Uzupeƚnienie artykuƚu ‘On known and less known relations of Leonhard Euler with Poland’ (DOI: 10.4467/23921749SHS.16.005.6148)

In this note we publish a short letter from Leonhard Euler’s son, Johann Albrecht Euler, the Secretary of the Imperial Academy in St. Petersburg, to Marcin Poczobutt-Odlanicki, the Vilnius astronomer. The fate of this letter seemed unknown, but we know its content now. The main news in this correspondence was the discovery of a comet by the astronomer Anders Johan Lexell.W tej nocie publikujemy krótki list Johanna Albrechta Eulera, sekretarza Rosyjskiej Akademii Nauk w St. Petersburgu do Marcina Poczobutta-Odlanickiego, astronoma wileńskiego. Los tego listu wydawaƚ się być nieznany, ale obecnie zostaƚ list ten zostaƚ zlokalizowany. Dokƚadnie znamy jego treść, której zasadniczą cześć stanowi informacja o odkryciu nowej komety przez astronoma Andersa Johana Lexella

Mach and Reynolds Number Effects on Transonic Buffet on the XRF-1 Transport Aircraft Wing at Flight Reynolds Number

This work provides an overview of aerodynamic data acquired in the European Transonic Windtunnel using an XRF-1 transport aircraft configuration both at cruise conditions and at the edges of the flight envelope. The goals and design of the wind tunnel test was described, highlighting the use of the cryogenic wind tunnel's capability to isolate the effects of Mach and Reynolds numbers and the dynamic pressure. The resulting dataset includes an aerodynamic baseline characterization of the full span model with vertical and horizontal tailplanes and without engine nacelles. The effects of different inflow conditions were studied using data from continuous polars, evaluating the changes in aeroelastic deformation which are proportional to $q/E$ and the influence of $M$ and $Re$ on the shock position. Off-design data was analyzed at the lowest and highest measured Mach numbers of 0.84 and 0.90, respectively. Wing lower surface flow and underside shock motion was analyzed at negative angles of attack using $c_p$ distribution and unsteady pressure transducer fluctuation data, identifying significant upstream displacement of the shock close to the leading edge. Wing upper side flow and the shock motion near buffet onset and beyond was analyzed using unsteady pressure data from point transducers and unsteady pressure sensitive paint (PSP) measurements. Buffet occurs at lower angles of attack at high Mach number, and without clearly defined lift break. Spectral contents at the acquired data points in the buffet range suggest broadband fluctuations at Strouhal numbers between 0.2 and 0.6, which is consistent with recent literature. The spanwise shock propagation velocities were determined independently via analysis of unsteady PSP and pressure transducers to be in the range between $u_s / u_{\infty} = 0.24$ and $0.32$

Heme Oxygenase-1 Induction and Organic Nitrate Therapy: Beneficial Effects on Endothelial Dysfunction, Nitrate Tolerance, and Vascular Oxidative Stress

Organic nitrates are a group of very effective anti-ischemic drugs. They are used for the treatment of patients with stable angina, acute myocardial infarction, and chronic congestive heart failure. A major therapeutic limitation inherent to organic nitrates is the development of tolerance, which occurs during chronic treatment with these agents, and this phenomenon is largely based on induction of oxidative stress with subsequent endothelial dysfunction. We therefore speculated that induction of heme oxygenase-1 (HO-1) could be an efficient strategy to overcome nitrate tolerance and the associated side effects. Indeed, we found that hemin cotreatment prevented the development of nitrate tolerance and vascular oxidative stress in response to chronic nitroglycerin therapy. Vice versa, pentaerithrityl tetranitrate (PETN), a nitrate that was previously reported to be devoid of adverse side effects, displayed tolerance and oxidative stress when the HO-1 pathway was blocked pharmacologically or genetically by using HO-1+/– mice. Recently, we identified activation of Nrf2 and HuR as a principle mechanism of HO-1 induction by PETN. With the present paper, we present and discuss our recent and previous findings on the role of HO-1 for the prevention of nitroglycerin-induced nitrate tolerance and for the beneficial effects of PETN therapy

Mach and Reynolds number effects on transonic buffet on the XRF‑1 transport aircraft wing at flight Reynolds number

This work provides an overview of aerodynamic data acquired in the European Transonic Windtunnel using an XRF-1 transport aircraft configuration both at cruise conditions and at the edges of the flight envelope. The goals and design of the wind tunnel test were described, highlighting the use of the cryogenic wind tunnel’s capability to isolate the effects of M∞, Re∞ and the dynamic pressure q/E. The resulting dataset includes an aerodynamic baseline characterization of the full span model with vertical and horizontal tailplanes and without engine nacelles. The effects of different inflow conditions were studied using data from continuous polars, evaluating the changes in aeroelastic deformation which are proportional to q/E and the influence of M∞ and Re∞ on the shock position. Off-design data was analyzed at the lowest and highest measured Mach numbers of 0.84 and 0.90, respectively. Wing lower surface flow and underside shock motion was analyzed at negative angles of attack using cp distribution and unsteady pressure transducer fluctuation data, identifying significant upstream displacement of the shock close to the leading edge. Wing upper-side flow and the shock motion near buffet onset and beyond was analyzed using unsteady pressure data from point transducers and unsteady pressure-sensitive paint (PSP) measurements. Buffet occurs at lower angles of attack at high Mach number, and without clearly defined lift break. Spectral contents at the acquired data points in the buffet range suggest broadband fluctuations at Strouhal numbers between 0.2 and 0.6, which is consistent with recent literature. The spanwise shock propagation velocities were determined independently via analysis of unsteady PSP and pressure transducers to be in the range between us∕u∞ = 0.24 and 0.32, which is similarly in line with published datasets using other swept wing aircraft models

Prevalence of Uncontrolled Hypertension in Patients With Fabry Disease

Background: Fabry disease is a rare X-linked disease arising from deficiency of α-galactosidase A. It results in early death related to renal, cardiac, and cerebrovascular disease, which are also important outcomes in patients with elevated blood pressure (BP). The prevalence of uncontrolled hypertension, as well as the effect of enzyme replacement therapy on BP, in patients with Fabry disease is unknown. Methods: We examined uncontrolled hypertension (systolic BP [SBP] ≥130 mm Hg or diastolic BP [DBP] ≥80 mm Hg) among 391 patients with Fabry disease who were participating in the Fabry Outcome Survey (FOS). Results: Uncontrolled hypertension was present in 57% of men and 47% of women. In patients with chronic kidney disease (CKD) stage 1 (n100), median SBP was 120 mm Hg and median DBP was 74 mm Hg. In patients with CKD stage 2 (n172), median SBP was 125 mm Hg and median DBP was 75 mm Hg. In patients with CKD stage 3 (n63), median SBP was 130 mm Hg and median DBP was 75 mm Hg. There was a significant decrease in both SBP and DBP during a 2-year course of enzyme replacement therapy. Conclusions: This study revealed a high prevalence of uncontrolled hypertension among patients with Fabry disease. Thus there is a need to improve BP control and renoprotection in patients with Fabry diseas

Airborne limb-imaging measurements of temperature, HNO3, O3, ClONO2, H2O and CFC-12 during the Arctic winter 2015/2016: characterization, in situ validation and comparison to Aura/MLS

The Gimballed Limb Observer for Radiance Imaging of the Atmosphere (GLORIA) was operated on board the German High Altitude and Long Range Research Aircraft (HALO) during the PGS (POLSTRACC/GW-LCYCLE/SALSA) aircraft campaigns in the Arctic winter 2015/2016. Research flights were conducted from 17 December 2015 until 18 March 2016 within 25–87°N, 80°W–30°E. From the GLORIA infrared limb-emission measurements, two-dimensional cross sections of temperature, HNO3, O3, ClONO2, H2O and CFC-12 are retrieved. During 15 scientific flights of the PGS campaigns the GLORIA instrument measured more than 15000 atmospheric profiles at high spectral resolution. Dependent on flight altitude and tropospheric cloud cover, the profiles retrieved from the measurements typically range between 5 and 14km, and vertical resolutions between 400 and 1000m are achieved. The estimated total (random and systematic) 1σ errors are in the range of 1 to 2K for temperature and 10% to 20% relative error for the discussed trace gases. Comparisons to in situ instruments deployed on board HALO have been performed. Over all flights of this campaign the median differences and median absolute deviations between in situ and GLORIA observations are −0.75 K ± 0.88K for temperature, −0.03 ppbv ± 0.85ppbv for HNO3, −3.5 ppbv ± 116.8ppbv for O3, −15.4 pptv ± 102.8pptv for ClONO2, −0.13 ppmv ± 0.63ppmv for H2O and −19.8 pptv ± 46.9pptv for CFC-12. Seventy-three percent of these differences are within twice the combined estimated errors of the cross-compared instruments. Events with larger deviations are explained by atmospheric variability and different sampling characteristics of the instruments. Additionally, comparisons of GLORIA HNO3 and O3 with measurements of the Aura Microwave Limb Sounder (MLS) instrument show highly consistent structures in trace gas distributions and illustrate the potential of the high-spectral-resolution limb-imaging GLORIA observations for resolving narrow mesoscale structures in the upper troposphere and lower stratosphere (UTLS)

Diurnal variations of BrONO₂ observed by MIPAS-B at midlatitudes and in the Arctic

The first stratospheric measurements of the diurnal variation in the inorganic bromine (Bry) reservoir species BrONO2 around sunrise and sunset are reported. Arctic flights of the balloon-borne Michelson Interferometer for Passive Atmospheric Sounding (MIPAS-B) were carried out from Kiruna (68° N, Sweden) in January 2010 and March 2011 inside the stratospheric polar vortices where diurnal variations of BrONO2 around sunrise have been observed. High nighttime BrONO2 volume mixing ratios of up to 21 pptv (parts per trillion by volume) were detected in late winter 2011 in the absence of polar stratospheric clouds (PSCs). In contrast, the amount of measured BrONO2 was significantly lower in January 2010 due to low available NO2 amounts (for the build-up of BrONO2), the heterogeneous destruction of BrONO2 on PSC particles, and the gas-phase interaction of BrO (the source to form BrONO2) with ClO. A further balloon flight took place at midlatitudes from Timmins (49° N, Canada) in September 2014. Mean BrONO2 mixing ratios of 22 pptv were observed after sunset in the altitude region between 21 and 29 km. Measurements are compared and discussed with the results of a multi-year simulation performed with the chemistry climate model ECHAM5/MESSy Atmospheric Chemistry (EMAC). The calculated temporal variation in BrONO2 largely reproduces the balloon-borne observations. Using the nighttime simulated ratio between BrONO2 and Bry, the amount of Bry observed by MIPAS-B was estimated to be about 21–25 pptv in the lower stratosphere

Global distribution of mean age of stratospheric air from MIPAS SF6 measurements

Global distributions of profiles of sulphur hexafluoride (SF6) have been retrieved from limb emission spectra recorded by the Michelson Interferometer for Passive Atmospheric Sounding (MIPAS) on Envisat covering the period September 2002 to March 2004. Individual SF6 profiles have a precision of 0.5 pptv below 25 km altitude and a vertical resolution of 4–6 km up to 35 km altitude. These data have been validated versus in situ observations obtained during balloon flights of a cryogenic whole-air sampler. For the tropical troposphere a trend of 0.230±0.008 pptv/yr has been derived from the MIPAS data, which is in excellent agreement with the trend from ground-based flask and in situ measurements from the National Oceanic and Atmospheric Administration Earth System Research Laboratory, Global Monitoring Division. For the data set currently available, based on at least three days of data per month, monthly 5° latitude mean values have a 1 o standard error of 1%. From the global SF6 distributions, global daily and monthly distributions of the apparent mean age of air are inferred by application of the tropical tropospheric trend derived from MIPAS data. The inferred mean ages are provided for the full globe up to 90° N/S, and have a 1 o standard error of 0.25 yr. They range between 0 (near the tropical tropopause) and 7 years (except for situations of mesospheric intrusions) and agree well with earlier observations. The seasonal variation of the mean age of stratospheric air indicates episodes of severe intrusion of mesospheric air during each Northern and Southern polar winter observed, long-lasting remnants of old, subsided polar winter air over the spring and summer poles, and a rather short period of mixing with midlatitude air and/or upward transport during fall in October/November (NH) and April/May (SH), respectively, with small latitudinal gradients, immediately before the new polar vortex starts to form. The mean age distributions further confirm that SF6 is destroyed in the mesosphere to a considerable degree. Model calculations with the Karlsruhe simulation model of the middle atmosphere (KASIMA) chemical transport model agree well with observed global distributions of the mean age only if the SF6 sink reactions in the mesosphere are included in the model

Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo.

The effect of acute inhibition of both mTORC1 and mTORC2 on metabolism is unknown. A single injection of the mTOR kinase inhibitor, AZD8055, induced a transient, yet marked increase in fat oxidation and insulin resistance in mice, whereas the mTORC1 inhibitor rapamycin had no effect. AZD8055, but not rapamycin reduced insulin-stimulated glucose uptake into incubated muscles, despite normal GLUT4 translocation in muscle cells. AZD8055 inhibited glycolysis in MEF cells. Abrogation of mTORC2 activity by SIN1 deletion impaired glycolysis and AZD8055 had no effect in SIN1 KO MEFs. Re-expression of wildtype SIN1 rescued glycolysis. Glucose intolerance following AZD8055 administration was absent in mice lacking the mTORC2 subunit Rictor in muscle, and in vivo glucose uptake into Rictor-deficient muscle was reduced despite normal Akt activity. Taken together, acute mTOR inhibition is detrimental to glucose homeostasis in part by blocking muscle mTORC2, indicating its importance in muscle metabolism in vivo