336 research outputs found
Magnetic helicity transported by flux emergence and shuffling motions in Solar Active Region NOAA 10930
We present a new methodology which can determine magnetic helicity transport
by the passage of helical magnetic field lines from sub-photosphere and the
shuffling motions of foot-points of preexisting coronal field lines separately.
It is well known that only the velocity component which is perpendicular to the
magnetic field () has contribution to the helicity
accumulation. Here, we demonstrate that can be deduced
from horizontal motion and vector magnetograms, under a simple relation of
as suggested by
Dmoulin & Berger (2003). Then after dividing
into two components, as one is tangential and the other is normal to the solar
surface, we can determine both terms of helicity transport. Active region (AR)
NOAA 10930 is analyzed as an example during its solar disk center passage by
using data obtained by the Spectro-Polarimeter and the Narrowband Filter Imager
of Solar Optical Telescope on board Hinode. We find that in our calculation,
the helicity injection by flux emergence and shuffling motions have the same
sign. During the period we studied, the main contribution of helicity
accumulation comes from the flux emergence effect, while the dynamic transient
evolution comes from the shuffling motions effect. Our observational results
further indicate that for this AR, the apparent rotational motion in the
following sunspot is the real shuffling motions on solar surface
Field-Induced Magnetic Transitions in Single Crystals of RZn_2 ( R=Pr, Nd, Dy )(Magnetism)
Temperature dependence of magnetic susceptibility and high field magnetism are studied for single crystals of antiferromagnetic compounds PrZn_2, NdZn_2 and DyZn_2. The paramagnetic Curie temperatures are anisotropic and different field-induced transitions are observed along each crystal axis direction
Chromospheric Anemone Jets as Evidence of Ubiquitous Reconnection
The heating of the solar chromosphere and corona is a long-standing puzzle in
solar physics. Hinode observations show the ubiquitous presence of
chromospheric anemone jets outside sunspots in active regions. They are
typically 3 to 7 arc seconds = 2000 to 5000 kilometers long and 0.2 to 0.4 arc
second = 150 to 300 kilometers wide, and their velocity is 10 to 20 kilometers
per second. These small jets have an inverted Y-shape, similar to the shape of
x-ray anemone jets in the corona. These features imply that magnetic
reconnection similar to that in the corona is occurring at a much smaller
spatial scale throughout the chromosphere and suggest that the heating of the
solar chromosphere and corona may be related to small-scale ubiquitous
reconnection.Comment: 10 pages, 5 figure
Chemotherapeutic Treatment of Priapism in Metastatic Rectal Cancer
A 65-year-old man was admitted with penile tenderness and dysuria due to priapism. Enhanced computed tomography revealed metastatic tumors in the liver, lung, sacrum and lymph nodes. Advanced rectal cancer, detected by colonoscopy as a primary tumor, was treated with chemotherapy (FOLFOX4). Although the rectal cancer showed no change, five months of chemotherapy improveid the priapism, suggesting that chemotherapy can improve rare symptoms of rectal cancer
Evolution and Flare Activity of Delta-Sunspots in Cycle 23
The emergence and magnetic evolution of solar active regions (ARs) of
beta-gamma-delta type, which are known to be highly flare-productive, were
studied with the SOHO/MDI data in Cycle 23. We selected 31 ARs that can be
observed from their birth phase, as unbiased samples for our study. From the
analysis of the magnetic topology (twist and writhe), we obtained the following
results. i) Emerging beta-gamma-delta ARs can be classified into three
topological types as "quasi-beta", "writhed" and "top-to-top". ii) Among them,
the "writhed" and "top-to-top" types tend to show high flare activity. iii) As
the signs of twist and writhe agree with each other in most cases of the
"writhed" type (12 cases out of 13), we propose a magnetic model in which the
emerging flux regions in a beta-gamma-delta AR are not separated but united as
a single structure below the solar surface. iv) Almost all the "writhed"-type
ARs have downward knotted structures in the mid portion of the magnetic flux
tube. This, we believe, is the essential property of beta-gamma-delta ARs. v)
The flare activity of beta-gamma-delta ARs is highly correlated not only with
the sunspot area but also with the magnetic complexity. vi) We suggest that
there is a possible scaling-law between the flare index and the maximum umbral
area
Comprehensive Mapping of Common Immunodominant Epitopes in the West Nile Virus Nonstructural Protein 1 Recognized by Avian Antibody Responses
West Nile virus (WNV) is a mosquito-borne flavivirus that primarily infects birds but occasionally infects humans and horses. Certain species of birds, including crows, house sparrows, geese, blue jays and ravens, are considered highly susceptible hosts to WNV. The nonstructural protein 1 (NS1) of WNV can elicit protective immune responses, including NS1-reactive antibodies, during infection of animals. The antigenicity of NS1 suggests that NS1-reactive antibodies could provide a basis for serological diagnostic reagents. To further define serological reagents for diagnostic use, the antigenic sites in NS1 that are targeted by host immune responses need to be identified and the potential diagnostic value of individual antigenic sites also needs to be defined. The present study describes comprehensive mapping of common immunodominant linear B-cell epitopes in the WNV NS1 using avian WNV NS1 antisera. We screened antisera from chickens, ducks and geese immunized with purified NS1 for reactivity against 35 partially overlapping peptides covering the entire WNV NS1. This study identified twelve, nine and six peptide epitopes recognized by chicken, duck and goose antibody responses, respectively. Three epitopes (NS1-3, 14 and 24) were recognized by antibodies elicited by immunization in all three avian species tested. We also found that NS1-3 and 24 were WNV-specific epitopes, whereas the NS1-14 epitope was conserved among the Japanese encephalitis virus (JEV) serocomplex viruses based on the reactivity of avian WNV NS1 antisera against polypeptides derived from the NS1 sequences of viruses of the JEV serocomplex. Further analysis showed that the three common polypeptide epitopes were not recognized by antibodies in Avian Influenza Virus (AIV), Newcastle Disease Virus (NDV), Duck Plague Virus (DPV) and Goose Parvovirus (GPV) antisera. The knowledge and reagents generated in this study have potential applications in differential diagnostic approaches and subunit vaccines development for WNV and other viruses of the JEV serocomplex
IFNβ Protects Neurons from Damage in a Murine Model of HIV-1 Associated Brain Injury.
Infection with human immunodeficiency virus-1 (HIV-1) causes brain injury. Type I interferons (IFNα/β) are critical mediators of any anti-viral immune response and IFNβ has been implicated in the temporary control of lentiviral infection in the brain. Here we show that transgenic mice expressing HIV-1 envelope glycoprotein 120 in their central nervous system (HIVgp120tg) mount a transient IFNβ response and provide evidence that IFNβ confers neuronal protection against HIVgp120 toxicity. In cerebrocortical cell cultures, neuroprotection by IFNβ against gp120 toxicity is dependent on IFNα receptor 1 (IFNAR1) and the β-chemokine CCL4, as IFNAR1 deficiency and neutralizing antibodies against CCL4, respectively, abolish the neuroprotective effects. We find in vivo that IFNβ mRNA is significantly increased in HIVgp120tg brains at 1.5, but not 3 or 6 months of age. However, a four-week intranasal IFNβ treatment of HIVgp120tg mice starting at 3.5 months of age increases expression of CCL4 and concomitantly protects neuronal dendrites and pre-synaptic terminals in cortex and hippocampus from gp120-induced damage. Moreover, in vivo and in vitro data suggests astrocytes are a major source of IFNβ-induced CCL4. Altogether, our results suggest exogenous IFNβ as a neuroprotective factor that has potential to ameliorate in vivo HIVgp120-induced brain injury
Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high-effort behavior
Midbrain dopamine neurons are crucial for many behavioral and cognitive functions. As the major excitatory input, glutamatergic afferents are important for control of the activity and plasticity of dopamine neurons. However, the role of glutamatergic input as a whole onto dopamine neurons remains unclear. Here we developed a mouse line in which glutamatergic inputs onto dopamine neurons are specifically impaired, and utilized this genetic model to directly test the role of glutamatergic inputs in dopamine-related functions. We found that while motor coordination and reward learning were largely unchanged, these animals showed prominent deficits in effort-related behavioral tasks. These results provide genetic evidence that glutamatergic transmission onto dopaminergic neurons underlies incentive motivation, a willingness to exert high levels of effort to obtain reinforcers, and have important implications for understanding the normal function of the midbrain dopamine system.Fil: Hutchison, M. A.. National Institutes of Health; Estados UnidosFil: Gu, X.. National Institutes of Health; Estados UnidosFil: Adrover, Martín Federico. National Institutes of Health; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Lee, M. R.. National Institutes of Health; Estados UnidosFil: Hnasko, T. S.. University of California at San Diego; Estados UnidosFil: Alvarez, V. A.. National Institutes of Health; Estados UnidosFil: Lu, W.. National Institutes of Health; Estados Unido
Usefulness of blood supply visualization by indocyanine green fluorescence for reconstruction during esophagectomy
Meta-Analysis of the Prognostic Impact of Anemia in Patients Undergoing Percutaneous Coronary Intervention
This study was funded by an award from the North Staffordshire Medical Institute, Stoke-on-Trent, United Kingdom.Peer reviewedPostprin
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