was developed de novo to more readily describe the complexity of nanomaterials and associated small molecules. In this paper, we have discussed the main features of each file format and how to use them for sharing nanomaterial descriptions and assay metadata. CONCLUSION: The ISA-TAB-Nano file formats provide a general and flexible framework to record and integrate nanomaterial descriptions, assay data (metadata and endpoint measurements) and protocol information. Like ISA-TAB, ISA-TAB-Nano supports the use of ontology terms to promote standardized descriptions and to facilitate search and integration of the data. The ISA-TAB-Nano specification has been submitted as an ASTM work item to obtain community feedback and to provide a nanotechnology data-sharing standard for public development and adoption

BPS black holes, the Hesse potential, and the topological string

The Hesse potential is constructed for a class of four-dimensional N=2 supersymmetric effective actions with S- and T-duality by performing the relevant Legendre transform by iteration. It is a function of fields that transform under duality according to an arithmetic subgroup of the classical dualities reflecting the monodromies of the underlying string compactification. These transformations are not subject to corrections, unlike the transformations of the fields that appear in the effective action which are affected by the presence of higher-derivative couplings. The class of actions that are considered includes those of the FHSV and the STU model. We also consider heterotic N=4 supersymmetric compactifications. The Hesse potential, which is equal to the free energy function for BPS black holes, is manifestly duality invariant. Generically it can be expanded in terms of powers of the modulus that represents the inverse topological string coupling constant, $g_s$, and its complex conjugate. The terms depending holomorphically on $g_s$ are expected to correspond to the topological string partition function and this expectation is explicitly verified in two cases. Terms proportional to mixed powers of $g_s$ and $\bar g_s$ are in principle present.Comment: 28 pages, LaTeX, added comment