Cardiac troponin T and echocardiographic dimensions after repeated sprint vs. moderate intensity continuous exercise in healthy young males

Regular physical exercise can positively influence cardiac function; however, investigations have shown an increase of myocardial damage biomarkers after acute prolonged endurance exercises. We investigated the effect of repeated sprint vs. moderate long duration exercise on markers of myocardial necrosis, as well as cardiac dimensions and functions. Thirteen healthy males performed two different running sessions (randomized, single blinded cross-over design): 60 minutes moderate intensity continuous training (MCT, at 70% of peak heart rate (HRpeak)) and two series of 12 × 30-second sprints with set recovery periods in-between (RST, at 90% HRpeak). Venous blood samples for cardiac troponin T (cTnT), creatine kinase (CK) and MB isoenzyme (CK-MB) were taken 1 and 4 hours after exercise sessions. After each session electrocardiographic (ECG) and transthoracic echocardiographic (TTE) data were recorded. Results showed that all variables - average heart rate, serum lactate concentration during RST, subjective exertion and cTnT after RST - were significantly higher compared to MCT. CK and CK-MB significantly increased regardless of exercise protocol, while ECG and TTE indicated normal cardiac function. Our results provide evidence that RST contributes significantly to cTnT and CK release. This biomarker increase seems to reflect a physiological rather than a pathological phenomenon in healthy, exercising subjects

Prediabetes conversion to Normoglycemia is superior adding a low-carbohydrate and energy deficit formula diet to lifestyle intervention - a 12-month subanalysis of the ACOORH trial

Lifestyle interventions have been shown to reverse hyperglycemia to normoglycemia. However, these effects are not long-lasting and are accompanied with high dropout rates. As formula diets have been shown to be simple in usage and effective in improving glycemic control, we hypothesised that adding a low-carbohydrate and energy deficit formula diet to a low-intensity lifestyle intervention is superior in reversing prediabetes compared with lifestyle intervention alone. In this predefined subanalysis of an international, multicenter randomised controlled trial (Almased Concept against Overweight and Obesity and Related Health Risk (ACOORH) study (ID DRKS00006811)), 141 persons with prediabetes were randomised (1:2) into either a control group with lifestyle intervention only (CON, n = 45) or a lifestyle intervention group accompanied with a formula diet (INT, n = 96). Both groups were equipped with telemonitoring devices. INT received a low-carbohydrate formula diet substituting three meals/day (~1200 kcal/day) within the first week, two meals/day during week 2–4, and one meal/day during week 5–26 (1300–1500 kcal/day). Follow-up was performed after 52 weeks and 105 participants (75%, INT: n = 74; CON: n = 31) finished the 26-week intervention phase. Follow-up data after 52 weeks were available from 93 participants (66%, INT: n = 65; CON: n = 28). Compared with CON, significantly more INT participants converted to normoglycemia after 52 weeks (50% vs. 31%; p 0.05). The risk reduction led to a number-needed-to-treat of 5.3 for INT. Lifestyle intervention with a low-carbohydrate formula diet reduces prediabetes prevalence stronger than lifestyle intervention alone and is effective for type 2 diabetes prevention

50 Jahre Neubau Universitätsbibliothek Stuttgart 2011

T e i l 1 Impressum, Sponsoren - Seite 4 Stephan, Werner: Einleitung und Dank - Seite 9 Einfachheit in Form und Material - less is more: Klaus-Jürgen Zabel über den Bau der Universitätsbibliothek (Interview mit Ottmar Pertschi und Christiane Rambach) - Seite 13 Paulus, Stefan: Amerika als Vorbild? Anmerkungen zu den politischen und kulturhistorischen Bedingungen an (west)deutschen Universitäten in den 1950er Jahren - Seite 19 Hering, Jürgen: Max Kade und die Technische Hochschule Stuttgart - Seite 41 Becker, Norbert: Die Technische Hochschule Stuttgart und ihre Bibliothek in der Nachkriegszeit - Seite 63 T e i l 2 Rambach, Christiane: Eine Bibliothek sucht ihren Standort - Seite 75 T e i l 3 Rambach, Christiane: Architekten auf Reisen: "new standards in library design" in Stuttgart - Seite 97 T e i l 4 Philipp, Klaus Jan: Die Universitätsbibliothek im architekturgeschichtlichen Kontext - Seite 125 Huster-Braumann, Henriette: Maximilian Debus: die Universitätsbibliothek und ihre Schrift - Seite 145 T e i l 5 Jost, Holger; Stürzebecher, Jörg: Moderate Moderne: Innenraumgestaltung der Universitätsbibliothek Stuttgart - Seite 153 T e i l 6 Küster, Bärbel: Kunst und Konsens 1958 - 1962: zur Ankaufsgeschichte der Plastik von Hans Uhlmann für die Universitätsbibliothek Stuttgart - Seite 171 Szymczyk-Eggert, Elisabeth: Die Zweigbibliothek auf dem Campus in Stuttgart-Vaihingen: vom Provisorium zur Dauereinrichtung - Seite 191 T e i l 7 Stephan, Werner: Bibliotheken der Zukunft - Seite 221 T e i l 8 Anhang: Architekten der Universitätsbibliothek: Volkart, Zabel, Klauss und Koschlig (Christiane Rambach) - Seite 233 Richtfest am 31. Juli 1959 (Schwäbisches Stück zum Richtfest der THB am 31. Juli 1959 von Hans Volkart - Richtspruch des Zimmerpoliers der AG Kübler und Züblin zum Richtfest der Universitätsbibliothek am 31. Juli 1959) - Seite 237 "Es lebe die Bibliothek!" Interne Bibliothekseinweihung am 17. Februar 1962 - Seite 243 Skizzen (Gedanken zu einem Anbau an die Universitätsbibliothek Stuttgart von Klaus-Jürgen Zabel 2011 - Ihre Universitätsbibliothek zum Selberbauen von Stefan Pertschi) - Seite 247 Literatur zum Bau der Universitätsbibliothek Stuttgart (eine Auswahl - Christiane Rambach) - Seite 253 Abkürzungsverzeichnis, Abbildungsnachweise - Seite 258 Namen- und Sachregister (Ottmar Pertschi) - Seite 263 Autorenverzeichnis - S. 27

TRITEX : chromosome-scale sequence assembly of Triticeae genomes with open-source tools

Chromosome-scale genome sequence assemblies underpin pan-genomic studies. Recent genome assembly efforts in the large-genome Triticeae crops wheat and barley have relied on the commercial closed-source assembly algorithm DeNovoMagic. We present TRITEX, an open-source computational workflow that combines paired-end, mate-pair, 10X Genomics linked-read with chromosome conformation capture sequencing data to construct sequence scaffolds with megabase-scale contiguity ordered into chromosomal pseudomolecules. We evaluate the performance of TRITEX on publicly available sequence data of tetraploid wild emmer and hexaploid bread wheat, and construct an improved annotated reference genome sequence assembly of the barley cultivar Morex as a community resource.Peer reviewe

High-protein, low-glycaemic meal replacement decreases fasting insulin and inflammation markers — a 12-month subanalysis of the ACOORH trial

Abstract: Lifestyle interventions, including meal replacement, are effective in the prevention and treatment of type-2-diabetes and overweight. Since insulin is the key weight regulator, we hypothesised that addition of meal replacement to a lifestyle intervention reduces insulin levels more effective than lifestyle intervention alone. In the international, multicenter randomised-controlled ACOORH-trial (Almased-Concept-against-Overweight-and-Obesity-and-Related-Health-Risk) overweight or obese persons with criteria of metabolic syndrome (n=463) were randomised into two groups. Both groups received nutritional advice focussing on carbohydrate restriction and telemonitoring devices. The intervention group substituted all three main meals/day in week 1, two meals/day in week 2–4, and one meal/day in week 5–26 with a protein-rich, low-glycaemic meal replacement. Data were collected at baseline, after 1, 3, 6 and 12 months. All datasets providing insulin data (n=446) were included in this predefined subanalysis. Significantly stronger reductions of insulin (-3.3±8.7μU/ml vs. -1.6±9.8μU/ml), weight (-6.1±5.kg vs. -3.2±4.6kg) and inflammation markers were observed in the intervention group. Insulin reduction correlated with weight reduction and strongest weight loss (-7.6±4.9kg) was observed in those participants with insulin decrease >2μU/ml. These results underline the potential of meal replacement-based lifestyle interventions in diabetes prevention, and measurement of insulin may serve as an indicator for adherence to carbohydrate restriction

Effects of a protein-rich, low-glycaemic meal replacement on changes in dietary intake and body weight following a weight-management intervention—the ACOORH trial

Although meal replacement can lead to weight reduction, there is uncertainty whether this dietary approach implemented into a lifestyle programme can improve long-term dietary intake. In this subanalysis of the Almased Concept against Overweight and Obesity and Related Health Risk (ACOORH) study (n = 463), participants with metabolic risk factors were randomly assigned to either a meal replacement-based lifestyle intervention group (INT) or a lifestyle intervention control group (CON). This subanalysis relies only on data of participants (n = 119) who returned correctly completed dietary records at baseline, and after 12 and 52 weeks. Both groups were not matched for nutrient composition at baseline. These data were further stratified by sex and also associated with weight change. INT showed a higher increase in protein intake related to the daily energy intake after 12 weeks (+6.37% [4.69; 8.04] vs. +2.48% [0.73; 4.23], p 0.001) of intervention compared to CON. Fat and carbohydrate intake related to the daily energy intake were more strongly reduced in the INT compared to CON (both p 0.01). After sex stratification, particularly INT-women increased their total protein intake after 12 (INT: +12.7 g vs. CON: −5.1 g, p = 0.021) and 52 weeks (INT: +5.7 g vs. CON: −16.4 g, p = 0.002) compared to CON. Protein intake was negatively associated with weight change (r = −0.421; p 0.001) after 12 weeks. The results indicate that a protein-rich dietary strategy with a meal replacement can improve long-term nutritional intake, and was associated with weight loss

Early and strong leptin reduction is predictive for long-term weight loss during high-protein, low-glycaemic meal replacement: a subanalysis of the randomised-controlled ACOORH trial

Lifestyle interventions including meal replacement are suitable for prevention and treatment of obesity and type-2-diabetes. Since leptin is involved in weight regulation, we hypothesised that a meal replacement-based lifestyle intervention would reduce leptin levels more effectively than lifestyle intervention alone. In the international, multicentre, randomised-controlled ACOORH-trial (Almased-Concept-against-Overweight-and-Obesity-and-Related- Health-Risk), overweight or obese participants with metabolic syndrome criteria ( = 463) were randomised into two groups and received telemonitoring devices and nutritional advice. The intervention group additionally used a protein-rich, low-glycaemic meal replacement. Data were collected at baseline, after 1, 3, 6, and 12 months. All datasets providing leptin data ( = 427) were included in this predefined subanalysis. Serum leptin levels significantly correlated with sex, body mass index, weight, and fat mass at baseline ( < 0.0001). Stronger leptin reduction has been observed in the intervention compared to the control group with the lowest levels after 1 month of intervention (estimated treatment difference -3.4 µg/L [1.4; 5.4] for females; -2.2 µg/L [1.2; 3.3] for males; < 0.001 each) and was predictive for stronger reduction of body weight and fat mass ( < 0.001 each) over 12 months. Strongest weight loss was observed after 6 months (-5.9 ± 5.1 kg in females of the intervention group vs. -2.9 ± 4.9 kg in the control group ( < 0.0001); -6.8 ± 5.3 kg vs. -4.1 ± 4.4 kg ( = 0.003) in males) and in those participants with combined leptin and insulin decrease. A meal replacement-based lifestyle intervention effectively reduces leptin which is predictive for long-term weight loss

A chromosome conformation capture ordered sequence of the barley genome

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