Diagnostic value of far-IR water ice features in T Tauri disks

This paper investigates how the far-IR water ice features can be used to infer properties of disks around T Tauri stars and the water ice thermal history. We explore the power of future observations with SOFIA/HIRMES and SPICA's proposed far-IR instrument SAFARI. A series of detailed radiative transfer disk models around a representative T Tauri star are used to investigate how the far-IR water ice features at 45 and 63 micron change with key disk properties: disk size, grain sizes, disk dust mass, dust settling, and ice thickness. In addition, a series of models is devised to calculate the water ice emission features from warmup, direct deposit and cooldown scenarios of the water ice in disks. Photodesorption from icy grains in disk surfaces weakens the mid-IR water ice features by factors 4-5. The far-IR water ice emission features originate from small grains at the surface snow line in disks at distance of 10-100 au. Unless this reservoir is missing in disks (e.g. transitional disks with large cavities), the feature strength is not changing. Grains larger than 10 micron do not contribute to the features. Grain settling (using turbulent description) is affecting the strength of the ice features by at most 15%. The strength of the ice feature scales with the disk dust mass and water ice fraction on the grains, but saturates for dust masses larger than 1.e-4 Msun and for ice mantles that increase the dust mass by more than 50%. The various thermal histories of water ice leave an imprint on the shape of the features (crystalline/amorphous) as well as on the peak strength and position of the 45 micron feature. SOFIA/HIRMES can only detect crystalline ice features much stronger than simulated in our standard T Tauri disk model in deep exposures (1 hr). SPICA/SAFARI can detect the typical ice features in our standard T Tauri disk model in short exposures (10 min). (abbreviated)Comment: accepted for publication in A&

A tunnel and a traffic jam: How transition disks maintain a detectable warm dust component despite the presence of a large planet-carved gap

We combined hydrodynamical simulations of planet-disk interactions with dust evolution models that include coagulation and fragmentation of dust grains over a large range of radii and derived observational properties using radiative transfer calculations. We studied the role of the snow line in the survival of the inner disk of transition disks. Inside the snow line, the lack of ice mantles in dust particles decreases the sticking efficiency between grains. As a consequence, particles fragment at lower collision velocities than in regions beyond the snow line. This effect allows small particles to be maintained for up to a few Myrs within the first astronomical unit. These particles are closely coupled to the gas and do not drift significantly with respect to the gas. For lower mass planets (1$M_{\rm{Jup}}$), the pre-transition appearance can be maintained even longer because dust still trickles through the gap created by the planet, moves invisibly and quickly in the form of relatively large grains through the gap, and becomes visible again as it fragments and gets slowed down inside of the snow line. The global study of dust evolution of a disk with an embedded planet, including the changes of the dust aerodynamics near the snow line, can explain the concentration of millimetre-sized particles in the outer disk and the survival of the dust in the inner disk if a large dust trap is present in the outer disk. This behaviour solves the conundrum of the combination of both near-infrared excess and ring-like millimetre emission observed in several transition disks.Comment: Accepted for publication in A&A (including acknowledgments

GLI1 Confers Profound Phenotypic Changes upon LNCaP Prostate Cancer Cells That Include the Acquisition of a Hormone Independent State

The GLI (GLI1/GLI2) transcription factors have been implicated in the development and progression of prostate cancer although our understanding of how they actually contribute to the biology of these common tumours is limited. We observed that GLI reporter activity was higher in normal (PNT-2) and tumourigenic (DU145 and PC-3) androgen-independent cells compared to androgen-dependent LNCaP prostate cancer cells and, accordingly, GLI mRNA levels were also elevated. Ectopic expression of GLI1 or the constitutively active ΔNGLI2 mutant induced a distinct cobblestone-like morphology in LNCaP cells that, regarding the former, correlated with increased GLI2 as well as expression of the basal/stem-like markers CD44, β1-integrin, ΔNp63 and BMI1, and decreased expression of the luminal marker AR (androgen receptor). LNCaP-GLI1 cells were viable in the presence of the AR inhibitor bicalutamide and gene expression profiling revealed that the transcriptome of LNCaP-GLI1 cells was significantly closer to DU145 and PC-3 cells than to control LNCaP-pBP (empty vector) cells, as well as identifying LCN2/NGAL as a highly induced transcript which is associated with hormone independence in breast and prostate cancer. Functionally, LNCaP-GLI1 cells displayed greater clonal growth and were more invasive than control cells but they did not form colonies in soft agar or prostaspheres in suspension suggesting that they do not possess inherent stem cell properties. Moreover, targeted suppression of GLI1 or GLI2 with siRNA did not reverse the transformed phenotype of LNCaP-GLI1 cells nor did double GLI1/GLI2 knockdowns activate AR expression in DU145 or PC-3 cells. As such, early targeting of the GLI oncoproteins may hinder progression to a hormone independent state but a more detailed understanding of the mechanisms that maintain this phenotype is required to determine if their inhibition will enhance the efficacy of anti-hormonal therapy through the induction of a luminal phenotype and increased dependency upon AR function

A Realistic Roadmap to Formation Flying Space Interferometry

The ultimate astronomical observatory would be a formation flying space interferometer, combining sensitivity and stability with high angular resolution. The smallSat revolution offers a new and maturing prototyping platform for space interferometry and we put forward a realistic plan for achieving first stellar fringes in space by 2030

Thermal imaging of dust hiding the black hole in NGC 1068

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Thermal imaging of dust hiding the black hole in the Active Galaxy NGC 1068

In the widely accepted 'Unified Model' solution of the classification puzzle of Active Galactic Nuclei, the orientation of a dusty accretion torus around the central black hole dominates their appearance. In 'type-1' systems, the bright nucleus is visible at the centre of a face-on torus. In 'type-2' systems the thick, nearly edge-on torus hides the central engine. Later studies suggested evolutionary effects and added dusty clumps and polar winds but left the basic picture intact. However, recent high-resolution images of the archetypal type-2 galaxy NGC 1068 suggested a more radical revision. They displayed a ring-like emission feature which the authors advocated to be hot dust surrounding the black hole at the radius where the radiation from the central engine evaporates the dust. That ring is too thin and too far tilted from edge-on to hide the central engine, and ad hoc foreground extinction is needed to explain the type-2 classification. These images quickly generated reinterpretations of the type 1-2 dichotomy. Here we present new multi-band mid-infrared images of NGC1068 that detail the dust temperature distribution and reaffirm the original model. Combined with radio data, our maps locate the central engine below the previously reported ring and obscured by a thick, nearly edge-on disk, as predicted by the Unified Model. We also identify emission from polar flows and absorbing dust that is mineralogically distinct from that towards the Milky Way centre

Thermal imaging of dust hiding the black hole in the Active Galaxy NGC 1068

In the widely accepted 'Unified Model' solution of the classification puzzle of Active Galactic Nuclei, the orientation of a dusty accretion torus around the central black hole dominates their appearance. In 'type-1' systems, the bright nucleus is visible at the centre of a face-on torus. In 'type-2' systems the thick, nearly edge-on torus hides the central engine. Later studies suggested evolutionary effects and added dusty clumps and polar winds but left the basic picture intact. However, recent high-resolution images of the archetypal type-2 galaxy NGC 1068 suggested a more radical revision. They displayed a ring-like emission feature which the authors advocated to be hot dust surrounding the black hole at the radius where the radiation from the central engine evaporates the dust. That ring is too thin and too far tilted from edge-on to hide the central engine, and ad hoc foreground extinction is needed to explain the type-2 classification. These images quickly generated reinterpretations of the type 1-2 dichotomy. Here we present new multi-band mid-infrared images of NGC1068 that detail the dust temperature distribution and reaffirm the original model. Combined with radio data, our maps locate the central engine below the previously reported ring and obscured by a thick, nearly edge-on disk, as predicted by the Unified Model. We also identify emission from polar flows and absorbing dust that is mineralogically distinct from that towards the Milky Way centre

Thermal imaging of dust hiding the black hole in the Active Galaxy NGC 1068

In the widely accepted 'Unified Model' solution of the classification puzzle of Active Galactic Nuclei, the orientation of a dusty accretion torus around the central black hole dominates their appearance. In 'type-1' systems, the bright nucleus is visible at the centre of a face-on torus. In 'type-2' systems the thick, nearly edge-on torus hides the central engine. Later studies suggested evolutionary effects and added dusty clumps and polar winds but left the basic picture intact. However, recent high-resolution images of the archetypal type-2 galaxy NGC 1068 suggested a more radical revision. They displayed a ring-like emission feature which the authors advocated to be hot dust surrounding the black hole at the radius where the radiation from the central engine evaporates the dust. That ring is too thin and too far tilted from edge-on to hide the central engine, and ad hoc foreground extinction is needed to explain the type-2 classification. These images quickly generated reinterpretations of the type 1-2 dichotomy. Here we present new multi-band mid-infrared images of NGC1068 that detail the dust temperature distribution and reaffirm the original model. Combined with radio data, our maps locate the central engine below the previously reported ring and obscured by a thick, nearly edge-on disk, as predicted by the Unified Model. We also identify emission from polar flows and absorbing dust that is mineralogically distinct from that towards the Milky Way centre

Thermal imaging of dust hiding the black hole in the Active Galaxy NGC 1068

In press at NatureIn the widely accepted 'Unified Model' solution of the classification puzzle of Active Galactic Nuclei, the orientation of a dusty accretion torus around the central black hole dominates their appearance. In 'type-1' systems, the bright nucleus is visible at the centre of a face-on torus. In 'type-2' systems the thick, nearly edge-on torus hides the central engine. Later studies suggested evolutionary effects and added dusty clumps and polar winds but left the basic picture intact. However, recent high-resolution images of the archetypal type-2 galaxy NGC 1068 suggested a more radical revision. They displayed a ring-like emission feature which the authors advocated to be hot dust surrounding the black hole at the radius where the radiation from the central engine evaporates the dust. That ring is too thin and too far tilted from edge-on to hide the central engine, and ad hoc foreground extinction is needed to explain the type-2 classification. These images quickly generated reinterpretations of the type 1-2 dichotomy. Here we present new multi-band mid-infrared images of NGC1068 that detail the dust temperature distribution and reaffirm the original model. Combined with radio data, our maps locate the central engine below the previously reported ring and obscured by a thick, nearly edge-on disk, as predicted by the Unified Model. We also identify emission from polar flows and absorbing dust that is mineralogically distinct from that towards the Milky Way centre

Astro2020 Science White Paper. The Future of Exoplanet Direct Detection

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