33 research outputs found

    Global Tipping Points Report 2023: Ch1.5: Climate tipping point interactions and cascades.

    Get PDF
    This chapter reviews interactions between climate tipping systems and assesses the potential risk of cascading effects. After a definition of tipping system interactions, we map out the current state of the literature on specific interactions between climate tipping systems that may be important for the overall stability of the climate system. For this, we gather evidence from model simulations, observations and conceptual understanding, as well as archetypal examples of palaeoclimate reconstructions where propagating transitions were potentially at play. This chapter concludes by identifying crucial knowledge gaps in tipping system interactions that should be resolved in order to improve risk assessments of cascading transitions under future climate change scenarios

    Erratum to: Methods for evaluating medical tests and biomarkers

    Get PDF
    [This corrects the article DOI: 10.1186/s41512-016-0001-y.]

    Evidence synthesis to inform model-based cost-effectiveness evaluations of diagnostic tests: a methodological systematic review of health technology assessments

    Get PDF
    Background: Evaluations of diagnostic tests are challenging because of the indirect nature of their impact on patient outcomes. Model-based health economic evaluations of tests allow different types of evidence from various sources to be incorporated and enable cost-effectiveness estimates to be made beyond the duration of available study data. To parameterize a health-economic model fully, all the ways a test impacts on patient health must be quantified, including but not limited to diagnostic test accuracy. Methods: We assessed all UK NIHR HTA reports published May 2009-July 2015. Reports were included if they evaluated a diagnostic test, included a model-based health economic evaluation and included a systematic review and meta-analysis of test accuracy. From each eligible report we extracted information on the following topics: 1) what evidence aside from test accuracy was searched for and synthesised, 2) which methods were used to synthesise test accuracy evidence and how did the results inform the economic model, 3) how/whether threshold effects were explored, 4) how the potential dependency between multiple tests in a pathway was accounted for, and 5) for evaluations of tests targeted at the primary care setting, how evidence from differing healthcare settings was incorporated. Results: The bivariate or HSROC model was implemented in 20/22 reports that met all inclusion criteria. Test accuracy data for health economic modelling was obtained from meta-analyses completely in four reports, partially in fourteen reports and not at all in four reports. Only 2/7 reports that used a quantitative test gave clear threshold recommendations. All 22 reports explored the effect of uncertainty in accuracy parameters but most of those that used multiple tests did not allow for dependence between test results. 7/22 tests were potentially suitable for primary care but the majority found limited evidence on test accuracy in primary care settings. Conclusions: The uptake of appropriate meta-analysis methods for synthesising evidence on diagnostic test accuracy in UK NIHR HTAs has improved in recent years. Future research should focus on other evidence requirements for cost-effectiveness assessment, threshold effects for quantitative tests and the impact of multiple diagnostic tests

    Erratum to: Methods for evaluating medical tests and biomarkers

    Get PDF
    [This corrects the article DOI: 10.1186/s41512-016-0001-y.]

    Chapter 4. Conclusions

    No full text
    Rapid and successful economic growth is not the sole prerogative of democratic governments, as the experiences of other less democratic governments in Asia (Taiwan, South Korea, Singapore under Lee Kwan Yu, and Indonesia under Suharto) have shown. Intellectuals within the Chinese and Vietnamese elite have not failed to notice this observation. On the other hand, the Vietnamese political system, here defined in terms of state-society relations, can no longer be viewed as a monolithically one p..

    Chapter 1. The political system: state-party relations reconsidered. Changing state, party and society relations

    No full text
    The political system: state-party relations reconsidered After reunification in 1976 the Vietnamese Politburo decided to extend the “DRV model” to the South, i.e., a Stalinist version of a planned economy with emphasis on rapid industrialization with State Owned Enterprises (SOEs), collectivization of agriculture, and strong capital accumulation. The Mekong delta was collectivized and rice trade came under state control. Between 1977 and 1979 the Second Five Year Plan failed as a result of th..

    Vietnam: One-Party State and the Mimicry of the Civil Society

    No full text
    Are the issues of civil society, “good governance”, and the role of NGOs in Vietnam part of a discursive discourse that is linked to a growing development industry in which development studies and economics dominate? Kleinen questions these issues based upon longitudinal research in Vietnam since the early 1990s. In this study, an effort is made to explain the concrete interactions between authorities of the Vietnamese one-party state and its citizens by introducing an attitude of participants to conceal their real intentions with the intent to disguise their actions in order to obtain benefits for their own. Using the concept of mimicry the author tries to grasp what it means to live in a society where political and economic life is dominated by elite groups and were social change is coming from different directions. Two case studies are presented here: one in which local stakeholders of home stay tourism achieve their goals to develop an acceptable form of co-habitation with ethnic minorities without questioning the state. Another case study focuses upon the rapid urbanization of the periphery of Hanoi where land grabbing and private economic gains of outsiders are at loggerheads with local experiences and perceptions of state-village relationships. The question remains what it means for Vietnam's modernization and the prospects of a civil society

    Làng Việt - Đối diện tương lai hồi sinh quá khứ

    No full text
    276 tr. ; 24 cm
    corecore